Cardioplegic solutions for myocardial preservation: analysis of hypothermic arrest, potassium arrest, and procaine arrest.

Abstract:

:Separate effects of perfusion hypothermia, potassium arrest, and procaine arrest were studied in 150 hearts using the isolated rat heart preparation. Aortic flow rate (AFR), coronary flow rate (CFR), and heart rate (HR) were measured before and after ischemic periods of 90 to 300 min. Prior to the ischemic period, the aortic root was infused with Krebs-Henseleit buffer (KHB), buffer with 30 mEq KCl/L (KHB + K), or buffer with 0.2% procaine (KHB + P), at 15 degrees or 5 degrees C. During the ischemic period the hearts were maintained at 15 degrees or 5 degrees C in a hypothermic chamber. The three solutions had similar recoveries of AFR at 15 degrees and 5 degrees C following ischemic periods of 90, 180, and 240 min. The KHB + K and KHB + P had better recoveries of AFR than KHB at 5 degrees C and 300 min of ischemia. The KHB + K and KHB + P also caused more rapid arrest and a higher incidence of spontaneous recovery of sinus rhythm. Arrest at 5 degrees C was equal to or superior to arrest at 15 degrees C. Perfusion hypothermia is the main component of cold cardioplegia. The addition of procaine or potassium results in increased functional recovery at extended ischemic times at 5 degrees C, more rapid arrest, and better electrical recovery.

journal_name

Circulation

journal_title

Circulation

authors

Harlan BJ,Ross D,Macmanus Q,Knight R,Luber J,Starr A

subject

Has Abstract

pub_date

1978-09-01 00:00:00

pages

I114-8

issue

3 Pt 2

eissn

0009-7322

issn

1524-4539

journal_volume

58

pub_type

杂志文章
  • A quarter century of drug treatment of dyslipoproteinemia, with a focus on the new HMG-CoA reductase inhibitor fluvastatin.

    abstract::Disorders associated with the overproduction or delayed clearance of beta-very low density lipoprotein and low density lipoprotein (LDL) are strikingly related to premature coronary artery disease. There are five recognized classes of LDL-lowering drugs, each acting through different basic mechanisms. The increased pr...

    journal_title:Circulation

    pub_type: 杂志文章,评审

    doi:

    authors: Levy RI,Troendle AJ,Fattu JM

    更新日期:1993-04-01 00:00:00

  • Ultrasonic echolucent carotid plaques predict future strokes.

    abstract:BACKGROUND:We tested prospectively the hypothesis that stroke development can be predicted by echolucency of carotid atherosclerotic plaques in previously symptomatic and asymptomatic patients. METHODS AND RESULTS:We followed incidence of ipsilateral ischemic strokes for 4.4 years in 111 asymptomatic and 135 symptomat...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章

    doi:10.1161/hc2601.091704

    authors: Grønholdt ML,Nordestgaard BG,Schroeder TV,Vorstrup S,Sillesen H

    更新日期:2001-07-03 00:00:00

  • The evolution of chemokine release supports a bimodal mechanism of spinal cord ischemia and reperfusion injury.

    abstract:BACKGROUND:Paraplegia remains a devastating complication of thoracic aortic surgery. The mechanism of the antecedent spinal cord ischemia and reperfusion injury (IR) remains poorly described. IR involves 2 injuries, an initial ischemic insult and subsequent inflammatory amplification of the injury. This mechanism is co...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.111.080275

    authors: Smith PD,Puskas F,Meng X,Lee JH,Cleveland JC Jr,Weyant MJ,Fullerton DA,Reece TB

    更新日期:2012-09-11 00:00:00

  • Coronary artery surgery study (CASS): a randomized trial of coronary bypass surgery. Eight years follow-up and survival in patients with reduced ejection fraction.

    abstract::Survival data after 8 years of follow-up for all patients and after 7 years for certain subgroups are reported from CASS, a randomized trial of surgical or medical treatment assignment in patients with coronary artery disease who have less than severe angina or are asymptomatic after myocardial infarction. After 8 yea...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章

    doi:

    authors: Killip T,Passamani E,Davis K

    更新日期:1985-12-01 00:00:00

  • Autoregulation of cardiac output by passive elastic characteristics of the vascular capacitance system.

