Assessment of aortic valve stenosis severity: A new index based on the energy loss concept.

Abstract:

BACKGROUND:Fluid energy loss across stenotic aortic valves is influenced by factors other than the valve effective orifice area (EOA). We propose a new index that will provide a more accurate estimate of this energy loss. METHODS AND RESULTS:An experimental model was designed to measure EOA and energy loss in 2 fixed stenoses and 7 bioprosthetic valves for different flow rates and 2 different aortic sizes (25 and 38 mm). The results showed that the relationship between EOA and energy loss is influenced by both flow rate and aortic cross-sectional area (A(A)) and that the energy loss is systematically higher (15+/-2%) in the large aorta. The coefficient (EOAxA(A))/(A(A)-EOA) accurately predicted the energy loss in all situations (r(2)=0.98). This coefficient is more closely related to the increase in left ventricular workload than EOA. To account for varying flow rates, the coefficient was indexed for body surface area in a retrospective study of 138 patients with moderate or severe aortic stenosis. The energy loss index measured by Doppler echocardiography was superior to the EOA in predicting the end points, which were defined as death or aortic valve replacement. An energy loss index

journal_name

Circulation

journal_title

Circulation

authors

Garcia D,Pibarot P,Dumesnil JG,Sakr F,Durand LG

doi

10.1161/01.cir.101.7.765

subject

Has Abstract

pub_date

2000-02-22 00:00:00

pages

765-71

issue

7

eissn

0009-7322

issn

1524-4539

journal_volume

101

pub_type

杂志文章
  • Results of reoperation for unsuccessful coronary artery bypass surgery.

    abstract::Twenty-one reoperations for relief of angina have been performed at Stanford Medical Center in patients who had had previously unsuccessful direct coronary artery surgery. Complete releif of angina was obtained in seven (33%), improvement of angina in six (29%), and no change in angina in eight (38%) after these opera...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:

    authors:

    更新日期:1975-08-01 00:00:00

  • Detection of adenoviral genome in the myocardium of adult patients with idiopathic left ventricular dysfunction.

    abstract:BACKGROUND:The use of molecular biological techniques has demonstrated the importance of enteroviral infection of the myocardium in the pathogenesis of myocarditis and dilated cardiomyopathy in adults and adenovirus and enterovirus infection in children. The aim of this study was to determine the frequency of adenovira...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.99.10.1348

    authors: Pauschinger M,Bowles NE,Fuentes-Garcia FJ,Pham V,Kühl U,Schwimmbeck PL,Schultheiss HP,Towbin JA

    更新日期:1999-03-16 00:00:00

  • Arrhythmia burden in adults with surgically repaired tetralogy of Fallot: a multi-institutional study.

    abstract:BACKGROUND:The arrhythmia burden in tetralogy of Fallot, types of arrhythmias encountered, and risk profile may change as the population ages. METHODS AND RESULTS:The Alliance for Adult Research in Congenital Cardiology (AARCC) conducted a multicenter cross-sectional study to quantify the arrhythmia burden in tetralog...

    journal_title:Circulation

    pub_type: 杂志文章,多中心研究

    doi:10.1161/CIRCULATIONAHA.109.928481

    authors: Khairy P,Aboulhosn J,Gurvitz MZ,Opotowsky AR,Mongeon FP,Kay J,Valente AM,Earing MG,Lui G,Gersony DR,Cook S,Ting JG,Nickolaus MJ,Webb G,Landzberg MJ,Broberg CS,Alliance for Adult Research in Congenital Cardiology (AARCC).

