Abstract:
:The pathogenesis of paradoxical hypertension after resection of coarctation of the aorta was investigated by comparing the course of seven children undergoing repair of coarctation with five acyanotic children undergoing elective cardiovascular surgery. During the first 24 hours after surgery, all coarctation patients demonstrated a rise in systolic blood pressure (35 +/- 15.5 mm Hg; P less than 0.001), a significant depression in cold pressor test response, and only a slight elevation in plasma renin activity. In the next 24-72 hours, coarctation patients developed a rise in diastolic blood pressure (26.8 +/- 10.6 mm Hg; P less than 0.001), plasma renin activity (22.9 +/- 10.2/ml/hr; P less than 0.001) and fluid retention. By contrast, control patients had no significant postoperative changes. Abdominal pain occurred in five coarctation patients during the period of maximal plasma renin activity. The data suggest that the sympathetic nervous system may be responsible for the initial phase of hypertension after coarctation resection and that the renin angiotension system plays a major role in the second phase of hypertension and in the pathogenesis of mesenteric arteritis.
journal_name
Circulationjournal_title
Circulationauthors
Rocchini AP,Rosenthal A,Barger AC,Castaneda AR,Nadas ASdoi
10.1161/01.cir.54.3.382subject
Has Abstractpub_date
1976-09-01 00:00:00pages
382-7issue
3eissn
0009-7322issn
1524-4539journal_volume
54pub_type
杂志文章相关文献
CIRCULATION文献大全abstract:BACKGROUND:Sirt7, 1 of the 7 members of the mammalian sirtuin family, promotes oncogenic transformation. Tumor growth and metastasis require fibrotic and angiogenic responses. Here, we investigated the role of Sirt7 in cardiovascular tissue repair process. METHODS AND RESULTS:In wild-type mice, Sirt7 expression increa...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.114.014821
更新日期:2015-09-22 00:00:00
abstract::This investigation was designed to assess the potential use of laser coronary angioplasty as an intraoperative adjunct in the surgical treatment of ischemic heart disease. Among 17 postmortem hearts, simulated laser coronary angioplasty was performed at 53 sites with a No. 4F guiding catheter and 240 micron (200 micro...
journal_title:Circulation
pub_type: 杂志文章
doi:
更新日期:1985-09-01 00:00:00
abstract:BACKGROUND:High-mobility group box-1 (HMGB1) is a nuclear factor released by necrotic cells and by activated immune cells. HMGB1 signals via members of the toll-like receptor family and the receptor for advanced glycation end products (RAGE). Although HMGB1 has been implicated in ischemia/reperfusion (I/R) injury of th...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.108.769331
更新日期:2008-06-24 00:00:00
abstract:BACKGROUND:The arrhythmia burden in tetralogy of Fallot, types of arrhythmias encountered, and risk profile may change as the population ages. METHODS AND RESULTS:The Alliance for Adult Research in Congenital Cardiology (AARCC) conducted a multicenter cross-sectional study to quantify the arrhythmia burden in tetralog...
journal_title:Circulation
pub_type: 杂志文章,多中心研究
doi:10.1161/CIRCULATIONAHA.109.928481
更新日期:2010-08-31 00:00:00
abstract:BACKGROUND:Thrombi are known to induce activation of the coagulation system, which may be a mechanism for progression of thrombosis and its recurrence after thrombolysis. This study was designed to characterize the relative role of thrombin and activated factor X (factor Xa) as mediators of procoagulant activity of who...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.92.4.962
更新日期:1995-08-15 00:00:00
abstract:BACKGROUND:Although dyslipoproteinemia is associated with arterial atherothrombosis, little is known about plasma lipoproteins in venous thrombosis patients. METHODS AND RESULTS:We determined plasma lipoprotein subclass concentrations using nuclear magnetic resonance spectroscopy and antigenic levels of apolipoprotein...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.104.521344
更新日期:2005-08-09 00:00:00
abstract:BACKGROUND:Atherosclerosis is complicated by cardiovascular events such as myocardial infarction, stroke, or peripheral arterial occlusive disease. Inflammation and pathological neovascularization are thought to precipitate plaque rupture or erosion, both causes of arterial thrombosis and cardiovascular events. We test...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.CIR.0000146787.16297.E8
更新日期:2004-11-02 00:00:00
abstract:BACKGROUND:Several centers favor replacing a diseased native heart valve with a tissue rather than a mechanical prosthesis, even in younger adult patients. However, long-term data supporting this approach are lacking. We examined the survival implications of selecting a tissue versus a mechanical prosthesis at initial ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.106.681429
更新日期:2007-09-11 00:00:00
