Abstract:
BACKGROUND:Two different techniques have been developed for radiofrequency catheter ablation of typical atrioventricular nodal reentry (AVNRT). Lesions made anteriorly near the apex of the triangle of Koch usually eliminate fast pathway function, whereas lesions made posteriorly near the ostium of the coronary sinus selectively affect slow pathway function. The current study compares the safety, efficacy, and electrophysiological effects of these two techniques in a prospective, randomized fashion. METHODS AND RESULTS:Fifty consecutive patients with typical AVNRT were randomly assigned to receive radiofrequency lesions either anteriorly (n = 22) or posteriorly (n = 28). If the initial approach failed to eliminate inducibility of AVNRT after 1 hour or 10 applications of radiofrequency energy, the alternative ablation technique was used. Patients underwent repeat electrophysiological testing 48 hours and 3 months after ablation. The primary success rates of the anterior and posterior techniques were similar (55% versus 68%, p = NS). All of the patients who failed the initial approach were successfully treated by the alternative technique without developing high-grade atrioventricular block. One patient developed right bundle branch block during an anterior lesion, and another patient developed complete atrioventricular block as the result of a posterior lesion. CONCLUSIONS:The posterior approach to radiofrequency catheter modification of the atrioventricular node is as effective as the anterior approach, and both techniques are associated with a low risk of complications. As long as AVNRT persists, it appears safe to cross over from one technique to the other.
journal_name
Circulationjournal_title
Circulationauthors
Langberg JJ,Leon A,Borganelli M,Kalbfleisch SJ,el-Atassi R,Calkins H,Morady Fdoi
10.1161/01.cir.87.5.1551subject
Has Abstractpub_date
1993-05-01 00:00:00pages
1551-6issue
5eissn
0009-7322issn
1524-4539journal_volume
87pub_type
临床试验,杂志文章,随机对照试验相关文献
CIRCULATION文献大全abstract:BACKGROUND:Oxidized LDL (oxLDL) is thought to play a key role in the inflammatory response in the arterial vessel wall. METHODS AND RESULTS:In a prospective, nested, case-control study, the association between plasma oxLDL and risk of an acute coronary heart disease (CHD) event was investigated in men without prevalen...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.104.529297
更新日期:2005-08-02 00:00:00
abstract:BACKGROUND:Adipocyte-derived hormones may represent a mechanism linking insulin resistance to cardiovascular disease. In the present study, we evaluated the direct effects of resistin, a novel adipocyte-derived hormone, on endothelial activation. METHODS AND RESULTS:Endothelial cells (ECs) were incubated with human re...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.CIR.0000084503.91330.49
更新日期:2003-08-12 00:00:00
abstract:BACKGROUND:It is uncertain whether Helicobacter pylori is associated with ischemic syndromes and whether this association is mediated by the induction of atherosclerosis. In this study, we tested the hypothesis that atherosclerotic stroke shows a selective association with virulent H pylori strains. METHODS AND RESULT...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.0000023894.10871.2f
更新日期:2002-07-30 00:00:00
abstract::Malignant hyperthermia is a disease resulting from defective cellular membranes, usually presenting as drug-induced pyrexic crises. We describe four patients with life threatening ventricular arrhythmias or chest pain in the absence of pyrexic crises. Three presented with life threatening arrhythmias and the fourth wi...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.58.5.916
更新日期:1978-11-01 00:00:00
abstract:BACKGROUND:Many members of families with inherited long-QT (LQT) syndrome have mutations in HERG, a gene encoding a cardiac potassium channel that is modulated by extracellular potassium. We hypothesized that an increase in serum potassium would normalize repolarization in these patients. METHODS AND RESULTS:We studie...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.94.5.1018
更新日期:1996-09-01 00:00:00
abstract:BACKGROUND:Advances in surgical technique and perioperative myocardial protection have reduced the risk of aortic and mitral valve surgery. Improved methods of valve repair have reduced the proportion of patients who require valve replacement. However, patients who require valve replacement often have advanced disease ...
journal_title:Circulation
pub_type: 杂志文章
doi:
更新日期:1996-11-01 00:00:00
abstract:BACKGROUND:The regulation of the cardiac neutral endopeptidase (EC 24.10, NEP) that degrades bradykinin and natriuretic peptides has been investigated in human cardiac hypertrophy and heart failure. Methods and Results- NEP mRNA was quantitated by real-time polymerase chain reaction (PCR) in left ventricular biopsies f...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/hc0302.103593
更新日期:2002-01-22 00:00:00
abstract:BACKGROUND:The introduction of limited approaches to the heart and the avoidance of cardiopulmonary bypass (CPB) aim to reduce the invasiveness of CABG by decreasing the systemic release of inflammatory cytokines, such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and IL-8, as well as the anti-inflammatory ...
