N-terminal-pro-brain natriuretic peptide predicts outcome after hospital discharge in heart failure patients.

abstract：:Heart failure with preserved ejection fraction (HFpEF) is a complex syndrome with an increasingly recognized heterogeneity in pathophysiology. Exercise intolerance is the hallmark of HFpEF and appears to be caused by both cardiac and peripheral abnormalities in the arterial tree and skeletal muscle. Mitochondrial abno...

journal_title：Circulation

authors： Kumar AA,Kelly DP,Chirinos JA

更新日期：2019-03-12 00:00:00

abstract：BACKGROUND:The influence of changes in heart rate on myocardial contractility (the force-frequency effect) differs under various experimental conditions, including the anesthetized versus the conscious state. METHODS AND RESULTS:To assess the influence of beta-adrenergic stimulation on force-frequency effects on myoca...

journal_title：Circulation

authors： Kambayashi M,Miura T,Oh BH,Rockman HA,Murata K,Ross J Jr

更新日期：1992-08-01 00:00:00

abstract：BACKGROUND:Reduced renal function is associated with a poorer prognosis and increased bleeding risk in patients with acute coronary syndromes and may therefore alter the risk-benefit ratio with antiplatelet therapies. In the Platelet Inhibition and Patient Outcomes (PLATO) trial, ticagrelor compared with clopidogrel re...

journal_title：Circulation

authors： James S,Budaj A,Aylward P,Buck KK,Cannon CP,Cornel JH,Harrington RA,Horrow J,Katus H,Keltai M,Lewis BS,Parikh K,Storey RF,Szummer K,Wojdyla D,Wallentin L

更新日期：2010-09-14 00:00:00

abstract：BACKGROUND:Coronary heart disease (CHD) is the leading cause of morbidity and mortality in persons with type 2 diabetes mellitus (T2DM). Electron-beam computed tomography (EBCT) detects coronary artery calcium (CAC), a marker of atherosclerotic plaque. Few studies have described EBCT-defined CHD among ethnic minorities...

journal_title：Circulation

authors： Araneta MR,Barrett-Connor E

更新日期：2004-11-02 00:00:00

abstract：:All of the electrophysiological mechanisms of arrhythmias are sensitive to the influences of the autonomic nervous system, particularly to its adrenergic limb. Arrhythmogenic areas may also be dependent on the inhomogeneity of these influences because of their pathophysiological structure and/or the neurogenic or humo...

journal_title：Circulation

authors： Coumel P,Leenhardt A

更新日期：1991-04-01 00:00:00

abstract：:In 72% of 143 patients undergoing a second coronary bypass grafting, mural or occlusive late thrombosis was observed histologically in 69% of 173 resected grafts. Late thrombosis was particularly prevalent in atherosclerotic grafts (80.2% vs. 40.4% in nonatherosclerotic grafts) and was always noted in 16 grafts with a...

journal_title：Circulation

authors： Solymoss BC,Nadeau P,Millette D,Campeau L

更新日期：1988-09-01 00:00:00

abstract：:Although laparoscopic surgery accounts for >2 million surgical procedures every year, the current preoperative risk scores and guidelines do not adequately assess the risks of laparoscopy. In general, laparoscopic procedures have a lower risk of morbidity and mortality compared with operations requiring a midline lapa...

journal_title：Circulation

authors： Atkinson TM,Giraud GD,Togioka BM,Jones DB,Cigarroa JE

更新日期：2017-02-14 00:00:00

abstract：:High frequency notching of the QRS complex is associated with transmural infarction, cardiomyopathies, and ventricular hypertrophy from any cause. The mechanism producing notching is unknown; but the presence of a discrete anatomic lesion is not an essential feature. The hypothesis that notching was produced by activa...

journal_title：Circulation

authors： Vanderark CR,Reynolds EW

更新日期：1975-02-01 00:00:00

abstract：BACKGROUND:We tested the hypothesis that long-term administration of the specific angiotensin II subtype 1 (AT1)-receptor blocker BMS-186295 will regress hypertrophy and modify left ventricular angiotensin converting enzyme (ACE) expression in rats with ascending aortic stenosis. METHODS AND RESULTS:Six weeks after su...

journal_title：Circulation

authors： Weinberg EO,Lee MA,Weigner M,Lindpaintner K,Bishop SP,Benedict CR,Ho KK,Douglas PS,Chafizadeh E,Lorell BH

更新日期：1997-03-18 00:00:00

abstract：BACKGROUND:Impaired fibrinolytic activity has been linked to the presence and severity of allograft vasculopathy (Tx CAD). This impairment may be associated with the presence of certain fibrinolytic protein gene polymorphisms. METHODS AND RESULTS:To investigate the relation between donor-specific fibrinolytic protein ...

journal_title：Circulation

authors： Benza RL,Grenett HE,Bourge RC,Kirklin JK,Naftel DC,Castro PF,McGiffin DC,George JF,Booyse FM

更新日期：1998-11-24 00:00:00

abstract：:Background- Cardiovagal baroreflex sensitivity (BRS) declines with age but is favorably modulated by habitual aerobic exercise. We tested the hypothesis that compliance (transducing capacity) of an elastic artery in which baroreceptors are located is associated with these age-exercise interactions. Methods and Results...

