Cardiac manifestations of malignant hyperthermia susceptibility.

abstract：BACKGROUND:A subgroup of patients with hypertrophic obstructive cardiomyopathy remain severely symptomatic despite optimal medical therapy. Septal myectomy reduces or eliminates left ventricular outflow obstruction and produces marked symptomatic improvement. With the recent advent of alternative methods for treatment ...

journal_title：Circulation

authors： McCully RB,Nishimura RA,Tajik AJ,Schaff HV,Danielson GK

更新日期：1996-08-01 00:00:00

abstract：:The specific and sensitivity of serum creatine phosphokinase cardiac specific isoenzyme (MB) in the diagnosis of acute myocardial infarction (AMI) was evaluated. An ion-exchange chromatographic technique was used to isolate MB. Sera layered on mini-columns of DEAE-Sephadex were eluted with Tris-buffered sodium chlorid...

journal_title：Circulation

authors： Varat MA,Mercer DW

更新日期：1975-05-01 00:00:00

abstract：BACKGROUND:Biological pacemakers (BPM) implanted in canine left bundle branch function competitively with electronic pacemakers (EPM). We hypothesized that BPM engineered with the use of mE324A mutant murine HCN2 (mHCN2) genes would improve function over mHCN2 and that BPM/EPM tandems confer advantage over either appro...

journal_title：Circulation

authors： Bucchi A,Plotnikov AN,Shlapakova I,Danilo P Jr,Kryukova Y,Qu J,Lu Z,Liu H,Pan Z,Potapova I,KenKnight B,Girouard S,Cohen IS,Brink PR,Robinson RB,Rosen MR

更新日期：2006-09-05 00:00:00

abstract：BACKGROUND:The Doppler wire-derived (relative) coronary flow velocity reserve (CVR) that is used to evaluate functional significance of a coronary stenosis is a method performed only by interventional cardiologists. An angiographic method would be useful in the diagnostic catheterization laboratory. For this purpose, w...

journal_title：Circulation

authors： Stoel MG,Zijlstra F,Visser CA

更新日期：2003-06-24 00:00:00

abstract：:A consecutive series of 17 patients surgically treated for asymptomatic coronary artery disease was surveyed for survival, clinical status, and graft patency after a mean follow-up of 75 months. Documented myocardial infarction (MI), 14 transmural and 3 subendocardial, was the major indication for catheterization. All...

journal_title：Circulation

authors： Thurer RL,Lytle BW,Cosgrove DM,Loop FD

更新日期：1979-08-01 00:00:00

abstract：:The mechanism of atrial flutter is controversial. A 76-year-old woman with rheumatic heart disease was referred to our clinic with an unusual rhythm disturbance which initially appeared to be classic atrial flutter at a rate of 300 beats/min. Later tracings, however, demonstrated a rate exactly one-half that of the ea...

journal_title：Circulation

authors： Homcy CJ,Lorell B,Yurchak PM

更新日期：1979-09-01 00:00:00

abstract：BACKGROUND:Retrospective studies in dialysis patients have reported increased survival after coronary artery bypass (CAB) compared with coronary artery stenting and PTCA. The purpose of this study was to compare the long-term outcome of renal transplant recipients after stent, PTCA, or CAB with or without internal mamm...

journal_title：Circulation

authors： Herzog CA,Ma JZ,Collins AJ

更新日期：2004-06-15 00:00:00

abstract：BACKGROUND:Early childhood introduction of nutritional habits aimed at atherosclerosis prevention reduces children's serum total cholesterol concentration, but its effect on vascular endothelial function is unknown. METHODS AND RESULTS:Between 1990 and 1992, we randomized healthy 7-month-old infants (n=1062) to interv...

journal_title：Circulation

authors： Raitakari OT,Rönnemaa T,Järvisalo MJ,Kaitosaari T,Volanen I,Kallio K,Lagström H,Jokinen E,Niinikoski H,Viikari JS,Simell O

更新日期：2005-12-13 00:00:00

abstract：:Analysis of the Framingham Heart Study experience between 1958 and 1970 showed a progressive increase in the rate of treatment and control of hypertension. With cross-sectional criteria to define diastolic hypertension, the treatment rate rose from 35% in 1958 through 1960 to 69% in 1968 through 1970 (p less than .001...

journal_title：Circulation

authors： Shea S,Cook EF,Kannel WB,Goldman L

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND:Serum paraoxonase (PON1), an enzyme carried on HDL, inhibits LDL oxidation, and in human population studies, low PON1 activity is associated with atherosclerosis. In addition, PON1 knockout mice are more susceptible to lipoprotein oxidation and atherosclerosis. To evaluate whether PON1 protects against ather...

