Abstract:
BACKGROUND:Vascular smooth muscle cell growth factors are postulated to contribute to cardiac allograft vasculopathy (CAV). Few data quantitatively address the timing, location, or stimuli for growth factor expression and relationship to CAV. METHODS AND RESULTS:Acidic fibroblast growth factor (aFGF) mRNA expression was determined in serial endomyocardial biopsies during the first year after transplantation. Patients with high levels of aFGF mRNA and elevations after the early posttransplant period had significantly more severe CAV than patients with low aFGF and no late elevations. CONCLUSIONS:Parenchymal aFGF expression varies between patients and in the same patient over time and correlates with development of CAV.
journal_name
Circulationjournal_title
Circulationauthors
Miller GG,Davis SF,Atkinson JB,Chomsky DB,Pedroso P,Reddy VS,Drinkwater DC,Zhao XM,Pierson RNdoi
10.1161/01.cir.100.24.2396subject
Has Abstractpub_date
1999-12-14 00:00:00pages
2396-9issue
24eissn
0009-7322issn
1524-4539journal_volume
100pub_type
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