Growth properties of cardiac stem cells are a novel biomarker of patients' outcome after coronary bypass surgery.

Abstract:

BACKGROUND:The efficacy of bypass surgery in patients with ischemic cardiomyopathy is not easily predictable; preoperative clinical conditions may be similar, but the outcome may differ significantly. We hypothesized that the growth reserve of cardiac stem cells (CSCs) and circulating cytokines promoting CSC activation are critical determinants of ventricular remodeling in this patient population. METHODS AND RESULTS:To document the growth kinetics of CSCs, population-doubling time, telomere length, telomerase activity, and insulin-like growth factor-1 receptor expression were measured in CSCs isolated from 38 patients undergoing bypass surgery. Additionally, the blood levels of insulin-like growth factor-1, hepatocyte growth factor, and vascular endothelial growth factor were evaluated. The variables of CSC growth were expressed as a function of the changes in wall thickness, chamber diameter and volume, ventricular mass-to-chamber volume ratio, and ejection fraction, before and 12 months after surgery. A high correlation was found between indices of CSC function and cardiac anatomy. Negative ventricular remodeling was not observed if CSCs retained a significant growth reserve. The high concentration of insulin-like growth factor-1 systemically pointed to the insulin-like growth factor-1-insulin-like growth factor-1 receptor system as a major player in the adaptive response of the myocardium. hepatocyte growth factor, a mediator of CSC migration, was also high in these patients preoperatively, as was vascular endothelial growth factor, possibly reflecting the vascular growth needed before bypass surgery. Conversely, a decline in CSC growth was coupled with wall thinning, chamber dilation, and depressed ejection fraction. CONCLUSIONS:The telomere-telomerase axis, population-doubling time, and insulin-like growth factor-1 receptor expression in CSCs, together with a high circulating level of insulin-like growth factor-1, represent a novel biomarker able to predict the evolution of ischemic cardiomyopathy following revascularization.

journal_name

Circulation

journal_title

Circulation

authors

D'Amario D,Leone AM,Iaconelli A,Luciani N,Gaudino M,Kannappan R,Manchi M,Severino A,Shin SH,Graziani F,Biasillo G,Macchione A,Smaldone C,De Maria GL,Cellini C,Siracusano A,Ottaviani L,Massetti M,Goichberg P,Leri A,

doi

10.1161/CIRCULATIONAHA.113.006591

subject

Has Abstract

pub_date

2014-01-14 00:00:00

pages

157-72

issue

2

eissn

0009-7322

issn

1524-4539

pii

CIRCULATIONAHA.113.006591

journal_volume

129

pub_type

杂志文章,收录出版
  • Uncontrolled and apparent treatment resistant hypertension in the United States, 1988 to 2008.

    abstract:BACKGROUND:Despite progress, many hypertensive patients remain uncontrolled. Defining characteristics of uncontrolled hypertensives may facilitate efforts to improve blood pressure control. METHODS AND RESULTS:Subjects included 13,375 hypertensive adults from National Health and Nutrition Examination Surveys (NHANESs)...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.111.030189

    authors: Egan BM,Zhao Y,Axon RN,Brzezinski WA,Ferdinand KC

    更新日期:2011-08-30 00:00:00

  • Endoventricular remodeling of left ventricular aneurysm. Functional, clinical, and electrophysiological results.

    abstract:BACKGROUND:Recent advances in surgical techniques for the repair of left ventricular aneurysms (LVAs) include the use of an endoventricular patch to exclude the aneurysm cavity. This technique has replaced conventional linear plication of the aneurysm. The endoventricular patch technique remodels the left ventricular c...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.92.9.98

    authors: Grossi EA,Chinitz LA,Galloway AC,Delianides J,Schwartz DS,McLoughlin DE,Keller N,Kronzon I,Spencer FC,Colvin SB

    更新日期:1995-11-01 00:00:00

  • Value of programmed ventricular stimulation after tetralogy of fallot repair: a multicenter study.

    abstract:BACKGROUND:Studies have consistently shown that ventricular tachycardia (VT) and sudden cardiac death (SCD) complicate the long-term outcome after tetralogy of Fallot repair, yet the diagnostic and predictive value of electrophysiological testing in this population is uncertain. METHODS AND RESULTS:A multicenter cohor...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1161/01.CIR.0000126495.11040.BD

    authors: Khairy P,Landzberg MJ,Gatzoulis MA,Lucron H,Lambert J,Marçon F,Alexander ME,Walsh EP

