Abstract:
:Acute occlusion of the circumflex branch of the left coronary artery was produced in chronically instrumented conscious dogs. Tracer microspheres were used to measure during an established time period, the distribution of collateral flow within the infarcting myocardium. For up to 2 hours after coronary occlusion the amount and distribution of the collateral flow remained unchanged. Two to 4 hours after coronary occlusion the subendocardial flow fell to almost zero and the subepicardial flow rose. Between 6 and 48 hours subepicardial and total collateral flow rose markedly. A no-reflow phenomenon is responsible for the decline of collateral flow in the subendocardium. Evidence for this hypothesis was provided by releasing the artery 1,2, 4 and 6 hours after occlusion. The amount of subendocardium that could not be reperfused was small after 1 hour and large after 6 hours of occlusion. When the total collateral flow was very low, the subepicardium was not able to be reperfused and a transmural myocardial infarction developed. We conclude that the time delay between onset of ischemia and the appearance of a no-reflow phenomenon depends upon the amount of collateral flow. The occurrence of a no-reflow phenomenon in the subendocardium increases the amount of flow to the subepicardium which increases its chances of survival. Beyond the sixth hour after occlusion the total amount of collateral flow increases which is interpreted as a reduction of collateral resistance by passive caliber changes of the collateral vessels. DNA-synthesis that signal active caliber changes through cellular proliferation were always detected 24 hours after complete occlusion of a coronary artery regardless whether the time between onset of stenosis until complete occlusion was varied between 36 hours and 5 days. When the time to complete occlusion was 4 days, myocardial infarction was prevented due to growth-transformation of pre-existing collaterals. Four phases of collateral reactions in acute coronary occlusion were observed: redistribution of available collateral flow in favor of the subepicardium (t = 1 to 4 hours after occlusion), 2) increase of total collateral flow due to passive "stretch" of collateral vessels (t = 4 to 24 hours after occlusion), 3) radial growth of collateral vessels due to active cellular proliferation, (t = 24 hours to 5 days) 4) cellular proliferation to ensure a normal wall thickness in growth'transformed collaterals (t = 5 days to 20 days after coronary occlusion). In subacute coronary occlusion the first phase does, of course, not apply.
journal_name
Circulationjournal_title
Circulationauthors
Schaper W,Pasyk Ssubject
Has Abstractpub_date
1976-03-01 00:00:00pages
I57-62issue
3 Suppleissn
0009-7322issn
1524-4539journal_volume
53pub_type
杂志文章相关文献
CIRCULATION文献大全abstract::Electrocardiograms from 5,129 examined persons, 2,449 men and 2,680 women, 16 years of age or older, were classified according to the Minnesota code of Blackburn and associates. The R wave amplitude criteria for possible left ventricular hypertrophy were fulfilled in 193 tracings from 135 men and 58 women. Age and sex...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.33.2.270
更新日期:1966-02-01 00:00:00
abstract:BACKGROUND:Although phase 2 reentry is said to be responsible for initiation of ventricular tachycardia (VT) in Brugada syndrome, information about the activation sequence during VT is limited. METHODS AND RESULTS:We developed an experimental Brugada syndrome model using a canine isolated right ventricular preparation...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.CIR.0000105762.94855.46
更新日期:2004-01-06 00:00:00
abstract:BACKGROUND:Higher levels of physical activity are associated with fewer cardiovascular disease (CVD) events. Although the precise mechanisms underlying this inverse association are unclear, differences in several cardiovascular risk factors may mediate this effect. METHODS AND RESULTS:In a prospective study of 27,055 ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.107.729939
更新日期:2007-11-06 00:00:00
abstract::Frank lead vectorcardiograms (VCG) from four carefully selected patient subgroups (226 patients) were analyzed to develop optimal criteria for the diagnosis of anterior myocardial infarction. Specificity was evaluated using 100 healthy volunteers under age 30 and 80 patients with normal left ventriculogram and normal ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.53.2.229
更新日期:1976-02-01 00:00:00
abstract::We assessed the reversibility of functional and morphological changes of arterialized vein segments by returning them to the venous circulation. Thirteen dogs underwent right carotid and femoral veno-arterial grafting. After 12 weeks, veno-arterial grafts were removed for contractility (norepinephrine [NE] and 5-hydro...
journal_title:Circulation
pub_type: 杂志文章
doi:
更新日期:1990-11-01 00:00:00
abstract:BACKGROUND:Cardiovascular disease is the major cause of death in older women. Information on the relation of menopause and hormone replacement therapy with carotid atherosclerosis is limited. METHODS AND RESULTS:We examined cross-sectionally the association of menopausal status, years since last menstruation, and horm...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.94.8.1857
更新日期:1996-10-15 00:00:00
abstract::Catheter ablation has gained a prominent role in the management of atrial fibrillation (AF), with recent data providing positive evidence on hard outcomes, including hospitalization and mortality. Ablation, however, exposes the patient to a rather unique situation, combining risks for both major bleeding and thromboem...
