Adrenergic receptors and sensitization of adenylyl cyclase in acute myocardial ischemia.

abstract：BACKGROUND:Since the clinical introduction of dynamic cardiomyoplasty, a discrepancy has been observed between unchanged measurements of cardiac function and improved clinical outcome. METHODS AND RESULTS:We performed a beat-to-beat analysis of cardiac performance at rest in nine cardiomyoplasty patients 6 to 24 month...

journal_title：Circulation

authors： Schreuder JJ,van der Veen FH,van der Velde ET,Delahaye F,Alfieri O,Jegaden O,Lorusso R,Jansen JR,van Ommen V,Finet G

更新日期：1995-04-01 00:00:00

abstract：BACKGROUND:Angiogenic placental growth factor (PlGF) concentrations rise during pregnancy, peaking at the end of midpregnancy. Low PlGF concentrations during pregnancy are associated with pregnancy complications with recognized later-life cardiovascular risk. We hypothesized that low PlGF concentrations, especially in ...

journal_title：Circulation

authors： Benschop L,Schalekamp-Timmermans S,Broere-Brown ZA,Roeters van Lennep JE,Jaddoe VWV,Roos-Hesselink JW,Ikram MK,Steegers EAP,Roberts JM,Gandley RE

更新日期：2019-04-02 00:00:00

abstract：:Long-term tocainide therapy has been evaluated in 17 patients with ventricular arrhythmias. Ventricular tachycardia and/or fibrillation was recurrent and sustained in nine patients, and symptomatic but unsustained in three others. Five patients had frequent but only mildly symptomatic ventricular irritability. In all ...

journal_title：Circulation

authors： Winkle RA,Meffin PJ,Harrison DC

更新日期：1978-05-01 00:00:00

abstract：BACKGROUND:The alpha(v)beta3 integrin plays a critical role in cell proliferation and migration. We hypothesized that vascular cell proliferation, a hallmark of injury-induced remodeling, can be tracked by targeting alpha(v)beta3 integrin expression in vivo. METHODS AND RESULTS:RP748, a novel 111In-labeled alpha(v)bet...

journal_title：Circulation

authors： Sadeghi MM,Krassilnikova S,Zhang J,Gharaei AA,Fassaei HR,Esmailzadeh L,Kooshkabadi A,Edwards S,Yalamanchili P,Harris TD,Sinusas AJ,Zaret BL,Bender JR

更新日期：2004-07-06 00:00:00

abstract：:A case of progressive pulmonary hypertension in a child with a small ventricular septal defect is presented. Natural history studies have indicated that children with small ventricular septal defects can be followed conservatively. This case represents a contradiction to that rule and suggests that further study must ...

journal_title：Circulation

authors： Bisset GS 3rd,Hirschfeld SS

更新日期：1983-02-01 00:00:00

abstract：:Systolic time intervals, stroke volume, cardiac output and (dZ/dt)/RZ index were serially estimated in 51 normal healthy volunteers at sea level, for ten days after air induction to 3658 m altitude and on return to sea level. The subjects were divided into three groups and were administered a diuretic, beta methyldigo...

journal_title：Circulation

authors： Balasubramanian V,Behl A,Das GS,Wadhwa AK,Mathew OP,Hoon RS

更新日期：1978-06-01 00:00:00

abstract：BACKGROUND:Significant gender-related differences exist in the development of left ventricular hypertrophy (LVH). In addition, administration of 17beta-estradiol (E2) to ovariectomized female mice attenuates the development of LVH, demonstrating an antagonistic role for E2 in this process, although no molecular mechani...

journal_title：Circulation

authors： Babiker FA,De Windt LJ,van Eickels M,Thijssen V,Bronsaer RJ,Grohé C,van Bilsen M,Doevendans PA

更新日期：2004-01-20 00:00:00

abstract：:Coronary artery bypass grafts, angioplasty, and thrombolysis are beneficial procedures for patients with coronary artery disease. However, these procedures can fail by mechanisms related to interactions between platelets and the damaged arterial wall. An experimental model for studying some of the mechanisms of platel...

