Novel small leucine-rich repeat protein podocan is a negative regulator of migration and proliferation of smooth muscle cells, modulates neointima formation, and is expressed in human atheroma.

abstract：BACKGROUND:Assessment of systemic right ventricular (RV) function is a key point in the follow-up of patients with transposition of the great arteries (TGA). Current echocardiographic assessment of RV function is at best an estimate, and cardiac magnetic resonance (CMR) is considered the gold standard. However, this te...

journal_title：Circulation

authors： Salehian O,Schwerzmann M,Merchant N,Webb GD,Siu SC,Therrien J

更新日期：2004-11-16 00:00:00

abstract：BACKGROUND:Hypertrophic cardiomyopathy patients exhibit myocardial energetic impairment, but a causative role for this energy deficiency in the pathophysiology of hypertrophic cardiomyopathy remains unproven. We hypothesized that the metabolic modulator perhexiline would ameliorate myocardial energy deficiency and ther...

journal_title：Circulation

authors： Abozguia K,Elliott P,McKenna W,Phan TT,Nallur-Shivu G,Ahmed I,Maher AR,Kaur K,Taylor J,Henning A,Ashrafian H,Watkins H,Frenneaux M

更新日期：2010-10-19 00:00:00

abstract：:The indications for biventricular versus left ventricular mechanical circulatory support as a bridge to cardiac transplantation are not well established. In this study, 27 potential heart transplant candidates who were in imminent risk of dying before donor heart procurement were implanted with Thoratec prosthetic ven...

journal_title：Circulation

authors： Farrar DJ,Hill JD,Gray LA Jr,Galbraith TA,Chow E,Hershon JJ

更新日期：1989-11-01 00:00:00

abstract：BACKGROUND:The role of valve surgery in left-sided infective endocarditis has not been evaluated in randomized controlled trials. We examined the association between valve surgery and all-cause 6-month mortality among patients with left-sided infective endocarditis. METHODS AND RESULTS:A total of 546 consecutive patie...

journal_title：Circulation

authors： Tleyjeh IM,Ghomrawi HM,Steckelberg JM,Hoskin TL,Mirzoyev Z,Anavekar NS,Enders F,Moustafa S,Mookadam F,Huskins WC,Wilson WR,Baddour LM

更新日期：2007-04-03 00:00:00

abstract：BACKGROUND:The mechanisms of thrombosis on plaque erosion are poorly understood. We examined the potential role of endothelial apoptosis in endothelial erosion and vessel thrombosis. METHODS AND RESULTS:Segments of New Zealand White rabbit femoral arteries were temporarily isolated in vivo. One artery was incubated wi...

journal_title：Circulation

authors： Durand E,Scoazec A,Lafont A,Boddaert J,Al Hajzen A,Addad F,Mirshahi M,Desnos M,Tedgui A,Mallat Z

更新日期：2004-06-01 00:00:00

abstract：BACKGROUND:In previous studies comparing regional 201Tl (201Tl) and 18fluorodeoxyglucose (FDG) activity in patients with chronic coronary artery disease and left ventricular dysfunction, we hypothesized that regions with mild-to-moderate reduction in FDG activity and regions with mild-to-moderate irreversible 201Tl def...

journal_title：Circulation

authors： Perrone-Filardi P,Bacharach SL,Dilsizian V,Maurea S,Frank JA,Bonow RO

更新日期：1992-10-01 00:00:00

abstract：BACKGROUND:Exposure to risk factors such as hypertension or hypercholesterolemia decreases the bioavailability of endothelium-derived nitric oxide (NO) and impairs endothelium-dependent vasodilation. Recently, a circulating endogenous NO synthase inhibitor, asymmetric dimethylarginine (ADMA), has been detected in human...