journal_title:Circulation
pub_type: 临床试验,杂志文章
doi:10.1161/01.cir.102.suppl_3.iii-95
更新日期:2000-11-07 00:00:00
abstract::Patency of the femoral artery of infants and children who previously had percutaneous arterial catheterization at a weight of less than 25 kg was studied angiographically. During the study period, 118 patients had repeat arterial catheterization. 48 from the opposite leg. Femoral artery occlusion was found in four pat...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.56.1.102
更新日期:1977-07-01 00:00:00
abstract:BACKGROUND:Patients with congenital heart disease (CHD) and heterotaxy show high postsurgical morbidity/mortality, with some developing respiratory complications. Although this finding is often attributed to the CHD, airway clearance and left-right patterning both require motile cilia function. Thus, airway ciliary dys...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.111.079780
更新日期:2012-05-08 00:00:00
abstract:BACKGROUND:The diagnosis of long QT syndrome (LQTS) is rather straightforward. We were surprised by realizing that, despite long-standing experience, we were making occasional diagnostic errors by considering as affected subjects who, over time, resulted as not affected. These individuals were all actively practicing s...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.120.048916
更新日期:2020-12-22 00:00:00
abstract:BACKGROUND:Early-generation drug-eluting stents releasing sirolimus (SES) or paclitaxel (PES) are associated with increased risk of very late stent thrombosis occurring >1 year after stent implantation. It is unknown whether the risk of very late stent thrombosis persists with newer-generation everolimus-eluting stents...
journal_title:Circulation
pub_type: 杂志文章,多中心研究
doi:10.1161/CIRCULATIONAHA.111.058560
更新日期:2012-03-06 00:00:00
abstract::The predictive value of the myocardial scintigraphy with 99mTc-pyrophosphate was studied in 100 patients admitted to the coronary care unit with suspected acute myocardial infarction. None of the 21 patients with normal scintigrams had acute myocardial infraction by other criteria. Fifty-five percent of patients with ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.57.2.320
更新日期:1978-02-01 00:00:00
abstract:BACKGROUND:Unlike skeletal myocytes, mammalian adult cardiomyocytes cannot regenerate after injury. A possible strategy to increase viability and augment ventricular function after myocardial injury is fetal myocardial tissue transplantation. The engrafted fetal cells are a potential source of growth factors and can be...
journal_title:Circulation
pub_type: 杂志文章
doi:
更新日期:1996-11-01 00:00:00
abstract:BACKGROUND:Endothelin-1 (ET-1) is a potent positive inotrope in vitro, but its physiological effects on intrinsic myocardial contractile function in humans in vivo are unknown. Plasma ET-1 levels are elevated in heart failure, and ET-1 may be involved in the pathophysiology of this condition. However, its effects on co...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.101.2.142
更新日期:2000-01-18 00:00:00
abstract:BACKGROUND:The relationship of LPA single nucleotide polymorphisms (SNPs), apolipoprotein(a) isoforms, and lipoprotein(a) [Lp(a)] levels with major adverse cardiovascular events (MACE) in different ethnic groups is not well known. METHODS:LPA SNPs, apolipoprotein(a) isoforms, Lp(a), and oxidized phospholipids on apoli...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.116.024611
更新日期:2017-01-17 00:00:00
abstract:BACKGROUND:Ticagrelor, when compared with clopidogrel, reduced the 12-month risk of vascular death/myocardial infarction and stroke in patients with ST-elevation acute coronary syndromes intended to undergo primary percutaneous coronary intervention in the PLATelet inhibition and patient Outcomes (PLATO) trial. This pr...
journal_title:Circulation
pub_type: 杂志文章,随机对照试验
doi:10.1161/CIRCULATIONAHA.111.047530
更新日期:2012-01-24 00:00:00
abstract::Acute myocardial ischemia leads to a gradual increase in beta-adrenergic receptors at the cell surface. This increase occurs rapidly after onset of global ischemia (15 minutes) and persists even after prolonged periods of global ischemia. This alteration can be observed both in vivo and in vitro in isolated perfused h...
