Improvement of regional myocardial metabolism after coronary thrombolysis induced with tissue-type plasminogen activator or streptokinase.

abstract：BACKGROUND:Female sex is an independent risk factor for torsade de pointes in long-QT syndrome. In women, QT interval and torsade de pointes risk fluctuate dynamically during the menstrual cycle and pregnancy. Accumulating clinical evidence suggests a role for progesterone; however, the effect of progesterone on cardia...

journal_title：Circulation

authors： Nakamura H,Kurokawa J,Bai CX,Asada K,Xu J,Oren RV,Zhu ZI,Clancy CE,Isobe M,Furukawa T

更新日期：2007-12-18 00:00:00

abstract：BACKGROUND:The myocardial protective role of heat shock protein (HSP) has been demonstrated, and there has been increasing interest in stress response in the heart. We examined the DNA-binding activity of heat shock transcription factor (HSF), by which the transcription of heat shock genes is mainly regulated, during h...

journal_title：Circulation

authors： Nishizawa J,Nakai A,Higashi T,Tanabe M,Nomoto S,Matsuda K,Ban T,Nagata K

更新日期：1996-11-01 00:00:00

abstract：BACKGROUND:Administration of protease inhibitors (PIs) to HIV-infected individuals has been associated with hyperlipidemia. In this study, we characterized the lipoprotein profile in subjects receiving ritonavir, indinavir, or nelfinavir, alone or in combination with saquinavir. METHODS AND RESULTS:Plasma lipoprotein ...

journal_title：Circulation

authors： Périard D,Telenti A,Sudre P,Cheseaux JJ,Halfon P,Reymond MJ,Marcovina SM,Glauser MP,Nicod P,Darioli R,Mooser V

更新日期：1999-08-17 00:00:00

abstract：:Hemodynamic effects of dobutamine and dopamine (both 5, 10, 15 microgram/kg/min) and epinephrine (0.04 microgram/kg/min) were studied immediately following cessation of cardiopulmonary bypass in 34 patients with preoperative evidence of left ventricular dysfunction. Significant increases in mean cardiac index were see...

journal_title：Circulation

authors： Steen PA,Tinker JH,Pluth JR,Barnh;rst DA,Tarhan S

更新日期：1978-02-01 00:00:00

abstract：:The cellular electrophysiologic effects of myocardial ablation performed in vitro with argon laser energy were compared with those of high-energy electrical shocks. A border zone of injured but nonnecrotic tissue surrounding the site of energy delivery was present after tissue ablation by both energy modalities. A dec...

journal_title：Circulation

authors： Levine JH,Merillat JC,Stern M,Weisman HF,Kadish AH,Moore EN,Spear JF,Fonger J,Guarnieri T

更新日期：1987-07-01 00:00:00

abstract：:Fifty-six patients undergoing orthotopic cardiac transplantation were given Minnesota ALG prophylactically or therapeutically for acute cardiac rejection. During a follow-up period of 0-28 months (mean follow-up period, 11.9 months), the actuarial survival for the entire group was 96% and 86% at 30 days and 1 year, re...

journal_title：Circulation

authors： Keith FM,Magilligan DJ Jr,Lakier JB,Drost CJ

更新日期：1988-11-01 00:00:00

abstract：BACKGROUND:Fortilin, a recently characterized nuclear antiapoptotic factor structurally distinct from inhibitor of apoptosis proteins (IAPs) and Bcl-2 family member proteins, has been suggested to be involved in cell survival and regulation of apoptosis within the cardiovascular system. In this continued investigation,...

journal_title：Circulation

authors： Tulis DA,Mnjoyan ZH,Schiesser RL,Shelat HS,Evans AJ,Zoldhelyi P,Fujise K

更新日期：2003-01-07 00:00:00

abstract：BACKGROUND:Recombinant staphylokinase (STAR) was shown recently to offer promise for coronary arterial thrombolysis in patients with evolving myocardial infarction. The present multicenter randomized open trial was designed to assess the thrombolytic efficacy, safety, and fibrin specificity of STAR relative to accelera...

