Double-blind placebo-controlled trial of digoxin in symptomatic paroxysmal atrial fibrillation.

abstract：BACKGROUND:The combination of a single-bolus fibrinolytic and a low-molecular-weight heparin may facilitate prehospital reperfusion and further improve clinical outcome in patients with ST-elevation myocardial infarction. METHODS AND RESULTS:In the prehospital setting, 1639 patients with ST-elevation myocardial infarc...

journal_title：Circulation

authors： Wallentin L,Goldstein P,Armstrong PW,Granger CB,Adgey AA,Arntz HR,Bogaerts K,Danays T,Lindahl B,Mäkijärvi M,Verheugt F,Van de Werf F

更新日期：2003-07-15 00:00:00

abstract：BACKGROUND:Patients with chronic granulomatous disease (CGD) experience immunodeficiency because of defects in the phagocyte NADPH oxidase and the concomitant reduction in reactive oxygen intermediates. This may result in a reduction in atherosclerotic injury. METHODS AND RESULTS:We prospectively assessed the prevalen...

journal_title：Circulation

authors： Sibley CT,Estwick T,Zavodni A,Huang CY,Kwan AC,Soule BP,Long Priel DA,Remaley AT,Rudman Spergel AK,Turkbey EB,Kuhns DB,Holland SM,Malech HL,Zarember KA,Bluemke DA,Gallin JI

更新日期：2014-12-02 00:00:00

abstract：:Aortic root motion was studied in 24 normal volunteers at rest and during the Valsalva maneuver, isometric exercise, and amyl nitrite inhalation. In addition root motion was correlated with the stroke volumes determined at cardiac catheterization in 24 patients. The root has distinct systolic movement, the amplitude a...

journal_title：Circulation

authors： Pratt RC,Parisi AF,Harrington JJ,Sasahara AA

更新日期：1976-06-01 00:00:00

abstract：BACKGROUND:Therapy with racemic compounds produces effects that can be attributed to both (S)- and (R)-enantiomers. Here we have tested the hypothesis that an enantiomer-enantiomer interaction would modulate the effects of treatment with a racemate, the antiarrhythmic propafenone. Previous studies have shown that while...

journal_title：Circulation

authors： Kroemer HK,Fromm MF,Bühl K,Terefe H,Blaschke G,Eichelbaum M

更新日期：1994-05-01 00:00:00

abstract：BACKGROUND:Coronary spastic angina (CSA) is a common disease among East Asians, including Japanese. The prevalence of alcohol flushing syndrome associated with deficient activity of the variant aldehyde dehydrogenase 2 (ALDH2*2) genotype is prevalent among East Asians. We examined whether CSA is associated with the ALD...

journal_title：Circulation

authors： Mizuno Y,Harada E,Morita S,Kinoshita K,Hayashida M,Shono M,Morikawa Y,Murohara T,Nakayama M,Yoshimura M,Yasue H

更新日期：2015-05-12 00:00:00

abstract：:We compared the effects of a cardioselective beta-adrenergic blocking drug, metoprolol, with a nonselective beta-adrenergic blocker, propranolol, on the response of 10 normal men to dynamic treadmill exercise. The volunteers underwent a standard graded exercise test to exhaustion while receiving placebo; propranolol, ...

journal_title：Circulation

authors： Sklar J,Johnston GD,Overlie P,Gerber JG,Brammell HL,Gal J,Nies AS

更新日期：1982-05-01 00:00:00

abstract：BACKGROUND:The incidence of cardiovascular disease (CVD), coronary heart disease (CHD), and type 2 diabetes mellitus (T2DM) has not been well defined in persons with the metabolic syndrome (at least 3 of the following: abdominal adiposity, low HDL cholesterol, high triglycerides, hypertension, and impaired fasting gluc...

journal_title：Circulation

authors： Wilson PW,D'Agostino RB,Parise H,Sullivan L,Meigs JB

更新日期：2005-11-15 00:00:00

abstract：BACKGROUND:Recent studies suggest that bone morphogenetic protein-2 (BMP-2), a transforming growth factor-beta superfamily member cytokine, plays an important role both in vascular development and pathophysiological processes, including endothelial activation that is likely to contribute to the development of coronary ...

journal_title：Circulation

authors： Csiszar A,Smith KE,Koller A,Kaley G,Edwards JG,Ungvari Z

更新日期：2005-05-10 00:00:00

abstract：:The ability of predischarge quantitative exercise thallium-201 (201T1) scintigraphy to predict future cardiac events was evaluated prospectively in 140 consecutive patients with uncomplicated acute myocardial infarction; the results were compared with those of submaximal exercise treadmill testing and coronary angiogr...

journal_title：Circulation

authors： Gibson RS,Watson DD,Craddock GB,Crampton RS,Kaiser DL,Denny MJ,Beller GA

更新日期：1983-08-01 00:00:00

abstract：:The rapid injection into the coronary circulation of solutions containing microbubbles produces an ultrasonic contrast effect in the myocardium. The time-intensity curves generated by sequential videodensitometric analysis of contrast intensity, which is corrected for myocardial background intensity, resembles the cur...