    abstract::After a change in cardiac output, the magnitude of potential blood volume redistribution was investigated in 10 dogs anesthetized with chloralose. All of the venous return was pumped into a reservoir, using servocontrolled pumps to maintain fixed superior and inferior vena cava pressures. The cardiac output was set at...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.81.1.360

    authors: Rothe CF,Gaddis ML

    更新日期:1990-01-01 00:00:00

  • Effect of Alirocumab on Mortality After Acute Coronary Syndromes.

    abstract:BACKGROUND:Previous trials of PCSK9 (proprotein convertase subtilisin-kexin type 9) inhibitors demonstrated reductions in major adverse cardiovascular events, but not death. We assessed the effects of alirocumab on death after index acute coronary syndrome. METHODS:ODYSSEY OUTCOMES (Evaluation of Cardiovascular Outcom...

    journal_title:Circulation

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1161/CIRCULATIONAHA.118.038840

    authors: Steg PG,Szarek M,Bhatt DL,Bittner VA,Brégeault MF,Dalby AJ,Diaz R,Edelberg JM,Goodman SG,Hanotin C,Harrington RA,Jukema JW,Lecorps G,Mahaffey KW,Moryusef A,Ostadal P,Parkhomenko A,Pordy R,Roe MT,Tricoci P,Vogel R

    更新日期:2019-07-09 00:00:00

  • Effects of platelet glycoprotein IIb/IIIa blockade with tirofiban on adverse cardiac events in patients with unstable angina or acute myocardial infarction undergoing coronary angioplasty. The RESTORE Investigators. Randomized Efficacy Study of Tirofiban

    abstract:BACKGROUND:Adverse cardiovascular events associated with thrombotic occlusion occur in 4% to 12.8% of patients after coronary angioplasty. Recently, potent antiplatelet agents have been used to reduce those thrombotic complications. Tirofiban is a highly selective, short-acting inhibitor of fibrinogen binding to platel...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1161/01.cir.96.5.1445

    authors:

    更新日期:1997-09-02 00:00:00

  • Population characteristics according to recruitment source.

    abstract::Considerable variability was observed among recruitment sources and centers in the proportion of first protocol visits proceeding to entry. Some of the reasons for these differences are explored. Several characteristics of the participants were also analyzed to determine whether significant variability existed among r...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:

    authors: Hunninghake DB,Knoke J,LaDouceur M,Peterson F

    更新日期:1982-12-01 00:00:00

  • Adiponectin specifically increased tissue inhibitor of metalloproteinase-1 through interleukin-10 expression in human macrophages.

    abstract:BACKGROUND:Vascular inflammation and subsequent matrix degradation play an important role in the development of atherosclerosis. We previously reported that adiponectin, an adipose-specific plasma protein, accumulated to the injured artery and attenuated vascular inflammatory response. Clinically, high plasma adiponect...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.CIR.0000127953.98131.ED

    authors: Kumada M,Kihara S,Ouchi N,Kobayashi H,Okamoto Y,Ohashi K,Maeda K,Nagaretani H,Kishida K,Maeda N,Nagasawa A,Funahashi T,Matsuzawa Y

    更新日期:2004-05-04 00:00:00

  • Assessing myocardial viability and infarct transmurality with left ventricular electromechanical mapping in patients with stable coronary artery disease: validation by delayed-enhancement magnetic resonance imaging.

    abstract:BACKGROUND:This study was designed to define myocardial viability and establish practical cut-off values for differentiating normal myocardial tissue from subendocardial and transmural scar tissue by using electromechanical mapping (EMM). We validated our results by delayed-enhancement cardiac MRI (DE-MRI). METHODS AN...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章

    doi:10.1161/01.cir.0000026394.01888.18

    authors: Perin EC,Silva GV,Sarmento-Leite R,Sousa AL,Howell M,Muthupillai R,Lambert B,Vaughn WK,Flamm SD

    更新日期:2002-08-20 00:00:00

  • Mitochondrial Dysfunction in Heart Failure With Preserved Ejection Fraction.

    abstract::Heart failure with preserved ejection fraction (HFpEF) is a complex syndrome with an increasingly recognized heterogeneity in pathophysiology. Exercise intolerance is the hallmark of HFpEF and appears to be caused by both cardiac and peripheral abnormalities in the arterial tree and skeletal muscle. Mitochondrial abno...