journal_title：Circulation

authors： Folts J

更新日期：1991-06-01 00:00:00

abstract：BACKGROUND:The angiogenic function of endothelial cells is regulated by numerous mechanisms, but the impact of long noncoding RNAs (lncRNAs) has hardly been studied. We set out to identify novel and functionally important endothelial lncRNAs. METHODS:Epigenetically controlled lncRNAs in human umbilical vein endothelia...

journal_title：Circulation

authors： Leisegang MS,Fork C,Josipovic I,Richter FM,Preussner J,Hu J,Miller MJ,Epah J,Hofmann P,Günther S,Moll F,Valasarajan C,Heidler J,Ponomareva Y,Freiman TM,Maegdefessel L,Plate KH,Mittelbronn M,Uchida S,Künne C,Stello

更新日期：2017-07-04 00:00:00

abstract：BACKGROUND:Hypertension and other vascular diseases are more prevalent in diabetic patients than in the general population. In humans and in several animal models of diabetes, a disturbance of endothelium-dependent responses has been shown. Oxyhemoglobin is one of the most known modulators of these endothelium-dependen...

journal_title：Circulation

authors： Rodríguez-Mañas L,Arribas S,Girón C,Villamor J,Sánchez-Ferrer CF,Marín J

更新日期：1993-11-01 00:00:00

abstract：BACKGROUND:Evidence suggests that the vessel wall contains an oxidase similar, if not identical, to phagocytic NADPH oxidase. We tested the contribution of this specific oxidase to the progression of atherosclerosis and the regulation of blood pressure. METHODS AND RESULTS:An examination of aortic rings from wild-type...

journal_title：Circulation

authors： Hsich E,Segal BH,Pagano PJ,Rey FE,Paigen B,Deleonardis J,Hoyt RF,Holland SM,Finkel T

更新日期：2000-03-21 00:00:00

abstract：BACKGROUND:Predictors of antiplatelet therapy discontinuation (ATD) during the first year after drug-eluting stent implantation are poorly known. METHODS AND RESULTS:This was a prospective study with 3-, 6-, 9-, and 12-month follow-up of patients receiving at least 1 drug-eluting stent between January and April 2008 i...

journal_title：Circulation

authors： Ferreira-González I,Marsal JR,Ribera A,Permanyer-Miralda G,García-Del Blanco B,Martí G,Cascant P,Martín-Yuste V,Brugaletta S,Sabaté M,Alfonso F,Capote ML,De La Torre JM,Ruíz-Lera M,Sanmiguel D,Cárdenas M,Pujol B,Baz JA

更新日期：2010-09-07 00:00:00

abstract：BACKGROUND:Whether catheter ablation (CA) is superior to amiodarone (AMIO) for the treatment of persistent atrial fibrillation (AF) in patients with heart failure is unknown. METHODS AND RESULTS:This was an open-label, randomized, parallel-group, multicenter study. Patients with persistent AF, dual-chamber implantable...

journal_title：Circulation

authors： Di Biase L,Mohanty P,Mohanty S,Santangeli P,Trivedi C,Lakkireddy D,Reddy M,Jais P,Themistoclakis S,Dello Russo A,Casella M,Pelargonio G,Narducci ML,Schweikert R,Neuzil P,Sanchez J,Horton R,Beheiry S,Hongo R,Hao S,

更新日期：2016-04-26 00:00:00

abstract：BACKGROUND:Systemic delivery of bone marrow-derived mesenchymal stem cells (BM-MSCs) is an attractive approach for myocardial repair. We aimed to test this strategy in a rat model after myocardial infarction (MI). METHODS AND RESULTS:BM-MSCs were obtained from rat bone marrow, expanded in vitro to a purity of >50%, an...

journal_title：Circulation

authors： Barbash IM,Chouraqui P,Baron J,Feinberg MS,Etzion S,Tessone A,Miller L,Guetta E,Zipori D,Kedes LH,Kloner RA,Leor J