journal_title：Circulation

authors： Tward A,Xia YR,Wang XP,Shi YS,Park C,Castellani LW,Lusis AJ,Shih DM

更新日期：2002-07-23 00:00:00

abstract：BACKGROUND:Endothelial progenitor cells (EPCs) circulate in adult peripheral blood (PB) and contribute to neovascularization. However, little is known regarding whether EPCs and their putative precursor, CD34-positive mononuclear cells (MNC(CD34+)), are mobilized into PB in acute ischemic events in humans. METHODS AND...

journal_title：Circulation

authors： Shintani S,Murohara T,Ikeda H,Ueno T,Honma T,Katoh A,Sasaki K,Shimada T,Oike Y,Imaizumi T

更新日期：2001-06-12 00:00:00

abstract：BACKGROUND:Cyclosporin A is reported to impair endothelium-mediated vasorelaxation and induce endothelin release in some noncoronary vascular beds. We wished to determine whether acute cyclosporine administration induces endothelial dysfunction in coronary conductance or resistance arteries. METHODS AND RESULTS:We exa...

journal_title：Circulation

authors： Sudhir K,MacGregor JS,DeMarco T,De Groot CJ,Taylor RN,Chou TM,Yock PG,Chatterjee K

更新日期：1994-12-01 00:00:00

abstract：BACKGROUND:Hypercholesterolemia causes an upregulation of vascular angiotensin II type 1 (AT1) receptor expression in cell culture and animal models. The presented studies were undertaken to examine AT1 receptor overexpression in hypercholesterolemic men and therapeutic interventions thereof by HMG CoA reductase inhibi...

journal_title：Circulation

authors： Nickenig G,Bäumer AT,Temur Y,Kebben D,Jockenhövel F,Böhm M

更新日期：1999-11-23 00:00:00

abstract：BACKGROUND:The purpose of this study was to assess the long-term value of dobutamine-atropine stress echocardiography (DSE) for prediction of late cardiac events in patients with proven or suspected coronary artery disease. METHODS AND RESULTS:Clinical data and DSE results were analyzed in 1734 consecutive patients un...

journal_title：Circulation

authors： Poldermans D,Fioretti PM,Boersma E,Bax JJ,Thomson IR,Roelandt JR,Simoons ML

更新日期：1999-02-16 00:00:00

abstract：BACKGROUND:The role of a cluster of risk factors characteristic for the insulin resistance syndrome as a predictor for coronary heart disease (CHD) has not been studied previously. METHODS AND RESULTS:Clustering of cardiovascular risk factors was analyzed by factor analysis to investigate whether these clusters (facto...

journal_title：Circulation

authors： Lempiäinen P,Mykkänen L,Pyörälä K,Laakso M,Kuusisto J

更新日期：1999-07-13 00:00:00

abstract：:Identification of regional myocardial ischemia by TQ-ST segment mapping, while commonly used, is relatively imprecise and nonspecific. In 41 open-chest dogs we examined whether monophasic action potentials (MAPs) recorded from the myocardial surface by means of a new contact-electrode technique could be used to more p...

journal_title：Circulation

authors： Franz MR,Flaherty JT,Platia EV,Bulkley BH,Weisfeldt ML

更新日期：1984-03-01 00:00:00

abstract：:Paclitaxel drug-coated balloons and drug-eluting stents became commercially available for the treatment of intermittent claudication in 2015 and 2012, respectively. Both devices demonstrated superiority in limb revascularization compared with non-paclitaxel-coated devices and were rapidly accepted into clinical practi...

journal_title：Circulation

authors： Beckman JA,White CJ

更新日期：2019-10-15 00:00:00

abstract：:The endothelin (ET) system is comprised of 4 active ETs, with ET-1 being the predominant isoform in the cardiovascular system. Because of the potent vasoconstricting and mitogenic effects of ET-1 and its involvement in various cardiovascular diseases, blockade of the ET receptor has received considerable attention. ET...

journal_title：Circulation

authors： Rich S,McLaughlin VV

更新日期：2003-11-04 00:00:00

abstract：BACKGROUND:We recently reported that sodium channel block can produce opposite effects on action potential duration (APD) and refractoriness in epicardial versus endocardial tissues of the canine ventricle. In addition, strong sodium channel current inhibition was found to cause loss of the action potential dome in epi...

journal_title：Circulation

authors： Krishnan SC,Antzelevitch C

更新日期：1993-02-01 00:00:00

abstract：BACKGROUND:The long-term success of coronary bypass surgery is dependent on graft patency after surgery. This trial was designed to determine if aspirin improved saphenous vein graft or internal mammary artery (IMA) graft patency between 1 and 3 years after coronary artery bypass grafting (CABG). METHODS AND RESULTS:A...

journal_title：Circulation

authors： Goldman S,Copeland J,Moritz T,Henderson W,Zadina K,Ovitt T,Kern KB,Sethi G,Sharma GV,Khuri S

