Time-series analysis of heart rate variability during submaximal exercise. Evidence for reduced cardiac vagal tone in animals susceptible to ventricular fibrillation.

abstract：:To assess the effects on the heart itself of coronary thrombolysis induced with either tissue-type plasminogen activator (t-PA) or streptokinase (SK), we performed positron emission tomography with 11C-palmitate in 19 patients with initial transmural myocardial infarction immediately after admission and again within 4...

journal_title：Circulation

authors： Sobel BE,Geltman EM,Tiefenbrunn AJ,Jaffe AS,Spadaro JJ Jr,Ter-Pogossian MM,Collen D,Ludbrook PA

更新日期：1984-05-01 00:00:00

abstract：BACKGROUND:The effect of effective refractory period (ERP) shortening on the vulnerability and characteristics of induced functional reentry in the ventricle remain poorly defined. We hypothesized that ERP shortening increases ventricular vulnerability to reentry and accelerates its rate, as is the case in the atrium. ...

journal_title：Circulation

authors： Uchida T,Yashima M,Gotoh M,Qu Z,Garfinkel A,Weiss JN,Fishbein MC,Mandel WJ,Chen PS,Karagueuzian HS

更新日期：1999-02-09 00:00:00

abstract：:This article provides a selective overview of epidemiologic studies on the relationship between psychosocial factors and blood pressure elevation. The review focuses on English-language reports published since 1975 and emphasizes two broad areas of research: changes in mean blood pressures of third world populations u...

journal_title：Circulation

authors： James SA

更新日期：1987-07-01 00:00:00

abstract：BACKGROUND:The mechanism of delayed preconditioning induced by activation of adenosine A(1) receptors (A(1)ARs) is not fully understood. We determined the role of inducible nitric oxide synthase (iNOS) in mediating adenosine-induced late cardioprotection using pharmacological inhibitors and iNOS gene-knockout mice. ME...

journal_title：Circulation

authors： Zhao T,Xi L,Chelliah J,Levasseur JE,Kukreja RC

更新日期：2000-08-22 00:00:00

abstract：BACKGROUND:Improvements are known to occur in right ventricular (RV) ejection fraction after the use of a left ventricular assist device (LVAD); less is known, however, about the mechanism of this improvement. The concept of ventricular/arterial coupling was applied to investigate whether systolic pump function or afte...

journal_title：Circulation

authors： Morita S,Kormos RL,Mandarino WA,Eishi K,Kawai A,Gasior TA,Deneault LG,Armitage JM,Hardesty RL,Griffith BP

更新日期：1992-11-01 00:00:00

abstract：BACKGROUND:Hypercholesterolemia is associated with endothelial dysfunction. On the basis of the hypothesis that high plasma cholesterol per se may be a sufficient stimulus to upregulate endothelial adhesiveness and that this phenomenon might be reversible, soluble endothelial leukocyte adhesion molecules (sELAMs) were ...

journal_title：Circulation

authors： Sampietro T,Tuoni M,Ferdeghini M,Ciardi A,Marraccini P,Prontera C,Sassi G,Taddei M,Bionda A

更新日期：1997-09-02 00:00:00

abstract：BACKGROUND:The T2G1s monoclonal antifibrin antibody binds specifically to fibrin but not to fibrinogen. METHODS AND RESULTS:In a canine model of acute arterial thrombosis, we determined the feasibility of imaging thrombi using a 99mTc-labeled Fab' fragment. In 14 dogs, 10 carotid and 13 femoral artery thrombi were pro...

journal_title：Circulation

authors： Cerqueira MD,Stratton JR,Vracko R,Schaible TF,Ritchie JL

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:Myocardial perfusion during adenosine-induced hyperemia is used both in clinical diagnosis of coronary heart disease and for scientific investigations of the myocardial microcirculation. The objective of this study was to clarify whether adenosine-induced hyperemia is dependent on endothelial NO production o...

journal_title：Circulation

authors： Buus NH,Bøttcher M,Hermansen F,Sander M,Nielsen TT,Mulvany MJ

更新日期：2001-11-06 00:00:00

abstract：:Defibrillation/cardioversion thresholds were measured in 33 patients undergoing defibrillator implants. Each patient had a 12 cm2 patch placed near the left ventricular apex via a thoracotomy and a 10 cm2 spring lead placed pervenously at the right atrial-superior vena caval junction. Ventricular tachycardia of stable...

journal_title：Circulation

authors： Winkle RA,Stinson EB,Bach SM Jr,Echt DS,Oyer P,Armstrong K

更新日期：1984-04-01 00:00:00

abstract：BACKGROUND:Although the use of physical signs for the diagnosis of ventricular tachycardia (VT) was described in the early 1900s, their value in this role has never been systematically assessed. METHODS AND RESULTS:Using a blinded, randomized protocol, we examined the ability of 26 clinicians to detect ventriculoatria...

