Vasodilatation to arachidonic acid in humans. An insight into endogenous prostanoids and effects of aspirin.

abstract：:Variations in the frequency of complex ventricular arrhythmias were evaluated by consecutive 24-hour long-term electrocardiographic recordings over 4 days using a two-channel recorder and computer-assisted analysis system with a weighted relative mean error of 7.5 +/ 5% (SD). Twenty patients (mean age 58 +/- 9 years ...

journal_title：Circulation

authors： Michelson EL,Morganroth J

更新日期：1980-04-01 00:00:00

abstract：BACKGROUND:Q waves on a 12-lead ECG are markers of a prior myocardial infarction (MI). However, they may regress or even disappear over time, and there is no specific ECG sign of a non-Q-wave MI. Fragmented QRS complexes (fQRSs), which include various RSR' patterns, without a typical bundle-branch block are markers of ...

journal_title：Circulation

authors： Das MK,Khan B,Jacob S,Kumar A,Mahenthiran J

更新日期：2006-05-30 00:00:00

abstract：BACKGROUND:Tetralogy of Fallot is the most common form of congenital heart disease in implantable cardioverter-defibrillator (ICD) recipients, yet little is known about the value of ICDs in this patient population. METHODS AND RESULTS:We conducted a multicenter cohort study in high-risk patients with Tetralogy of Fall...

journal_title：Circulation

authors： Khairy P,Harris L,Landzberg MJ,Viswanathan S,Barlow A,Gatzoulis MA,Fernandes SM,Beauchesne L,Therrien J,Chetaille P,Gordon E,Vonder Muhll I,Cecchin F

更新日期：2008-01-22 00:00:00

abstract：BACKGROUND:During the 1980s, mortality from coronary artery disease (CAD) decreased markedly in the United States. This raises the question of whether a parallel decrease occurred in excess mortality due to CAD in patients undergoing surgical correction of valvular regurgitation. METHODS AND RESULTS:Survival of 752 pa...

journal_title：Circulation

authors： Tribouilloy CM,Enriquez-Sarano M,Schaff HV,Orszulak TA,Fett SL,Bailey KR,Tajik AJ,Frye RL

更新日期：1998-11-10 00:00:00

abstract：:We evaluated the accuracy of the recently reported technique of estimating intraventricular volume by measurement of intracavitary electrical conductance in six isolated, ejecting, canine left ventricles. Left ventricular volumes were measured directly by a previously validated servosystem that employed an electrocond...

journal_title：Circulation

authors： Burkhoff D,van der Velde E,Kass D,Baan J,Maughan WL,Sagawa K

更新日期：1985-08-01 00:00:00

abstract：:Myocardial fiber disarray is a distinctive histopathologic finding seen in asymmetric hypertrophic cardiomyopathy. We studied 14 hearts with aortic atresia and intact interventricular septum, six hearts with pulmonic atresia and intact interventricular septum, eight normal infant hearts matched for age of the study he...

journal_title：Circulation

authors： Bulkley BH,D'Amico B,Taylor AL

更新日期：1983-01-01 00:00:00

abstract：BACKGROUND:In various heart disease paradigms, atria show stronger fibrotic responses than ventricles. The possibility that atrial and ventricular fibroblasts respond differentially to pathological stimuli has not been examined. METHODS AND RESULTS:We compared various morphological, secretory, and proliferative respon...

journal_title：Circulation

authors： Burstein B,Libby E,Calderone A,Nattel S

更新日期：2008-04-01 00:00:00

abstract：:In studies to ascertain the basis of dynamic changes in the P wave, bipolar epicardial potentials were recorded from multiple atrial electrodes in dogs. One hundred to 120 activation times were displayed by a digital computer and used to construct atrial isotemporal activation sequence maps. Changes in heart rate or b...

journal_title：Circulation

authors： Boineau JP,Schuessler RB,Mooney CR,Wylds AC,Miller CB,Hudson RD,Borremans JM,Brockus CW

更新日期：1978-12-01 00:00:00

abstract：BACKGROUND:In patients with mitral stenosis, reduced cardiac output or altered pulmonary hemodynamics may increase sympathetic nerve activity. However, the magnitude of the increase in sympathetic activity in such patients and the effect of valvuloplasty on this activity are unknown. METHODS AND RESULTS:We microneurog...

journal_title：Circulation

authors： Ashino K,Gotoh E,Sumita S,Moriya A,Ishii M

更新日期：1997-11-18 00:00:00

abstract：BACKGROUND:The pathogenesis of impaired endothelium-dependent coronary vasodilation in angina pectoris and normal coronary arteriograms (microvascular angina pectoris) is not known. We examined whether supplementation with L-arginine, a precursor of endothelium-derived nitric oxide, improves endothelium-dependent coron...

journal_title：Circulation

authors： Egashira K,Hirooka Y,Kuga T,Mohri M,Takeshita A

更新日期：1996-07-15 00:00:00

abstract：BACKGROUND:Recent data highlight a vital link between well-performed cardiopulmonary resuscitation (CPR) and survival after cardiac arrest; however, the quality of CPR as actually performed by trained healthcare providers is largely unknown. We sought to measure in-hospital chest compression rates and to determine comp...