    journal_title:Circulation

    pub_type: 杂志文章,评审

    doi:10.1161/CIRCULATIONAHA.118.036259

    authors: Kumar AA,Kelly DP,Chirinos JA

    更新日期:2019-03-12 00:00:00

  • L-4F, an apolipoprotein A-1 mimetic, restores nitric oxide and superoxide anion balance in low-density lipoprotein-treated endothelial cells.

    abstract:BACKGROUND:Low-density lipoprotein (LDL) impairs endothelial cell function by uncoupling endothelial nitric oxide synthase (eNOS) activity, which allows superoxide anion (O2*-)) to be generated rather than nitric oxide (*NO). Recent reports indicate that apolipoprotein (apo) A-1 mimetics inhibit the development of athe...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.0000061949.17174.b6

    authors: Ou Z,Ou J,Ackerman AW,Oldham KT,Pritchard KA Jr

    更新日期:2003-03-25 00:00:00

  • Protective effect of propylthiouracil independent of its hypothyroid effect on atherogenesis in cholesterol-fed rabbits: PTEN induction and inhibition of vascular smooth muscle cell proliferation and migration.

    abstract:BACKGROUND:Propylthiouracil (PTU) is used to treat hyperthyroid patients by its hypothyroid effect. PTU also is found to have potent antioxidant and immunosuppressive effects. These findings suggest that PTU may play a role in the prevention of atherosclerosis. METHODS AND RESULTS:This study evaluates the effect of PT...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.CIR.0000140764.15398.F3

    authors: Chen WJ,Lin KH,Lai YJ,Yang SH,Pang JH

    更新日期:2004-09-07 00:00:00

  • Aspirin in the treatment of acute myocardial infarction in elderly Medicare beneficiaries. Patterns of use and outcomes.

    abstract:BACKGROUND:Although aspirin is an effective, inexpensive, and safe treatment of acute myocardial infarction, the frequency of use of aspirin in actual medical practice is not known. Elderly patients, a group with low rates of utilization of effective therapies such as thrombolytic therapy, also may be at risk of not re...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.92.10.2841

    authors: Krumholz HM,Radford MJ,Ellerbeck EF,Hennen J,Meehan TP,Petrillo M,Wang Y,Kresowik TF,Jencks SF

    更新日期:1995-11-15 00:00:00

  • Sex-Specific Trends in Acute Myocardial Infarction Within an Integrated Healthcare Network, 2000 Through 2014.

    abstract:BACKGROUND:In recent decades, the rates of incident acute myocardial infarction (AMI) have declined in the United States, yet disparities by sex remain. In an integrated healthcare delivery system, we examined temporal trends in incident AMI among women and men. METHODS:We identified hospitalized AMI among members ≥35...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.119.044738

    authors: Mefford MT,Li BH,Qian L,Reading SR,Harrison TN,Scott RD,Cavendish JJ,Jacobsen SJ,Kanter MH,Woodward M,Reynolds K

    更新日期:2020-02-18 00:00:00

  • Role of monocyte chemoattractant protein-1 in cardiovascular remodeling induced by chronic blockade of nitric oxide synthesis.

    abstract:BACKGROUND:Chronic inhibition of endothelial nitric oxide (NO) synthesis by the administration of N:(omega)-nitro-L-arginine methyl ester (L-NAME) to rats induces early vascular inflammatory changes (monocyte infiltration into coronary vessels and monocyte chemoattractant protein-1 [MCP-1] expression) as well as subseq...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.102.18.2243

    authors: Koyanagi M,Egashira K,Kitamoto S,Ni W,Shimokawa H,Takeya M,Yoshimura T,Takeshita A

    更新日期:2000-10-31 00:00:00

  • Factors controlling the development of arterial lesions after injury.

    abstract::This review discusses the role of growth factors on the proliferation of smooth muscle cells (SMCs) in injured arteries. We have used a variety of procedures to injure rat carotid arteries and noted that removal of endothelium followed by platelet adherence does not always initiate SMC replication. Furthermore, thromb...

    journal_title:Circulation

    pub_type: 杂志文章,评审

    doi:

    authors: Reidy MA,Fingerle J,Lindner V

    更新日期:1992-12-01 00:00:00

  • Dilation angioplasty of congenital or operative narrowings of venous channels.