journal_title：Circulation

authors： Miyazaki H,Matsuoka H,Cooke JP,Usui M,Ueda S,Okuda S,Imaizumi T

更新日期：1999-03-09 00:00:00

abstract：BACKGROUND:Plaque rupture with subsequent thrombosis is recognized as the underlying pathophysiology of most acute coronary syndromes and stroke. Thus, direct thrombus visualization may be beneficial for both diagnosis and guidance of therapy. We sought to test the feasibility of direct imaging of acute and subacute th...

journal_title：Circulation

authors： Botnar RM,Perez AS,Witte S,Wiethoff AJ,Laredo J,Hamilton J,Quist W,Parsons EC Jr,Vaidya A,Kolodziej A,Barrett JA,Graham PB,Weisskoff RM,Manning WJ,Johnstone MT

更新日期：2004-04-27 00:00:00

abstract：BACKGROUND:Diffuse myocardial fibrosis is a final end point in most cardiac diseases. It is missed by the cardiovascular magnetic resonance (CMR) late gadolinium enhancement technique. Currently, quantifying diffuse myocardial fibrosis requires invasive biopsy, with inherent risk and sampling error. We have developed a...

journal_title：Circulation

authors： Flett AS,Hayward MP,Ashworth MT,Hansen MS,Taylor AM,Elliott PM,McGregor C,Moon JC

更新日期：2010-07-13 00:00:00

abstract：BACKGROUND:Although type B aortic dissection has been treated with beta blockers to lower the arterial blood pressure (BP), there has been little evidences about reduction in heart rate (HR). We assessed whether tight HR control improved the outcome of medical treatment in patients with aortic dissection. METHODS AND ...

journal_title：Circulation

authors： Kodama K,Nishigami K,Sakamoto T,Sawamura T,Hirayama T,Misumi H,Nakao K

更新日期：2008-09-30 00:00:00

abstract：:An increasing number of premature ventricular stimuli are being used during programmed stimulation of the heart in the investigation of patients with documented or suspected ventricular arrhythmias. To analyze the significance of the different types of ventricular arrhythmias that are initiated, we evaluated in a pros...

journal_title：Circulation

authors： Brugada P,Green M,Abdollah H,Wellens HJ

更新日期：1984-01-01 00:00:00

abstract：:Both the Veterans Administration Cooperative Study and the European Coronary Surgery Study have provided only brief accounts of graft patency rates in their surgically treated patients. In the Veterans Administration Cooperative Study, at an average of 1 year after operation, 69% of the grafts were patent among 208 pa...

journal_title：Circulation

authors： Bourassa MG,Fisher LD,Campeau L,Gillespie MJ,McConney M,Lespérance J

更新日期：1985-12-01 00:00:00

abstract：BACKGROUND:Drugs that simultaneously decrease platelet function and inflammation may improve the treatment of cardiovascular disorders. Here, we determined whether dipyridamole and aspirin, a combination therapy used to prevent recurrent stroke, regulates gene expression in platelet-monocyte inflammatory model systems....

journal_title：Circulation

authors： Weyrich AS,Denis MM,Kuhlmann-Eyre JR,Spencer ED,Dixon DA,Marathe GK,McIntyre TM,Zimmerman GA,Prescott SM

更新日期：2005-02-08 00:00:00

abstract：BACKGROUND:Dual antiplatelet therapy with aspirin and a P2Y12 inhibitor has been shown to reduce the risk of major adverse cardiovascular events (MACE) compared with aspirin alone after percutaneous coronary intervention (PCI) or acute coronary syndrome but with increased risk of bleeding. The safety of discontinuing a...

journal_title：Circulation

authors： O'Donoghue ML,Murphy SA,Sabatine MS

更新日期：2020-08-11 00:00:00

abstract：BACKGROUND:Heat shock protein (HSP)60 is an abundant protein found primarily in the mitochondria, though 15% to 20% is found in the cytosol. Previously we observed that HSP60 complexes with bax in the cytosol. Reduction in HSP60 precipitates translocation of bax to the mitochondria and apoptosis. We hypothesized that H...

