Abstract:
BACKGROUND:Predictors of antiplatelet therapy discontinuation (ATD) during the first year after drug-eluting stent implantation are poorly known. METHODS AND RESULTS:This was a prospective study with 3-, 6-, 9-, and 12-month follow-up of patients receiving at least 1 drug-eluting stent between January and April 2008 in 29 hospitals. Individual- and hospital-level predictors of ATD were assessed by hierarchical-multinomial regression analysis. ATD could be assessed in 1622 candidates for follow-up (82.5%). A total of 234 patients (14.4%) interrupted at least 1 antiplatelet therapy drug, predominantly clopidogrel (n=182, 11.8%). Bleeding events or invasive procedures led to ATD in 109 patients. This was predicted by renal impairment (odds ratio [OR] 2.81, 95% confidence interval [CI] 1.48 to 5.34), prior major hemorrhage (OR 3.77, 95% CI 1.41 to 10.03), and peripheral arterial disease (OR 1.78, 95% CI 1.01 to 3.15). Medical decisions led to ATD in 70 patients; this was predicted by long-term use of anticoagulant therapy (OR 3.88, 95% CI 1.26 to 11.98), undergoing the procedure in a private hospital (OR 13.3, 95% CI 1.69 to 105), and not receiving instructions about medication (OR 2.8, 95% CI 1.23 to 6.36). Thirty-nine patients interrupted ATD on their own initiative, mainly immigrants (OR 3.78, 95% CI 1.2 to 11.98) and consumers of psychotropic drugs (OR 2.58, 95% CI 1.3 to 5.12). CONCLUSIONS:ATD during the first year after drug-eluting stent implantation is based mainly on patient decision or a medical decision not associated with major bleeding events or major surgical procedures. Individual- and hospital-level variables are important to predict ATD.
journal_name
Circulationjournal_title
Circulationauthors
Ferreira-González I,Marsal JR,Ribera A,Permanyer-Miralda G,García-Del Blanco B,Martí G,Cascant P,Martín-Yuste V,Brugaletta S,Sabaté M,Alfonso F,Capote ML,De La Torre JM,Ruíz-Lera M,Sanmiguel D,Cárdenas M,Pujol B,Baz JAdoi
10.1161/CIRCULATIONAHA.110.938290subject
Has Abstractpub_date
2010-09-07 00:00:00pages
1017-25issue
10eissn
0009-7322issn
1524-4539pii
CIRCULATIONAHA.110.938290journal_volume
122pub_type
临床试验,杂志文章相关文献
CIRCULATION文献大全abstract:BACKGROUND:Up to 30% of patients with end-stage heart failure experience biventricular failure that requires biventricular mechanical support. For these patients, only bulky extracorporeal or implantable displacement pumps or the total artificial heart have been available to date, which enables only limited quality of ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.110.011502
更新日期:2011-09-13 00:00:00
abstract::Acute occlusion of the circumflex branch of the left coronary artery was produced in chronically instrumented conscious dogs. Tracer microspheres were used to measure during an established time period, the distribution of collateral flow within the infarcting myocardium. For up to 2 hours after coronary occlusion the ...
journal_title:Circulation
pub_type: 杂志文章
doi:
更新日期:1976-03-01 00:00:00
abstract:BACKGROUND:Brugada syndrome (BrS) primarily associates with the loss of sodium channel function. Previous studies showed features consistent with sodium current (INa) deficit in patients carrying desmosomal mutations, diagnosed with arrhythmogenic cardiomyopathy (or arrhythmogenic right ventricular cardiomyopathy). Exp...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.113.003077
更新日期:2014-03-11 00:00:00
abstract:BACKGROUND:Controversy exists as to whether off-pump CABG with local occlusion results in clinically significant myocardial ischemia during the occlusion period. This study was undertaken to delineate the effects of transient local coronary artery occlusion on regional systolic function. METHODS AND RESULTS:Eight cons...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.100.suppl_2.ii-125
更新日期:1999-11-09 00:00:00
abstract:BACKGROUND:Peripheral adiposity confers protection against diabetes and atherosclerosis in elderly women. The underlying mechanisms, however, remain to be elucidated. METHODS AND RESULTS:On the basis on dual-energy X-ray absorptiometry measurements of central fat mass (CFM) and peripheral fat mass (PFM), we identified...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.CIR.0000144470.55149.E5
更新日期:2004-10-12 00:00:00
abstract:BACKGROUND:Operator-independent isotropic 3D MRI may greatly simplify the assessment of complex morphology in congenital heart disease. We sought to evaluate the reliability of this new approach. METHODS AND RESULTS:In 31 adolescent and adult patients (age, 6 to 42 years; median, 16 years) with congenital heart diseas...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.CIR.0000134282.35183.AD
更新日期:2004-07-13 00:00:00
abstract:BACKGROUND:Intravascular irradiation with beta-emitters has been proposed for inhibition of restenosis in coronary arteries after balloon angioplasty or stent implantation. Previous studies have shown the effectiveness of gamma-radiation to prevent recurrent restenosis, even in the presence of an implanted stent. The l...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.98.19.2024
更新日期:1998-11-10 00:00:00
