Extensive myocardial fiber disarray in aortic and pulmonary atresia. Relevance to hypertrophic cardiomyopathy.

abstract：:Proton (hydrogen-1) magnetic resonance imaging techniques have potential for the detection and characterization of changes associated with myocardial ischemia. Since image contrast is dependent on T1 and T2 relaxation times, we examined these parameters in a canine preparation of occlusion of the left anterior descend...

journal_title：Circulation

authors： Johnston DL,Brady TJ,Ratner AV,Rosen BR,Newell JB,Pohost GM,Okada RD

更新日期：1985-03-01 00:00:00

abstract：BACKGROUND:Depletion of L-arginine (L-arg), the substrate for nitric oxide (NO) synthesis, could be one of the mechanisms responsible for the reduced production of NO and decreased coronary flow (CF) during reperfusion. This, in turn, may adversely affect mechanical function. We aimed to study the benefits of exogenous...

journal_title：Circulation

authors： Amrani M,Gray CC,Smolenski RT,Goodwin AT,London A,Yacoub MH

更新日期：1997-11-04 00:00:00

abstract：:Heart-lung transplantation results in afferent and efferent denervation of the transplanted organs including interruption of the central connections from the low-pressure receptors in the atria and pulmonary veins. We investigated whether the cardiovascular and neurohumoral responses to the postural stimulus of head-u...

journal_title：Circulation

authors： Banner NR,Williams TD,Patel N,Chalmers J,Lightman SL,Yacoub MH

更新日期：1990-09-01 00:00:00

abstract：BACKGROUND:Repolarization dispersion (Rd) is frequently mentioned as a predictor of cardiac abnormalities. We present a new measure of Rd based on the root-mean-square (RMS) curve of an ECG lead set and compare its performance with that of the commonly used QT dispersion (QTd) measure with the use of recovery times mea...

journal_title：Circulation

authors： Fuller MS,Sándor G,Punske B,Taccardi B,MacLeod RS,Ershler PR,Green LS,Lux RL

更新日期：2000-08-08 00:00:00

abstract：BACKGROUND:The goal of this study was to examine a possible association between systemic microinflammation, as reflected by C-reactive protein (CRP) serum levels, and coronary vasomotion in patients with coronary risk factors but with angiographically normal coronary arteries. METHODS AND RESULTS:Coronary vasomotor fu...

journal_title：Circulation

authors： Schindler TH,Nitzsche EU,Olschewski M,Magosaki N,Mix M,Prior JO,Facta AD,Solzbach U,Just H,Schelbert HR

更新日期：2004-08-31 00:00:00

abstract：BACKGROUND:β1-2-adrenergic receptors (AR) are key regulators of cardiac contractility and remodeling in response to catecholamines. β3-AR expression is enhanced in diseased human myocardium, but its impact on remodeling is unknown. METHODS AND RESULTS:Mice with cardiac myocyte-specific expression of human β3-AR (β3-TG...

journal_title：Circulation

authors： Belge C,Hammond J,Dubois-Deruy E,Manoury B,Hamelet J,Beauloye C,Markl A,Pouleur AC,Bertrand L,Esfahani H,Jnaoui K,Götz KR,Nikolaev VO,Vanderper A,Herijgers P,Lobysheva I,Iaccarino G,Hilfiker-Kleiner D,Tavernier G,La

更新日期：2014-01-28 00:00:00

abstract：BACKGROUND:To further evaluate the mechanism of beta-blocker-induced benefits in heart failure, the relationships between bisoprolol-induced hemodynamic effects and survival were studied during the Cardiac Insufficiency BIsoprolol Study (CIBIS). METHODS AND RESULTS:In 557 patients studied, bisoprolol significantly red...

journal_title：Circulation

authors： Lechat P,Escolano S,Golmard JL,Lardoux H,Witchitz S,Henneman JA,Maisch B,Hetzel M,Jaillon P,Boissel JP,Mallet A

更新日期：1997-10-07 00:00:00

abstract：BACKGROUND:Plaque rupture with subsequent thrombosis is recognized as the underlying pathophysiology of most acute coronary syndromes and stroke. Thus, direct thrombus visualization may be beneficial for both diagnosis and guidance of therapy. We sought to test the feasibility of direct imaging of acute and subacute th...

journal_title：Circulation

authors： Botnar RM,Perez AS,Witte S,Wiethoff AJ,Laredo J,Hamilton J,Quist W,Parsons EC Jr,Vaidya A,Kolodziej A,Barrett JA,Graham PB,Weisskoff RM,Manning WJ,Johnstone MT

更新日期：2004-04-27 00:00:00

abstract：BACKGROUND:Cardiac resynchronization therapy has emerged as an important therapy for advanced systolic heart failure. Among available cardiac resynchronization therapy pacing modes that restore ventricular synchrony, it is uncertain whether simultaneous biventricular (BiV), sequential BiV, or left ventricular (LV) paci...