更新日期：1994-03-01 00:00:00

abstract：BACKGROUND:Frequently the definitive operation for patients with a right ventricle (RV) that is too small to support full cardiac output is a modified Fontan operation. However, other surgical options exist that incorporate a small RV in the atriopulmonary pathway when biventricular repair is not feasible because of RV...

journal_title：Circulation

authors： Gentles TL,Keane JF,Jonas RA,Marx GE,Mayer JE Jr

更新日期：1994-11-01 00:00:00

abstract：:Dispatcher-delivered telephone instruction in cardiopulmonary resuscitation (CPR) has been proposed to increase rates of bystander CPR in cases of out-of-hospital cardiac arrest. We tested the efficacy of a previously developed CPR message using a recording mannikin in a high stress, simulated cardiac arrest scenario....

journal_title：Circulation

authors： Kellermann AL,Hackman BB,Somes G

更新日期：1989-11-01 00:00:00

abstract：:Both the Veterans Administration Cooperative Study and the European Coronary Surgery Study have provided only brief accounts of graft patency rates in their surgically treated patients. In the Veterans Administration Cooperative Study, at an average of 1 year after operation, 69% of the grafts were patent among 208 pa...

journal_title：Circulation

authors： Bourassa MG,Fisher LD,Campeau L,Gillespie MJ,McConney M,Lespérance J

更新日期：1985-12-01 00:00:00

abstract：BACKGROUND:Intravascular irradiation with beta-emitters has been proposed for inhibition of restenosis in coronary arteries after balloon angioplasty or stent implantation. Previous studies have shown the effectiveness of gamma-radiation to prevent recurrent restenosis, even in the presence of an implanted stent. The l...

journal_title：Circulation

authors： Amols HI,Trichter F,Weinberger J

更新日期：1998-11-10 00:00:00

abstract：BACKGROUND:Vascular smooth muscle cell growth factors are postulated to contribute to cardiac allograft vasculopathy (CAV). Few data quantitatively address the timing, location, or stimuli for growth factor expression and relationship to CAV. METHODS AND RESULTS:Acidic fibroblast growth factor (aFGF) mRNA expression w...

journal_title：Circulation

authors： Miller GG,Davis SF,Atkinson JB,Chomsky DB,Pedroso P,Reddy VS,Drinkwater DC,Zhao XM,Pierson RN

更新日期：1999-12-14 00:00:00

abstract：OBJECTIVE:To assess the outcome of 3 different surgical approaches for treatment of acute aortic dissection type A (AADA). METHODS AND RESULTS:Between October 1990 and October 2003, we operated on 295 patients (pts) for AADA. Follow-up was complete for 257 pts (87%). Supracommissural replacement (SCR) of the ascending...

journal_title：Circulation

authors： Kallenbach K,Oelze T,Salcher R,Hagl C,Karck M,Leyh RG,Haverich A

更新日期：2004-09-14 00:00:00

abstract：BACKGROUND:The absence of functional dystrophin in Duchenne muscular dystrophy (DMD) patients and in mdx mice results in progressive muscle degeneration associated with necrosis, fibrosis, and inflammation. Because vascular supply plays a key role in tissue repair, we examined whether new blood vessel development was a...

journal_title：Circulation

authors： Straino S,Germani A,Di Carlo A,Porcelli D,De Mori R,Mangoni A,Napolitano M,Martelli F,Biglioli P,Capogrossi MC

更新日期：2004-11-23 00:00:00

abstract：BACKGROUND:Several studies demonstrated ischemic microvascular damage in patients with acute myocardial infarction (AMI). In this study, myocardial contrast echocardiography (MCE) was used to assess the temporal changes in myocardial perfusion after reflow and to investigate the relation between MCE findings and myocar...

journal_title：Circulation

authors： Ito H,Iwakura K,Oh H,Masuyama T,Hori M,Higashino Y,Fujii K,Minamino T

更新日期：1995-02-01 00:00:00

abstract：BACKGROUND:Ventricular tachyarrhythmias are the major clinical manifestation of arrhythmogenic right ventricular disease. Although antiarrhythmic therapy has been widely advocated, there is only limited information available on the efficacy of antiarrhythmic drugs in these patients. METHODS AND RESULTS:The short- and ...

journal_title：Circulation

authors： Wichter T,Borggrefe M,Haverkamp W,Chen X,Breithardt G

更新日期：1992-07-01 00:00:00

abstract：BACKGROUND:Chronic orthostatic intolerance (COI) is a debilitating autonomic condition in young adults. Its neurohumoral and hemodynamic profiles suggest possible alterations of postural sympathetic function and of baroreflex control of heart rate (HR). METHODS AND RESULTS:In 16 COI patients and 16 healthy volunteers,...

journal_title：Circulation

authors： Furlan R,Jacob G,Snell M,Robertson D,Porta A,Harris P,Mosqueda-Garcia R

更新日期：1998-11-17 00:00:00