    更新日期:2010-08-31 00:00:00

  • Deletion of angiotensin II type 2 receptor exaggerated atherosclerosis in apolipoprotein E-null mice.

    abstract:BACKGROUND:The role of angiotensin II (Ang II) type 2 (AT2) receptor in atherosclerosis was explored with the use of AT2 receptor/apolipoprotein E (ApoE)-double-knockout (AT2/ApoE-DKO) mice, with a focus on oxidative stress. METHODS AND RESULTS:After treatment with a high-cholesterol diet (1.25% cholesterol) for 10 we...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.104.525550

    authors: Iwai M,Chen R,Li Z,Shiuchi T,Suzuki J,Ide A,Tsuda M,Okumura M,Min LJ,Mogi M,Horiuchi M

    更新日期:2005-09-13 00:00:00

  • A recombinant, chimeric enzyme with a novel mechanism of action leading to greater potency and selectivity than tissue-type plasminogen activator.

    abstract:BACKGROUND:Early intervention with thrombolytic agents has been shown unequivocally to reduce mortality after acute myocardial infarction. Presently used agents have disadvantages such as short half-life, immunogenicity, hypotension, and bleeding complications. Therefore, there is a need to develop improved thrombolyti...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.86.2.548

    authors: Robinson JH,Browne MJ,Carey JE,Chamberlain PD,Chapman CG,Cronk DW,Dodd I,Entwisle C,Esmail AF,Kalindjian SB

    更新日期:1992-08-01 00:00:00

  • Pathogenesis of paradoxical hypertension after coarctation resection.

    abstract::The pathogenesis of paradoxical hypertension after resection of coarctation of the aorta was investigated by comparing the course of seven children undergoing repair of coarctation with five acyanotic children undergoing elective cardiovascular surgery. During the first 24 hours after surgery, all coarctation patients...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.54.3.382

    authors: Rocchini AP,Rosenthal A,Barger AC,Castaneda AR,Nadas AS

    更新日期:1976-09-01 00:00:00

  • Short-term effect of atrial fibrillation on atrial contractile function in humans.

    abstract:BACKGROUND:Conversion of chronic atrial fibrillation (AF) is associated with atrial stunning, but the short-term effect of a brief episode of AF on left atrial appendage (LAA) emptying velocity is unknown. The purpose of this study was to determine whether a short episode of AF affects left atrial function and whether ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.99.23.3024

    authors: Daoud EG,Marcovitz P,Knight BP,Goyal R,Man KC,Strickberger SA,Armstrong WF,Morady F

    更新日期:1999-06-15 00:00:00

  • Elevated matrix metalloproteinase-9 associated with stroke or cardiovascular death in patients with carotid stenosis.

    abstract:BACKGROUND:Matrix metalloproteinase-9 could exhibit an important role in the destabilization of atherosclerotic carotid plaques. We hypothesized that in patients with carotid stenosis, elevated levels of plasma matrix metalloproteinase-9 are associated with ipsilateral stroke or cardiovascular death. METHODS AND RESUL...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.105.593483

    authors: Eldrup N,Grønholdt ML,Sillesen H,Nordestgaard BG

    更新日期:2006-10-24 00:00:00

  • Age-dependent impairment of reendothelialization after arterial injury: role of vascular endothelial growth factor.

    abstract:BACKGROUND:The mechanisms responsible for the association between advanced age and atherosclerotic diseases are not clear. Because atherosclerosis develops in response to local endothelial injuries, we investigated the effect of aging on vascular healing and reendothelialization. METHODS AND RESULTS:Endothelium denuda...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.0000050652.47145.4c

    authors: Gennaro G,Ménard C,Michaud SE,Rivard A

    更新日期:2003-01-21 00:00:00

  • Different contributions of endothelin-A and endothelin-B receptors in postischemic cardiac dysfunction and norepinephrine overflow in rat hearts.

    abstract:BACKGROUND:Endothelin (ET)-1 and norepinephrine (NE) are involved in myocardial ischemia/reperfusion injury. We investigated the role of ET-1 in ischemia/reperfusion-induced NE overflow and cardiac dysfunction using a selective ET(A) receptor antagonist (ABT-627), a selective ET(B) receptor antagonist (A-192621), and t...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.CIR.0000153351.86708.F7

    authors: Yamamoto S,Matsumoto N,Kanazawa M,Fujita M,Takaoka M,Gariepy CE,Yanagisawa M,Matsumura Y

    更新日期:2005-01-25 00:00:00

  • Mitral leaflet remodeling in dilated cardiomyopathy.