    abstract::Balloon dilation angioplasty was attempted in 10 infants and children with severe congenital or operative "venous" obstructions. In five children the obstructions were "vena caval" and followed repair for transposition of the great vessels (four patients) or orthotopic liver transplantation (one patient). In the four ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.70.3.457

    authors: Lock JE,Bass JL,Castaneda-Zuniga W,Fuhrman BP,Rashkind WJ,Lucas RV Jr

    更新日期:1984-09-01 00:00:00

  • Mitral leaflet adaptation to ventricular remodeling: occurrence and adequacy in patients with functional mitral regurgitation.

    abstract:BACKGROUND:Functional mitral regurgitation (MR) is caused by systolic traction on the mitral leaflets related to ventricular distortion. Little is known about whether chronic tethering causes the mitral leaflet area to adapt to the geometric needs imposed by tethering, in part because of inability to reconstruct leafle...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.107.749440

    authors: Chaput M,Handschumacher MD,Tournoux F,Hua L,Guerrero JL,Vlahakes GJ,Levine RA

    更新日期:2008-08-19 00:00:00

  • Adrenocortical, autonomic, and inflammatory causes of the metabolic syndrome: nested case-control study.

    abstract:BACKGROUND:The causes of metabolic syndrome (MS), which may be a precursor of coronary disease, are uncertain. We hypothesize that disturbances in neuroendocrine and cardiac autonomic activity (CAA) contribute to development of MS. We examine reversibility and the power of psychosocial and behavioral factors to explain...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.0000038364.26310.bd

    authors: Brunner EJ,Hemingway H,Walker BR,Page M,Clarke P,Juneja M,Shipley MJ,Kumari M,Andrew R,Seckl JR,Papadopoulos A,Checkley S,Rumley A,Lowe GD,Stansfeld SA,Marmot MG

    更新日期:2002-11-19 00:00:00

  • Systolic and diastolic mechanics in stress cardiomyopathy.

    abstract:BACKGROUND:Stress cardiomyopathy (SCM) is a peculiar form of reversible left ventricular dysfunction seen predominantly in women and occurs in response to emotional or physical stress. Because dysfunction in SCM is reversible and that of acute myocardial infarction (MI) is not, we hypothesized that these fundamental me...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.113.002781

    authors: Medeiros K,O'Connor MJ,Baicu CF,Fitzgibbons TP,Shaw P,Tighe DA,Zile MR,Aurigemma GP

    更新日期:2014-04-22 00:00:00

  • Adenosine enhances neuroexcitability by inhibiting a slow postspike afterhyperpolarization in rabbit vagal afferent neurons.

    abstract:BACKGROUND:Electrophysiological mechanisms by which adenosine may activate cardiac afferent neurons are unknown. Slow afterhyperpolarizations (AHPs) follow action potentials in a subset of vagal C afferents, rendering them inexcitable. The purpose of this study was to test the hypothesis that adenosine increases vagal ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.103.9.1325

    authors: Middlekauff HR,Doering A,Weiss JN

    更新日期:2001-03-06 00:00:00

  • Forecasting the future of cardiovascular disease in the United States: a policy statement from the American Heart Association.

    abstract:BACKGROUND:Cardiovascular disease (CVD) is the leading cause of death in the United States and is responsible for 17% of national health expenditures. As the population ages, these costs are expected to increase substantially. METHODS AND RESULTS:To prepare for future cardiovascular care needs, the American Heart Asso...

    journal_title:Circulation

    pub_type: 共识发展会议,杂志文章

    doi:10.1161/CIR.0b013e31820a55f5

    authors: Heidenreich PA,Trogdon JG,Khavjou OA,Butler J,Dracup K,Ezekowitz MD,Finkelstein EA,Hong Y,Johnston SC,Khera A,Lloyd-Jones DM,Nelson SA,Nichol G,Orenstein D,Wilson PW,Woo YJ,American Heart Association Advocacy Coordinating

    更新日期:2011-03-01 00:00:00

  • Cyclooxygenase-2 inhibition increases mortality, enhances left ventricular remodeling, and impairs systolic function after myocardial infarction in the pig.

    abstract:BACKGROUND:Cyclooxygenase (COX)-2 expression in the heart increases after myocardial infarction (MI). In murine models of MI, COX-2 inhibition preserves left ventricular dimensions and function. We studied the effect of selective COX-2 inhibition on left ventricular remodeling and function after MI in a pig model. MET...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.106.647230

    authors: Timmers L,Sluijter JP,Verlaan CW,Steendijk P,Cramer MJ,Emons M,Strijder C,Gründeman PF,Sze SK,Hua L,Piek JJ,Borst C,Pasterkamp G,de Kleijn DP