    更新日期:2004-04-27 00:00:00

  • Downregulation of delayed rectifier K(+) currents in dogs with chronic complete atrioventricular block and acquired torsades de pointes.

    abstract:BACKGROUND:Acquired QT prolongation enhances the susceptibility to torsades de pointes (TdP). Clinical and experimental studies indicate ventricular action potential prolongation, increased regional dispersion of repolarization, and early afterdepolarizations as underlying factors. We examined whether K(+)-current alte...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.100.24.2455

    authors: Volders PG,Sipido KR,Vos MA,Spätjens RL,Leunissen JD,Carmeliet E,Wellens HJ

    更新日期:1999-12-14 00:00:00

  • Abciximab suppresses the rise in levels of circulating inflammatory markers after percutaneous coronary revascularization.

    abstract:BACKGROUND:Previous investigators have shown that systemic markers of inflammation may be increased in patients with acute ischemic syndromes or after percutaneous coronary revascularization and that persistent elevation in these markers is predictive of excess risk of subsequent adverse cardiac events. By virtue of it...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1161/01.cir.104.2.163

    authors: Lincoff AM,Kereiakes DJ,Mascelli MA,Deckelbaum LI,Barnathan ES,Patel KK,Frederick B,Nakada MT,Topol EJ

    更新日期:2001-07-10 00:00:00

  • Long-term results of the radial artery used for myocardial revascularization.

    abstract:BACKGROUND:No information is available on the long-term results of radial artery (RA) grafts used as coronary artery bypass conduits. METHODS AND RESULTS:In this report, we describe the long-term (105+/-9 months) angiographic results of a series of 90 consecutive patients in whom the RA was used as a coronary artery b...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章

    doi:10.1161/01.CIR.0000087402.13786.D0

    authors: Possati G,Gaudino M,Prati F,Alessandrini F,Trani C,Glieca F,Mazzari MA,Luciani N,Schiavoni G

    更新日期:2003-09-16 00:00:00

  • Endothelial-to-mesenchymal transition in pulmonary hypertension.

    abstract:BACKGROUND:The vascular remodeling responsible for pulmonary arterial hypertension (PAH) involves predominantly the accumulation of α-smooth muscle actin-expressing mesenchymal-like cells in obstructive pulmonary vascular lesions. Endothelial-to-mesenchymal transition (EndoMT) may be a source of those α-smooth muscle a...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.114.008750

    authors: Ranchoux B,Antigny F,Rucker-Martin C,Hautefort A,Péchoux C,Bogaard HJ,Dorfmüller P,Remy S,Lecerf F,Planté S,Chat S,Fadel E,Houssaini A,Anegon I,Adnot S,Simonneau G,Humbert M,Cohen-Kaminsky S,Perros F

    更新日期:2015-03-17 00:00:00

  • Mechanisms of improving regional and global ventricular function by preload alterations during acute ischemia in the canine left ventricle.

    abstract::We examined the influence of left ventricular end-diastolic pressure (LVEDP) on the mechanical interaction between ischemic and nonischemic areas during acute myocardial ischemia. Circumferentially oriented ultrasonic segment gauges were implanted in the midwall of the anterior apex and posterior apex of the left vent...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.72.5.1125

    authors: Lew WY,Ban-Hayashi E

    更新日期:1985-11-01 00:00:00

  • Flecainide-induced arrhythmia in canine ventricular epicardium. Phase 2 reentry?

    abstract:BACKGROUND:We recently reported that sodium channel block can produce opposite effects on action potential duration (APD) and refractoriness in epicardial versus endocardial tissues of the canine ventricle. In addition, strong sodium channel current inhibition was found to cause loss of the action potential dome in epi...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.87.2.562

    authors: Krishnan SC,Antzelevitch C

    更新日期:1993-02-01 00:00:00

  • Temporal trends in event rates after Q-wave myocardial infarction: the Framingham Heart Study.

