Endogenous fibrinolytic system in chronic large-vessel thromboembolic pulmonary hypertension.

abstract：BACKGROUND:Drug-coated balloons (DCBs) are a predominant revascularization therapy for symptomatic femoropopliteal artery disease. Because of the differences in excipients, paclitaxel dose, and coating morphologies, varying clinical outcomes have been observed with different DCBs. We report the results of 2 studies inv...

journal_title：Circulation

authors： Krishnan P,Faries P,Niazi K,Jain A,Sachar R,Bachinsky WB,Cardenas J,Werner M,Brodmann M,Mustapha JA,Mena-Hurtado C,Jaff MR,Holden AH,Lyden SP

更新日期：2017-09-19 00:00:00

abstract：BACKGROUND:In patients with acute myocardial infarction (AMI), hyperglycemia predicts death, but the prognostic significance of hypoglycemia is controversial. METHODS AND RESULTS:We evaluated the prognostic significance of hypoglycemia and hyperglycemia in 30 536 AMI patients in a post hoc analysis of 2 large trials o...

journal_title：Circulation

authors： Goyal A,Mehta SR,Díaz R,Gerstein HC,Afzal R,Xavier D,Liu L,Pais P,Yusuf S

更新日期：2009-12-15 00:00:00

abstract：BACKGROUND:Ventricular tachyarrhythmias are the major clinical manifestation of arrhythmogenic right ventricular disease. Although antiarrhythmic therapy has been widely advocated, there is only limited information available on the efficacy of antiarrhythmic drugs in these patients. METHODS AND RESULTS:The short- and ...

journal_title：Circulation

authors： Wichter T,Borggrefe M,Haverkamp W,Chen X,Breithardt G

更新日期：1992-07-01 00:00:00

abstract：BACKGROUND:Heart failure (HF) is responsible for a huge burden in hospital care. Our goal was to evaluate the value of N-terminal-pro-brain natriuretic peptide (NT-proBNP) in predicting death or hospital readmission after discharge of HF patients. METHODS AND RESULTS:We included 182 patients consecutively admitted to ...

journal_title：Circulation

authors： Bettencourt P,Azevedo A,Pimenta J,Friões F,Ferreira S,Ferreira A

更新日期：2004-10-12 00:00:00

abstract：:To determine the evolution of amyloid heart disease, 28 patients with familial amyloid polyneuropathy (FAP) were studied by echocardiography. The incidence and degree of the abnormalities were correlated with the neurologic disabilities, duration of the illness, and age in cross-sectional studies. Serial studies were ...

journal_title：Circulation

authors： Hongo M,Ikeda S

更新日期：1986-02-01 00:00:00

abstract：BACKGROUND:Reperfusion injury is insufficiently addressed in current clinical management of acute limb ischemia. Controlled reperfusion carries an enormous clinical potential and was tested in a new reality-driven rodent model. METHODS AND RESULTS:Acute hind-limb ischemia was induced in Wistar rats and maintained for ...

journal_title：Circulation

authors： Dick F,Li J,Giraud MN,Kalka C,Schmidli J,Tevaearai H

更新日期：2008-11-04 00:00:00

abstract：BACKGROUND:Adenosine receptor activation has been proposed to explain the cardioprotective effect of ischemic preconditioning in rabbit hearts. We tested this hypothesis in a rat model by assessing whether administration of an adenosine antagonist could block the protective effect of preconditioning and whether adenosi...

journal_title：Circulation

authors： Li Y,Kloner RA

更新日期：1993-05-01 00:00:00

abstract：BACKGROUND:Endothelin (ET), a coronary vasoconstrictor, mediates its activity through the specific receptors ET-A and ET-B, which may demonstrate different activity under pathophysiological conditions. Thoracic inferior vena cava constriction (TIVCC) is an experimental model of congestive heart failure that is characte...

