Physical activity and coronary heart disease in men: The Harvard Alumni Health Study.


BACKGROUND:The quantity and intensity of physical activity required for the primary prevention of coronary heart disease (CHD) remain unclear. Therefore, we examined the association of the quantity and intensity of physical activity with CHD risk and the impact of other coronary risk factors. METHODS AND RESULTS:We followed 12 516 middle-aged and older men (mean age 57.7 years, range 39 to 88 years) from 1977 through 1993. Physical activity was assessed at baseline in kilojoules per week (4.2 kJ=1 kcal) from blocks walked, flights climbed, and participation in sports or recreational activities. During follow-up, 2,135 cases of incident CHD, including myocardial infarction, angina pectoris, revascularization, and coronary death, occurred. Compared with men expending <2,100 kJ/wk, men expending 2,100 to 4,199, 4,200 to 8,399, 8,400 to 12,599, and >/=12,600 kJ/wk had multivariate relative risks of 0.90, 0.81, 0.80, and 0.81, respectively (P: for trend=0.003). When we considered the independent effects of specific physical activity components, only total sports or recreational activities (P: for trend=0.042) and vigorous activities (P: for trend=0.02) were inversely associated with the risk of CHD. These associations did not differ within subgroups of men defined by coronary risk factors. Finally, among men with multiple coronary risk factors, those expending >/=4,200 kJ/wk had reduced CHD risk compared with men expending <4,200 kJ/wk. CONCLUSIONS:Total physical activity and vigorous activities showed the strongest reductions in CHD risk. Moderate and light activities, which may be less precisely measured, showed nonsignificant inverse associations. The association between physical activity and a reduced risk of CHD also extends to men with multiple coronary risk factors.






Sesso HD,Paffenbarger RS Jr,Lee IM




Has Abstract


2000-08-29 00:00:00












  • Effects of aortopulmonary collaterals on cerebral cooling and cerebral metabolic recovery after circulatory arrest.

    abstract:BACKGROUND:Aortopulmonary collaterals (APC) have been associated with an increased risk of choreoathetosis after deep hypothermic circulatory arrest (DHCA). To study the effects of APC on cerebral hemodynamics and metabolism before and after DHCA, a piglet model was developed. METHODS AND RESULTS:Protocol 1: Eight 4- ...


    pub_type: 杂志文章


    authors: Kirshbom PM,Skaryak LA,DiBernardo LR,Kern FH,Greeley WJ,Gaynor JW,Ungerleider RM

    更新日期:1995-11-01 00:00:00

  • Catecholamine metabolic pathways and exercise training. Plasma and urine catecholamines, metabolic enzymes, and chromogranin-A.

    abstract:BACKGROUND:Because acute exercise increases systemic catecholamines, we sought to determine whether exercise training would alter daily or exercise-related catecholamine release and inactivation. METHODS AND RESULTS:In 24-hour urine collections, catecholamines and metabolites provided indexes of overall oxidative deam...


    pub_type: 杂志文章


    authors: Rogers PJ,Tyce GM,Weinshilboum RM,O'Connor DT,Bailey KR,Bove AA

    更新日期:1991-12-01 00:00:00

  • Inhibition of prostaglandin E2 synthesis in abdominal aortic aneurysms: implications for smooth muscle cell viability, inflammatory processes, and the expansion of abdominal aortic aneurysms.

    abstract:BACKGROUND:There is no treatment proven to limit the growth of abdominal aortic aneurysms, in which the histological hallmarks include inflammation and medial atrophy, with apoptosis of smooth muscle cells and destruction of elastin. METHODS AND RESULTS:Aneurysm biopsies were used for explant cultures, the preparation...


    pub_type: 杂志文章


    authors: Walton LJ,Franklin IJ,Bayston T,Brown LC,Greenhalgh RM,Taylor GW,Powell JT

    更新日期:1999-07-06 00:00:00

  • Beta2-adrenergic receptor polymorphisms and risk of incident cardiovascular events in the elderly.

    abstract:BACKGROUND:Genetic polymorphisms at codons 16 and 27 of the beta2-adrenergic receptor have been associated with altered response to sympathetic stimulation. We examined these polymorphisms in relation to cardiovascular event risk in the Cardiovascular Health Study. METHODS AND RESULTS:A total of 808 black and 4441 whi...