    abstract:BACKGROUND:Short-term (<30 day) mortality after Q-wave myocardial infarction (MI) has declined over the decades, but it is unclear if rates of long-term sequelae after Q-wave MI have improved. METHODS AND RESULTS:In 546 Framingham Heart Study subjects (388 men with a mean age of 60 years; 158 women with a mean age of ...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章

    doi:10.1161/01.cir.100.20.2054

    authors: Guidry UC,Evans JC,Larson MG,Wilson PW,Murabito JM,Levy D

    更新日期:1999-11-16 00:00:00

  • Endothelial function in healthy 11-year-old children after dietary intervention with onset in infancy: the Special Turku Coronary Risk Factor Intervention Project for children (STRIP).

    abstract:BACKGROUND:Early childhood introduction of nutritional habits aimed at atherosclerosis prevention reduces children's serum total cholesterol concentration, but its effect on vascular endothelial function is unknown. METHODS AND RESULTS:Between 1990 and 1992, we randomized healthy 7-month-old infants (n=1062) to interv...

    journal_title:Circulation

    pub_type: 杂志文章,随机对照试验

    doi:10.1161/CIRCULATIONAHA.105.583195

    authors: Raitakari OT,Rönnemaa T,Järvisalo MJ,Kaitosaari T,Volanen I,Kallio K,Lagström H,Jokinen E,Niinikoski H,Viikari JS,Simell O

    更新日期:2005-12-13 00:00:00

  • Rheumatic fever and the HLA complex. A cosegregation study.

    abstract:BACKGROUND:Considering the controversial results published in the literature concerning associations between human leukocyte antigens (HLA) and rheumatic fever (RF), the purpose of the present study was to investigate by means of cosegregation analysis the participation of HLA genes in susceptibility to RF. METHODS AN...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.89.1.138

    authors: Gerbase-DeLima M,Scala LC,Temin J,Santos DV,Otto PA

    更新日期:1994-01-01 00:00:00

  • Mechanisms of coronary microcirculatory dysfunction in patients with aortic stenosis and angiographically normal coronary arteries.

    abstract:BACKGROUND:Development of left ventricular hypertrophy in aortic stenosis (AS) is accompanied by coronary microcirculatory dysfunction, demonstrated by an impaired coronary vasodilator reserve (CVR). However, evidence for regional abnormalities in myocardial blood flow (MBF) and the potential mechanisms is limited. The...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章

    doi:10.1161/hc0402.102931

    authors: Rajappan K,Rimoldi OE,Dutka DP,Ariff B,Pennell DJ,Sheridan DJ,Camici PG

    更新日期:2002-01-29 00:00:00

  • Right Ventricular Fibrosis.

    abstract::The role of right ventricular (RV) fibrosis in pulmonary hypertension (PH) remains a subject of ongoing discussion. Alterations of the collagen network of the extracellular matrix may help prevent ventricular dilatation in the pressure-overloaded RV. At the same time, fibrosis impairs cardiac function, and a growing b...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.118.035326

    authors: Andersen S,Nielsen-Kudsk JE,Vonk Noordegraaf A,de Man FS

    更新日期:2019-01-08 00:00:00

  • Ionic mechanisms of electronic inhibition and concealed conduction in rabbit atrioventricular nodal myocytes.

    abstract:BACKGROUND:The term "concealed conduction" is used in electrocardiography when a proximal (atrial or ventricular) impulse penetrates the atrioventricular (AV) node but fails to traverse it completely. Its penetration into the node is inferred by its after effects on the propagation of succeeding impulses. Concealed AV ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.88.4.1634

    authors: Liu Y,Zeng W,Delmar M,Jalife J

    更新日期:1993-10-01 00:00:00

  • Serum elastase activity, serum elastase inhibitors, and occurrence of carotid atherosclerotic plaques: the Etude sur le Vieillissement Artériel (EVA) study.

    abstract:BACKGROUND:In the last decades, interest has increased in the potential deleterious atherogenic effects of some cellular elastase activities. The results of experimental and clinical investigations were inconsistent. In this report, we assessed the associations of serum elastase activity and serum elastase inhibitors w...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.0000017329.51160.ef

    authors: Zureik M,Robert L,Courbon D,Touboul PJ,Bizbiz L,Ducimetière P

    更新日期:2002-06-04 00:00:00

  • Computer simulation of systemic circulation and clot lysis dynamics during thrombolytic therapy that accounts for inner clot transport and reaction.