journal_title：Circulation

authors： Monahan KD,Tanaka H,Dinenno FA,Seals DR

更新日期：2001-10-02 00:00:00

abstract：:Recent studies have shown that blood flow during closed-chest cardiopulmonary resuscitation (CPR) results primarily from generalized changes in intrathoracic pressure rather than direct compression of the heart. Since ascending aortic and right atrial pressures rise and fall synchronously and to comparable levels duri...

journal_title：Circulation

authors： Ditchey RV,Winkler JV,Rhodes CA

更新日期：1982-08-01 00:00:00

abstract：BACKGROUND:Second trimester routine ultrasound evaluation of the fetal heart by means of the four-chamber view has been proposed for prenatal detection of cardiac anomalies. The aim of this study was to evaluate the efficacy of this procedure. METHODS AND RESULTS:A prospective follow-up study on 6922 scanned fetuses w...

journal_title：Circulation

authors： Buskens E,Grobbee DE,Frohn-Mulder IM,Stewart PA,Juttmann RE,Wladimiroff JW,Hess J

更新日期：1996-07-01 00:00:00

abstract：BACKGROUND:Because acute exercise increases systemic catecholamines, we sought to determine whether exercise training would alter daily or exercise-related catecholamine release and inactivation. METHODS AND RESULTS:In 24-hour urine collections, catecholamines and metabolites provided indexes of overall oxidative deam...

journal_title：Circulation

authors： Rogers PJ,Tyce GM,Weinshilboum RM,O'Connor DT,Bailey KR,Bove AA

更新日期：1991-12-01 00:00:00

abstract：BACKGROUND:Adenosine receptor activation has been proposed to explain the cardioprotective effect of ischemic preconditioning in rabbit hearts. We tested this hypothesis in a rat model by assessing whether administration of an adenosine antagonist could block the protective effect of preconditioning and whether adenosi...

journal_title：Circulation

authors： Li Y,Kloner RA

更新日期：1993-05-01 00:00:00

abstract：BACKGROUND:This study evaluated the hypothesis that transendocardial injections of autologous mononuclear bone marrow cells in patients with end-stage ischemic heart disease could safely promote neovascularization and improve perfusion and myocardial contractility. METHODS AND RESULTS:Twenty-one patients were enrolled...

journal_title：Circulation

authors： Perin EC,Dohmann HF,Borojevic R,Silva SA,Sousa AL,Mesquita CT,Rossi MI,Carvalho AC,Dutra HS,Dohmann HJ,Silva GV,Belém L,Vivacqua R,Rangel FO,Esporcatte R,Geng YJ,Vaughn WK,Assad JA,Mesquita ET,Willerson JT

更新日期：2003-05-13 00:00:00

abstract：BACKGROUND:National and international guidelines recommend fasting lipid panel measurement for risk stratification of patients for prevention of cardiovascular events. However, the prognostic value of fasting versus nonfasting low-density lipoprotein cholesterol (LDL-C) is uncertain. METHODS AND RESULTS:Patients enrol...

journal_title：Circulation

authors： Doran B,Guo Y,Xu J,Weintraub H,Mora S,Maron DJ,Bangalore S

更新日期：2014-08-12 00:00:00

abstract：BACKGROUND:Two different techniques have been developed for radiofrequency catheter ablation of typical atrioventricular nodal reentry (AVNRT). Lesions made anteriorly near the apex of the triangle of Koch usually eliminate fast pathway function, whereas lesions made posteriorly near the ostium of the coronary sinus se...

journal_title：Circulation

authors： Langberg JJ,Leon A,Borganelli M,Kalbfleisch SJ,el-Atassi R,Calkins H,Morady F

更新日期：1993-05-01 00:00:00

abstract：BACKGROUND:Biventricular direct cardiac compression (DCC) can potentially support the failing heart without the complications associated with a blood/device interface. The effect of uniform DCC on left and right ventricular performance was evaluated in 7 isolated canine heart preparations. METHODS AND RESULTS:A comput...

journal_title：Circulation

authors： Artrip JH,Wang J,Leventhal AR,Tsitlik JE,Levin HR,Burkhoff D

更新日期：1999-04-27 00:00:00

abstract：BACKGROUND:The clinical significance and pathophysiological mechanisms of reverse redistribution on stress-redistribution thallium-201 myocardial scintigraphy in patients with chronic coronary artery disease are unclear. Recent studies have shown that thallium-201 reinjection is a useful technique for the detection of ...

journal_title：Circulation

authors： Marin-Neto JA,Dilsizian V,Arrighi JA,Freedman NM,Perrone-Filardi P,Bacharach SL,Bonow RO

更新日期：1993-10-01 00:00:00

abstract：BACKGROUND:Cardiac troponin I (cTnI), a sensitive and specific marker of myocardial cell injury, is useful in diagnosing and assessing prognosis in acute coronary syndromes. Small studies report that cTnI is elevated in severe heart failure (HF) and may predict adverse outcomes. METHODS AND RESULTS:The present study e...