journal_title：Circulation

authors： Gupta S,Knowlton AA

更新日期：2002-11-19 00:00:00

abstract：BACKGROUND:AL amyloidosis with heart failure is associated with decreased longitudinal myocardial contraction measured by pulsed tissue Doppler imaging. We sought to clarify whether new modalities of myocardial strain Doppler (change in length per unit length) or strain rate (the temporal derivative of strain) were mor...

journal_title：Circulation

authors： Koyama J,Ray-Sequin PA,Falk RH

更新日期：2003-05-20 00:00:00

abstract：BACKGROUND:Women receive less evidence-based medical care than men and have higher rates of death after acute myocardial infarction (AMI). It is unclear whether efforts undertaken to improve AMI care have mitigated these sex disparities in the current era. METHODS AND RESULTS:Using the Get With the Guidelines-Coronary...

journal_title：Circulation

authors： Jneid H,Fonarow GC,Cannon CP,Hernandez AF,Palacios IF,Maree AO,Wells Q,Bozkurt B,Labresh KA,Liang L,Hong Y,Newby LK,Fletcher G,Peterson E,Wexler L,Get With the Guidelines Steering Committee and Investigators.

更新日期：2008-12-16 00:00:00

abstract：BACKGROUND:There are few comparative data regarding long-term nonfatal outcomes for women versus men after coronary artery bypass grafting (CABG). This study compares gender differences in cardiac events in a population of hospital survivors up to 11 years after isolated CABG surgery in Ontario, Canada. METHODS AND RE...

journal_title：Circulation

authors： Guru V,Fremes SE,Austin PC,Blackstone EH,Tu JV

更新日期：2006-01-31 00:00:00

abstract：BACKGROUND:The incidence of perinatal morbidity arising from birth hypoxia or asphyxia has not changed significantly in recent years despite marked improvements in labor management. Perinatal mortality in these circumstances may therefore reflect antenatal compromise and subsequent alteration of the fetal capacity to r...

journal_title：Circulation

authors： Gardner DS,Fowden AL,Giussani DA

更新日期：2002-10-22 00:00:00

abstract：:To study the variability of the fraction of CPK released from the infarcted heart which enters the serum (serum entry ratio, or SER) with size and model of infarction, nine dogs underwent homogeneous infarctions (LAD ligation) of varying sizes, and 10 dogs underwent scattered infarctions (left coronary embolization). ...

journal_title：Circulation

authors： Cairns JA,Missirlis E,Fallen EL

更新日期：1978-12-01 00:00:00

abstract：BACKGROUND:Cardiac tissue engineering offers the prospect of a novel treatment for acquired or congenital heart defects. We have created vascularized pieces of beating cardiac muscle in the rat that are as thick as the adult rat right ventricle wall. METHOD AND RESULTS:Neonatal rat cardiomyocytes in Matrigel were impl...

journal_title：Circulation

authors： Morritt AN,Bortolotto SK,Dilley RJ,Han X,Kompa AR,McCombe D,Wright CE,Itescu S,Angus JA,Morrison WA

更新日期：2007-01-23 00:00:00

abstract：BACKGROUND:We determined the intraclass correlation coefficients (ICC) of repeated measures of the mean levels and variability of RR and muscle sympathetic nerve activity (MSNA) in 7 normal subjects. We examined whether spontaneous fluctuations in RR and MSNA over repeated measurements were mirrored by changes in spect...

journal_title：Circulation

authors： van de Borne P,Montano N,Zimmerman B,Pagani M,Somers VK

更新日期：1997-12-16 00:00:00

abstract：:In Phase I of the NHLBI trial of Thrombolysis in Myocardial Infarction (TIMI), 290 patients admitted within 7 hr after onset of acute infarction were randomly assigned to intravenous treatment with either streptokinase (SK) or recombinant tissue-type plasminogen activator (rt-PA). Left ventricular function was measure...