journal_title:Circulation
pub_type: 杂志文章,评审
doi:
更新日期:1990-09-01 00:00:00
abstract:BACKGROUND:Diabetes is an independent risk factor for the development of neointimal hyperplasia and subsequent vein graft failure after coronary or peripheral artery bypass grafting. We evaluate a new mouse model of surgical vein grafting to investigate the mechanisms of neointimal formation in the setting of type 2 di...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.105.001339
更新日期:2006-07-04 00:00:00
abstract:BACKGROUND:Intracoronary stents may be effective when used as "bail-out" devices for acute complications after percutaneous transluminal coronary angioplasty. Furthermore, preliminary reports have demonstrated some promising results with stents with regard to the reduction of restenosis. Several stent devices are avail...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.83.5.1788
更新日期:1991-05-01 00:00:00
abstract::To determine how survival and clinical status were related to left ventricular (LV) size and systolic function after mitral valve replacement, 104 patients (48 mitral regurgitation [MR], 33 mitral stenosis [MS], and 23 MS/MR) with isolated mitral valve replacement were evaluated before and after surgery. Preoperative ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.81.4.1173
更新日期:1990-04-01 00:00:00
abstract:BACKGROUND:Early results of sirolimus-eluting stent implantation showed a nearly complete abolition of neointimal hyperplasia. The question remains, however, whether the early promising results will still be evident at long-term follow-up. The objective of our study was to evaluate the efficiency of sirolimus-eluting s...
journal_title:Circulation
pub_type: 临床试验,杂志文章
doi:10.1161/01.cir.0000034447.02535.d5
更新日期:2002-09-24 00:00:00
abstract:BACKGROUND:Growth factors such as platelet-derived growth factor (PDGF) have been postulated to be important mediators of neointimal formation in balloon-injured artery. Binding of growth factors to their receptors activates intrinsic receptor tyrosine kinase, resulting in tyrosine phosphorylation of receptors themselv...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.96.6.1906
更新日期:1997-09-16 00:00:00
abstract::Myocardial ischemia has, for many decades, been viewed as an all-or-none process that causes myocardial necrosis when prolonged and severe, but whose effects are transient when it is brief or mild. In view of the evidence that the ischemic process may "hit, run and stun," perhaps our thinking about the consequences of...
journal_title:Circulation
pub_type: 杂志文章,评审
doi:10.1161/01.cir.66.6.1146
更新日期:1982-12-01 00:00:00
abstract::The effects of encainide on ventricular arrhythmia and left ventricular function were studied in 21 patients with chronic, high-grade ventricular arrhythmia using a prospective, 3-month, placebo-controlled, single-blind trial design. Encainide caused a 96% decrease in the average hourly frequency of ventricular premat...
journal_title:Circulation
pub_type: 临床试验,杂志文章
doi:10.1161/01.cir.65.6.1134
更新日期:1982-06-01 00:00:00
abstract::Of 1,801 patients in the 1985-1986 Percutaneous Transluminal Coronary Angioplasty (PTCA) Registry, 122 (6.8%) had periprocedural occlusion (4.9% in the catheterization laboratory, 1.9% outside the laboratory). Baseline patient factors independently associated with increased occlusion rates included triple-vessel disea...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.82.3.739
更新日期:1990-09-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to describe a new technique for catheter ablation of left lateral accessory pathways (APs) by radiofrequency energy applied at the epicardium through the coronary sinus wall using a unipolar configuration. METHODS AND RESULTS:In an overall group of 212 patients with left latera...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.86.5.1464
更新日期:1992-11-01 00:00:00
abstract:BACKGROUND:We examined the associations of a range of parental and early life characteristics with systolic blood pressure at 5 years of age. METHODS AND RESULTS:Information from 3864 children who were followed up prospectively from their mother's first antenatal clinic assessment was used. Maternal age, body mass ind...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.CIR.0000145165.80130.B5
更新日期:2004-10-19 00:00:00
abstract:BACKGROUND:Each month, the number of transplant candidates added to the waiting list exceeds the number of transplantations performed, and many outpatients deteriorate to require transplantation urgently. The current list of 2400 candidates and the average wait of 8 months continue to increase. METHODS AND RESULTS:To ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.89.1.450
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND:The optimal strategy for treating coronary bifurcation lesions remains a subject of debate. With bare-metal stents, single-stent approaches appear to be superior to systematic 2-stent strategies. Drug-eluting stents, however, have low rates of restenosis and might offer improved outcomes with complex stentin...
journal_title:Circulation
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1161/CIRCULATIONAHA.109.888297
更新日期:2010-03-16 00:00:00