journal_title：Circulation

authors： Horwich TB,Patel J,MacLellan WR,Fonarow GC

更新日期：2003-08-19 00:00:00

abstract：BACKGROUND:We investigated whether differentiation of embryonic stem cells (ESCs) in ischemic myocardium enhances their immunogenicity, thereby increasing their chance for rejection. METHODS AND RESULTS:In one series, 129/SvJ-derived mouse ESCs (ES-D3 line) were transplanted by direct myocardial injection (1 x 10(6) c...

journal_title：Circulation

authors： Swijnenburg RJ,Tanaka M,Vogel H,Baker J,Kofidis T,Gunawan F,Lebl DR,Caffarelli AD,de Bruin JL,Fedoseyeva EV,Robbins RC

更新日期：2005-08-30 00:00:00

abstract：:The electrophysiologic mechanisms for the initiation and termination of re-entrant ventricular arrhythmias (RVA) were critically analyzed in dogs 3-7 days following ligation of the anterior descending coronary artery, utilizing direct recordings of the re-entrant pathway (RP) from the epicardial surface of the infarct...

journal_title：Circulation

authors： El-Sherif N,Hope RR,Scherlag BJ,Lazzara R

更新日期：1977-05-01 00:00:00

abstract：BACKGROUND:Endurance athletes have higher high density lipoprotein (HDL) concentrations than sedentary controls. To examine the mechanism for this effect, we compared HDL apoprotein metabolism in 10 endurance athletes aged 34 +/- 6 years (mean +/- SD) and 10 sedentary men aged 36 +/- 8 years. METHODS AND RESULTS:Subje...

journal_title：Circulation

authors： Thompson PD,Cullinane EM,Sady SP,Flynn MM,Chenevert CB,Herbert PN

更新日期：1991-07-01 00:00:00

abstract：BACKGROUND:Patients with anorexia nervosa exhibit abnormal myocardial repolarization and are susceptible to sudden cardiac death. Exercise testing is useful in unmasking QT prolongation in disorders associated with abnormal repolarization. We characterized QT adaptation during exercise in anorexia. METHODS AND RESULTS...

journal_title：Circulation

authors： Padfield GJ,Escudero CA,DeSouza AM,Steinberg C,Gibbs K,Puyat JH,Lam PY,Sanatani S,Sherwin E,Potts JE,Sandor G,Krahn AD

更新日期：2016-02-09 00:00:00

abstract：:In this paper we examine the relationship between risk factors and angiographically determined coronary artery disease for blacks and whites enrolled in the Coronary Artery Surgery Study (CASS). Analysis of data from the CASS registry indicated that blacks had a higher incidence of hypertension and current cigarette s...

journal_title：Circulation

authors： Maynard C,Fisher LD,Passamani ER,Pullum T

更新日期：1986-07-01 00:00:00

abstract：:In our approach to dynamic cardiomyoplasty, which consists of wrapping a skeletal muscle around the heart and stimulating the former in synchrony with heart contractions to augment ventricular contractility, we have transferred a latissimus dorsi muscle flap to the heart by way of a partial resection of the second rib...

journal_title：Circulation

authors： Chachques JC,Grandjean P,Schwartz K,Mihaileanu S,Fardeau M,Swynghedauw B,Fontaliran F,Romero N,Wisnewsky C,Perier P

更新日期：1988-11-01 00:00:00

abstract：BACKGROUND:Prolonged metabolic abnormalities have been demonstrated previously in postischemic myocardium, including relative increases in glucose uptake and abnormal fatty acid kinetics. However, quantitative metabolic information is limited, and the time course of changes in MVO2 in postischemic myocardium is unknown...

journal_title：Circulation

authors： Buxton DB,Mody FV,Krivokapich J,Phelps ME,Schelbert HR

更新日期：1992-05-01 00:00:00

abstract：BACKGROUND:Little is known of the prognostic significance of mitral regurgitation (MR) on transcatheter aortic valve replacement (TAVR), the impact of TAVR on MR severity, and the variables associated with possible post-TAVR improvement in MR. We evaluated these issues in a multicenter registry of patients undergoing C...

journal_title：Circulation

authors： Bedogni F,Latib A,De Marco F,Agnifili M,Oreglia J,Pizzocri S,Latini RA,Lanotte S,Petronio AS,De Carlo M,Ettori F,Fiorina C,Poli A,Cirri S,De Servi S,Ramondo A,Tarantini G,Marzocchi A,Fiorilli R,Klugmann S,Ussia GP

更新日期：2013-11-05 00:00:00

abstract：BACKGROUND:Cardiac tissue engineering offers the prospect of a novel treatment for acquired or congenital heart defects. We have created vascularized pieces of beating cardiac muscle in the rat that are as thick as the adult rat right ventricle wall. METHOD AND RESULTS:Neonatal rat cardiomyocytes in Matrigel were impl...

journal_title：Circulation

authors： Morritt AN,Bortolotto SK,Dilley RJ,Han X,Kompa AR,McCombe D,Wright CE,Itescu S,Angus JA,Morrison WA

更新日期：2007-01-23 00:00:00