journal_title：Circulation

authors： Vanderschueren S,Barrios L,Kerdsinchai P,Van den Heuvel P,Hermans L,Vrolix M,De Man F,Benit E,Muyldermans L,Collen D

更新日期：1995-10-15 00:00:00

abstract：BACKGROUND:Although previous studies have shown functional improvements in patients who undergo coronary artery bypass graft (CABG) surgery, data are conflicting on whether the gains achieved by women are similar to or less than those achieved by men. METHODS AND RESULTS:We compared physical and psychological function...

journal_title：Circulation

authors： Vaccarino V,Lin ZQ,Kasl SV,Mattera JA,Roumanis SA,Abramson JL,Krumholz HM

更新日期：2003-11-25 00:00:00

abstract：BACKGROUND:Intimal thickenings of the coronary arteries of newborn children are composed mainly of smooth muscle cell proliferations. To investigate whether thickening of the intima in infants is associated with a family history of coronary artery disease (CAD), we studied the relation of coronary death of grandparents...

journal_title：Circulation

authors： Kaprio J,Norio R,Pesonen E,Sarna S

更新日期：1993-06-01 00:00:00

abstract：:Mitral pressure half-time (T1/2) is widely used as an independent measure of mitral valve area in patients undergoing percutaneous mitral valvotomy. However, fluid dynamics theory predicts T1/2 to be strongly dependent on chamber compliance and the peak transmitral gradient, which are variables that change dramaticall...

journal_title：Circulation

authors： Thomas JD,Wilkins GT,Choong CY,Abascal VM,Palacios IF,Block PC,Weyman AE

更新日期：1988-10-01 00:00:00

abstract：:Diminished glomerular filtration rate, proteinuria, and large hypercellular congested glomeruli with segmental sclerosis are found in late survivors with cyanotic congenital heart disease (CCHD). Hyperuricemia is common, acute gouty arthritis is less common than uric acid levels would predict, and overt tophaceous dep...

journal_title：Circulation

authors： Ross EA,Perloff JK,Danovitch GM,Child JS,Canobbio MM

更新日期：1986-03-01 00:00:00

abstract：BACKGROUND:Observational studies have shown better survival in patients undergoing coronary artery bypass grafting (CABG) with 2 arterial grafts compared with 1. However, whether a third arterial graft is associated with incremental benefit remains uncertain. We sought to analyze the outcomes of 3 versus 2 arterial gra...

journal_title：Circulation

authors： Rocha RV,Tam DY,Karkhanis R,Nedadur R,Fang J,Tu JV,Gaudino M,Royse A,Fremes SE

更新日期：2018-11-06 00:00:00

abstract：BACKGROUND:It is still unclear what role the sinus node may play in the genesis or perpetuation of atrial fibrillation. Therefore, we studied the electrical activity in different regions of the sinus node during atrial fibrillation. METHODS AND RESULTS:In Langendorff-perfused rabbit hearts, paroxysms of atrial fibrill...

journal_title：Circulation

authors： Kirchhof CJ,Allessie MA

更新日期：1992-07-01 00:00:00

abstract：BACKGROUND:Adhesion of monocytes to the endothelium is an initial step in the early stages of atherosclerosis and inflammation. Granulocyte-macrophage colony-stimulating factor (GM-CSF) stimulates a range of functional activities of monocytes, including regulation of monocyte adhesion and induction of cytokine producti...

journal_title：Circulation

authors： Takahashi M,Kitagawa S,Masuyama JI,Ikeda U,Kasahara T,Takahashi YI,Furukawa Y,Kano S,Shimada K

更新日期：1996-03-15 00:00:00

abstract：BACKGROUND:This study examines the cellular basis for the phenotypic appearance of broad-based T waves, increased transmural dispersion of repolarization (TDR), and torsade de pointes (TdP) induced by beta-adrenergic agonists under conditions mimicking the LQT1 form of the congenital long-QT syndrome. METHODS AND RESU...