abstract:BACKGROUND:Activated fibroblasts (myofibroblasts) play a critical role in cardiac fibrosis; however, their origin in the diseased heart remains unclear, warranting further investigation. Recent studies suggest the contribution of bone marrow fibroblast progenitor cells (BM-FPCs) in pressure overload-induced cardiac fib...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.117.027889
更新日期:2017-09-05 00:00:00
abstract::Cardiac arrest systems of care are successfully coordinating community, emergency medical services, and hospital efforts to improve the process of care for patients who have had a cardiac arrest. As a result, the number of people surviving sudden cardiac arrest is increasing. However, physical, cognitive, and emotiona...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIR.0000000000000747
更新日期:2020-03-24 00:00:00
abstract:BACKGROUND:Enteroviridae such as coxsackievirus B3 (CVB3) are important infectious agents involved in viral heart disease, hepatitis, and pancreatitis, but no specific antiviral therapy is available. METHODS AND RESULTS:The aim of the present study was to evaluate the impact of RNA interference on viral replication, c...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.CIR.0000160360.02040.AB
更新日期:2005-04-05 00:00:00
abstract:BACKGROUND:Intermittent claudication (IC) is associated with an increased risk of cardiovascular disease morbidity and mortality. The relation of alcohol consumption to the risk of IC remains controversial. The purpose of this study was to assess the relation of alcohol consumption and type of beverage to the developme...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.102.25.3092
更新日期:2000-12-19 00:00:00
abstract:BACKGROUND:Patients with acute ischemic right ventricular dysfunction often develop hemodynamic compromise, yet most manifest spontaneous early clinical improvement and later recovery of global right ventricular performance. This study was designed to delineate the determinants of right ventricular performance followin...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.88.2.696
更新日期:1993-08-01 00:00:00
abstract::Thirteen patients with proven Q fever endocarditis and three additional patients with probable endocarditis are reviewed. The most helpful diagnostic test is the demonstration of a high complement fixing antibody titre to Phase 1 antigen of Coxiella burneti. The macroscopic pathology of the aortic valve is described a...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.53.4.680
更新日期:1976-04-01 00:00:00
abstract::Plasma and lipoprotein cholesterol and triglyceride concentrations were measured in Pima Indians, a genetically homogeneous population with a high prevalence of obesity and diabetes and a low frequency of coronary heart disease. The data for nondiabetic Pima Indians were compared with those of U.S. Caucasians measured...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.68.4.714
更新日期:1983-10-01 00:00:00
abstract::We report noninvasive and invasive studies designed to clarify the mechanism of the third heart sound (S3) in humans. The noninvasive observations were made using a miniature accelerometer attached to the skin surface at the cardiac apex. In subjects with no S3, the tracings were either flat or showed very low undulat...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.67.2.399
更新日期:1983-02-01 00:00:00
abstract:BACKGROUND:Specific transcription factors (TFs) modulate cardiac gene expression in murine models of heart failure, but their relevance in human subjects remains untested. We developed and applied a computational approach called transcriptional genomics to test the hypothesis that a discrete set of cardiac TFs is assoc...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.106.632430
更新日期:2006-09-19 00:00:00
abstract::Intravascular ultrasound imaging is a promising new method for assessing vascular morphology. We evaluated the capability of intravascular ultrasound to quantify pulmonary artery (PA) morphology in vitro and explored the feasibility of in vivo PA imaging in animals and humans. In the in vitro study of 15 PA segments, ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.81.6.2007
更新日期:1990-06-01 00:00:00
abstract::Diffuse coronary artery disease is frequently untreatable by coronary artery bypass or angioplasty. Many such "no-option" patients have been subjects for trials of angiogenesis using growth factor manipulation or laser injury. We think these novel revascularization strategies are limited by insufficient inflow to puta...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.103.21.2539
更新日期:2001-05-29 00:00:00
abstract:BACKGROUND:Collaterals limit infarct size, preserve viability, and reduce mortality in patients with acute myocardial infarction. In patients with stable coronary disease, collaterals are associated with less angina and ischemia during angioplasty and fewer ischemic events during follow-up. The role of collaterals has ...
