Sex differences in medical care and early death after acute myocardial infarction.

abstract：BACKGROUND:The Fick principle (cardiac output = oxygen uptake ( O2)/systemic arterio-venous oxygen difference) is used to determine cardiac output in numerous clinical situations. However, estimated rather than measured O2 is commonly used because of complexities of the measurement, though the accuracy of estimation re...

journal_title：Circulation

authors： Narang N,Thibodeau JT,Levine BD,Gore MO,Ayers CR,Lange RA,Cigarroa JE,Turer AT,de Lemos JA,McGuire DK

更新日期：2014-01-14 00:00:00

abstract：BACKGROUND:There are few data regarding medium-term outcome of coronary artery bypass grafting (CABG) in patients with severe left ventricular (LV) systolic dysfunction, particularly in the modern era, and even less assessing preoperative factors that might identify patients at highest risk. METHODS AND RESULTS:Three ...

journal_title：Circulation

authors： Hillis GS,Zehr KJ,Williams AW,Schaff HV,Orzulak TA,Daly RC,Mullany CJ,Rodeheffer RJ,Oh JK

更新日期：2006-07-04 00:00:00

abstract：BACKGROUND:The purpose of the present study was to investigate plasma lipid-independent mechanisms for the sex difference in the development of atherosclerosis. METHODS AND RESULTS:In the first experiment, 20 male and 20 female rabbits were balloon-injured in the middle thoracic aorta and maintained at the same plasma...

journal_title：Circulation

authors： Holm P,Andersen HL,Arrøe G,Stender S

更新日期：1998-12-15 00:00:00

abstract：BACKGROUND:Extracellular matrix proteins, such as laminins, and endothelial cells are known to influence cardiomyocyte performance; however, the underlying molecular mechanisms remain poorly understood. METHODS AND RESULTS:We used a forward genetic screen in zebrafish to identify novel genes required for myocardial fu...

journal_title：Circulation

authors： Knöll R,Postel R,Wang J,Krätzner R,Hennecke G,Vacaru AM,Vakeel P,Schubert C,Murthy K,Rana BK,Kube D,Knöll G,Schäfer K,Hayashi T,Holm T,Kimura A,Schork N,Toliat MR,Nürnberg P,Schultheiss HP,Schaper W,Schaper J,

更新日期：2007-07-31 00:00:00

abstract：BACKGROUND:Heat shock proteins (HSPs) are well known for their ability to "protect" the structure and function of native macromolecules, particularly as they traffic across membranes. Considering the role of key mitochondrial proteins in apoptosis and the known antiapoptotic effects of HSP27 and HSP72, we postulated th...

journal_title：Circulation

authors： Kirchhoff SR,Gupta S,Knowlton AA

更新日期：2002-06-18 00:00:00

abstract：BACKGROUND:The cardiovascular adaptation to bed rest leads to orthostatic intolerance, characterized by an excessive fall in stroke volume (SV) in the upright position. We hypothesized that this large fall in SV is due to a change in cardiac mechanics. METHODS AND RESULTS:We measured pulmonary capillary wedge pressure...

journal_title：Circulation

authors： Levine BD,Zuckerman JH,Pawelczyk JA

更新日期：1997-07-15 00:00:00

abstract：BACKGROUND:Dual antiplatelet therapy in older versus younger patients with acute coronary syndromes is understudied. Low-dose prasugrel (5 mg/d) is recommended for younger, lower-body-weight patients and elderly patients with acute coronary syndromes to mitigate the bleeding risk of standard-dose prasugrel (10 mg/d). ...

journal_title：Circulation

authors： Roe MT,Goodman SG,Ohman EM,Stevens SR,Hochman JS,Gottlieb S,Martinez F,Dalby AJ,Boden WE,White HD,Prabhakaran D,Winters KJ,Aylward PE,Bassand JP,McGuire DK,Ardissino D,Fox KA,Armstrong PW

更新日期：2013-08-20 00:00:00

abstract：:To define the prevalence, frequency and characteristics of premature ventricular complexes (PVCs) in adults free of recognizable heart disease, we performed 24-hour ambulatory electrocardiography on 101 subjects (51 men and 50 women, mean age 48.8 years) in whom physical examination, chest x-ray, ECG, echocardiogram, ...

journal_title：Circulation

authors： Kostis JB,McCrone K,Moreyra AE,Gotzoyannis S,Aglitz NM,Natarajan N,Kuo PT

更新日期：1981-06-01 00:00:00

abstract：BACKGROUND:Perioperative management of patients with complete mixing of pulmonary and systemic blood centers on approximately equating pulmonary (Qp) and systemic (Qs) blood flow (Qp/Qs approximately 1). This empirically derived target is opposed by theoretical studies advocating a target Qp/Qs well below 1. We studied...

journal_title：Circulation

authors： Francis DP,Willson K,Thorne SA,Davies LC,Coats AJ

更新日期：1999-11-23 00:00:00

abstract：BACKGROUND:Coronary calcification detected by electron beam tomography may improve cardiovascular risk prediction. The technique is particularly promising in the elderly because the predictive power of cardiovascular risk factors weakens with age. We investigated the prognostic value of coronary calcification for cardi...