journal_title：Circulation

authors： Shimizu W,Antzelevitch C

更新日期：1998-11-24 00:00:00

abstract：BACKGROUND:Left ventricular outflow tract obstruction (LVOTO) occurs in 4% to 5% of patients after prosthetic ring mitral valve repair. Major anatomic factors incriminated in the genesis of LVOTO include degenerative mitral valve insufficiency with excess leaflet tissue, nondilated left ventricular cavity, and narrow m...

journal_title：Circulation

authors： Jebara VA,Mihaileanu S,Acar C,Brizard C,Grare P,Latremouille C,Chauvaud S,Fabiani JN,Deloche A,Carpentier A

更新日期：1993-11-01 00:00:00

abstract：:This is a report of a 10-year-old child who underwent surgery for complex congenital heart disease consisting of corrected transposition of the great vessels, ventricular septal defect, patent ductus arterisus, severe left-sided atrioventricular (AV) valve insuffieicney (Ebstein's deformity) and Wolff-Parkinson-White ...

journal_title：Circulation

authors： Benson DW Jr,Gallagher JJ,Oldham HN,Sealy WC,Sterba R,Spach MS

更新日期：1980-06-01 00:00:00

abstract：:Between 1976 and 1982, 413 consecutive patients underwent valvular replacement with a bioprosthesis. Aortic valve replacement was performed in 240 patients, mitral valve replacement in 132, and multiple-valve replacement in 41. Four prostheses were employed: Carpentier-Edwards porcine (n = 336), Angel-Shiley porcine (...

journal_title：Circulation

authors： Teoh KH,Ivanov J,Weisel RD,Darcel IC,Rakowski H

更新日期：1989-09-01 00:00:00

abstract：BACKGROUND:Several echocardiographic dyssynchrony indexes have been proposed to identify responders to cardiac resynchronization therapy using tissue velocity and strain. The present study aimed to compare tissue velocity-derived and strain-derived dyssynchrony indexes in patients with or without systolic dysfunction a...

journal_title：Circulation

authors： Miyazaki C,Powell BD,Bruce CJ,Espinosa RE,Redfield MM,Miller FA,Hayes DL,Cha YM,Oh JK

更新日期：2008-05-20 00:00:00

abstract：BACKGROUND:The aim of the present study was to evaluate dynamic changes in aortic regurgitant (AR) orifice area with the use of calibrated electromagnetic (EM) flowmeters and to validate a color Doppler flow convergence (FC) method for evaluating effective AR orifice area and regurgitant volume. METHODS AND RESULTS:In...

journal_title：Circulation

authors： Shiota T,Jones M,Yamada I,Heinrich RS,Ishii M,Sinclair B,Holcomb S,Yoganathan AP,Sahn DJ

更新日期：1996-02-01 00:00:00

abstract：BACKGROUND:NADH/NADPH oxidase is an important source of superoxide in the vasculature. Recently, we found that polymorphism of the gene p22phox, a critical component of this oxidase, is associated with a risk of coronary artery disease. The aim of this study was to investigate the localization of p22phox in human coron...

journal_title：Circulation

authors： Azumi H,Inoue N,Takeshita S,Rikitake Y,Kawashima S,Hayashi Y,Itoh H,Yokoyama M

更新日期：1999-10-05 00:00:00

abstract：BACKGROUND:Smooth muscle cell (SMC) migration and proliferation critically influence the clinical course of vascular disease. We tested the effect of the novel small leucine-rich repeat protein podocan on SMC migration and proliferation using a podocan-deficient mouse in combination with a model of arterial injury and ...

journal_title：Circulation

authors： Hutter R,Huang L,Speidl WS,Giannarelli C,Trubin P,Bauriedel G,Klotman ME,Fuster V,Badimon JJ,Klotman PE