    abstract:BACKGROUND:Normal mammalian mitral leaflets have regional heterogeneity of biochemical composition, collagen fiber orientation, and geometric deformation. How leaflet shape and regional geometry are affected in dilated cardiomyopathy is unknown. METHODS AND RESULTS:Nine sheep had 8 radio-opaque markers affixed to the ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.105.000554

    authors: Timek TA,Lai DT,Dagum P,Liang D,Daughters GT,Ingels NB Jr,Miller DC

    更新日期:2006-07-04 00:00:00

  • Effect of surgical reduction of left ventricular outflow obstruction on hemodynamics, coronary flow, and myocardial metabolism in hypertrophic cardiomyopathy.

    abstract::To assess the impact of operative reduction of left ventricular outflow obstruction in hypertrophic cardiomyopathy, measurements of great cardiac vein flow, oxygen and lactate content, left ventricular pressures, and cardiac index were measured at rest and during pacing stress in 20 consecutive patients (13, myotomy-m...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.79.4.766

    authors: Cannon RO 3rd,McIntosh CL,Schenke WH,Maron BJ,Bonow RO,Epstein SE

    更新日期:1989-04-01 00:00:00

  • Clinical pharmacology and antiarrhythmic efficacy of encainide in patients with chronic ventricular arrhythmias.

    abstract::We determined the pharmacokinetics, efficacy and therapeutic plasma concentration of encainide, a new antiarrhythmic drug that affects His-Purkinje conduction but not ventricular refractoriness. Nine patients with frequent and complex premature ventricular complexes were studied in a 3-day double-blind protocol. Each ...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章

    doi:10.1161/01.cir.64.2.290

    authors: Winkle RA,Peters F,Kates RE,Tucker C,Harrison DC

    更新日期:1981-08-01 00:00:00

  • Diastolic vibration of the interventricular septum in aortic insufficiency.

    abstract::The echocardiograms of 46 patients with aortic insufficiency which manifested typical high frequency vibrations of the anterior mitral valve leaflet were reviewed. All patients had overt clinical evidence of aortic insufficiency which was confirmed by angiography in 17 cases. In 17 cases (eight of whom underwent cat...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.51.4.589

    authors: Cope GD,Kisslo JA,Johnson ML,Myers S

    更新日期:1975-04-01 00:00:00

  • Echocardiography in Chagas heart disease.

    abstract:BACKGROUND:Chagas heart disease is a frequent cause of morbidity and mortality in Latin America. Echocardiography provides useful diagnostic and prognostic information and is an important tool in the management of patients with Chagas disease. METHODS AND RESULTS:A search for relevant publications was obtained from ME...

    journal_title:Circulation

    pub_type: 杂志文章,评审

    doi:10.1161/CIRCULATIONAHA.106.627323

    authors: Acquatella H

    更新日期:2007-03-06 00:00:00

  • Peripartum myocarditis and cardiomyopathy.

    abstract::The clinical and pathologic features of 18 consecutive patients with peripartum cardiomyopathy at The Johns Hopkins Hospital were examined in an attempt to define the incidence of myocarditis and to determine its response to immunosuppressive agents. In addition to routine studies, patients were evaluated with echocar...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.81.3.922

    authors: Midei MG,DeMent SH,Feldman AM,Hutchins GM,Baughman KL

    更新日期:1990-03-01 00:00:00

  • Sympathoinhibitory effects of atrial natriuretic factor in normal humans.

    abstract::In rats, atrial natriuretic factor (ANF) reduces sympathetic nerve activity (SNA) reflexively by sensitizing cardiac mechanoreceptors with inhibitory vagal afferents. We performed three series of experiments in 26 normal young men to document whether ANF inhibits SNA in humans and if so, to determine potential mechani...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.81.6.1860

    authors: Floras JS

    更新日期:1990-06-01 00:00:00

  • American College of Cardiology and American Heart Association methodology for the selection and creation of performance measures for quantifying the quality of cardiovascular care.

    abstract::The ability to quantify the quality of cardiovascular care critically depends on the translation of recommendations for high-quality care into the measurement of that care. As payers and regulatory agencies increasingly seek to quantify healthcare quality, the implications of the measurement process on practicing phys...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.CIR.0000157096.95223.D7

    authors: Spertus JA,Eagle KA,Krumholz HM,Mitchell KR,Normand SL,American College of Cardiology.,American Heart Association Task Force on Performance Measures.