journal_title:Circulation
pub_type: 杂志文章,评审
doi:10.1161/CIRCULATIONAHA.117.033326
更新日期:2018-08-07 00:00:00
abstract::Echocardiographic and cardiac catheterization findings were compared in 61 patients with mitral stenosis without other significant lesions in an attempt to determine the clinical usefulness of echocardiography in the assessment of such patients. There was a poor correlation between the E-F slope on the echocardiogram ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.52.4.664
更新日期:1975-10-01 00:00:00
abstract:BACKGROUND:β1-2-adrenergic receptors (AR) are key regulators of cardiac contractility and remodeling in response to catecholamines. β3-AR expression is enhanced in diseased human myocardium, but its impact on remodeling is unknown. METHODS AND RESULTS:Mice with cardiac myocyte-specific expression of human β3-AR (β3-TG...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.113.004940
更新日期:2014-01-28 00:00:00
abstract:BACKGROUND:Mechanisms by which neutrophils are attracted to the myocardium in ischemia/reperfusion are not fully defined. Lipopolysaccharide-induced CXC chemokine (LIX), cytokine-induced neutrophil chemoattractant (KC), and macrophage inflammatory protein-2 (MIP-2) are rodent chemokines with potent neutrophil-chemotact...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.103.18.2296
更新日期:2001-05-08 00:00:00
abstract:BACKGROUND:Coronary blood flow occurs mainly during the diastolic phase of each cardiac cycle and is mainly dependent on diastolic driving pressure, especially in the left anterior descending coronary artery (LAD). We hypothesized that calculation of the ratio of the diastolic driving pressure of a stenotic LAD to its ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.102.19.2365
更新日期:2000-11-07 00:00:00
abstract::Experience with percutaneous transluminal coronary angioplasty (PTCA) of multiple vessels was reviewed to assess short-term outcome and long-term results. PTCA of multiple vessels was performed in 100 of the initial 500 patients (20%) who underwent PTCA at the Medical College of Virginia between July 1979 and August 1...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.72.6.1314
更新日期:1985-12-01 00:00:00
abstract:BACKGROUND:We investigated the feasibility of bioluminescence imaging (BLI) for the in vivo assessment of cardiac allograft viability and visualization of passenger leukocytes during the course of acute rejection. METHODS AND RESULTS:Hearts of FVB (H-2q) luciferase-green fluorescent protein transgenic mice (beta-actin...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.104.524777
更新日期:2005-08-30 00:00:00
abstract::The automatic implantable cardioverter-defibrillator (ICD) is highly effective in reducing sudden death rates in patients with life-threatening ventricular tachyarrhythmias. However, the magnitude of the ability of the ICD to improve overall survival is less certain. Data supporting the contention that the ICD prolong...
journal_title:Circulation
pub_type: 杂志文章,评审
doi:10.1161/01.cir.89.4.1851
更新日期:1994-04-01 00:00:00
abstract:BACKGROUND:Previous trials of PCSK9 (proprotein convertase subtilisin-kexin type 9) inhibitors demonstrated reductions in major adverse cardiovascular events, but not death. We assessed the effects of alirocumab on death after index acute coronary syndrome. METHODS:ODYSSEY OUTCOMES (Evaluation of Cardiovascular Outcom...
journal_title:Circulation
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1161/CIRCULATIONAHA.118.038840
更新日期:2019-07-09 00:00:00
abstract:BACKGROUND:Digoxin is commonly prescribed in symptomatic paroxysmal atrial fibrillation (AF) but has never been evaluated in this condition. METHODS AND RESULTS:From a multicenter registry, 43 representative patients with frequent symptomatic AF episodes were recruited into a randomized, double-blind crossover compari...
journal_title:Circulation
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1161/01.cir.99.21.2765
更新日期:1999-06-01 00:00:00
abstract:BACKGROUND:Angiogenesis is a critical feature of plaque development in atherosclerosis and might play a key role in both the initiation and later rupture of plaques that lead to myocardial infarction and stroke. The precursory molecular or cellular events that initiate plaque growth and that ultimately contribute to pl...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.CIR.0000093185.16083.95
更新日期:2003-11-04 00:00:00
abstract:BACKGROUND:Ventricular septal defect (VSD) complicating acute myocardial infarction has been studied primarily in small, prethrombolytic-era trials. Our goal was to determine clinical predictors and angiographic and clinical outcomes of this complication in the thrombolytic era. METHODS AND RESULTS:We compared enrollm...