journal_title：Circulation

authors： Garratt CJ,Griffith MJ,Young G,Curzen N,Brecker S,Rickards AF,Camm AJ

更新日期：1994-12-01 00:00:00

abstract：BACKGROUND:The incidence and cause of sudden cardiac death (SCD) in athletes is debated with hypertrophic cardiomyopathy often reported as the most common cause. METHODS AND RESULTS:A database of all National Collegiate Athletic Association deaths (2003-2013) was developed. Additional information and autopsy reports w...

journal_title：Circulation

authors： Harmon KG,Asif IM,Maleszewski JJ,Owens DS,Prutkin JM,Salerno JC,Zigman ML,Ellenbogen R,Rao AL,Ackerman MJ,Drezner JA

更新日期：2015-07-07 00:00:00

abstract：BACKGROUND:Varicose veins are a common problem with no approved medical therapies. Although it is believed that varicose vein pathogenesis is multifactorial, there is limited understanding of the genetic and environmental factors that contribute to their formation. Large-scale studies of risk factors for varicose veins...

journal_title：Circulation

authors： Fukaya E,Flores AM,Lindholm D,Gustafsson S,Zanetti D,Ingelsson E,Leeper NJ

更新日期：2018-12-18 00:00:00

abstract：:We used Doppler echocardiography to quantitate the changes in intracardiac blood flow velocities and right and left ventricular stroke volumes in 80 normal human fetuses from 19 to 40 weeks gestation. Blood flow velocity spectra across the aortic, pulmonary, tricuspid, and mitral valves were digitized to obtain peak v...

journal_title：Circulation

authors： Kenny JF,Plappert T,Doubilet P,Saltzman DH,Cartier M,Zollars L,Leatherman GF,St John Sutton MG

更新日期：1986-12-01 00:00:00

abstract：:An aneurysm of the membranous septum was found frequently in patients with ventricular septal defect; although appearance at catheterization during infancy was not common, aneurysms were detected in about half of the patients older than 2 years of age. A significant decrease in the left-to-right shunt occurred with th...

journal_title：Circulation

authors： Nugent EW,Freedom RM,Rowe RD,Wagner HR,Rees JK

更新日期：1977-08-01 00:00:00

abstract：:Experimental studies demonstrate that short-term regional perfusion-contraction matching, in which the energy demands of regional myocardial contraction are reduced to match the diminished myocardial substrate supply, occurs during states of low coronary blood flow under resting conditions and during exercise-induced ...

journal_title：Circulation

authors： Ross J Jr

更新日期：1991-03-01 00:00:00

abstract：:Between 1973 and 1983, 90 patients with tricuspid atresia underwent the Fontan operation at the Mayo Clinic. Operative mortality was 12% overall and decreased to 7% during the second 5 year period. At postoperative follow-up of 65 patients (1 to 10 years, mean 4), 50 (86%) of 58 present survivors were in excellent con...

journal_title：Circulation

authors： Mair DD,Rice MJ,Hagler DJ,Puga FJ,McGoon DC,Danielson GK

更新日期：1985-09-01 00:00:00

abstract：BACKGROUND:Catheter-based intrapericardial (IPC) delivery of therapeutic agents has recently been demonstrated. Paclitaxel is known to inhibit vascular smooth muscle cell proliferation. This study examined the effect of IPC instillation of paclitaxel on neointimal proliferation after balloon overstretch of porcine coro...

journal_title：Circulation

authors： Hou D,Rogers PI,Toleikis PM,Hunter W,March KL

更新日期：2000-09-26 00:00:00

abstract：BACKGROUND:Prosthetic valve thrombosis during pregnancy is life-threatening for mother and fetus, and the treatment of this complication is unclear. Cardiac surgery in pregnancy is associated with very high maternal and fetal mortality and morbidity. Thrombolytic therapy has rarely been used in these patients. The aim ...

journal_title：Circulation

authors： Özkan M,Çakal B,Karakoyun S,Gürsoy OM,Çevik C,Kalçık M,Oğuz AE,Gündüz S,Astarcioglu MA,Aykan AÇ,Bayram Z,Biteker M,Kaynak E,Kahveci G,Duran NE,Yıldız M

更新日期：2013-07-30 00:00:00

abstract：BACKGROUND:Thrombi are known to induce activation of the coagulation system, which may be a mechanism for progression of thrombosis and its recurrence after thrombolysis. This study was designed to characterize the relative role of thrombin and activated factor X (factor Xa) as mediators of procoagulant activity of who...

journal_title：Circulation

authors： Prager NA,Abendschein DR,McKenzie CR,Eisenberg PR

更新日期：1995-08-15 00:00:00

abstract：:We assessed the effects of ethanol and autonomic blockade on left ventricular function in nine normal subjects, age 20--35 years, using M-mode echocardiography and systolic time intervals. On day 1, measurements were made of heart rate, mean velocity of circumferential fiber shortening, and left ventricular pre-ejecti...