    更新日期:2005-04-05 00:00:00

  • Multimodal fetal transesophageal echocardiography for fetal cardiac intervention in sheep.

    abstract:BACKGROUND:The overall performance of available mechanical intravascular ultrasound catheters for fetal transesophageal echocardiography during fetoscopic fetal cardiac interventions in sheep has been limited by radioelectronic interference, low system frame rates, and low acoustic outputs. Therefore, a more reliable d...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/hc4001.097937

    authors: Kohl T,Westphal M,Strümper D,Achenbach S,Halimeh S,Petry P,Aryee S,Buller T,Aleksiene R,Asfour B,Witteler R,Vogt J,Van Aken H,Scheld HH

    更新日期:2001-10-09 00:00:00

  • Early changes in ventricular geometry and ventricular septal defect size following Rastelli operation or intraventricular baffle repair for conotruncal anomaly. A cause for development of subaortic stenosis.

    abstract:BACKGROUND:Obstruction to left ventricular outflow can be seen after surgical repair of congenital heart disease in which a ventricular septal defect (VSD) is closed by means of a baffle to the systemic great artery arising from the right ventricle (Rastelli operation, intraventricular repair, for conotruncal anomaly)....

    journal_title:Circulation

    pub_type: 临床试验,杂志文章

    doi:

    authors: Rychik J,Jacobs ML,Norwood WI

    更新日期:1994-11-01 00:00:00

  • Preoperative risk evaluation and stratification of long-term survival after valve replacement for aortic stenosis. Reasons for earlier operative intervention.

    abstract::Predictability of prognosis was analyzed in 630 patients who were alive 30 days after valve replacement (1965-1986) for aortic stenosis. Follow-up totaled 4,072 patient-years. During the operative periods of 1965-1971 (n = 62), 1972-1976 (n = 164), 1977-1981 (n = 158), and 1982-1986 (n = 246), decreases in cardiothora...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.82.1.124

    authors: Lund O

    更新日期:1990-07-01 00:00:00

  • Coronary atherosclerosis is associated with left ventricular dysfunction and dilatation in aortic stenosis.

    abstract::Patients with aortic stenosis develop widely variable patterns of left ventricular hypertrophy and dysfunction. We postulated that coronary atherosclerosis (CAD) may be associated with impaired left ventricular function and chamber dilatation in patients with aortic stenosis. Left ventricular mass and volumes were qua...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.82.6.2068

    authors: Vekshtein VI,Alexander RW,Yeung AC,Plappert T,Sutton MG,Ganz P,Selwyn AP,Bittl JA

    更新日期:1990-12-01 00:00:00

  • 17beta-estradiol restores endothelial nitric oxide release to shear stress in arterioles of male hypertensive rats.

    abstract:BACKGROUND:Endothelial nitric oxide (NO)-mediated responses are impaired in arterioles of male spontaneously hypertensive rats (SHR), but they are still present in female SHR. We hypothesized that in vitro incubation of arterioles of male SHR with estrogen will restore NO-mediated responses by upregulation of endotheli...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.101.1.94

    authors: Huang A,Sun D,Koller A,Kaley G

    更新日期:2000-01-04 00:00:00

  • Effect of NO donors on LV diastolic function in patients with severe pressure-overload hypertrophy.

    abstract:BACKGROUND:Previous experimental studies have shown that nitric oxide (NO) modulates cardiac function by an abbreviation of systolic contraction and an enhancement of diastolic relaxation. However, the response to NO donors of patients with severe pressure-overload hypertrophy and diastolic dysfunction is unknown. MET...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章

    doi:10.1161/01.cir.99.18.2396

    authors: Matter CM,Mandinov L,Kaufmann PA,Vassalli G,Jiang Z,Hess OM

    更新日期:1999-05-11 00:00:00

  • Effect of activation of the H1 receptor on coronary hemodynamics in man.