journal_title：Circulation

authors： Cannan CR,Burnett JC Jr,Lerman A

更新日期：1996-02-15 00:00:00

abstract：BACKGROUND:Patients with anorexia nervosa exhibit abnormal myocardial repolarization and are susceptible to sudden cardiac death. Exercise testing is useful in unmasking QT prolongation in disorders associated with abnormal repolarization. We characterized QT adaptation during exercise in anorexia. METHODS AND RESULTS...

journal_title：Circulation

authors： Padfield GJ,Escudero CA,DeSouza AM,Steinberg C,Gibbs K,Puyat JH,Lam PY,Sanatani S,Sherwin E,Potts JE,Sandor G,Krahn AD

更新日期：2016-02-09 00:00:00

abstract：:Ventricular septal defects are the most common congenital heart defect. They vary greatly in location, clinical presentation, associated lesions, and natural history. The present article describes the clinical aspects of ventricular septal defects and current management strategies. ...

journal_title：Circulation

authors： Minette MS,Sahn DJ

更新日期：2006-11-14 00:00:00

abstract：BACKGROUND:The outcome of patients with corrected transposition of the great arteries (CTGA) is variably affected by associated intracardiac defects, tricuspid valve competence, and systemic right ventricular (RV) function. The relative importance of these factors in long-term outcome has not been evaluated. METHODS A...

journal_title：Circulation

authors： Prieto LR,Hordof AJ,Secic M,Rosenbaum MS,Gersony WM

更新日期：1998-09-08 00:00:00

abstract：:Because acute segmental wall motion abnormalities (SWMAs) of the left ventricle are highly sensitive and specific indicators of myocardial ischemia, this study compared the incidence and significance of ischemia, as detected by two-dimensional transesophageal echocardiography and surface electrocardiography, during an...

journal_title：Circulation

authors： Smith JS,Cahalan MK,Benefiel DJ,Byrd BF,Lurz FW,Shapiro WA,Roizen MF,Bouchard A,Schiller NB

更新日期：1985-11-01 00:00:00

abstract：BACKGROUND:Cardiac hypertrophy and subsequent heart failure triggered by chronic hypertension represent major challenges for cardiovascular research. Beyond neurohormonal and myocyte signaling pathways, growing evidence suggests inflammatory signaling pathways as therapeutically targetable contributors to this process....

journal_title：Circulation

authors： Heymans S,Corsten MF,Verhesen W,Carai P,van Leeuwen RE,Custers K,Peters T,Hazebroek M,Stöger L,Wijnands E,Janssen BJ,Creemers EE,Pinto YM,Grimm D,Schürmann N,Vigorito E,Thum T,Stassen F,Yin X,Mayr M,de Windt LJ,

更新日期：2013-09-24 00:00:00

abstract：BACKGROUND:Sudden Unexplained Death Syndrome (SUDS) is the leading cause of death in young, healthy, Southeast Asian men. The role of an implantable cardioverter defibrillator (ICD) for mortality reduction in these patients remains unclear. METHODS AND RESULTS:The Defibrillator Versus beta-Blockers for Unexplained Dea...

journal_title：Circulation

authors： Nademanee K,Veerakul G,Mower M,Likittanasombat K,Krittayapong R,Bhuripanyo K,Sitthisook S,Chaothawee L,Lai MY,Azen SP

更新日期：2003-05-06 00:00:00

abstract：BACKGROUND:The long-term success of coronary bypass surgery is dependent on graft patency after surgery. This trial was designed to determine if aspirin improved saphenous vein graft or internal mammary artery (IMA) graft patency between 1 and 3 years after coronary artery bypass grafting (CABG). METHODS AND RESULTS:A...

journal_title：Circulation

authors： Goldman S,Copeland J,Moritz T,Henderson W,Zadina K,Ovitt T,Kern KB,Sethi G,Sharma GV,Khuri S