journal_title:Circulation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.CIR.0000143105.42988.FD
更新日期:2004-09-28 00:00:00
abstract:BACKGROUND:Cholesterol-lowering therapy can improve cardiovascular morbidity and mortality in patients with atherosclerosis. Although the mechanisms responsible are unclear, these benefits precede macroscopic changes in the vasculature. Emerging evidence that improvement in endothelial function may occur requires subst...
journal_title:Circulation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.cir.95.5.1126
更新日期:1997-03-04 00:00:00
abstract:BACKGROUND:Ischemic preconditioning attenuates the effects of subsequent sustained ischemia by a mechanism involving adenosine and G proteins in several species. Adenosine is not involved in ischemic preconditioning of rat hearts, the mechanisms of which are poorly understood. METHODS AND RESULTS:Reduction of isometri...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.92.8.2259
更新日期:1995-10-15 00:00:00
abstract:BACKGROUND:Second trimester routine ultrasound evaluation of the fetal heart by means of the four-chamber view has been proposed for prenatal detection of cardiac anomalies. The aim of this study was to evaluate the efficacy of this procedure. METHODS AND RESULTS:A prospective follow-up study on 6922 scanned fetuses w...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.94.1.67
更新日期:1996-07-01 00:00:00
abstract:BACKGROUND:Chronic heart failure (CHF) is associated with endothelial dysfunction including impaired endothelium-mediated, flow-dependent dilation (FDD). There is evidence for increased radical formation in CHF, raising the possibility that nitric oxide is inactivated by radicals, thereby impairing endothelial function...
journal_title:Circulation
pub_type: 临床试验,杂志文章
doi:10.1161/01.cir.97.4.363
更新日期:1998-02-03 00:00:00
abstract:BACKGROUND:Metformin is first-line therapy for type 2 diabetes mellitus, although its effects on the cardiovascular system are unproved. METHODS:In this post hoc analysis, patients in SAVOR-TIMI 53 (Saxagliptin and Cardiovascular Outcomes in Patients With Type 2 Diabetes Mellitus) with baseline biomarker samples (n=12...
journal_title:Circulation
pub_type: 临床试验,杂志文章
doi:10.1161/CIRCULATIONAHA.119.040144
更新日期:2019-09-17 00:00:00
abstract:BACKGROUND:High-pressure distension during harvesting damages the saphenous vein (SV) and may contribute to subsequent coronary artery bypass graft (CABG) occlusion. Application of vasodilator agents to the SV during harvesting may reduce the need for high-pressure distension and improve graft quality. We tested the ef...
journal_title:Circulation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.cir.92.9.31
更新日期:1995-11-01 00:00:00
abstract::The effect of aortocoronary saphenous bypass graft surgery on survival of functional class I and II patients was studied in 619 patients entered in the Seattle Heart Watch when they had coronary arteriography. Cox's regression analysis was used to correct for differences in baseline characteristics that occur as a res...
journal_title:Circulation
pub_type: 杂志文章
doi:
更新日期:1980-08-01 00:00:00
abstract:BACKGROUND:Ambulatory outpatients (n = 150) with a history of paroxysmal supraventricular arrhythmia were studied to establish the characteristics of the first recurrence of symptomatic tachycardia (time to first recurrence, heart rate during tachycardia, and observed rhythm that was regular versus irregular) when no a...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.87.4.1114
更新日期:1993-04-01 00:00:00
abstract:BACKGROUND:In patients with atrial fibrillation, intracardiac atrial defibrillation causes discomfort. An easily applicable, short-acting analgesic and anxiolytic drug would increase acceptability of this new treatment mode. METHODS AND RESULTS:In a double-blind, placebo-controlled manner, the effect of intranasal but...
journal_title:Circulation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.cir.99.14.1837
更新日期:1999-04-13 00:00:00
abstract:BACKGROUND:Repolarization dispersion (Rd) is frequently mentioned as a predictor of cardiac abnormalities. We present a new measure of Rd based on the root-mean-square (RMS) curve of an ECG lead set and compare its performance with that of the commonly used QT dispersion (QTd) measure with the use of recovery times mea...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.102.6.685
更新日期:2000-08-08 00:00:00