journal_title：Circulation

authors： Child JS,Kovick RB,Levisman JA,Pearce ML

更新日期：1979-01-01 00:00:00

abstract：BACKGROUND:Cardiovascular disease (CVD) is the leading cause of death in the United States and is responsible for 17% of national health expenditures. As the population ages, these costs are expected to increase substantially. METHODS AND RESULTS:To prepare for future cardiovascular care needs, the American Heart Asso...

journal_title：Circulation

authors： Heidenreich PA,Trogdon JG,Khavjou OA,Butler J,Dracup K,Ezekowitz MD,Finkelstein EA,Hong Y,Johnston SC,Khera A,Lloyd-Jones DM,Nelson SA,Nichol G,Orenstein D,Wilson PW,Woo YJ,American Heart Association Advocacy Coordinating

更新日期：2011-03-01 00:00:00

abstract：:Thirteen male patients with NYHA class IV congestive heart failure refractory to conventional therapy were treated with oral fenoximone, a new imidazole compound with inotropic and vasodilator effects, for a mean duration of 11 weeks (range 2 to 34). On initial hemodynamic evaluation, the effects of oral fenoximone we...

journal_title：Circulation

authors： Shah PK,Amin DK,Hulse S,Shellock F,Swan HJ

更新日期：1985-02-01 00:00:00

abstract：:Transthyretin amyloid cardiomyopathy (ATTR-CM) results in a restrictive cardiomyopathy caused by extracellular deposition of transthyretin, normally involved in the transportation of the hormone thyroxine and retinol-binding protein, in the myocardium. Enthusiasm about ATTR-CM has grown as a result of 3 simultaneous a...

journal_title：Circulation

authors： Kittleson MM,Maurer MS,Ambardekar AV,Bullock-Palmer RP,Chang PP,Eisen HJ,Nair AP,Nativi-Nicolau J,Ruberg FL,American Heart Association Heart Failure and Transplantation Committee of the Council on Clinical Cardiology.

更新日期：2020-07-07 00:00:00

abstract：BACKGROUND:Bereavement is a period of increased risk of cardiovascular death. There is limited understanding of the potential contribution of quality of cardiovascular disease management to this increased risk. METHODS AND RESULTS:In a UK primary-care database, 12 722 older individuals with preexisting cardiovascular ...

journal_title：Circulation

authors： Shah SM,Carey IM,Harris T,Dewilde S,Victor CR,Cook DG

更新日期：2013-12-24 00:00:00

abstract：BACKGROUND:Multiple excitation wavelets are present during ventricular fibrillation (VF). The underlying wavelet organization of VF is unclear. Phase singularities (PSs)-locations of ambiguous activation state-underlie reentry and wavelet splitting and represent the sources of VF. Understanding the mechanisms of PS for...

journal_title：Circulation

authors： Valderrábano M,Chen PS,Lin SF

更新日期：2003-07-22 00:00:00

abstract：:Scanning and transmission electron microscopic studies were made of: 1) 15 glutaraldehyde-treated porcine valvular heterografts that had been implanted in patients for periods of time ranging from 2 days to 76 months; 2) unimplanted, commercially processed porcine aortic valves; and 3) unprocessed porcine aortic valve...

journal_title：Circulation

authors： Ferrans VJ,Spray TL,Billingham ME,Roberts WC

更新日期：1978-09-01 00:00:00

abstract：BACKGROUND:Human cardiac troponin I is known to be phosphorylated at multiple amino acid residues by several kinases. Advances in mass spectrometry allow sensitive detection of known and novel phosphorylation sites and measurement of the level of phosphorylation simultaneously at each site in myocardial samples. METHO...

journal_title：Circulation

authors： Zhang P,Kirk JA,Ji W,dos Remedios CG,Kass DA,Van Eyk JE,Murphy AM

更新日期：2012-10-09 00:00:00

abstract：BACKGROUND:This experiment sought to determine the effects of fish oil on superoxide anion production in the myocardium and coronary arteries of atherosclerotic monkeys. Recent evidence indicates that dietary supplementation with fish oil preserves normal vasomotion of atherosclerotic coronary arteries and reduces dama...

journal_title：Circulation

authors： Supari F,Ungerer T,Harrison DG,Williams JK

更新日期：1995-02-15 00:00:00

abstract：BACKGROUND:Heart failure (HF) is responsible for a huge burden in hospital care. Our goal was to evaluate the value of N-terminal-pro-brain natriuretic peptide (NT-proBNP) in predicting death or hospital readmission after discharge of HF patients. METHODS AND RESULTS:We included 182 patients consecutively admitted to ...

journal_title：Circulation

authors： Bettencourt P,Azevedo A,Pimenta J,Friões F,Ferreira S,Ferreira A

更新日期：2004-10-12 00:00:00

abstract：:Calcium metabolism may play an important role in the pathogenesis of myocardial ischemic injury. The effect of the sarcolemmal calcium flux inhibitor, verapamil, on myocardial necrosis was studied in dogs subjected to temporary coronary artery occlusion. One group of dogs was untreated. A second group was given 0.8 mg...

journal_title：Circulation

authors： Reimer KA,Lowe JE,Jennings RB

更新日期：1977-04-01 00:00:00