    abstract:BACKGROUND:We developed a computer model to predict lysis rates of thrombi for intravenous thrombolytic regimens based on the convective/diffusive penetration of reacting and adsorbing fibrinolytic species from the circulation into the proximal face of a dissolving clot. METHODS AND RESULTS:Solution of a one-compartme...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.94.4.763

    authors: Anand S,Diamond SL

    更新日期:1996-08-15 00:00:00

  • The role of left ventricular conduction in the electrogenesis of left ventricular hypertrophy. An electrophysiologic study in man.

    abstract::Various electrocardiographic and vectorcardiographic (ECG-VCG) patterns of ventricular conduction disturbances are inducible by premature right atrial stimulation (PRAS). These patterns are a consequence of different degrees of refractoriness in the specialized ventricular conduction system. We observed that the inter...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.59.5.1044

    authors: Piccolo E,Raviele A,Delise P,Dainese F,Pascotto P,Totaro G,Sartori F,D'Este D

    更新日期:1979-05-01 00:00:00

  • Sustained improvement in left ventricular function and mortality by intracoronary streptokinase administration during evolving myocardial infarction.

    abstract::One hundred eighty-eight patients with acute myocardial infarction were studied prospectively from August 1980 to September 1982. One hundred thirty-six of these patients were entered into a intracoronary streptokinase study after informed consent was obtained. The remaining 52 patients, who either met exclusion crite...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.68.1.131

    authors: Smalling RW,Fuentes F,Matthews MW,Freund GC,Hicks CH,Reduto LA,Walker WE,Sterling RP,Gould KL

    更新日期:1983-07-01 00:00:00

  • Anatomic features in victims of sudden coronary death. Coronary artery pathology.

    abstract::Study of the detailed pathology of the myocardium and coronary arteries in ambulatory subjects dying suddenly of coronary heart disease shows that they can be divided into two groups. In one group, there is atherosclerosis with a new vascular event involving coronary thrombosis, which initiates acute myocardial ischem...

    journal_title:Circulation

    pub_type: 杂志文章,评审

    doi:

    authors: Davies MJ

    更新日期:1992-01-01 00:00:00

  • Intracardiac thrombosis and embolism in patients with cardiac amyloidosis.

    abstract:BACKGROUND:Patients with primary amyloidosis (AL type) have a poor prognosis, in part due to frequent cardiac involvement. Although intracardiac thrombus has been reported in anecdotal cases, neither its frequency nor its role in causing mortality is known. Furthermore, the clinical and echocardiographic variables that...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.107.697763

    authors: Feng D,Edwards WD,Oh JK,Chandrasekaran K,Grogan M,Martinez MW,Syed IS,Hughes DA,Lust JA,Jaffe AS,Gertz MA,Klarich KW

    更新日期:2007-11-20 00:00:00

  • Secondary prevention of stroke and transient ischemic attack: is more platelet inhibition the answer?

    abstract:BACKGROUND:Recurrent cerebrovascular events constitute an estimated 200,000 of the 700,000 strokes reported annually in the United States, which makes secondary stroke prevention an important goal in the management of disease among patients who have experienced stroke or transient ischemic attack. METHODS AND RESULTS:...

    journal_title:Circulation

    pub_type: 杂志文章,评审

    doi:10.1161/CIRCULATIONAHA.106.653741

    authors: Liao JK

    更新日期:2007-03-27 00:00:00

  • Aneurysm of the membraous septum in ventricular septal defect.

    abstract::An aneurysm of the membranous septum was found frequently in patients with ventricular septal defect; although appearance at catheterization during infancy was not common, aneurysms were detected in about half of the patients older than 2 years of age. A significant decrease in the left-to-right shunt occurred with th...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:

    authors: Nugent EW,Freedom RM,Rowe RD,Wagner HR,Rees JK

    更新日期:1977-08-01 00:00:00

  • Nonselective cation currents regulate membrane potential of rabbit coronary arterial cell: modulation by lysophosphatidylcholine.