    pub_type: 杂志文章


    authors: Heckbert SR,Hindorff LA,Edwards KL,Psaty BM,Lumley T,Siscovick DS,Tang Z,Durda JP,Kronmal RA,Tracy RP

    更新日期:2003-04-22 00:00:00

  • Additional lead improves defibrillation efficacy with an abdominal 'hot can' electrode system.

    abstract:BACKGROUND:Although the left prepectoral site is preferred for "hot can" placement, this site is unavailable in some patients. We evaluated the influence of electrode location on defibrillation thresholds with alternative hot can and transvenous lead configurations. METHODS AND RESULTS:Three interrelated studies were ...


    pub_type: 杂志文章


    authors: Yamanouchi Y,Mowrey KA,Niebauer MJ,Tchou PJ,Wilkoff BL

    更新日期:1997-12-16 00:00:00

  • Arterial neovascularization and inflammation in vulnerable patients: early and late signs of symptomatic atherosclerosis.

    abstract:BACKGROUND:Atherosclerosis is complicated by cardiovascular events such as myocardial infarction, stroke, or peripheral arterial occlusive disease. Inflammation and pathological neovascularization are thought to precipitate plaque rupture or erosion, both causes of arterial thrombosis and cardiovascular events. We test...


    pub_type: 杂志文章


    authors: Fleiner M,Kummer M,Mirlacher M,Sauter G,Cathomas G,Krapf R,Biedermann BC

    更新日期:2004-11-02 00:00:00

  • Hypothermia in comatose survivors from out-of-hospital cardiac arrest: pilot trial comparing 2 levels of target temperature.

    abstract:BACKGROUND:It is recommended that comatose survivors of out-of-hospital cardiac arrest should be cooled to 32° to 34°C for 12 to 24 hours. However, the optimal level of cooling is unknown. The aim of this pilot study was to obtain initial data on the effect of different levels of hypothermia. We hypothesized that deepe...


    pub_type: 杂志文章,随机对照试验


    authors: Lopez-de-Sa E,Rey JR,Armada E,Salinas P,Viana-Tejedor A,Espinosa-Garcia S,Martinez-Moreno M,Corral E,Lopez-Sendon J

    更新日期:2012-12-11 00:00:00

  • Evaluation of Microvascular Injury in Revascularized Patients With ST-Segment-Elevation Myocardial Infarction Treated With Ticagrelor Versus Prasugrel.

    abstract:BACKGROUND:Despite successful restoration of epicardial vessel patency with primary percutaneous coronary intervention, coronary microvascular injury occurs in a large proportion of patients with ST-segment-elevation myocardial infarction, adversely affecting clinical and functional outcome. Ticagrelor has been reporte...


    pub_type: 杂志文章


    authors: van Leeuwen MAH,van der Hoeven NW,Janssens GN,Everaars H,Nap A,Lemkes JS,de Waard GA,van de Ven PM,van Rossum AC,Ten Cate TJF,Piek JJ,von Birgelen C,Escaned J,Valgimigli M,Diletti R,Riksen NP,van Mieghem NM,Nijveldt R,

    更新日期:2019-01-29 00:00:00

  • Extent and direction of arterial remodeling in stable versus unstable coronary syndromes : an intravascular ultrasound study.

    abstract:BACKGROUND:The morphological characteristics of coronary plaques in patients with stable versus unstable coronary syndromes have been described in vivo with intravascular ultrasound, but the relationship between arterial remodeling and clinical presentation is not well known. METHODS AND RESULTS:We studied 85 patients...


    pub_type: 杂志文章


    authors: Schoenhagen P,Ziada KM,Kapadia SR,Crowe TD,Nissen SE,Tuzcu EM

    更新日期:2000-02-15 00:00:00

  • Hyperlipidemia and coronary disease. Correction of the increased thrombogenic potential with cholesterol reduction.

    abstract:BACKGROUND:Hypercholesterolemia is a risk factor for coronary disease, and platelet reactivity is increased with hypercholesterolemia, suggesting a prethrombotic risk. The aim of this study was to measure mural platelet thrombus formation on an injured arterial wall in a model simulating vessel stenosis and plaque rupt...