journal_title:Circulation
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1161/01.cir.101.1.27
更新日期:2000-01-04 00:00:00
abstract:BACKGROUND:Peripheral adiposity confers protection against diabetes and atherosclerosis in elderly women. The underlying mechanisms, however, remain to be elucidated. METHODS AND RESULTS:On the basis on dual-energy X-ray absorptiometry measurements of central fat mass (CFM) and peripheral fat mass (PFM), we identified...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.CIR.0000144470.55149.E5
更新日期:2004-10-12 00:00:00
abstract:BACKGROUND:Treatment of aortocaval fistulae (ACFs) by open surgery is known to be a high-risk procedure. In this experimental study, we developed a percutaneous model of ACF to test a new nonsurgical method of treatment of ACF using endovascular stent grafts. METHODS AND RESULTS:An ACF was created percutaneously in ei...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.94.1.108
更新日期:1996-07-01 00:00:00
abstract:BACKGROUND:Left ventricular noncompaction is a cardiomyopathy characterized by excessive trabeculation of the left ventricle, progressive myocardial dysfunction, and early mortality. Left ventricular noncompaction has a heterogeneous clinical presentation that includes arrhythmia and sudden cardiac death. METHODS AND ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.113.002511
更新日期:2013-06-04 00:00:00
abstract:BACKGROUND:Resetting has been used to characterize reentrant circuits causing clinical tachycardias. METHODS AND RESULTS:To determine the mechanisms of resetting, sustained ventricular tachycardia was induced in dogs with 4-day-old myocardial infarctions by programmed stimulation. Premature stimulation was accomplishe...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.103.8.1148
更新日期:2001-02-27 00:00:00
abstract:BACKGROUND:The first compounds considered for stent-based delivery, such as heparin, were chosen on the basis of promising tissue culture and animal experiments, and yet they have failed to stop restenosis clinically. More recent compounds, such as paclitaxel, are of a different sort, being hydrophobic in nature, and t...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/hc3101.092214
更新日期:2001-07-31 00:00:00
abstract::Depression of myocardial conduction velocity can be an important mechanism of action of antiarrhythmic drugs but it can also facilitate arrhythmogenesis. We used lidocaine in an anesthetized canine preparation to address the hypothesis that drug-induced rate-dependent conduction velocity depression causes ventricular ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.81.3.1024
更新日期:1990-03-01 00:00:00
abstract:BACKGROUND:HMG CoA reductase inhibitors (or statins), a new class of lipid-lowering compounds, have raised expectations for more widespread use than that of the older lipid-lowering drugs. Not only are they more effective in lowering LDL cholesterol, but they are better tolerated as well. No data exist concerning the e...
journal_title:Circulation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.cir.90.4.1679
更新日期:1994-10-01 00:00:00
abstract:BACKGROUND:Selection of treatment in vasovagal syndrome should be guided by the mechanism of symptoms. This study determined whether a simple drug test may assess one mechanism. METHODS AND RESULTS:To identify patients at risk of severe cardioinhibitory response of vagal origin, we infused 20 mg ATP into 316 patients ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.96.4.1201
更新日期:1997-08-19 00:00:00
abstract:BACKGROUND:Early-generation drug-eluting stents releasing sirolimus (SES) or paclitaxel (PES) are associated with increased risk of very late stent thrombosis occurring >1 year after stent implantation. It is unknown whether the risk of very late stent thrombosis persists with newer-generation everolimus-eluting stents...
journal_title:Circulation
pub_type: 杂志文章,多中心研究
doi:10.1161/CIRCULATIONAHA.111.058560
更新日期:2012-03-06 00:00:00
abstract::From January 1968 to June 1975 tricuspid regurgitation was encountered in 238 patients of a total of 1074 patients undergoing operations on the mitral valve. During this time tricuspid annuloplasty (TA) was performed in 137 patients and the tricuspid valve was replaced (TVR) in 101 patients. Comparison of hospital mor...
journal_title:Circulation
pub_type: 杂志文章
doi:
更新日期:1976-12-01 00:00:00
abstract:BACKGROUND:Ghrelin is a novel growth hormone-releasing peptide that has been shown to improve cachexia in heart failure and cancer and to ameliorate the hemodynamic and metabolic disturbances in septic shock. Because cytokine-induced inflammation is critical in these pathological states and because the growth hormone s...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.CIR.0000127956.43874.F2
更新日期:2004-05-11 00:00:00
abstract::Serial sections of the conduction system (CS) were performed in two patients with recurrent tachyarrhythmias. Case 1, a 34-year-old female who had dual atrioventricular (AV) nodal pathways with recurrent paroxysmal supraventricular tachycardia, committed suicide. Autopsy revealed an abnormally formed atrial septum wit...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.59.3.593
更新日期:1979-03-01 00:00:00