更新日期：1994-03-01 00:00:00

abstract：:Common conditions predisposing to atherosclerosis, such as hypercholesterolemia, hypertension, diabetes, and smoking, are associated with endothelial dysfunction. Endothelial function has largely been assessed as endothelium-dependent vasomotion, at least in part based on the assumption that impaired endothelium-depen...

journal_title：Circulation

authors： Landmesser U,Hornig B,Drexler H

更新日期：2004-06-01 00:00:00

abstract：BACKGROUND:The CAPRICORN trial has shown that carvedilol improved outcome in patients with left ventricular dysfunction after acute myocardial infarction treated with ACE inhibitors. The aim of this substudy was to determine the effects of carvedilol on left ventricular remodeling in this patient group. METHODS AND RE...

journal_title：Circulation

authors： Doughty RN,Whalley GA,Walsh HA,Gamble GD,López-Sendón J,Sharpe N,CAPRICORN Echo Substudy Investigators.

更新日期：2004-01-20 00:00:00

abstract：BACKGROUND:Tissue-type plasminogen activator (tPA) and urokinase-type plasminogen activator (uPA) are thought to play critical roles in vascular remodeling after injury, with tPA mediating intravascular clot lysis and uPA modulating cell migration within the vessel wall. In human vascular disease, however, thrombus org...

journal_title：Circulation

authors： Schäfer K,Konstantinides S,Riedel C,Thinnes T,Müller K,Dellas C,Hasenfuss G,Loskutoff DJ

更新日期：2002-10-01 00:00:00

abstract：BACKGROUND:Left ventricular wall motion (WM) abnormalities have recognized prognostic significance in patients with coronary or other heart diseases; however, whether abnormal WM predicts adverse events in adults without overt cardiovascular disease has not been assessed. Our objective was to determine whether echocard...

journal_title：Circulation

authors： Cicala S,de Simone G,Roman MJ,Best LG,Lee ET,Wang W,Welty TK,Galloway JM,Howard BV,Devereux RB

更新日期：2007-07-10 00:00:00

abstract：:Prior studies have demonstrated the presence of inhomogeneities in myocardial [K+]e after serial 10-minute occlusions of the left anterior descending coronary artery in the pig, even within restricted locations of an ischemic zone. These inhomogeneities are thought to underlie the electrophysiological abnormalities re...

journal_title：Circulation

authors： Johnson TA,Engle CL,Boyd LM,Koch GG,Gwinn M,Gettes LS

更新日期：1991-02-01 00:00:00

abstract：:The indications for biventricular versus left ventricular mechanical circulatory support as a bridge to cardiac transplantation are not well established. In this study, 27 potential heart transplant candidates who were in imminent risk of dying before donor heart procurement were implanted with Thoratec prosthetic ven...

journal_title：Circulation

authors： Farrar DJ,Hill JD,Gray LA Jr,Galbraith TA,Chow E,Hershon JJ

更新日期：1989-11-01 00:00:00

abstract：BACKGROUND:The safety of drug-eluting stents in ST-segment elevation myocardial infarction (STEMI) continues to be debated. Pathological studies have demonstrated an association between uncovered struts and subsequent stent thrombosis. Optical coherence tomography can detect stent strut coverage in vivo on a micron-sca...

journal_title：Circulation

authors： Guagliumi G,Costa MA,Sirbu V,Musumeci G,Bezerra HG,Suzuki N,Matiashvili A,Lortkipanidze N,Mihalcsik L,Trivisonno A,Valsecchi O,Mintz GS,Dressler O,Parise H,Maehara A,Cristea E,Lansky AJ,Mehran R,Stone GW

更新日期：2011-01-25 00:00:00

abstract：:Between January 1, 1970, and December 31, 1974, 2981 patients underwent coronary arteriography. Twelve acute coronary dissections or embolizations occurred, an incidence of 0.4%. The incidences of acute occlusions for the Sones and Judkins techniques were 0.19% (4/2077 studies) and 0.88% (8/940), respectively. No inst...