    pub_type: 杂志文章


    authors: Lacoste L,Lam JY,Hung J,Letchacovski G,Solymoss CB,Waters D

    更新日期:1995-12-01 00:00:00

  • Pace mapping using body surface potential maps to guide catheter ablation of accessory pathways in patients with Wolff-Parkinson-White syndrome.

    abstract::BACKGROUND. A pace mapping technique using body surface potential maps (BSPMs) was developed to guide the positioning of an ablation catheter at the ventricular insertion point of accessory pathways (AP) in patients with the Wolff-Parkinson-White syndrome (WPW). METHODS AND RESULTS. The study was performed on 30 WPW p...


    pub_type: 杂志文章


    authors: Dubuc M,Nadeau R,Tremblay G,Kus T,Molin F,Savard P

    更新日期:1993-01-01 00:00:00

  • A Population-Based Study of Abdominal Aortic Aneurysm Treatment in Finland 2000 to 2014.

    abstract:BACKGROUND:In the event of rupture of an abdominal aortic aneurysm (AAA), mortality is very high. AAA prevalence and incidence of ruptures have been reported to be decreasing. The treatment of AAA has also undergone a change in recent decades with a shift toward endovascular aneurysm repair (EVAR). Our aim was to evalu...


    pub_type: 临床试验,杂志文章,多中心研究


    authors: Laine MT,Laukontaus SJ,Sund R,Aho PS,Kantonen I,Albäck A,Venermo M

    更新日期:2017-10-31 00:00:00

  • Increased preferential absorption in human atherosclerotic plaque with oral beta carotene. Implications for laser endarterectomy.

    abstract::Patients undergoing carotid endarterectomy were pretreated with low-dose, oral beta carotene to determine whether the carotenoid content of plaque could be increased in vivo. Beta carotene-treated patients had a 50-fold increase in their plaque beta carotene level from 0.066 to 3.3 micrograms beta carotene/g plaque. M...


    pub_type: 杂志文章


    authors: Prince MR,LaMuraglia GM,MacNichol EF Jr

    更新日期:1988-08-01 00:00:00

  • Histopathology of embolic debris captured during transcatheter aortic valve replacement.

    abstract:BACKGROUND:Recent transcatheter aortic valve replacement studies have raised concerns about adverse cerebrovascular events. The etiopathology of the embolized material is currently unknown. METHODS AND RESULTS:A total of 40 patients underwent transcatheter aortic valve replacement with the use of a dual filter-based e...


    pub_type: 临床试验,杂志文章


    authors: Van Mieghem NM,Schipper ME,Ladich E,Faqiri E,van der Boon R,Randjgari A,Schultz C,Moelker A,van Geuns RJ,Otsuka F,Serruys PW,Virmani R,de Jaegere PP

    更新日期:2013-06-04 00:00:00

  • New indexes for assessing aortic regurgitation with two-dimensional Doppler echocardiographic measurement of the regurgitant aortic valvular area.

    abstract::Direct examination of the aortic orifice at the level of the aortic valves (aortic valvular orifice area, AVOA) in the short-axis plane was performed with a 3 MHz two-dimensional pulsed Doppler echocardiographic apparatus. The AVOA was mapped with the Doppler gate to detect or rule out the presence of a regurgitant ao...


    pub_type: 杂志文章


    authors: Veyrat C,Lessana A,Abitbol G,Ameur A,Benaim R,Kalmanson D

    更新日期:1983-11-01 00:00:00

  • Cardiac allograft vasculopathy: a review.

    abstract::Cardiac allograft vasculopathy (CAV) remains a troublesome long-term complication of heart transplantation. It is manifested by a unique and unusually accelerated form of coronary disease affecting both intramural and epicardial coronary arteries and veins.CAV is characterized by vascular injury induced by a variety o...


    pub_type: 杂志文章,评审


    authors: Weis M,von Scheidt W

    更新日期:1997-09-16 00:00:00

  • Aminoguanidine prevents the decreased myocardial compliance produced by streptozotocin-induced diabetes mellitus in rats.

    abstract:BACKGROUND:A decreased cardiac compliance is a major feature of the cardiomyopathy of diabetes mellitus. Either an increase in the resistance afterload to the LV or an increase in collagen cross-linking induced by the formation of advanced glycosylation end products (AGEs) of collagen may be responsible for the stiff m...