journal_title：Circulation

authors： Rao RK,Kumar UN,Schafer J,Viloria E,De Lurgio D,Foster E

更新日期：2007-04-24 00:00:00

abstract：:This study examined quantitative regional myocardial perfusion (RMP) measured by the washout of 133Xe at rest and after an isoproterenol challenge in 50 patients (group I) studied 8 to 14 days after they underwent saphenous vein bypass grafting to the left coronary artery, and compared this with RMP measured in the na...

journal_title：Circulation

authors： Schmidt DH,Blau FM,Hendrix LJ,Kamath ML,Ray G

更新日期：1985-04-01 00:00:00

abstract：BACKGROUND:To formally test whether the antiapoptotic protein bcl-2 would prevent programmed cell death in cardiac muscle cells provoked by p53, a known trigger of apoptosis in a variety of different cell types, we used replication defective adenovirus encoding either the bcl-2 and p53 genes to deliver bcl-2 and p53 to...

journal_title：Circulation

authors： Kirshenbaum LA,de Moissac D

更新日期：1997-09-02 00:00:00

abstract：BACKGROUND:Inhibition of fibrinolysis attributable to elevated concentrations of plasminogen activator inhibitor type 1 (PAI-1) in blood is associated with insulin resistance, hyperinsulinemia, and type 2 diabetes mellitus. Because we have shown that insulin can stimulate PAI-1 synthesis in vivo and because accelerated...

journal_title：Circulation

authors： Sobel BE,Woodcock-Mitchell J,Schneider DJ,Holt RE,Marutsuka K,Gold H

更新日期：1998-06-09 00:00:00

abstract：:Periodic fluctuations in the R-R interval have been used as noninvasive measures of cardiac autonomic tone. For example, a reduced heart rate variability has been shown to correlate with an increased mortality in patients recovering from myocardial infarction. The effects that physiologic perturbations such as exercis...

journal_title：Circulation

authors： Billman GE,Hoskins RS

更新日期：1989-07-01 00:00:00

abstract：:Fifty-six patients undergoing orthotopic cardiac transplantation were given Minnesota ALG prophylactically or therapeutically for acute cardiac rejection. During a follow-up period of 0-28 months (mean follow-up period, 11.9 months), the actuarial survival for the entire group was 96% and 86% at 30 days and 1 year, re...

journal_title：Circulation

authors： Keith FM,Magilligan DJ Jr,Lakier JB,Drost CJ

更新日期：1988-11-01 00:00:00

abstract：BACKGROUND:Multiple excitation wavelets are present during ventricular fibrillation (VF). The underlying wavelet organization of VF is unclear. Phase singularities (PSs)-locations of ambiguous activation state-underlie reentry and wavelet splitting and represent the sources of VF. Understanding the mechanisms of PS for...

journal_title：Circulation

authors： Valderrábano M,Chen PS,Lin SF

更新日期：2003-07-22 00:00:00

abstract：BACKGROUND:We measured the content and activities of components of the beta-adrenergic receptor-G protein-adenylate cyclase complex and adrenergic neurotransmitter levels in left and right ventricular myocardial preparations derived from 77 end-stage failing human hearts from patients with idiopathic dilated cardiomyop...

journal_title：Circulation

authors： Bristow MR,Anderson FL,Port JD,Skerl L,Hershberger RE,Larrabee P,O'Connell JB,Renlund DG,Volkman K,Murray J

更新日期：1991-09-01 00:00:00

abstract：BACKGROUND:Congestive heart failure (CHF) is characterized by enhanced immune activation, and immune-mediated mechanisms may play a pathogenic role in this disorder. Based on the immunomodulatory effects of intravenous immunoglobulin (IVIG), we hypothesized that IVIG could downregulate inflammatory responses in CHF pat...

journal_title：Circulation

authors： Gullestad L,Aass H,Fjeld JG,Wikeby L,Andreassen AK,Ihlen H,Simonsen S,Kjekshus J,Nitter-Hauge S,Ueland T,Lien E,Frøland SS,Aukrust P

更新日期：2001-01-16 00:00:00

abstract：:Originally described by Japanese authors in the 1990s, Takotsubo syndrome (TTS) generally presents as an acute myocardial infarction characterized by severe left ventricular dysfunction. TTS, however, differs from an acute coronary syndrome because patients have generally a normal coronary angiogram and left ventricul...

journal_title：Circulation

authors： Pelliccia F,Kaski JC,Crea F,Camici PG

更新日期：2017-06-13 00:00:00

abstract：BACKGROUND:prior studies indicated that ablation of the 4 major atrial ganglionated plexi (GP) suppressed atrial fibrillation. METHODS AND RESULTS:superparamagnetic nanoparticles (MNPs) made of Fe(3)O(4) (core), thermoresponsive polymeric hydrogel (shell), and neurotoxic agent (N-isopropylacrylamide monomer [NIPA-M]) ...

journal_title：Circulation

authors： Yu L,Scherlag BJ,Dormer K,Nguyen KT,Pope C,Fung KM,Po SS

更新日期：2010-12-21 00:00:00

abstract：:Proarrhythmic effects of flecainide acetate have been reported during exercise, but the mechanism for the arrhythmogenic interaction between flecainide and exercise is unknown. We hypothesized that the sinus tachycardia of exercise may enhance flecainide-induced conduction slowing by increasing use-dependent sodium ch...