journal_title：Circulation

authors： Abella BS,Sandbo N,Vassilatos P,Alvarado JP,O'Hearn N,Wigder HN,Hoffman P,Tynus K,Vanden Hoek TL,Becker LB

更新日期：2005-02-01 00:00:00

abstract：BACKGROUND:At physiological concentrations, 17beta-estradiol selectively enhances endothelium-dependent coronary vasodilation by an unknown mechanism in postmenopausal women. METHODS AND RESULTS:To assess the contribution of nitric oxide (NO) to the vascular effects of estradiol, we measured coronary epicardial and mi...

journal_title：Circulation

authors： Guetta V,Quyyumi AA,Prasad A,Panza JA,Waclawiw M,Cannon RO 3rd

更新日期：1997-11-04 00:00:00

abstract：:The pericardium, because of the nature of its pressure-volume relation, can influence left ventricular diastolic and systolic pump function. During an acute increase in heart size that results in the stretching of the pericardium, the elastic properties of the pericardium restrict further cardiac dilatation and curtai...

journal_title：Circulation

authors： Janicki JS

更新日期：1990-02-01 00:00:00

abstract：:The first stage of a repair of pulmonary atresia with intact ventricular septum (type I) was attempted in a 2-day-old infant. At surgery, decompression of the hypertensive small right ventricle was followed by a sudden loss of myocardial contractility and death. Postmortem examination revealed a fistula with a large o...

journal_title：Circulation

authors： O'Connor WN,Cottrill CM,Johnson GL,Noonan JA,Todd EP

更新日期：1982-04-01 00:00:00

abstract：BACKGROUND:In the monocrotaline (MCT)-treated rat, there is marked stimulation of DNA synthesis and megalocytosis of pulmonary arterial endothelial cells (PAECs) within 3 to 4 days, followed by pulmonary hypertension (PH) 10 to 14 days later. Growing evidence implicates caveolin-1 (cav-1) in plasma membrane rafts as a ...

journal_title：Circulation

authors： Mathew R,Huang J,Shah M,Patel K,Gewitz M,Sehgal PB

更新日期：2004-09-14 00:00:00

abstract：BACKGROUND:The future risk of myocardial infarction is commonly assessed using cardiovascular risk scores, coronary artery calcium score, or coronary artery stenosis severity. We assessed whether noncalcified low-attenuation plaque burden on coronary CT angiography (CCTA) might be a better predictor of the future risk ...

journal_title：Circulation

authors： Williams MC,Kwiecinski J,Doris M,McElhinney P,D'Souza MS,Cadet S,Adamson PD,Moss AJ,Alam S,Hunter A,Shah ASV,Mills NL,Pawade T,Wang C,Weir McCall J,Bonnici-Mallia M,Murrills C,Roditi G,van Beek EJR,Shaw LJ,Nicol E

更新日期：2020-05-05 00:00:00

abstract：BACKGROUND:Little is known about the behavior with regard to restenosis of multiple lesions within the same patient treated with intracoronary stenting. Our objective was to test the hypothesis that there is an intrapatient dependence of restenosis between lesions. METHODS AND RESULTS:Quantitative analysis was carried...

journal_title：Circulation

authors： Kastrati A,Schömig A,Elezi S,Schühlen H,Wilhelm M,Dirschinger J

更新日期：1998-06-23 00:00:00

abstract：BACKGROUND:Pharmacological ventricular rate control is an acceptable atrial fibrillation (AF) therapy limited by systemic toxicity. We postulate that focal catheter-based drug delivery into the atrioventricular nodal (AVN) region may effectively control ventricular rate during AF without systemic toxicity. This study e...

journal_title：Circulation

authors： Sigg DC,Hiniduma-Lokuge P,Coles JA Jr,Falkner P,Rose R,Urban JF,Ujhelyi MR

更新日期：2006-05-23 00:00:00

abstract：:Two hundred twenty-nine hospital survivors of acute myocardial infarction (MI) age 60 years or younger underwent coronary arteriography a median of 2 weeks after infarction and were followed a median of 24 months (range 6-62 months). For 62%, MI was the first presentation of coronary disease and 75% were in clinical K...

journal_title：Circulation

authors： Roubin GS,Harris PJ,Bernstein L,Kelly DT

更新日期：1983-04-01 00:00:00

abstract：BACKGROUND:We investigated whether L-arginine induces regression of preexisting atheromatous lesions and reversal of endothelial dysfunction in hypercholesterolemic rabbits, whether similar effects can be obtained by cholesterol-lowering therapy with lovastatin, and which mechanism leads to these effects. METHODS AND ...

journal_title：Circulation

authors： Böger RH,Bode-Böger SM,Brandes RP,Phivthong-ngam L,Böhme M,Nafe R,Mügge A,Frölich JC

