Nitric oxide modulates myocardial oxygen consumption in the failing heart.

abstract：:Vigorous hyperventilation was induced for five minutes immediately after a five-minute infusion of 100 ml of Tris-buffer (pH 10) in nine patients with Prinzmetal's variant angina. In eight of the patients, chest pain with ischemic changes in the electrocardiogram occurred during this procedure or within five minutes a...

journal_title：Circulation

authors： Yasue H,Nagao M,Omote S,Takizawa A,Miwa K,Tanaka S

更新日期：1978-07-01 00:00:00

abstract：BACKGROUND:Although molecular biological studies suggest a pathogenic link between enterovirus infection and dilated cardiomyopathy (DCM), the frequency of detection of enteroviral RNA is not consistently high in myocardial tissue from patients with DCM. A recent study has suggested that hepatitis C virus (HCV) may als...

journal_title：Circulation

authors： Okabe M,Fukuda K,Arakawa K,Kikuchi M

更新日期：1997-07-01 00:00:00

abstract：BACKGROUND:Reperfusion injury is insufficiently addressed in current clinical management of acute limb ischemia. Controlled reperfusion carries an enormous clinical potential and was tested in a new reality-driven rodent model. METHODS AND RESULTS:Acute hind-limb ischemia was induced in Wistar rats and maintained for ...

journal_title：Circulation

authors： Dick F,Li J,Giraud MN,Kalka C,Schmidli J,Tevaearai H

更新日期：2008-11-04 00:00:00

abstract：:Analysis of the Framingham Heart Study experience between 1958 and 1970 showed a progressive increase in the rate of treatment and control of hypertension. With cross-sectional criteria to define diastolic hypertension, the treatment rate rose from 35% in 1958 through 1960 to 69% in 1968 through 1970 (p less than .001...

journal_title：Circulation

authors： Shea S,Cook EF,Kannel WB,Goldman L

更新日期：1985-01-01 00:00:00

abstract：:The dynamics between mitral anulus motion, and, thus, motion of the base of the heart, and filling of the left atrium and ventricle were studied by Doppler echocardiography in 12 normal subjects and 28 patients with dilated cardiomyopathy. The normal motion of the mitral anulus is associated with two phases of inflow ...

journal_title：Circulation

authors： Keren G,Sonnenblick EH,LeJemtel TH

更新日期：1988-09-01 00:00:00

abstract：BACKGROUND:Tissue-type plasminogen activator (tPA) and urokinase-type plasminogen activator (uPA) are thought to play critical roles in vascular remodeling after injury, with tPA mediating intravascular clot lysis and uPA modulating cell migration within the vessel wall. In human vascular disease, however, thrombus org...

journal_title：Circulation

authors： Schäfer K,Konstantinides S,Riedel C,Thinnes T,Müller K,Dellas C,Hasenfuss G,Loskutoff DJ

更新日期：2002-10-01 00:00:00

abstract：:Fibrinopeptide A, platelet factor 4, beta-thromboglobulin, thromboxane B2, and 6-keto-prostaglandin F1 alpha were estimated by radioimmunoassay on venous plasma samples taken within 48 hr of admission from 16 consecutive patients with unstable angina and 15 patients with stable angina matched for clinical variables. T...

journal_title：Circulation

authors： Théroux P,Latour JG,Léger-Gauthier C,De Lara J

更新日期：1987-01-01 00:00:00

abstract：:Experimental studies demonstrate that short-term regional perfusion-contraction matching, in which the energy demands of regional myocardial contraction are reduced to match the diminished myocardial substrate supply, occurs during states of low coronary blood flow under resting conditions and during exercise-induced ...

journal_title：Circulation

authors： Ross J Jr

更新日期：1991-03-01 00:00:00

abstract：BACKGROUND:Platelet activation plays a pivotal role in the pathogenesis of acute coronary disease. Monocytes are involved in the progression of atherosclerosis and are potent activators of blood coagulation through their ability to synthesize tissue factor (TF). The aim of this study was to compare markers of monocyte ...

journal_title：Circulation

authors： Jude B,Agraou B,McFadden EP,Susen S,Bauters C,Lepelley P,Vanhaesbroucke C,Devos P,Cosson A,Asseman P

更新日期：1994-10-01 00:00:00

abstract：BACKGROUND:The physiological assessment of angiographically intermediate-severity stenoses remains problematic. Functional measurements of poststenotic intracoronary Doppler coronary flow reserve can be performed in humans but have not been correlated with hyperemic myocardial perfusion imaging or angiographic data in ...

journal_title：Circulation

authors： Miller DD,Donohue TJ,Younis LT,Bach RG,Aguirre FV,Wittry MD,Goodgold HM,Chaitman BR,Kern MJ

更新日期：1994-05-01 00:00:00

abstract：:Asymptomatic ischemia after myocardial infarction is a common clinical problem. As much as 50% of the postinfarction patient population who have ischemia on exercise testing may have no symptoms at all. In these patients, ischemia detected by either exercise testing or ambulatory electrocardiographic monitoring, with ...