    更新日期:2007-01-23 00:00:00

  • Incidence, Cause, and Comparative Frequency of Sudden Cardiac Death in National Collegiate Athletic Association Athletes: A Decade in Review.

    abstract:BACKGROUND:The incidence and cause of sudden cardiac death (SCD) in athletes is debated with hypertrophic cardiomyopathy often reported as the most common cause. METHODS AND RESULTS:A database of all National Collegiate Athletic Association deaths (2003-2013) was developed. Additional information and autopsy reports w...

    journal_title:Circulation

    pub_type: 杂志文章,评审

    doi:10.1161/CIRCULATIONAHA.115.015431

    authors: Harmon KG,Asif IM,Maleszewski JJ,Owens DS,Prutkin JM,Salerno JC,Zigman ML,Ellenbogen R,Rao AL,Ackerman MJ,Drezner JA

    更新日期:2015-07-07 00:00:00

  • Second natural history study of congenital heart defects. Results of treatment of patients with pulmonary valvar stenosis.

    abstract:BACKGROUND:From 1958 to 1969, 592 patients (mostly children) with pulmonary stenosis were admitted to the First Natural History Study of Congenital Heart Defects (NHS-1) after cardiac catheterization. Most with gradients < 50 mm Hg were managed medically; most with gradients > or = 80 mm Hg had pulmonary valvotomy. Amo...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:

    authors: Hayes CJ,Gersony WM,Driscoll DJ,Keane JF,Kidd L,O'Fallon WM,Pieroni DR,Wolfe RR,Weidman WH

    更新日期:1993-02-01 00:00:00

  • Sex differences in hospital mortality after coronary artery bypass surgery: evidence for a higher mortality in younger women.

    abstract:BACKGROUND:Data are conflicting over whether women have higher mortality than men after coronary artery bypass graft (CABG) surgery. Younger but not older women hospitalized for acute myocardial infarction have higher in-hospital mortality rates than men. We hypothesized that younger women also have higher in-hospital ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/hc1002.105133

    authors: Vaccarino V,Abramson JL,Veledar E,Weintraub WS

    更新日期:2002-03-12 00:00:00

  • Significance of a fragmented QRS complex versus a Q wave in patients with coronary artery disease.

    abstract:BACKGROUND:Q waves on a 12-lead ECG are markers of a prior myocardial infarction (MI). However, they may regress or even disappear over time, and there is no specific ECG sign of a non-Q-wave MI. Fragmented QRS complexes (fQRSs), which include various RSR' patterns, without a typical bundle-branch block are markers of ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.105.595892

    authors: Das MK,Khan B,Jacob S,Kumar A,Mahenthiran J

    更新日期:2006-05-30 00:00:00

  • Physician-directed patient self-management of left atrial pressure in advanced chronic heart failure.

    abstract:BACKGROUND:Previous studies suggest that management of ambulatory hemodynamics may improve outcomes in chronic heart failure. We conducted a prospective, observational, first-in-human study of a physician-directed patient self-management system targeting left atrial pressure. METHODS AND RESULTS:Forty patients with re...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1161/CIRCULATIONAHA.108.800490

    authors: Ritzema J,Troughton R,Melton I,Crozier I,Doughty R,Krum H,Walton A,Adamson P,Kar S,Shah PK,Richards M,Eigler NL,Whiting JS,Haas GJ,Heywood JT,Frampton CM,Abraham WT,Hemodynamically Guided Home Self-Therapy in Severe Hea

    更新日期:2010-03-09 00:00:00

  • Sternotomy approach for the modified Blalock-Taussig shunt.

    abstract:BACKGROUND:Since 1990, sternotomy has been the preferred approach for construction of a modified Blalock-Taussig shunt (MBTS) at Children's Hospital, Boston, Mass. In retrospect, we sought to test the hypothesis that this approach yields less mortality and morbidity than the traditional thoracotomy approach. METHODS A...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.92.9.256

    authors: Odim J,Portzky M,Zurakowski D,Wernovsky G,Burke RP,Mayer JE Jr,Castaneda AR,Jonas RA

    更新日期:1995-11-01 00:00:00