journal_title：Circulation

authors： Sheehan FH,Braunwald E,Canner P,Dodge HT,Gore J,Van Natta P,Passamani ER,Williams DO,Zaret B

更新日期：1987-04-01 00:00:00

abstract：BACKGROUND:Adenosine can initiate ischemic preconditioning, and mitochondrial ATP-sensitive potassium (K(ATP)) channels have emerged as the likely effectors. We sought to determine the mechanistic interactions between these 2 observations. METHODS AND RESULTS:The mitochondrial flavoprotein oxidation induced by diazoxi...

journal_title：Circulation

authors： Sato T,Sasaki N,O'Rourke B,Marbán E

更新日期：2000-08-15 00:00:00

abstract：BACKGROUND:Human endothelial and vascular smooth muscle cells synthesize prostanoids. Several of these have been implicated in the physiological and pathophysiological regulation of vascular tone; however, there is no direct evidence that human blood vessels synthesize sufficient prostanoid to alter vessel tone. METHO...

journal_title：Circulation

authors： Bhagat K,Collier J,Vallance P

更新日期：1995-10-15 00:00:00

abstract：BACKGROUND:The diagnosis of infective endocarditis (IE) in prosthetic valves and intracardiac devices is challenging because both the modified Duke criteria (DC) and echocardiography have limitations in this population. The added value of (18)F-fluorodeoxyglucose ((18)F-FDG) positron emission tomography (PET)/computed ...

journal_title：Circulation

authors： Pizzi MN,Roque A,Fernández-Hidalgo N,Cuéllar-Calabria H,Ferreira-González I,Gonzàlez-Alujas MT,Oristrell G,Gracia-Sánchez L,González JJ,Rodríguez-Palomares J,Galiñanes M,Maisterra-Santos O,Garcia-Dorado D,Castell-Conesa J,Alm

更新日期：2015-09-22 00:00:00

abstract：BACKGROUND:Early defibrillation is the most important intervention affecting survival from sudden cardiac arrest (SCA). To improve public access to early defibrillation, we established Piacenza Progetto Vita (PPV), the first system of out-of-hospital early defibrillation by first-responder volunteers. METHODS AND RESU...

journal_title：Circulation

authors： Capucci A,Aschieri D,Piepoli MF,Bardy GH,Iconomu E,Arvedi M

更新日期：2002-08-27 00:00:00

abstract：:Eighty-seven patients who had out-of-hospital cardiac arrests received defibrillating shocks delivered by minimally trained first responders before the arrival of paramedics in a city with short emergency response times. Their outcomes were compared with those of 370 other victims who received only basic life support ...

journal_title：Circulation

authors： Weaver WD,Copass MK,Bufi D,Ray R,Hallstrom AP,Cobb LA

更新日期：1984-05-01 00:00:00

abstract：:Subaortic stenosis is well known to complicate the clinical course of patients with single ventricle or univentricular hearts, and we have previously suggested that the development of subaortic stenosis in such patients may be causal to and/or accelerated by previous banding of the main pulmonary trunk. To further def...

journal_title：Circulation

authors： Freedom RM,Benson LN,Smallhorn JF,Williams WG,Trusler GA,Rowe RD

更新日期：1986-04-01 00:00:00

abstract：BACKGROUND:Inhomogeneity of dose distribution and anatomic aspects of the atherosclerotic plaque may influence the outcome of irradiated lesions after balloon angioplasty (BA). We evaluated the influence of delivered dose and morphological characteristics of coronary stenoses treated with beta-radiation after BA. METH...

journal_title：Circulation

authors： Sabaté M,Marijnissen JP,Carlier SG,Kay IP,van der Giessen WJ,Coen VL,Ligthart JM,Boersma E,Costa MA,Levendag PC,Serruys PW

更新日期：2000-05-30 00:00:00