Longitudinal analysis of fibroblast growth factor expression after transplantation and association with severity of cardiac allograft vasculopathy.

Abstract:

BACKGROUND:Vascular smooth muscle cell growth factors are postulated to contribute to cardiac allograft vasculopathy (CAV). Few data quantitatively address the timing, location, or stimuli for growth factor expression and relationship to CAV. METHODS AND RESULTS:Acidic fibroblast growth factor (aFGF) mRNA expression was determined in serial endomyocardial biopsies during the first year after transplantation. Patients with high levels of aFGF mRNA and elevations after the early posttransplant period had significantly more severe CAV than patients with low aFGF and no late elevations. CONCLUSIONS:Parenchymal aFGF expression varies between patients and in the same patient over time and correlates with development of CAV.

journal_name

Circulation

journal_title

Circulation

authors

Miller GG,Davis SF,Atkinson JB,Chomsky DB,Pedroso P,Reddy VS,Drinkwater DC,Zhao XM,Pierson RN

doi

10.1161/01.cir.100.24.2396

subject

Has Abstract

pub_date

1999-12-14 00:00:00

pages

2396-9

issue

24

eissn

0009-7322

issn

1524-4539

journal_volume

100

pub_type

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