更新日期：2003-08-19 00:00:00

abstract：BACKGROUND:Prenatal surgery for congenital anomalies can prevent fetal demise or alter the course of organ development, resulting in a more favorable condition at birth. The indications for fetal surgery continue to expand, yet little is known about the acute sequelae of fetal surgery on the human cardiovascular system...

journal_title：Circulation

authors： Rychik J,Tian Z,Cohen MS,Ewing SG,Cohen D,Howell LJ,Wilson RD,Johnson MP,Hedrick HL,Flake AW,Crombleholme TM,Adzick NS

更新日期：2004-09-21 00:00:00

abstract：:An isolated perfused working rat heart model was used to investigate the extent to which various protective agents, used either singly or in combination, were able to increase the resistance of the heart to periods of transient ischemia. The aim of the studies was to develop a solution which, if infused into the coron...

journal_title：Circulation

authors： Hearse DJ,Stewart DA,Braimbridge MV

更新日期：1976-08-01 00:00:00

abstract：BACKGROUND:Endothelin (ET), a coronary vasoconstrictor, mediates its activity through the specific receptors ET-A and ET-B, which may demonstrate different activity under pathophysiological conditions. Thoracic inferior vena cava constriction (TIVCC) is an experimental model of congestive heart failure that is characte...

journal_title：Circulation

authors： Cannan CR,Burnett JC Jr,Lerman A

更新日期：1996-02-15 00:00:00

abstract：BACKGROUND:Tissue-type plasminogen activator (tPA) and urokinase-type plasminogen activator (uPA) are thought to play critical roles in vascular remodeling after injury, with tPA mediating intravascular clot lysis and uPA modulating cell migration within the vessel wall. In human vascular disease, however, thrombus org...

journal_title：Circulation

authors： Schäfer K,Konstantinides S,Riedel C,Thinnes T,Müller K,Dellas C,Hasenfuss G,Loskutoff DJ

更新日期：2002-10-01 00:00:00

abstract：BACKGROUND:Human endothelial and vascular smooth muscle cells synthesize prostanoids. Several of these have been implicated in the physiological and pathophysiological regulation of vascular tone; however, there is no direct evidence that human blood vessels synthesize sufficient prostanoid to alter vessel tone. METHO...

journal_title：Circulation

authors： Bhagat K,Collier J,Vallance P

更新日期：1995-10-15 00:00:00

abstract：BACKGROUND:Posteroseptal ablation of the atrioventricular node (AVN) has been proposed as a means to slow the ventricular rate during atrial fibrillation (AF). The suggested mechanism is elimination of the AVN "slow pathway." On the basis of the unpredictable success of the procedure, we hypothesize that, in fact, the ...

journal_title：Circulation

authors： Garrigue S,Mowrey KA,Fahy G,Tchou PJ,Mazgalev TN

更新日期：1999-05-04 00:00:00

abstract：BACKGROUND:The clinical profiles and outcomes of patients treated surgically for acute type B aortic dissection (ABAD) are often reported for those in small series or for those cared for at a single institution over a long time period, during which a continuous evolution in techniques has occurred. Accordingly, we soug...

journal_title：Circulation

authors： Trimarchi S,Nienaber CA,Rampoldi V,Myrmel T,Suzuki T,Bossone E,Tolva V,Deeb MG,Upchurch GR Jr,Cooper JV,Fang J,Isselbacher EM,Sundt TM 3rd,Eagle KA,IRAD Investigators.

更新日期：2006-07-04 00:00:00

abstract：:From November 1981 to November 1982, intra-aortic balloon pumping (IABP) was used after surgery in eight patients who were from 6 weeks to 6 years old and who weighed from 4.2 to 16.2 kg. In seven patients, specially constructed intra-aortic balloons with 2.5 and 5.0 ml volumes mounted on No. 5F catheters were used. I...

journal_title：Circulation

authors： Veasy LG,Blalock RC,Orth JL,Boucek MM

更新日期：1983-11-01 00:00:00

abstract：BACKGROUND:Endogenous adenosine can protect the overloaded heart against the development of hypertrophy and heart failure, but the contribution of A(1) receptors (A(1)R) and A(3) receptors (A(3)R) is not known. METHODS AND RESULTS:To test the hypothesis that A(1)R and A(3)R can protect the heart against systolic overl...