    abstract:BACKGROUND:The effects of lysophosphatidylcholine (LPC) on electrophysiological activities and intracellular Ca2+ concentration ([Ca2+]i) were investigated in coronary arterial smooth muscle cells (CASMCs). METHODS AND RESULTS:The patch clamp techniques and Ca2+ measurements were applied to cultured rabbit CASMCs. The...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.0000039345.00481.1d

    authors: Terasawa K,Nakajima T,Iida H,Iwasawa K,Oonuma H,Jo T,Morita T,Nakamura F,Fujimori Y,Toyo-oka T,Nagai R

    更新日期:2002-12-10 00:00:00

  • Coronary sinus morphology in patients with atrioventricular junctional reentry tachycardia and other supraventricular tachyarrhythmias.

    abstract:BACKGROUND:Coronary sinus access by electrode catheters is easier in patients with atrioventricular junctional reentry tachycardia (AVJRT) than in patients with other supraventricular tachyarrhythmias. The reason for this has not been addressed. METHODS AND RESULTS:The size and shape of the proximal coronary sinus wer...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.92.3.436

    authors: Doig JC,Saito J,Harris L,Downar E

    更新日期:1995-08-01 00:00:00

  • Occurrence and properties of the hyperpolarization-activated current If in ventricular myocytes from normotensive and hypertensive rats during aging.

    abstract:BACKGROUND:Cellular electrophysiological alterations may contribute to arrhythmogenesis in cardiac hypertrophy. An L-like current occurs in left ventricular myocytes (LVMs) isolated from the hypertrophied heart of old spontaneously hypertensive rats (SHR). Factors that influence L occurrence during development of cardi...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.94.7.1674

    authors: Cerbai E,Barbieri M,Mugelli A

    更新日期:1996-10-01 00:00:00

  • Potential role of hepatocyte growth factor, a novel angiogenic growth factor, in peripheral arterial disease: downregulation of HGF in response to hypoxia in vascular cells.

    abstract:BACKGROUND:Although hepatocyte growth factor (HGF), a novel angiogenic growth factor, plays an important role in angiogenesis, regulation of local HGF production under hypoxia has not yet been clarified in vascular smooth muscle cells (VSMC) and endothelial cells (EC). Thus, we have studied the role of HGF in hypoxia-i...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.100.suppl_2.ii-301

    authors: Hayashi S,Morishita R,Nakamura S,Yamamoto K,Moriguchi A,Nagano T,Taiji M,Noguchi H,Matsumoto K,Nakamura T,Higaki J,Ogihara T

    更新日期:1999-11-09 00:00:00

  • Cytosolic heat shock protein 60, hypoxia, and apoptosis.

    abstract:BACKGROUND:Heat shock protein (HSP)60 is an abundant protein found primarily in the mitochondria, though 15% to 20% is found in the cytosol. Previously we observed that HSP60 complexes with bax in the cytosol. Reduction in HSP60 precipitates translocation of bax to the mitochondria and apoptosis. We hypothesized that H...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.0000038112.64503.6e

    authors: Gupta S,Knowlton AA

    更新日期:2002-11-19 00:00:00

  • Intracoronary radiation therapy improves the clinical and angiographic outcomes of diffuse in-stent restenotic lesions: results of the Washington Radiation for In-Stent Restenosis Trial for Long Lesions (Long WRIST) Studies.

    abstract:BACKGROUND:The Washington Radiation for In-Stent Restenosis Trial for long lesions (Long WRIST) was designed to determine the safety and efficacy of vascular brachytherapy for the treatment of diffuse in-stent restenosis. METHODS AND RESULTS:A total of 120 patients with diffuse in-stent restenosis in native coronary a...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1161/01.CIR.0000060497.91775.6D

    authors: Waksman R,Cheneau E,Ajani AE,White RL,Pinnow E,Torguson R,Deible R,Satler LF,Pichard AD,Kent KM,Teirstein PS,Lindsay J,Washington Radiation for In-Stent Restenosis Trial for Long Lesions Studies.

    更新日期:2003-04-08 00:00:00

  • Verapamil: its potential for causing serious complications in patients with hypertrophic cardiomyopathy.

    abstract::Verapamil is extremely effective in the treatment of patients with hypertrophic cardiomyopathy. However, the basic physiologic actions of the drug may lead to serious adverse effects. An appreciation of this and an understanding of when these adverse effects are most likely to occur will minimize the potential of vera...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.64.3.437

    authors: Epstein SE,Rosing DR

    更新日期:1981-09-01 00:00:00