journal_title：Circulation

authors： Vliegenthart R,Oudkerk M,Hofman A,Oei HH,van Dijck W,van Rooij FJ,Witteman JC

更新日期：2005-07-26 00:00:00

abstract：BACKGROUND:The purpose of this investigation was to establish normal values of RR variability for middle-aged persons and compare them with values found in patients early and late after myocardial infarction. We hypothesized that presence or absence of coronary heart disease, age, and sex (in this order of importance) ...

journal_title：Circulation

authors： Bigger JT Jr,Fleiss JL,Steinman RC,Rolnitzky LM,Schneider WJ,Stein PK

更新日期：1995-04-01 00:00:00

abstract：:To determine the effect of calcium-channel blockers on beta-adrenergic receptors, we studied the interactions of verapamil, diltiazem, and nifedipine with both human lymphocyte beta 2-adrenergic receptors and rat myocardial beta 1-adrenergic receptors by means of radioligand binding assays. We also determined the func...

journal_title：Circulation

authors： Feldman RD,Park GD,Lai CY

更新日期：1985-09-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to assess the long-term value of dobutamine-atropine stress echocardiography (DSE) for prediction of late cardiac events in patients with proven or suspected coronary artery disease. METHODS AND RESULTS:Clinical data and DSE results were analyzed in 1734 consecutive patients un...

journal_title：Circulation

authors： Poldermans D,Fioretti PM,Boersma E,Bax JJ,Thomson IR,Roelandt JR,Simoons ML

更新日期：1999-02-16 00:00:00

abstract：BACKGROUND:Evidence suggests that the vessel wall contains an oxidase similar, if not identical, to phagocytic NADPH oxidase. We tested the contribution of this specific oxidase to the progression of atherosclerosis and the regulation of blood pressure. METHODS AND RESULTS:An examination of aortic rings from wild-type...

journal_title：Circulation

authors： Hsich E,Segal BH,Pagano PJ,Rey FE,Paigen B,Deleonardis J,Hoyt RF,Holland SM,Finkel T

更新日期：2000-03-21 00:00:00

abstract：BACKGROUND:Adrenomedullin (AM) is a vasodilating peptide involved in the regulation of circulatory homeostasis and in the pathophysiology of certain cardiovascular diseases. To determine the extent to which chronic AM overproduction affects circulatory physiology under normal and pathological conditions, we used a prep...

journal_title：Circulation

authors： Shindo T,Kurihara H,Maemura K,Kurihara Y,Kuwaki T,Izumida T,Minamino N,Ju KH,Morita H,Oh-hashi Y,Kumada M,Kangawa K,Nagai R,Yazaki Y

更新日期：2000-05-16 00:00:00

abstract：:In studies to ascertain the basis of dynamic changes in the P wave, bipolar epicardial potentials were recorded from multiple atrial electrodes in dogs. One hundred to 120 activation times were displayed by a digital computer and used to construct atrial isotemporal activation sequence maps. Changes in heart rate or b...

journal_title：Circulation

authors： Boineau JP,Schuessler RB,Mooney CR,Wylds AC,Miller CB,Hudson RD,Borremans JM,Brockus CW

更新日期：1978-12-01 00:00:00

abstract：:Malperfusion of the thoracoabdominal aorta or its branches is a common complication of aortic dissection, often with a fatal outcome. Since 1985 we saw thoracoabdominal malperfusion in 13 patients with aortic dissection. During repair of an acute type A aortic dissection, the intimal flap was fenestrated in three case...

journal_title：Circulation

authors： Laas J,Heinemann M,Schaefers HJ,Daniel W,Borst HG

更新日期：1991-11-01 00:00:00

abstract：BACKGROUND:Analyses from randomized controlled trials suggest that bleeding in patients with acute myocardial infarction is associated with poor outcomes. Because these data are not generalizable to all patients with acute myocardial infarction, we sought to better understand the scope of this problem in a "real-world"...

journal_title：Circulation

authors： Spencer FA,Moscucci M,Granger CB,Gore JM,Goldberg RJ,Steg PG,Goodman SG,Budaj A,FitzGerald G,Fox KA,GRACE Investigators.

更新日期：2007-12-11 00:00:00

abstract：:Purine compounds modulate sympathetic neurotransmission; this modulation decreases nervous discharge by stimulating presynaptic inhibitory adenosine receptors, an effect antagonized by theophylline, and causes vasoconstriction through the stimulation of postsynaptic ATP receptors. In humans we evaluated the effect of ...

journal_title：Circulation

authors： Taddei S,Pedrinelli R,Salvetti A

更新日期：1990-12-01 00:00:00

abstract：:Myocardial fiber disarray is a distinctive histopathologic finding seen in asymmetric hypertrophic cardiomyopathy. We studied 14 hearts with aortic atresia and intact interventricular septum, six hearts with pulmonic atresia and intact interventricular septum, eight normal infant hearts matched for age of the study he...