更新日期：1997-08-19 00:00:00

abstract：BACKGROUND:Severe obesity can result in proteinuria and progressive glomerulosclerosis in humans and experimental animals. The associated renal disease is ameliorated by weight reduction and/or blockade of the renin-angiotensin system. Various growth factors, cytokines, and lipid mediators are implicated in the pathoge...

journal_title：Circulation

authors： Xu ZG,Lanting L,Vaziri ND,Li Z,Sepassi L,Rodriguez-Iturbe B,Natarajan R

更新日期：2005-04-19 00:00:00

abstract：:Plasma and lipoprotein cholesterol and triglyceride concentrations were measured in Pima Indians, a genetically homogeneous population with a high prevalence of obesity and diabetes and a low frequency of coronary heart disease. The data for nondiabetic Pima Indians were compared with those of U.S. Caucasians measured...

journal_title：Circulation

authors： Howard BV,Davis MP,Pettitt DJ,Knowler WC,Bennett PH

更新日期：1983-10-01 00:00:00

abstract：BACKGROUND:Recognition of the complex pathophysiology of heart failure and its high mortality has emphasized the need for prognostic markers that can be used in clinical assessment as well as in the design of mortality trials. Data from the Department of Veterans Affairs Cooperative Vasodilator-Heart Failure Trials (V-...

journal_title：Circulation

authors： Cohn JN,Johnson GR,Shabetai R,Loeb H,Tristani F,Rector T,Smith R,Fletcher R

更新日期：1993-06-01 00:00:00

abstract：BACKGROUND:The Na(+)/Ca(2+) exchange (NCX) extrudes Ca(2+) from cardiac myocytes, but it can also mediate Ca(2+) influx, load the sarcoplasmic reticulum with Ca(2+), and trigger Ca(2+) release from the sarcoplasmic reticulum. In ischemia/reperfusion or digitalis toxicity, increased levels of intracellular [Na(+)] ([Na(...

journal_title：Circulation

authors： Satoh H,Ginsburg KS,Qing K,Terada H,Hayashi H,Bers DM

更新日期：2000-03-28 00:00:00

abstract：BACKGROUND:Premedication with clopidogrel has reduced thrombotic complications after percutaneous coronary revascularization procedures. However, because of the enhanced and irreversible platelet inhibition by clopidogrel, patients requiring surgical revascularization have a higher risk of bleeding complications and tr...

journal_title：Circulation

authors： Kapetanakis EI,Medlam DA,Petro KR,Haile E,Hill PC,Dullum MK,Bafi AS,Boyce SW,Corso PJ

更新日期：2006-04-04 00:00:00

abstract：BACKGROUND:Angiogenesis is a critical feature of plaque development in atherosclerosis and might play a key role in both the initiation and later rupture of plaques that lead to myocardial infarction and stroke. The precursory molecular or cellular events that initiate plaque growth and that ultimately contribute to pl...

journal_title：Circulation

authors： Winter PM,Morawski AM,Caruthers SD,Fuhrhop RW,Zhang H,Williams TA,Allen JS,Lacy EK,Robertson JD,Lanza GM,Wickline SA

更新日期：2003-11-04 00:00:00

abstract：BACKGROUND:A prior diagnosis of diabetes mellitus is associated with adverse outcomes after acute myocardial infarction (MI), but the risk associated with a new diagnosis of diabetes in this setting has not been well defined. METHODS AND RESULTS:We assessed the risk of death and major cardiovascular events associated ...

journal_title：Circulation

authors： Aguilar D,Solomon SD,Køber L,Rouleau JL,Skali H,McMurray JJ,Francis GS,Henis M,O'Connor CM,Diaz R,Belenkov YN,Varshavsky S,Leimberger JD,Velazquez EJ,Califf RM,Pfeffer MA

更新日期：2004-09-21 00:00:00

abstract：:Medical treatment of heart disease has improved significantly in the past 30 years. The spectacular change in the natural history of rheumatic heart disease is apparent from a 1948 article that reported that 42% of children with rheumatic heart disease died of rheumatic infection or bacterial endocarditis. Antibiotics...

journal_title：Circulation

authors： Ross RS

更新日期：1979-12-01 00:00:00

abstract：BACKGROUND:Paraplegia remains a devastating complication of thoracic aortic surgery. The mechanism of the antecedent spinal cord ischemia and reperfusion injury (IR) remains poorly described. IR involves 2 injuries, an initial ischemic insult and subsequent inflammatory amplification of the injury. This mechanism is co...

journal_title：Circulation

authors： Smith PD,Puskas F,Meng X,Lee JH,Cleveland JC Jr,Weyant MJ,Fullerton DA,Reece TB

更新日期：2012-09-11 00:00:00

abstract：:Although previous studies in both animals and humans have suggested that cardiac baroreceptors modulate reflex sympathetic vasoconstriction during exercise, more recent studies in conscious animals have not supported this view. To further test this concept in humans, we measured sympathetic nerve discharge with intran...

journal_title：Circulation

authors： Scherrer U,Vissing SF,Victor RG

更新日期：1988-07-01 00:00:00