abstract:BACKGROUND:Ruling out acute myocardial infarction (AMI) on the basis of rapid assays for cardiac markers will allow early triage of patients and cost-effective use of available coronary care facilities. METHODS AND RESULTS:We studied the value of myoglobin, creatine kinase (CK)-MBmass, and troponin T in ruling out an ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.92.12.3401
更新日期:1995-12-15 00:00:00
abstract:BACKGROUND:We assessed the role of glucose and insulin in the regulation of circulating levels of soluble intercellular adhesion molecule-1 (sICAM-1) and vascular adhesion molecule-1 (sVCAM-1) in normal subjects and in patients with type 2 diabetes. METHODS AND RESULTS:Plasma glucose concentrations were acutely raised...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.101.19.2247
更新日期:2000-05-16 00:00:00
abstract:BACKGROUND:Pathological cardiac hypertrophy induced by stresses such as aging and neurohumoral activation is an independent risk factor for heart failure and is considered a target for the treatment of heart failure. However, the mechanisms underlying pathological cardiac hypertrophy remain largely unknown. We aimed to...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.117.028728
更新日期:2017-11-21 00:00:00
abstract::Oral flecainide acetate was administered to 34 patients with documented symptomatic paroxysmal supraventricular tachycardia (PSVT) with a double-blind, placebo-controlled, 8-week crossover trial design. PSVT was defined as a regular tachycardia of at least 120 beats/min without evidence of atrioventricular dissociatio...
journal_title:Circulation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.cir.83.1.119
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND:Impaired endothelium-dependent, nitric oxide (NO)-mediated vasodilation may contribute to increased vasomotor tone in patients with heart failure. Whether decreased endothelium-dependent, NO-mediated vasodilation in patients with heart failure is due to decreased synthesis or increased degradation of NO is u...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.99.16.2113
更新日期:1999-04-27 00:00:00
abstract::The morphologic consequences of transluminal angioplasty of stenotic atherosclerotic coronary arteries are unknown. This study describes the production of aortoiliac atherosclerosis in rabbits and reports the morphologic changes after transluminal angioplasty of stenotic arterial lesions. Atherosclerotic lesions were ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.61.4.778
更新日期:1980-04-01 00:00:00
abstract:BACKGROUND:There is an elevated risk for poor outcomes after heart transplant (HTx) in patients sensitized to human leukocyte antigens including graft dysfunction, acute cellular and antibody-mediated (AMR) rejection, and cardiac allograft vasculopathy. We report our experience with human leukocyte antigens-sensitized ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.107.709022
更新日期:2007-09-11 00:00:00
abstract::Intermittent aortic root infusion of a cold solution containing either potassium chloride (KCl) or diltiazem was performed in 32 dogs during a 2-hour aortic clamping. Half of the dogs in each group had a critical stenosis created on the circumflex artery before cardiopulmonary bypass. Global left ventricular (LV) func...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.65.6.1078
更新日期:1982-06-01 00:00:00
abstract:BACKGROUND:The acute effect of atrial fibrillation (AF) on the atrial effective refractory period (ERP) in humans is unknown. METHODS AND RESULTS:In 20 patients without structural heart disease, the atrial ERP was measured before and after pacing-induced AF at drive cycle lengths of 350 and 500 ms. Immediately after s...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.94.7.1600
更新日期:1996-10-01 00:00:00
abstract:BACKGROUND:This study reports on the trends in the volume and outcomes of coronary revascularization procedures performed on Medicare beneficiaries between 2008 and 2012. METHODS AND RESULTS:This retrospective study identifies all Medicare beneficiaries undergoing a coronary revascularization procedure: coronary arter...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.114.012485
更新日期:2015-01-27 00:00:00
abstract:BACKGROUND:Previous experimental studies have shown that nitric oxide (NO) modulates cardiac function by an abbreviation of systolic contraction and an enhancement of diastolic relaxation. However, the response to NO donors of patients with severe pressure-overload hypertrophy and diastolic dysfunction is unknown. MET...
journal_title:Circulation
pub_type: 临床试验,杂志文章
doi:10.1161/01.cir.99.18.2396
更新日期:1999-05-11 00:00:00
abstract::Ventilation with positive end-expiratory pressure (PEEP) is associated with reduced cardiac output, but the mechanisms involved are controversial. Possible explanations include increased intrathoracic pressure, reflex changes in myocardial inotropism, pulmonary vascular obstruction and abnormal ventricular interaction...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.66.1.108
更新日期:1982-07-01 00:00:00
abstract:BACKGROUND:Patients with peripheral arterial disease are at high risk of ischemic events and therefore are treated with antithrombotics. In patients with coronary artery disease or cerebrovascular disease, bleeding is related to the subsequent occurrence of ischemic events. Our objective was to assess whether this is a...