journal_title：Circulation

authors： Guss SB,Zir LM,Garrison HB,Daggett WM,Block PC,Dinsmore RE

更新日期：1975-12-01 00:00:00

abstract：:Analysis of the external brachial pulse recorded during standard blood pressure cuff deflation with use of a transducer with a wide frequency response has revealed a reproducible pattern with three distinct components that we have labeled K1, K2, and K3. K1 is a low-amplitude, low-frequency signal that is present with...

journal_title：Circulation

authors： Blank SG,West JE,Müller FB,Cody RJ,Harshfield GA,Pecker MS,Laragh JH,Pickering TG

更新日期：1988-06-01 00:00:00

abstract：BACKGROUND:C-reactive protein (CRP), a well-recognized marker of atherosclerosis, has recently been suggested to have a direct proinflammatory effect. The constitutive expression of low levels of CRP in normal plasma suggests the likelihood that a natural factor exists to neutralize the effect of CRP. This factor(s) ha...

journal_title：Circulation

authors： Wadham C,Albanese N,Roberts J,Wang L,Bagley CJ,Gamble JR,Rye KA,Barter PJ,Vadas MA,Xia P

更新日期：2004-05-04 00:00:00

abstract：:In patients treated with sulfinpyrazone, an apparent reduction in the incidence of sudden death and presumed ventricular fibrillation has been reported. Using an intact animal model without microcirculatory thrombosis, we studied the effects of sulfinpyrazone on ischemic myocardium in 58 anesthetized dogs divided into...

journal_title：Circulation

authors： Moschos CB,Escobinas AJ,Jorgensen OB Jr,Regan TJ

更新日期：1981-07-01 00:00:00

abstract：:D8/17, a B cell alloantigen, and its occurrence with DR/DQ antigens was examined in 54 patients with rheumatic heart disease and matched North Indian controls. Thirty-four patients (62.9%) carried D8/17 as compared with a frequency of 12.5% in controls (chi 2 by Yates', 18.75; p less than 0.0001). A marginally increas...

journal_title：Circulation

authors： Taneja V,Mehra NK,Reddy KS,Narula J,Tandon R,Vaidya MC,Bhatia ML

更新日期：1989-08-01 00:00:00

abstract：BACKGROUND:Traditional risk factors have been linked to atherosclerotic heart disease in women. However, the effect of risk factors and menopausal status on the mechanism of sudden coronary death is unknown. METHODS AND RESULTS:We examined 51 cases of sudden coronary death and 15 hearts from women who died of trauma. ...

journal_title：Circulation

authors： Burke AP,Farb A,Malcom GT,Liang Y,Smialek J,Virmani R

更新日期：1998-06-02 00:00:00

abstract：BACKGROUND:Atherosclerosis is a multifactorial disease in which inflammatory processes play an important role. Inflammation underlies lesion evolution at all stages, from establishment to plaque rupture and thrombosis. Costimulatory molecules of the tumor necrosis factor superfamily such as CD40/CD40L and OX40/OX40L ha...

journal_title：Circulation

authors： Olofsson PS,Söderström LA,Wågsäter D,Sheikine Y,Ocaya P,Lang F,Rabu C,Chen L,Rudling M,Aukrust P,Hedin U,Paulsson-Berne G,Sirsjö A,Hansson GK

更新日期：2008-03-11 00:00:00

abstract：:In 72% of 143 patients undergoing a second coronary bypass grafting, mural or occlusive late thrombosis was observed histologically in 69% of 173 resected grafts. Late thrombosis was particularly prevalent in atherosclerotic grafts (80.2% vs. 40.4% in nonatherosclerotic grafts) and was always noted in 16 grafts with a...

journal_title：Circulation

authors： Solymoss BC,Nadeau P,Millette D,Campeau L

更新日期：1988-09-01 00:00:00