journal_title：Circulation

authors： Quiñones A,Cheirif BJ

更新日期：1991-05-01 00:00:00

abstract：:Experimental studies demonstrate that short-term regional perfusion-contraction matching, in which the energy demands of regional myocardial contraction are reduced to match the diminished myocardial substrate supply, occurs during states of low coronary blood flow under resting conditions and during exercise-induced ...

journal_title：Circulation

authors： Ross J Jr

更新日期：1991-03-01 00:00:00

abstract：:Although ST-segment abnormalities during acute myocardial infarction are clinically important, the total thoracic distribution of these repolarization potentials has not been reported. To provide this information, 24 patients with acute myocardial infarction were studied. Isopotential body surface maps were constructe...

journal_title：Circulation

authors： Mirvis DM

更新日期：1980-10-01 00:00:00

abstract：BACKGROUND:Recent data highlight a vital link between well-performed cardiopulmonary resuscitation (CPR) and survival after cardiac arrest; however, the quality of CPR as actually performed by trained healthcare providers is largely unknown. We sought to measure in-hospital chest compression rates and to determine comp...

journal_title：Circulation

authors： Abella BS,Sandbo N,Vassilatos P,Alvarado JP,O'Hearn N,Wigder HN,Hoffman P,Tynus K,Vanden Hoek TL,Becker LB

更新日期：2005-02-01 00:00:00

abstract：BACKGROUND:Production of NO by inducible NO synthase (iNOS) has been implicated in the pathology of spontaneous and antigen-induced autoimmune diseases, and iNOS is expressed in the myocardium of patients with heart failure. It is not clear whether inflammatory murine autoimmune heart disease, an experimental model for...

journal_title：Circulation

authors： Bachmaier K,Neu N,Pummerer C,Duncan GS,Mak TW,Matsuyama T,Penninger JM

更新日期：1997-07-15 00:00:00

abstract：BACKGROUND:At physiological concentrations, 17beta-estradiol selectively enhances endothelium-dependent coronary vasodilation by an unknown mechanism in postmenopausal women. METHODS AND RESULTS:To assess the contribution of nitric oxide (NO) to the vascular effects of estradiol, we measured coronary epicardial and mi...

journal_title：Circulation

authors： Guetta V,Quyyumi AA,Prasad A,Panza JA,Waclawiw M,Cannon RO 3rd

更新日期：1997-11-04 00:00:00

abstract：BACKGROUND:In patients with symptoms of heart failure, elevations in B-type natriuretic peptide (BNP) accurately identify ventricular dysfunction. However, BNP levels are not specific for ventricular dysfunction in patients who do not have overt symptoms of heart failure, suggesting that other cardiac processes such as...

journal_title：Circulation

authors： Bibbins-Domingo K,Ansari M,Schiller NB,Massie B,Whooley MA

更新日期：2003-12-16 00:00:00

abstract：BACKGROUND:Perivascular adipose tissue (PVAT) surrounds most vessels and shares common features with brown adipose tissue (BAT). Although adaptive thermogenesis in BAT increases energy expenditure and is beneficial for metabolic diseases, little is known about the role of PVAT in vascular diseases such as atheroscleros...

journal_title：Circulation

authors： Chang L,Villacorta L,Li R,Hamblin M,Xu W,Dou C,Zhang J,Wu J,Zeng R,Chen YE

更新日期：2012-08-28 00:00:00

abstract：BACKGROUND:Continuous-flow rotary pumps with axial design are increasingly used for left ventricular assist support. The efficacy of this design compared with pulsatile, volume displacement pumps, with respect to characteristics of left ventricular unloading, and exercise performance remains largely unstudied. METHODS...

journal_title：Circulation

authors： Haft J,Armstrong W,Dyke DB,Aaronson KD,Koelling TM,Farrar DJ,Pagani FD

更新日期：2007-09-11 00:00:00

abstract：BACKGROUND:The differentiation of hypertrophic cardiomyopathy (HCM) from hypertensive left ventricular hypertrophy (H-LVH) on the basis of morphological information obtained by conventional echocardiography is occasionally problematic. We investigated whether strain rate (SR) imaging derived from tissue Doppler imaging...

journal_title：Circulation

authors： Kato TS,Noda A,Izawa H,Yamada A,Obata K,Nagata K,Iwase M,Murohara T,Yokota M

更新日期：2004-12-21 00:00:00

abstract：BACKGROUND:Brugada syndrome (BrS) primarily associates with the loss of sodium channel function. Previous studies showed features consistent with sodium current (INa) deficit in patients carrying desmosomal mutations, diagnosed with arrhythmogenic cardiomyopathy (or arrhythmogenic right ventricular cardiomyopathy). Exp...

journal_title：Circulation

authors： Cerrone M,Lin X,Zhang M,Agullo-Pascual E,Pfenniger A,Chkourko Gusky H,Novelli V,Kim C,Tirasawadichai T,Judge DP,Rothenberg E,Chen HS,Napolitano C,Priori SG,Delmar M

