Does retrograde warm blood cardioplegia provide equal protection to both ventricles? A magnetic resonance spectroscopy study in pigs.

abstract：BACKGROUND:Both glucose-insulin-potassium (GIK) and tri-iodothyronine (T3) may improve cardiovascular performance after coronary artery surgery (CABG) but their effects have not been directly compared and the effects of combined treatment are unknown. METHODS AND RESULTS:In 2 consecutive randomized double-blind placeb...

journal_title：Circulation

authors： Ranasinghe AM,Quinn DW,Pagano D,Edwards N,Faroqui M,Graham TR,Keogh BE,Mascaro J,Riddington DW,Rooney SJ,Townend JN,Wilson IC,Bonser RS

更新日期：2006-07-04 00:00:00

abstract：BACKGROUND:The study was designed to verify the concept of plaques "at risk" and whether inflammation could play a role in plaque rupture and thrombosis. METHODS AND RESULTS:In 20 patients who had died of acute myocardial infarction, the thrombosed coronary artery was identified and the site of plaque rupture was trac...

journal_title：Circulation

authors： van der Wal AC,Becker AE,van der Loos CM,Das PK

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND:Despite improvements in management, infective endocarditis remains associated with high mortality and morbidity. We describe temporal changes in the incidence, microbiology, and outcomes of infective endocarditis and the effect of changes in national antibiotic prophylaxis guidelines on incident infective en...

journal_title：Circulation

authors： Shah ASV,McAllister DA,Gallacher P,Astengo F,Rodríguez Pérez JA,Hall J,Lee KK,Bing R,Anand A,Nathwani D,Mills NL,Newby DE,Marwick C,Cruden NL

更新日期：2020-06-23 00:00:00

abstract：BACKGROUND:Atherosclerosis is a multifactorial disorder involving inflammatory processes. These responses are associated with robust activation of signaling cascades by diverse cell surface receptors in a variety of cell types. The processes that are involved in atherosclerosis would likely require intact Ras pathways,...

journal_title：Circulation

authors： George J,Afek A,Keren P,Herz I,Goldberg I,Haklai R,Kloog Y,Keren G

更新日期：2002-05-21 00:00:00

abstract：:The Persantine-Aspirin Reinfarction Study (PARIS) was a randomized, controlled, double-blind study of dipyridamole (Persantine) and aspirin in secondary prevention of coronary heart disease. Two thousand twenty-six men and women with myocardial infarction (MI) documented by electrocardiographic findings, clinical hist...

journal_title：Circulation

authors：

更新日期：1980-09-01 00:00:00

abstract：BACKGROUND:Patients with repaired coarctation are at increased risk of hypertension and cardiovascular disease despite successful repair. We studied the function of conduit arteries in upper and lower limbs of patients late after successful coarctation repair and its relation to age at surgery. METHODS AND RESULTS:Flo...

journal_title：Circulation

authors： de Divitiis M,Pilla C,Kattenhorn M,Zadinello M,Donald A,Leeson P,Wallace S,Redington A,Deanfield JE

更新日期：2001-09-18 00:00:00

abstract：BACKGROUND:MRI of specific components in atherosclerotic plaque may provide information on plaque stability and its potential to rupture. We evaluated gadofluorine in atherosclerotic rabbits using a new MR sequence that allows plaque detection within 1 hour after injection and assessed enhancement in lipid-rich and non...

journal_title：Circulation

authors： Sirol M,Itskovich VV,Mani V,Aguinaldo JG,Fallon JT,Misselwitz B,Weinmann HJ,Fuster V,Toussaint JF,Fayad ZA

更新日期：2004-06-15 00:00:00

abstract：BACKGROUND:Alpha-linolenic acid may protect against cardiovascular disease. We examined the association between adipose tissue alpha-linolenic acid and nonfatal acute myocardial infarction (MI) in a population-based case-control study in Costa Rica. METHODS AND RESULTS:The 482 case patients with a first nonfatal acute...

journal_title：Circulation

authors： Baylin A,Kabagambe EK,Ascherio A,Spiegelman D,Campos H

更新日期：2003-04-01 00:00:00

abstract：BACKGROUND:Epinephrine has been shown to impair pulmonary excretion of CO2 during resuscitation. This phenomenon was investigated in a rodent model of cardiac arrest and conventional resuscitation. METHODS AND RESULTS:The effects of racemic epinephrine were compared with the selective alpha 1-agonist methoxamine and w...

journal_title：Circulation

authors： Tang W,Weil MH,Gazmuri RJ,Sun S,Duggal C,Bisera J

更新日期：1991-11-01 00:00:00

abstract：BACKGROUND:Inflammatory vasculopathies, ranging from the vasculitides (Takayasu arteritis, giant cell arteritis, and polyarteritis nodosa) to atherosclerosis, display remarkable target tissue tropisms for selected vascular beds. Molecular mechanisms directing wall inflammation to restricted anatomic sites within the va...