journal_title:Circulation
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1161/CIRCULATIONAHA.109.858365
更新日期:2009-10-20 00:00:00
abstract:BACKGROUND:During septic shock, the vasoconstrictor response to norepinephrine is seriously blunted. Animal experiments suggest that hyperpolarization of smooth muscle cells by opening of potassium (K) channels underlies this phenomenon. In the present study, we examined whether K-channel blockers and/or nitric oxide (...
journal_title:Circulation
pub_type: 临床试验,杂志文章
doi:10.1161/CIRCULATIONAHA.105.590232
更新日期:2006-08-01 00:00:00
abstract:BACKGROUND:Systemic delivery of bone marrow-derived mesenchymal stem cells (BM-MSCs) is an attractive approach for myocardial repair. We aimed to test this strategy in a rat model after myocardial infarction (MI). METHODS AND RESULTS:BM-MSCs were obtained from rat bone marrow, expanded in vitro to a purity of >50%, an...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.CIR.0000084828.50310.6A
更新日期:2003-08-19 00:00:00
abstract:BACKGROUND:Coronary irradiation is a new concept to reduce restenosis. We evaluated the feasibility and safety of intracoronary irradiation with a balloon catheter filled with (188)Re, a liquid, high-energy beta-emitter. METHODS AND RESULTS:Irradiation with 15 Gy at 0.5-mm tissue depth was performed in 28 lesions afte...
journal_title:Circulation
pub_type: 临床试验,杂志文章
doi:10.1161/01.cir.101.20.2355
更新日期:2000-05-23 00:00:00
abstract:BACKGROUND:The majority of infrarenal abdominal aortic aneurysm (AAA) repairs in the United States are performed with endovascular methods. Baseline aortoiliac arterial anatomic characteristics are fundamental criteria for appropriate patient selection for endovascular aortic repair (EVAR) and key determinants of long-...
journal_title:Circulation
pub_type: 杂志文章,多中心研究
doi:10.1161/CIRCULATIONAHA.110.014902
更新日期:2011-06-21 00:00:00
abstract:BACKGROUND:Recent data suggest that the Berlin Heart EXCOR Pediatric ventricular assist device is superior to extracorporeal membrane oxygenation for bridge to heart transplantation. Published data are limited to 1 in 4 children who received the device as part of the US clinical trial. We analyzed outcomes for all US c...
journal_title:Circulation
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1161/CIRCULATIONAHA.112.000685
更新日期:2013-04-23 00:00:00
abstract::A family is reported in which two siblings had congenital complete heart block with resultant congestive heart failure, the father and paternal grandfather show adult-onset conduction defects, and the mother has systemic lupus erythematosis. The interaction of heredity and environment is discussed in this context. A r...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.56.6.1103
更新日期:1977-12-01 00:00:00
abstract:BACKGROUND:To identify patients at risk for postoperative myocardial injury and death, measuring cardiac troponin routinely after noncardiac surgery has been suggested. Such monitoring was implemented in our hospital. The aim of this study was to determine the predictive value of postoperative myocardial injury, as mea...
journal_title:Circulation
pub_type: 临床试验,杂志文章
doi:10.1161/CIRCULATIONAHA.113.002128
更新日期:2013-06-11 00:00:00
abstract::Analysis of the external brachial pulse recorded during standard blood pressure cuff deflation with use of a transducer with a wide frequency response has revealed a reproducible pattern with three distinct components that we have labeled K1, K2, and K3. K1 is a low-amplitude, low-frequency signal that is present with...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.77.6.1297
更新日期:1988-06-01 00:00:00
abstract:BACKGROUND:Coronary perforation is a life-threatening complication of percutaneous interventions. In the past few years, the implantation of covered stents has emerged as a strategy for treatment when the traditional conservative approach (ie, prolonged balloon inflation and reversal of anticoagulation) fails. METHODS...
journal_title:Circulation
pub_type: 临床试验,杂志文章
doi:10.1161/01.cir.102.25.3028
更新日期:2000-12-19 00:00:00
abstract:BACKGROUND:Heme oxygenase-1 (HO-1) catalyzes the degradation of heme into biliverdin, iron, and carbon monoxide (CO). Although HO-1 is induced in vascular smooth muscle cells (SMCs), the biological role of HO-1 in these cells has not been completely characterized. METHODS AND RESULTS:In the present study, we overexpre...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/hc0102.101369
更新日期:2002-01-01 00:00:00