    abstract::We evaluated the effects of selective activation of H1 receptors on coronary hemodynamics in 16 patients divided into two groups: group A, 11 patients with atypical angina or valvular heart disease and normal coronary arteries, and group B, five patients with spontaneous angina, four of whom had significant (greater t...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.73.6.1175

    authors: Vigorito C,Poto S,Picotti GB,Triggiani M,Marone G

    更新日期:1986-06-01 00:00:00

  • Estimation of central aortic pressure waveform by mathematical transformation of radial tonometry pressure. Validation of generalized transfer function.

    abstract:BACKGROUND:Central aortic pressures and waveform convey important information about cardiovascular status, but direct measurements are invasive. Peripheral pressures can be measured noninvasively, and although they often differ substantially from central pressures, they may be mathematically transformed to approximate ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.95.7.1827

    authors: Chen CH,Nevo E,Fetics B,Pak PH,Yin FC,Maughan WL,Kass DA

    更新日期:1997-04-01 00:00:00

  • Low-Attenuation Noncalcified Plaque on Coronary Computed Tomography Angiography Predicts Myocardial Infarction: Results From the Multicenter SCOT-HEART Trial (Scottish Computed Tomography of the HEART).

    abstract:BACKGROUND:The future risk of myocardial infarction is commonly assessed using cardiovascular risk scores, coronary artery calcium score, or coronary artery stenosis severity. We assessed whether noncalcified low-attenuation plaque burden on coronary CT angiography (CCTA) might be a better predictor of the future risk ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.119.044720

    authors: Williams MC,Kwiecinski J,Doris M,McElhinney P,D'Souza MS,Cadet S,Adamson PD,Moss AJ,Alam S,Hunter A,Shah ASV,Mills NL,Pawade T,Wang C,Weir McCall J,Bonnici-Mallia M,Murrills C,Roditi G,van Beek EJR,Shaw LJ,Nicol E

    更新日期:2020-05-05 00:00:00

  • Nitric oxide modulates myocardial oxygen consumption in the failing heart.

    abstract:BACKGROUND:Endogenous nitric oxide (NO) has been reported to inhibit oxygen consumption in the normal heart, so that nonselective inhibition of NO synthase (NOS) caused an increase of myocardial oxygen consumption (MVO2). Although endothelial NOS responses are depressed in congestive heart failure (CHF), inducible NOS ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.0000021120.90970.b9

    authors: Chen Y,Traverse JH,Du R,Hou M,Bache RJ

    更新日期:2002-07-09 00:00:00

  • Does retrograde warm blood cardioplegia provide equal protection to both ventricles? A magnetic resonance spectroscopy study in pigs.

    abstract:BACKGROUND:The degree of protection provided to the right ventricle during retrograde continuous normothermic blood cardioplegia (RCNBC) remains controversial. The purpose of this study was to determine whether RCNBC is able to provide "adequate" nutritive flow to both ventricles to prevent ischemic metabolism in norma...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:

    authors: Ye J,Sun J,Shen J,Gregorash L,Summers R,Salerno TA,Deslauriers R

    更新日期:1997-11-04 00:00:00

  • Results of Prevention of REStenosis with Tranilast and its Outcomes (PRESTO) trial.

    abstract:BACKGROUND:Restenosis after percutaneous coronary intervention (PCI) is a major problem affecting 15% to 30% of patients after stent placement. No oral agent has shown a beneficial effect on restenosis or on associated major adverse cardiovascular events. In limited trials, the oral agent tranilast has been shown to de...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1161/01.cir.0000028335.31300.da

    authors: Holmes DR Jr,Savage M,LaBlanche JM,Grip L,Serruys PW,Fitzgerald P,Fischman D,Goldberg S,Brinker JA,Zeiher AM,Shapiro LM,Willerson J,Davis BR,Ferguson JJ,Popma J,King SB 3rd,Lincoff AM,Tcheng JE,Chan R,Granett JR,P

    更新日期:2002-09-03 00:00:00