journal_title：Circulation

authors： Pryshchep O,Ma-Krupa W,Younge BR,Goronzy JJ,Weyand CM

更新日期：2008-09-16 00:00:00

abstract：:Optimal electrode position for long-term transvenous cardiac pacing is in the apex of the right ventricle. Intracardiac electrograms, surface electrocardiograms, frontal fluoroscopy, lateral roentgenograms, and pacing threshold levels were studied in two groups of patients: One group was comprised of five patients wit...

journal_title：Circulation

authors： Gulotta SJ

更新日期：1970-10-01 00:00:00

abstract：:A 28-year-old female undergoing elective total hip replacement experienced an anaphylactic reaction to succinylcholine. Hemodynamics, plasma histamine and catecholamines were measured. The tachycardia experienced during the reaction appeared to be secondary to the sympathoadrenal response rather than a direct chronotr...

journal_title：Circulation

authors： Moss J,Fahmy NR,Sunder N,Beaven MA

更新日期：1981-01-01 00:00:00

abstract：:To assess myocardial infarction quantitatively in 15 mm thick transverse sections of the canine heart in vivo we utilized a new technique, positron emission transaxial tomography (PETT) and cyclotron-produced 11C-palmitate (11C-P) injected intravenously. Results were compared to regional myocardial creatine phosphokin...

journal_title：Circulation

authors： Weiss ES,Ahmed SA,Welch MJ,Williamson JR,Ter-Pogossian MM,Sobel BE

更新日期：1977-01-01 00:00:00

abstract：BACKGROUND:The release of endothelium-derived relaxing factors has been shown experimentally to be of pivotal importance for the maintenance of coronary blood flow during increased demand. In humans with coronary atherosclerosis, endothelial vasodilator dysfunction is not confined only to epicardial conductance vessels...

journal_title：Circulation

authors： Zeiher AM,Krause T,Schächinger V,Minners J,Moser E

更新日期：1995-05-01 00:00:00

abstract：:We have shown previously that the physical properties of myocardium in dogs can be characterized with quantitative ultrasonic integrated backscatter and that interrogation of the tissue with ultrasound can delineate cardiac cycle-dependent changes in ultrasonic backscatter in normal tissue that disappear with ischemia...

journal_title：Circulation

authors： Vered Z,Barzilai B,Mohr GA,Thomas LJ 3rd,Genton R,Sobel BE,Shoup TA,Melton HE,Miller JG,Pérez JE

更新日期：1987-11-01 00:00:00

abstract：:To assess the effects on the heart itself of coronary thrombolysis induced with either tissue-type plasminogen activator (t-PA) or streptokinase (SK), we performed positron emission tomography with 11C-palmitate in 19 patients with initial transmural myocardial infarction immediately after admission and again within 4...

journal_title：Circulation

authors： Sobel BE,Geltman EM,Tiefenbrunn AJ,Jaffe AS,Spadaro JJ Jr,Ter-Pogossian MM,Collen D,Ludbrook PA

更新日期：1984-05-01 00:00:00

abstract：:Since platelet accumulation may be an important determinant of restenosis after angioplasty, the time course of 51Cr-labeled platelet accumulation after experimental angioplasty was evaluated in a deendothelialized, hypercholesterolemic rabbit preparation of atherosclerosis. Marked platelet accumulation (39.5 +/- 8.7 ...

journal_title：Circulation

authors： Wilentz JR,Sanborn TA,Haudenschild CC,Valeri CR,Ryan TJ,Faxon DP

更新日期：1987-03-01 00:00:00

abstract：BACKGROUND:With MRI, an index of myocardial perfusion reserve (MPRI) can be determined. We assessed the value of this technique for the noninvasive detection of coronary artery disease (CAD) in patients with suspected CAD. METHODS AND RESULTS:Eighty-four patients referred for a primary diagnostic coronary angiography ...

journal_title：Circulation

authors： Nagel E,Klein C,Paetsch I,Hettwer S,Schnackenburg B,Wegscheider K,Fleck E

更新日期：2003-07-29 00:00:00

abstract：BACKGROUND:Left ventricular (LV) mechanical dyssynchrony (LVMD) has emerged as a therapeutic target using cardiac resynchronization therapy (CRT) in selected patients with chronic heart failure. Current methods used to evaluate LVMD are technically difficult and do not assess LVMD of the whole LV simultaneously. We dev...

journal_title：Circulation

authors： Kapetanakis S,Kearney MT,Siva A,Gall N,Cooklin M,Monaghan MJ

更新日期：2005-08-16 00:00:00

abstract：BACKGROUND:Atrial dysrhythmia patients have exaggerated intra-atrial conduction delays and prolonged relative refractoriness in response to atrial premature depolarizations (APDs). Furthermore, atrial fibrillation (AF) is more readily inducible by APDs from the high right atrium (HRA) than the coronary sinus (CS). In t...

journal_title：Circulation

authors： Papageorgiou P,Monahan K,Boyle NG,Seifert MJ,Beswick P,Zebede J,Epstein LM,Josephson ME

更新日期：1996-08-01 00:00:00

abstract：BACKGROUND:Pulmonary hypertension is a fatal disease characterized by vasoconstriction and vascular remodeling. Loss of endothelial nitric oxide bioavailability is implicated in pulmonary hypertension pathogenesis. Recent evidence suggests that the cofactor tetrahydrobiopterin (BH4) is an important regulator of nitric ...