journal_title：Circulation

authors： Yeung AC,Barry J,Selwyn AP

更新日期：1990-09-01 00:00:00

abstract：:Statistical multivariate and conventional deterministic methods of computerized interpretation of the electrocardiogram (ECG) were compared in the analysis of 1711 pediatric orthogonal ECGs validated by nonelectrocardiographic criteria on the basis of clinical and anatomic diagnoses. Among 642 children catheterized fo...

journal_title：Circulation

authors： Brohet CR,Robert A,Derwael C,Fesler R,Stijns M,Vliers A,Braasseur LA

更新日期：1984-08-01 00:00:00

abstract：:Premature opening of the pulmonary valve (opening independent of atrial or ventricular systole) was originally described in a case of sinus of Valsalva rupture into the right atrium. Since that time we have observed five additional cases in which the pulmonary valve opened prematurely. Entities encountered included: 1...

journal_title：Circulation

authors： Wann LS,Weyman AE,Dillon JC,Feigenbaum H

更新日期：1977-01-01 00:00:00

abstract：BACKGROUND:Recent studies have identified critical roles for microRNAs (miRNAs) in a variety of cellular processes, including regulation of cardiomyocyte death. However, the signature of miRNA expression and possible roles of miRNA in the ischemic heart have been less well studied. METHODS AND RESULTS:We performed miR...

journal_title：Circulation

authors： Ren XP,Wu J,Wang X,Sartor MA,Jones K,Qian J,Nicolaou P,Pritchard TJ,Fan GC

更新日期：2009-05-05 00:00:00

abstract：BACKGROUND:Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is an inherited cardiomyopathy characterized by right ventricular dysfunction and ventricular arrhythmias. A recent study reported mutations in PKP2, encoding the desmosomal protein plakophilin-2, associated with ARVD/C. The purpose of our st...

journal_title：Circulation

authors： Dalal D,Molin LH,Piccini J,Tichnell C,James C,Bomma C,Prakasa K,Towbin JA,Marcus FI,Spevak PJ,Bluemke DA,Abraham T,Russell SD,Calkins H,Judge DP

更新日期：2006-04-04 00:00:00

abstract：BACKGROUND:Conversion of chronic atrial fibrillation (AF) is associated with atrial stunning, but the short-term effect of a brief episode of AF on left atrial appendage (LAA) emptying velocity is unknown. The purpose of this study was to determine whether a short episode of AF affects left atrial function and whether ...

journal_title：Circulation

authors： Daoud EG,Marcovitz P,Knight BP,Goyal R,Man KC,Strickberger SA,Armstrong WF,Morady F

更新日期：1999-06-15 00:00:00

abstract：:Twenty adult patients with predominant mitral valve disease and variable degrees of tricuspid incompetence (TI) were reinvestigated 6-28 months after mitral valve operation. Postoperatively, 10 of the 20 patients were in sinus rhythm, compared with four of 20 preoperatively. Right ventricula peak systolic pressure dec...

journal_title：Circulation

authors： Simon R,Oelert H,Borst HG,Lichtlen PR

更新日期：1980-08-01 00:00:00

abstract：:Seven of 214 patients (3%) with acute myocardial infarction (120 inferior and 94 anterior) developed atrial fibrillation within 3 hr of the onset of chest pain. All seven patients had an inferior infarction and in all seven the left circumflex artery was occluded proximal to the origin of its left atrial circumflex br...

journal_title：Circulation

authors： Hod H,Lew AS,Keltai M,Cercek B,Geft IL,Shah PK,Ganz W

更新日期：1987-01-01 00:00:00

abstract：:To determine the contribution of disopyramide's suggested opposing direct depressant and indirect acceleratory actions on sinus node function, we studied the effects of disopyramide, 1 x 10(-7) to 1 x 10(-4) M, on isolated rabbit sinus node preparations using standard microelectrode techniques. Transmembrane potential...

journal_title：Circulation

authors： Katoh T,Karagueuzian HS,Jordan J,Mandel WJ

更新日期：1982-12-01 00:00:00

abstract：BACKGROUND:Clinical depression is associated with an increased risk for mortality in patients with a recent myocardial infarction (MI). Reduced heart rate variability (HRV) has been suggested as a possible explanation for this association. The purpose of this study was to determine if depression is associated with redu...

journal_title：Circulation

authors： Carney RM,Blumenthal JA,Stein PK,Watkins L,Catellier D,Berkman LF,Czajkowski SM,O'Connor C,Stone PH,Freedland KE

更新日期：2001-10-23 00:00:00

abstract：BACKGROUND:Vasoactive drugs could alter the fluid restitution from the tissue and redistribute blood volume between the macrocirculation and microcirculation. METHODS AND RESULTS:With bolus injections of vasoactive drugs in anesthetized rabbits, we measured the changes in blood and plasma density for the determination...