    pub_type: 杂志文章


    authors: Norton GR,Candy G,Woodiwiss AJ

    更新日期:1996-05-15 00:00:00

  • Aortic valve repair for adult congenital heart disease: A 22-year experience.

    abstract:BACKGROUND:Aortic valve-preserving procedures have resulted in excellent outcomes in selected patients, particularly those with normal aortic valve leaflets and dilated aortic roots. However, several congenital heart lesions are associated with abnormal aortic valve leaflets. The long-term results of aortic valve repai...


    pub_type: 杂志文章


    authors: Rao V,Van Arsdell GS,David TE,Azakie A,Williams WG

    更新日期:2000-11-07 00:00:00

  • Cardiac histological substrate in patients with clinical phenotype of Brugada syndrome.

    abstract:BACKGROUND:The role of structural heart disease and sodium channel dysfunction in the induction of electrical instability in Brugada syndrome is still debated. METHODS AND RESULTS:We studied 18 consecutive patients (15 males, 3 females; mean age 42.0+/-12.4 years) with clinical phenotype of Brugada syndrome and normal...


    pub_type: 杂志文章


    authors: Frustaci A,Priori SG,Pieroni M,Chimenti C,Napolitano C,Rivolta I,Sanna T,Bellocci F,Russo MA

    更新日期:2005-12-13 00:00:00

  • Impaired maximal rate of left ventricular relaxation in patients with coronary artery disease and left ventricular dysfunction.

    abstract::It has been suggested that the rate of left ventricular (LV) relaxation is related to the inotropic state, end-systolic fiber length and peak LV pressure, but little information is available regarding the rate of LV relaxation in patients with coronary artery disease (CAD) and LV dysfunction. To assess the rate of LV ...


    pub_type: 杂志文章


    authors: Papapietro SE,Coghlan HC,Zissermann D,Russell RO Jr,Rackley CE,Rogers WJ

    更新日期:1979-05-01 00:00:00

  • Concealed ventricular parasystole uncovered in the form of ventricular escapes of variable coupling.

    abstract::Exit block from a parasystolic focus is recognized when automatic discharges fail to become manifest during the excitable phase of the ventricular cycle. In the present study, an apparently complete exit block and a persistently concealed ventricular parasystole (VP) resulted from an exit refractory period (ExRP) long...


    pub_type: 杂志文章


    authors: Nau GJ,Aldariz AE,Acunzo RS,Chiale PA,Elizari MV,Rosenbaum MB

    更新日期:1981-07-01 00:00:00

  • Effect of surgical reduction of left ventricular outflow obstruction on hemodynamics, coronary flow, and myocardial metabolism in hypertrophic cardiomyopathy.

    abstract::To assess the impact of operative reduction of left ventricular outflow obstruction in hypertrophic cardiomyopathy, measurements of great cardiac vein flow, oxygen and lactate content, left ventricular pressures, and cardiac index were measured at rest and during pacing stress in 20 consecutive patients (13, myotomy-m...


    pub_type: 杂志文章


    authors: Cannon RO 3rd,McIntosh CL,Schenke WH,Maron BJ,Bonow RO,Epstein SE

    更新日期:1989-04-01 00:00:00

  • Efficacy of Long-Term β-Blocker Therapy for Secondary Prevention of Long-Term Outcomes After Coronary Artery Bypass Grafting Surgery.

    abstract:BACKGROUND:Conflicting results from recent observational studies have raised questions concerning the benefit of β-blockers for patients undergoing coronary artery bypass grafting (CABG). Furthermore, the efficacy of long-term β-blocker therapy in CABG patients after hospital discharge is uncertain. METHODS AND RESULT...


    pub_type: 杂志文章


    authors: Zhang H,Yuan X,Zhang H,Chen S,Zhao Y,Hua K,Rao C,Wang W,Sun H,Hu S,Zheng Z

    更新日期:2015-06-23 00:00:00

  • Chronic changes in skeletal muscle histology and function in peripheral arterial disease.

    abstract:BACKGROUND:Peripheral arterial disease (PAD) is associated with an impairment in exercise performance and muscle function that is not fully explained by the reduced leg blood flow during exercise. This study characterized the effects of PAD on muscle function, histology, and metabolism. METHODS AND RESULTS:Twenty-six ...