journal_title：Circulation

authors： Khoo JP,Zhao L,Alp NJ,Bendall JK,Nicoli T,Rockett K,Wilkins MR,Channon KM

更新日期：2005-04-26 00:00:00

abstract：:Of 22 children with congenital complete heart block (CCHB) available for study, 14 (63.6%) were born to 11 mothers with clinical or laboratory evidence of connective tissue disease, primarily lupus erythematosus (LE). Seven mothers had both clinical and laboratory evidence of disease while four had only positive labor...

journal_title：Circulation

authors： McCue CM,Mantakas ME,Tingelstad JB,Ruddy S

更新日期：1977-07-01 00:00:00

abstract：:We assessed the reversibility of functional and morphological changes of arterialized vein segments by returning them to the venous circulation. Thirteen dogs underwent right carotid and femoral veno-arterial grafting. After 12 weeks, veno-arterial grafts were removed for contractility (norepinephrine [NE] and 5-hydro...

journal_title：Circulation

authors： Fann JI,Sokoloff MH,Sarris GE,Yun KL,Kosek JC,Miller DC

更新日期：1990-11-01 00:00:00

abstract：:Between 1972 and 1984, 100 consecutive neonates (less than or equal to 30 days old) underwent repair of coarctation of the aorta. Mean (+/- SD) age at operation was 12.0 +/- 8.0 days; mean weight was 3.1 +/- 0.5 kg. Simple coarctation was present in 29 patients (group I), 32 patients had additional ventricular septal ...

journal_title：Circulation

authors： Ziemer G,Jonas RA,Perry SB,Freed MD,Castaneda AR

更新日期：1986-09-01 00:00:00

abstract：BACKGROUND:Administration of angiogenic factors stimulates neovascularization in ischemic tissues. However, there is no evidence that angiogenesis can be induced in normoperfused skeletal muscles. We tested the hypothesis that adenovirus-mediated intramuscular (IM) gene transfer of the 121-amino-acid form of vascular e...

journal_title：Circulation

authors： Gowdak LH,Poliakova L,Wang X,Kovesdi I,Fishbein KW,Zacheo A,Palumbo R,Straino S,Emanueli C,Marrocco-Trischitta M,Lakatta EG,Anversa P,Spencer RG,Talan M,Capogrossi MC

更新日期：2000-08-01 00:00:00

abstract：:Trapidil (triazolopyrimidine) possesses activity against platelet-derived growth factor-induced cellular proliferation in vitro and intimal proliferation in vivo. The objective of this study was to determine if trapidil could prevent restenosis in experimentally induced atherosclerotic rabbits. New Zealand White rabbi...

journal_title：Circulation

authors： Liu MW,Roubin GS,Robinson KA,Black AJ,Hearn JA,Siegel RJ,King SB 3rd

更新日期：1990-03-01 00:00:00

abstract：BACKGROUND:Calcineurin is a calcium-regulated phosphatase that plays a major role in cardiac hypertrophy. We previously described that alternative splicing of the calcineurin Aβ (CnAβ) gene generates the CnAβ1 isoform, with a unique C-terminal region that is different from the autoinhibitory domain present in all other...

journal_title：Circulation

authors： Felkin LE,Narita T,Germack R,Shintani Y,Takahashi K,Sarathchandra P,López-Olañeta MM,Gómez-Salinero JM,Suzuki K,Barton PJ,Rosenthal N,Lara-Pezzi E

更新日期：2011-06-21 00:00:00

abstract：:In a porcine preparation of cardiac arrest, we demonstrated that there is a marked paradox of venous acidemia and arterial alkalemia. This paradox is related to decreased clearance of CO2 from the lungs when pulmonary blood flow is critically reduced. Accordingly, increased venous PCO2 rather than metabolic acidosis d...

journal_title：Circulation

authors： Grundler W,Weil MH,Rackow EC

更新日期：1986-11-01 00:00:00

abstract：BACKGROUND:Activation of protein kinase C-linked receptors and subsequent opening of the mitochondrial ATP-sensitive K(+) (mitoK(ATP)) channel are crucial in preconditioning (PC). This study examined whether postinfarct ventricular remodeling interferes with the PC mechanism. METHODS AND RESULTS:Two weeks before isola...

journal_title：Circulation

authors： Miki T,Miura T,Tsuchida A,Nakano A,Hasegawa T,Fukuma T,Shimamoto K

更新日期：2000-07-25 00:00:00

abstract：BACKGROUND:Transluminal stent-graft placement (TSGP) for aortic dissection is a relatively new procedure. We performed TSGPs to seal the primary entry site to treat and prevent complications of aortic dissection. The early to mid-term outcomes were analyzed. METHODS AND RESULTS:Thirty-seven patients with a primary int...

journal_title：Circulation

authors： Shimono T,Kato N,Yasuda F,Suzuki T,Yuasa U,Onoda K,Hirano T,Takeda K,Yada I

更新日期：2002-09-24 00:00:00