journal_title：Circulation

authors： Anderson SM,Rich GF,Roos C,Lee LP,Lee JS

更新日期：1994-07-01 00:00:00

abstract：:Syncope and sudden death occurs in certain purebred Pug dogs which have been found to have intermittent sinus pauses and paroxysmal second degree heart block on electrocardiographic (ECG) study. We have established a colony of such dogs to study this problem and here report the results of histological examination of t...

journal_title：Circulation

authors： James TN,Robertson BT,Waldo AL,Branch CE

更新日期：1975-12-01 00:00:00

abstract：BACKGROUND:Muscle sympathetic nerve activity (MSNA) is increased in patients with obstructive sleep apnea (OSA). We tested the hypothesis that tonic activation of excitatory chemoreceptor afferents contributes to the elevated sympathetic activity in OSA. METHODS AND RESULTS:Using a double-blind, randomized, vehicle-co...

journal_title：Circulation

authors： Narkiewicz K,van de Borne PJ,Montano N,Dyken ME,Phillips BG,Somers VK

更新日期：1998-03-17 00:00:00

abstract：BACKGROUND:Genetic testing for long-QT syndrome (LQTS) has diagnostic, prognostic, and therapeutic implications. Hundreds of causative mutations in 12 known LQTS-susceptibility genes have been identified. Genetic testing that includes the 3 most commonly mutated genes is available clinically. Distinguishing pathogenic ...

journal_title：Circulation

authors： Kapa S,Tester DJ,Salisbury BA,Harris-Kerr C,Pungliya MS,Alders M,Wilde AA,Ackerman MJ

更新日期：2009-11-03 00:00:00

abstract：BACKGROUND:It is not clear why some plaque ruptures lead to acute coronary syndromes (ACS) but others do not. METHODS AND RESULTS:We analyzed 80 plaque ruptures in 74 patients and compared culprit lesions of ACS patients with nonculprit lesions of ACS patients and lesions of non-ACS patients; both culprit and nonculpr...

journal_title：Circulation

authors： Fujii K,Kobayashi Y,Mintz GS,Takebayashi H,Dangas G,Moussa I,Mehran R,Lansky AJ,Kreps E,Collins M,Colombo A,Stone GW,Leon MB,Moses JW

更新日期：2003-11-18 00:00:00

abstract：BACKGROUND:The absence of functional dystrophin in Duchenne muscular dystrophy (DMD) patients and in mdx mice results in progressive muscle degeneration associated with necrosis, fibrosis, and inflammation. Because vascular supply plays a key role in tissue repair, we examined whether new blood vessel development was a...

journal_title：Circulation

authors： Straino S,Germani A,Di Carlo A,Porcelli D,De Mori R,Mangoni A,Napolitano M,Martelli F,Biglioli P,Capogrossi MC

更新日期：2004-11-23 00:00:00

abstract：:In a study of aerobically perfused rat hearts, the in situ photoactivation (530-590 nm) of rose bengal (a process that leads to the production of singlet oxygen and superoxide) has been shown to lead to the rapid development of electrocardiographic abnormalities and arrhythmias. With rose bengal concentrations of 1,00...

journal_title：Circulation

authors： Kusama Y,Bernier M,Hearse DJ

更新日期：1989-11-01 00:00:00

abstract：BACKGROUND:The relations of insulin sensitivity (IS) to hypertension incidence may vary according to baseline age, body mass index (BMI), and blood pressure (BP). METHODS AND RESULTS:We investigated the relations of IS (insulin sensitivity index, ISI(0,120)) to 4-year incidence of hypertension and BP progression in 19...

journal_title：Circulation

authors： Arnlöv J,Pencina MJ,Nam BH,Meigs JB,Fox CS,Levy D,D'Agostino RB,Vasan RS

更新日期：2005-09-20 00:00:00

abstract：BACKGROUND:Cardiovascular disease (CVD) fatality rates are higher for women than for men, yet obstructive coronary artery disease (CAD) is less prevalent in women. Coronary flow reserve (CFR), an integrated measure of large- and small-vessel CAD and myocardial ischemia, identifies patients at risk for CVD death, but is...

journal_title：Circulation

authors： Taqueti VR,Shaw LJ,Cook NR,Murthy VL,Shah NR,Foster CR,Hainer J,Blankstein R,Dorbala S,Di Carli MF

更新日期：2017-02-07 00:00:00

abstract：BACKGROUND:The effect of the increasing prevalence of obesity on blood pressure (BP) secular trends is unclear. We analyzed BP and body mass index secular trends between 1998 and 2006 in children and adolescents of the Seychelles, a rapidly developing island state in the African region. METHODS AND RESULTS:School-base...

journal_title：Circulation

authors： Chiolero A,Paradis G,Madeleine G,Hanley JA,Paccaud F,Bovet P

更新日期：2009-02-03 00:00:00