journal_title：Circulation

authors： Ranger S,Talajic M,Lemery R,Roy D,Nattel S

更新日期：1989-05-01 00:00:00

abstract：BACKGROUND:S100B, a 20-kDa, Ca2+-binding dimer, is a putative intrinsic negative regulator of myocardial hypertrophy expressed after myocardial infarction. S100B-overexpressing transgenic (TG) and S100B-knockout (KO) mice have been generated to assess the consequences of S100B expression and altered hypertrophy after i...

journal_title：Circulation

authors： Tsoporis JN,Marks A,Haddad A,Dawood F,Liu PP,Parker TG

更新日期：2005-02-08 00:00:00

abstract：BACKGROUND:Congenital long-QT syndrome (LQTS) is a primary arrhythmogenic syndrome stemming from perturbed cardiac repolarization. LQTS, which affects approximately 1 in 3000 persons, is 1 of the most common causes of autopsy-negative sudden death in the young. Since the sentinel discovery of cardiac channel gene mutat...

journal_title：Circulation

authors： Vatta M,Ackerman MJ,Ye B,Makielski JC,Ughanze EE,Taylor EW,Tester DJ,Balijepalli RC,Foell JD,Li Z,Kamp TJ,Towbin JA

更新日期：2006-11-14 00:00:00

abstract：:We quantitated the growth patterns of the normal fetal heart and the right and left ventricles from postmortem hearts obtained from 55 spontaneously aborted human fetuses from the completion of cardiogenesis to term. Fetal gestational age was assessed by menstrual history of the mother, crown-rump length, head circumf...

journal_title：Circulation

authors： St John Sutton MG,Raichlen JS,Reichek N,Huff DS

更新日期：1984-12-01 00:00:00

abstract：:Digitalis has been shown to improve the impaired ventricular function associated with coronary artery disease as well as to increase myocardial oxygen consumption and produce coronary vasoconstriction. To elucidate the net result of these contrasting effects, six patients with coronary artery disease and left ventricu...

journal_title：Circulation

authors： Vogel R,Kirch D,LeFree M,Frischknecht J,Steele P

更新日期：1977-09-01 00:00:00

abstract：:Study of the detailed pathology of the myocardium and coronary arteries in ambulatory subjects dying suddenly of coronary heart disease shows that they can be divided into two groups. In one group, there is atherosclerosis with a new vascular event involving coronary thrombosis, which initiates acute myocardial ischem...

journal_title：Circulation

authors： Davies MJ

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:Mild and moderate functional ischemic mitral insufficiency present at the time of surgical revascularization present clinical uncertainty. It is unclear whether the relatively poor outcomes in this cohort are dependent on valvular function or related to left ventricular dysfunction. The purpose of this study...

journal_title：Circulation

authors： Grossi EA,Crooke GA,DiGiorgi PL,Schwartz CF,Jorde U,Applebaum RM,Ribakove GH,Galloway AC,Grau JB,Colvin SB

更新日期：2006-07-04 00:00:00

abstract：:Few data are available regarding the effects of exercise training upon cardiac structure and performance in man. We evaluated the echograms of 24 normals before (PRE) and after (POST) 11 weeks of endurance exercise training. Conditioning consisted of a walk-jog-run protocol at 70% maximal heart rate for one hour four ...

journal_title：Circulation

authors： DeMaria AN,Neumann A,Lee G,Fowler W,Mason DT

更新日期：1978-02-01 00:00:00

abstract：BACKGROUND:We tested the hypothesis that real-time magnetic resonance imaging (MRI) can guide coronary artery catheterization in swine via a percutaneous femoral artery approach. METHODS AND RESULTS:In 12 pigs, we accessed femoral arteries percutaneously. We used 6- or 7-French coronary Judkins catheters filled with d...

journal_title：Circulation

authors： Omary RA,Green JD,Schirf BE,Li Y,Finn JP,Li D

更新日期：2003-06-03 00:00:00

abstract：BACKGROUND:The contractile dysfunction observed in end-stage myocardial hypertrophy has at its base an abnormality in myocyte function. However, whether depressed contractile function is related to an alteration in contractile protein function is presently unknown. METHODS AND RESULTS:Contractile force, tension, and c...

journal_title：Circulation

authors： Fan D,Wannenburg T,de Tombe PP

更新日期：1997-05-06 00:00:00

abstract：BACKGROUND:Cystathionine γ-lyase (CSE) produces H2S via enzymatic conversion of L-cysteine and plays a critical role in cardiovascular homeostasis. We investigated the effects of genetic modulation of CSE and exogenous H2S therapy in the setting of pressure overload-induced heart failure. METHODS AND RESULTS:Transvers...

journal_title：Circulation

authors： Kondo K,Bhushan S,King AL,Prabhu SD,Hamid T,Koenig S,Murohara T,Predmore BL,Gojon G Sr,Gojon G Jr,Wang R,Karusula N,Nicholson CK,Calvert JW,Lefer DJ

更新日期：2013-03-12 00:00:00