journal_title：Circulation

authors： Lu Z,Fassett J,Xu X,Hu X,Zhu G,French J,Zhang P,Schnermann J,Bache RJ,Chen Y

更新日期：2008-10-21 00:00:00

abstract：BACKGROUND:In hypertrophic cardiomyopathy, a spectrum of mitral leaflet abnormalities has been related to the mechanism of mitral systolic anterior motion (SAM), which causes both subaortic obstruction and mitral regurgitation. In the individual patient, SAM and regurgitation vary in parallel; clinically, however, grea...

journal_title：Circulation

authors： Schwammenthal E,Nakatani S,He S,Hopmeyer J,Sagie A,Weyman AE,Lever HM,Yoganathan AP,Thomas JD,Levine RA

更新日期：1998-09-01 00:00:00

abstract：:A definitive diagnosis of myocarditis requires right ventricular biopsy. Despite its specificity, however, right ventricular biopsy may lack sensitivity due to the focal nature of the disease. Because indium 111-monoclonal antimyosin antibody imaging can be used to detect myocardial necrosis, this procedure was perfor...

journal_title：Circulation

authors： Yasuda T,Palacios IF,Dec GW,Fallon JT,Gold HK,Leinbach RC,Strauss HW,Khaw BA,Haber E

更新日期：1987-08-01 00:00:00

abstract：:Left ventricular ejection fraction (LVEF) was measured by radionuclide angiography at rest and during supine bicycle exercise before and 3 months after coronary artery bypass graft surgery (CABG) in 20 patients with chronic stable angina. The right anterior oblique gated first-pass technique was used to assess LVEF re...

journal_title：Circulation

authors： Lim YL,Kalff V,Kelly MJ,Mason PJ,Currie PJ,Harper RW,Anderson ST,Federman J,Stirling GR,Pitt A

更新日期：1982-11-01 00:00:00

abstract：BACKGROUND:LDL and C-reactive protein (CRP) are important cardiovascular risk factors. Both LDL and CRP deposit in the arterial wall during atherogenesis. Stranded LDL is taken up by macrophages, causing foam cell formation. Because native LDL does not induce foam cell formation, we hypothesized that CRP may opsonize n...

journal_title：Circulation

authors： Zwaka TP,Hombach V,Torzewski J

更新日期：2001-03-06 00:00:00

abstract：:Thirty patients with triple-vessel coronary artery disease proven by angiography, symptomatic angina and a positive ECG stress test were evaluated with thallium-201 (201TI) scintigraphy. Twenty patients also had aortocoronary saphenous vein bypass surgery; 15 of them had repeat noninvasive evaluation. Seventy percent ...

journal_title：Circulation

authors： Leppo J,Yipintsoi T,Blankstein R,Bontemps R,Freeman LM,Zohman L,Scheuer J

更新日期：1979-04-01 00:00:00

abstract：:Calcium metabolism may play an important role in the pathogenesis of myocardial ischemic injury. The effect of the sarcolemmal calcium flux inhibitor, verapamil, on myocardial necrosis was studied in dogs subjected to temporary coronary artery occlusion. One group of dogs was untreated. A second group was given 0.8 mg...

journal_title：Circulation

authors： Reimer KA,Lowe JE,Jennings RB

更新日期：1977-04-01 00:00:00

abstract：BACKGROUND:Oral anticoagulation (OAC) therapy is effective in atrial fibrillation but requires vigilance to maintain the international normalized ratio in the therapeutic range. This report examines how differences in time in therapeutic range (TTR) between centers and between countries affect the outcomes of OAC thera...

journal_title：Circulation

authors： Connolly SJ,Pogue J,Eikelboom J,Flaker G,Commerford P,Franzosi MG,Healey JS,Yusuf S,ACTIVE W Investigators.

更新日期：2008-11-11 00:00:00