    pub_type: 杂志文章


    authors: Regensteiner JG,Wolfel EE,Brass EP,Carry MR,Ringel SP,Hargarten ME,Stamm ER,Hiatt WR

    更新日期:1993-02-01 00:00:00

  • Identification of 92-kD gelatinase in human coronary atherosclerotic lesions. Association of active enzyme synthesis with unstable angina.

    abstract:BACKGROUND:Acute coronary ischemia is usually initiated by rupture of atherosclerotic plaque, leading to intracoronary thrombosis and clinical sequelae. The proximate cause of plaque rupture is unknown. Accordingly, we investigated the potential role of the 92-kD gelatinase member of the matrix metalloproteinase family...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Brown DL,Hibbs MS,Kearney M,Loushin C,Isner JM

    更新日期:1995-04-15 00:00:00

  • Transcription Factor RUNX1 Regulates Platelet PCTP (Phosphatidylcholine Transfer Protein): Implications for Cardiovascular Events: Differential Effects of RUNX1 Variants.

    abstract:BACKGROUND:PCTP (phosphatidylcholine transfer protein) regulates the intermembrane transfer of phosphatidylcholine. Higher platelet PCTP expression is associated with increased platelet responses on activation of protease-activated receptor 4 thrombin receptors noted in black subjects compared with white subjects. Litt...


    pub_type: 杂志文章


    authors: Mao G,Songdej N,Voora D,Goldfinger LE,Del Carpio-Cano FE,Myers RA,Rao AK

    更新日期:2017-09-05 00:00:00

  • Matrix-dependent mechanism of neutrophil-mediated release and activation of matrix metalloproteinase 9 in myocardial ischemia/reperfusion.

    abstract:BACKGROUND:A key component of reperfusion of myocardial infarction is an immediate inflammatory response, which enhances tissue repair. Matrix turnover is crucial to tissue repair, and matrix metalloproteinases (MMPs) are key enzymes involved in matrix degradation. The hypothesis tested is that one inflammation-based e...


    pub_type: 杂志文章


    authors: Lindsey M,Wedin K,Brown MD,Keller C,Evans AJ,Smolen J,Burns AR,Rossen RD,Michael L,Entman M

    更新日期:2001-05-01 00:00:00

  • Differential effects of green tea-derived catechin on developing versus established atherosclerosis in apolipoprotein E-null mice.

    abstract:BACKGROUND:Oxidative stress has been implicated in vascular injury and atherogenesis, and antioxidant treatment has shown favorable results in preclinical studies. Despite this, antioxidant therapy has failed to show benefit in clinical trials. Failure of antioxidants in clinical trials may be partly because such thera...


    pub_type: 杂志文章


    authors: Chyu KY,Babbidge SM,Zhao X,Dandillaya R,Rietveld AG,Yano J,Dimayuga P,Cercek B,Shah PK

    更新日期:2004-05-25 00:00:00

  • Transluminal angioplasty: correlation of morphologic and angiographic findings in an experimental model.

    abstract::The morphologic consequences of transluminal angioplasty of stenotic atherosclerotic coronary arteries are unknown. This study describes the production of aortoiliac atherosclerosis in rabbits and reports the morphologic changes after transluminal angioplasty of stenotic arterial lesions. Atherosclerotic lesions were ...


    pub_type: 杂志文章


    authors: Block PC,Baughman KL,Pasternak RC,Fallon JT

    更新日期:1980-04-01 00:00:00

  • Use of direct angioplasty for treatment of patients with acute myocardial infarction in hospitals with and without on-site cardiac surgery. The Myocardial Infarction, Triage, and Intervention Project Investigators.

    abstract:BACKGROUND:In the Myocardial Infarction, Triage, and Intervention (MITI) registry of acute myocardial infarction, 441 (12%) of 3750 patients had direct angioplasty as initial treatment. Approximately half (233) were performed in hospitals with no on-site surgery. METHODS AND RESULTS:Procedure success rates, use of eme...


    pub_type: 杂志文章


    authors: Weaver WD,Litwin PE,Martin JS

    更新日期:1993-11-01 00:00:00