journal_title：Circulation

authors： Bulkley BH,D'Amico B,Taylor AL

更新日期：1983-01-01 00:00:00

abstract：BACKGROUND:Whether and to what extent complement is activated in acute myocardial infarction (AMI) and how it contributes to inflammation of the ischemic area are not yet clear. Fibrinolytic agents used for thrombolysis are known to activate complement in vitro and may contribute to its activation in vivo. The aim of t...

journal_title：Circulation

authors： Frangi D,Gardinali M,Conciato L,Cafaro C,Pozzoni L,Agostoni A

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND:Erosion and rupture of coronary atheromas are the events preceding the vast majority of acute coronary syndromes. The shoulder regions of atheromas, the sites at which erosion or rupture is most likely to occur, are the sites at which mast cells accumulate. These cells are filled with neutral proteases capab...

journal_title：Circulation

authors： Kovanen PT,Kaartinen M,Paavonen T

更新日期：1995-09-01 00:00:00

abstract：:The hypothesis tested in this study was that despite the presence of severe postischemic myocardial dysfunction ("stunning"), the extraction and subsequent intracellular washout of thallium 201 should be preserved as long as irreversible sarcolemmal membrane injury was avoided. To produce myocardial stunning, 19 open-...

journal_title：Circulation

authors： Moore CA,Cannon J,Watson DD,Kaul S,Beller GA

更新日期：1990-05-01 00:00:00

abstract：BACKGROUND:The results of angiographic studies have suggested that calcium channel-blocking agents may prevent new coronary lesion formation, the progression of minimal lesions, or both. METHODS AND RESULTS:The Prospective Randomized Evaluation of the Vascular Effects of Norvasc Trial (PREVENT) was a multicenter, rand...

journal_title：Circulation

authors： Pitt B,Byington RP,Furberg CD,Hunninghake DB,Mancini GB,Miller ME,Riley W

更新日期：2000-09-26 00:00:00

abstract：BACKGROUND:Risk factors for obstructive sleep apnea (OSA) and the development of subsequent cardiovascular (CV) complications differ by sex. We hypothesize that the relationship between OSA and high-sensitivity troponin T (hs-TnT), cardiac structure, and CV outcomes differs by sex. METHODS AND RESULTS:Seven hundred fi...

journal_title：Circulation

authors： Roca GQ,Redline S,Claggett B,Bello N,Ballantyne CM,Solomon SD,Shah AM

更新日期：2015-10-06 00:00:00

abstract：BACKGROUND:In patients with symptoms of heart failure, elevations in B-type natriuretic peptide (BNP) accurately identify ventricular dysfunction. However, BNP levels are not specific for ventricular dysfunction in patients who do not have overt symptoms of heart failure, suggesting that other cardiac processes such as...

journal_title：Circulation

authors： Bibbins-Domingo K,Ansari M,Schiller NB,Massie B,Whooley MA

更新日期：2003-12-16 00:00:00

abstract：:Cross-sectional echocardiographic studies of the aortic arch and proximal descending aorta were performed in 18 patients with coarctation of the aorta and 20 normal subjects. In normals the aortic arch and proximal descending aorta appeared as an arcuate, echo-free structure curving across the plane of the scan. There...

journal_title：Circulation

authors： Weyman AE,Caldwell RL,Hurwitz RA,Girod DA,Dillon JC,Feigenbaum H,Green D

更新日期：1978-03-01 00:00:00

abstract：BACKGROUND:Whether cardiac rehabilitation (CR) is effective in patients older than 75 years, who have been excluded from most trials, remains unclear. We enrolled patients 46 to 86 years old in a randomized trial and assessed the effects of 2 months of post-myocardial infarction (MI) CR on total work capacity (TWC, in ...

journal_title：Circulation

authors： Marchionni N,Fattirolli F,Fumagalli S,Oldridge N,Del Lungo F,Morosi L,Burgisser C,Masotti G

更新日期：2003-05-06 00:00:00

abstract：:Background: In ISCHEMIA, an initial invasive strategy did not significantly reduce rates of cardiovascular events or all-cause mortality compared with a conservative strategy in patients with stable ischemic heart disease and moderate/severe myocardial ischemia. The most frequent component of composite cardiovascular ...

journal_title：Circulation

authors： Chaitman BR,Alexander KP,Cyr DD,Berger JS,Reynolds HR,Bangalore S,Boden WE,Lopes RD,Demkow M,Perna GP,Riezebos RK,McFalls EO,Banerjee S,Bagai A,Gosselin G,O'Brien SM,Rockhold FW,Waters DD,Thygesen KA,Stone GW,Whit

更新日期：2020-12-03 00:00:00

abstract：BACKGROUND:High-altitude pulmonary edema (HAPE) is characterized by pulmonary hypertension, increased pulmonary capillary permeability, and hypoxemia. Treatment is limited to descent to lower altitude and administration of oxygen. METHODS AND RESULTS:We studied the acute effects of inhaled nitric oxide (NO), 50% oxyge...

journal_title：Circulation

authors： Anand IS,Prasad BA,Chugh SS,Rao KR,Cornfield DN,Milla CE,Singh N,Singh S,Selvamurthy W

更新日期：1998-12-01 00:00:00