更新日期：2013-11-26 00:00:00

abstract：BACKGROUND:The high cardiovascular morbidity and mortality in patients with end-stage kidney disease could be partially caused by extensive cardiovascular calcification. SNF472, intravenous myo-inositol hexaphosphate, selectively inhibits the formation and growth of hydroxyapatite. METHODS:This double-blind, placebo-c...

journal_title：Circulation

authors： Raggi P,Bellasi A,Bushinsky D,Bover J,Rodriguez M,Ketteler M,Sinha S,Salcedo C,Gillotti K,Padgett C,Garg R,Gold A,Perelló J,Chertow GM

更新日期：2020-03-03 00:00:00

abstract：BACKGROUND:Tumor necrosis factor alpha (TNF-alpha) increases in patients with severe congestive heart failure (CHF) and cachexia. Two naturally occurring modulators of TNF-alpha activity have been identified in human serum. These two soluble proteins are the extracellular domains of the TNF receptors (sTNF-RI and sTNF-...

journal_title：Circulation

authors： Ferrari R,Bachetti T,Confortini R,Opasich C,Febo O,Corti A,Cassani G,Visioli O

更新日期：1995-09-15 00:00:00

abstract：:The effects of verapamil (0.02-0.2 mg/kg) on contractility in normal and partially ischemic myocardium were compared with the changes following propranolol (0.01-1.0 mg/kg). Regional contractile function was studied in open-chest dogs with ultrasonic crystals and ischemia was controlled by graded occlusion of a caroti...

journal_title：Circulation

authors： Smith HJ,Goldstein RA,Griffith JM,Kent KM,Epstein SE

更新日期：1976-10-01 00:00:00

abstract：BACKGROUND:Approximately half of all patients with chronic heart failure (HF) have a decreased ejection fraction (EF) (systolic HF [SHF]); the other half have HF with a normal EF (diastolic HF [DHF]). However, the underlying pathophysiological differences between DHF and SHF patients are incompletely defined. The purpo...

journal_title：Circulation

authors： Zile MR,Bennett TD,St John Sutton M,Cho YK,Adamson PB,Aaron MF,Aranda JM Jr,Abraham WT,Smart FW,Stevenson LW,Kueffer FJ,Bourge RC

更新日期：2008-09-30 00:00:00

abstract：BACKGROUND:The Rho/Rho-associated kinase (Rho-kinase) system is implicated in various cellular functions, including migration, proliferation, and apoptosis. Because a possible role of the system is suggested in neointima formation after vascular injury, we sought to examine whether a new specific Rho-kinase inhibitor, ...

journal_title：Circulation

authors： Shibata R,Kai H,Seki Y,Kato S,Morimatsu M,Kaibuchi K,Imaizumi T

更新日期：2001-01-16 00:00:00

abstract：BACKGROUND:Tissue-type plasminogen activator (tPA) and urokinase-type plasminogen activator (uPA) are thought to play critical roles in vascular remodeling after injury, with tPA mediating intravascular clot lysis and uPA modulating cell migration within the vessel wall. In human vascular disease, however, thrombus org...

journal_title：Circulation

authors： Schäfer K,Konstantinides S,Riedel C,Thinnes T,Müller K,Dellas C,Hasenfuss G,Loskutoff DJ

更新日期：2002-10-01 00:00:00

abstract：BACKGROUND:We tested the hypothesis that long-term administration of the specific angiotensin II subtype 1 (AT1)-receptor blocker BMS-186295 will regress hypertrophy and modify left ventricular angiotensin converting enzyme (ACE) expression in rats with ascending aortic stenosis. METHODS AND RESULTS:Six weeks after su...

journal_title：Circulation

authors： Weinberg EO,Lee MA,Weigner M,Lindpaintner K,Bishop SP,Benedict CR,Ho KK,Douglas PS,Chafizadeh E,Lorell BH

更新日期：1997-03-18 00:00:00