更新日期：2014-03-11 00:00:00

abstract：BACKGROUND:Atrial fibrillation (AF), the most common clinical arrhythmia, is a major cause of morbidity and mortality. Although AF is often associated with other cardiovascular conditions, many patients present without an obvious etiology. Inherited forms of AF exist, but the causative gene has been defined only in a s...

journal_title：Circulation

authors： Ellinor PT,Shin JT,Moore RK,Yoerger DM,MacRae CA

更新日期：2003-06-17 00:00:00

abstract：BACKGROUND:Fluid energy loss across stenotic aortic valves is influenced by factors other than the valve effective orifice area (EOA). We propose a new index that will provide a more accurate estimate of this energy loss. METHODS AND RESULTS:An experimental model was designed to measure EOA and energy loss in 2 fixed ...

journal_title：Circulation

authors： Garcia D,Pibarot P,Dumesnil JG,Sakr F,Durand LG

更新日期：2000-02-22 00:00:00

abstract：BACKGROUND:Elevated levels of oxidized phospholipids (OxPLs) on apolipoprotein B-100 particles (OxPL/apoB) are associated with cardiovascular disease and predict new cardiovascular events. Elevated lipoprotein (a) [Lp(a)] levels are a risk factor for cardiovascular disease in whites and also in blacks if they carry sma...

journal_title：Circulation

authors： Tsimikas S,Clopton P,Brilakis ES,Marcovina SM,Khera A,Miller ER,de Lemos JA,Witztum JL

更新日期：2009-04-07 00:00:00

abstract：BACKGROUND:Pulmonary hypertension is a fatal disease characterized by vasoconstriction and vascular remodeling. Loss of endothelial nitric oxide bioavailability is implicated in pulmonary hypertension pathogenesis. Recent evidence suggests that the cofactor tetrahydrobiopterin (BH4) is an important regulator of nitric ...

journal_title：Circulation

authors： Khoo JP,Zhao L,Alp NJ,Bendall JK,Nicoli T,Rockett K,Wilkins MR,Channon KM

更新日期：2005-04-26 00:00:00

abstract：BACKGROUND:The quantity and intensity of physical activity required for the primary prevention of coronary heart disease (CHD) remain unclear. Therefore, we examined the association of the quantity and intensity of physical activity with CHD risk and the impact of other coronary risk factors. METHODS AND RESULTS:We fo...

journal_title：Circulation

authors： Sesso HD,Paffenbarger RS Jr,Lee IM

更新日期：2000-08-29 00:00:00

abstract：BACKGROUND:Beta-blockers improve clinical outcome when administered early after acute myocardial infarction. However, whether beta-blockers actually reduce the myocardial infarction size is still in dispute. Cardiac magnetic resonance imaging can accurately depict the left ventricular (LV) ischemic myocardium at risk (...

journal_title：Circulation

authors： Ibanez B,Prat-González S,Speidl WS,Vilahur G,Pinero A,Cimmino G,García MJ,Fuster V,Sanz J,Badimon JJ

更新日期：2007-06-12 00:00:00

abstract：BACKGROUND:Myocardial infarction with nonobstructive coronary arteries (MINOCA) is a puzzling clinical entity with no previous evaluation of the literature. This systematic review aims to (1) quantify the prevalence, risk factors, and 12-month prognosis in patients with MINOCA, and (2) evaluate potential pathophysiolog...

journal_title：Circulation

authors： Pasupathy S,Air T,Dreyer RP,Tavella R,Beltrame JF

更新日期：2015-03-10 00:00:00

abstract：:This article provides a selective overview of epidemiologic studies on the relationship between psychosocial factors and blood pressure elevation. The review focuses on English-language reports published since 1975 and emphasizes two broad areas of research: changes in mean blood pressures of third world populations u...

journal_title：Circulation

authors： James SA

更新日期：1987-07-01 00:00:00

abstract：:The healthcare system is undergoing a transition from paying for volume to paying for value. Clinicians, as well as public and private payers, are beginning to implement alternative delivery and payment models, such as the patient-centered medical home, accountable care organizations, and bundled payment arrangements....

journal_title：Circulation

authors： Bufalino VJ,Berkowitz SA,Gardner TJ,Piña IL,Konig M,AHA Expert Panel on Payment and Delivery System Reform.

更新日期：2017-08-15 00:00:00

abstract：BACKGROUND:Adhesion of monocytes to the endothelium is an initial step in the early stages of atherosclerosis and inflammation. Granulocyte-macrophage colony-stimulating factor (GM-CSF) stimulates a range of functional activities of monocytes, including regulation of monocyte adhesion and induction of cytokine producti...

journal_title：Circulation

authors： Takahashi M,Kitagawa S,Masuyama JI,Ikeda U,Kasahara T,Takahashi YI,Furukawa Y,Kano S,Shimada K

更新日期：1996-03-15 00:00:00