Anatomic features in victims of sudden coronary death. Coronary artery pathology.

abstract：:We studied isochronal maps of ventricular activation during ventricular arrhythmias induced by programmed premature stimulation in dogs 3-5 days after ligation of the left anterior descending coronary artery. The entire epicardial surface and selective intramural sites were recorded using a computerized multiplexing t...

journal_title：Circulation

authors： Mehra R,Zeiler RH,Gough WB,El-Sherif N

更新日期：1983-01-01 00:00:00

abstract：:Between 1970 and 1987, 112 patients were diagnosed as having thromboangiitis obliterans (TAO). The age was 42 +/- 11 years (mean +/- SD; range, 20-75 years); 23% were women, and 7% were more than 60 years old when they were first diagnosed. Ischemic ulcerations were present in 85 (76%) patients: 24 (28%) patients with...

journal_title：Circulation

authors： Olin JW,Young JR,Graor RA,Ruschhaupt WF,Bartholomew JR

更新日期：1990-11-01 00:00:00

abstract：BACKGROUND:The myocardial velocity gradient (MVG) is a recent index of regional myocardial function derived from endocardial and epicardial velocities obtained by tissue Doppler imaging (TDI). This index might be useful for discriminating between physiological and pathological left ventricular hypertrophy (LVH) and for...

journal_title：Circulation

authors： Derumeaux G,Mulder P,Richard V,Chagraoui A,Nafeh C,Bauer F,Henry JP,Thuillez C

更新日期：2002-04-02 00:00:00

abstract：BACKGROUND:Glycosphingolipids, integral components of the cell membrane, have been shown to serve as messengers, transducing growth factor-initiated phenotypes. Here, we have examined whether inhibition of glycosphingolipid synthesis could ameliorate atherosclerosis and arterial stiffness in transgenic mice and rabbits...

journal_title：Circulation

authors： Chatterjee S,Bedja D,Mishra S,Amuzie C,Avolio A,Kass DA,Berkowitz D,Renehan M

更新日期：2014-06-10 00:00:00

abstract：BACKGROUND:The pathogenesis of impaired endothelium-dependent coronary vasodilation in angina pectoris and normal coronary arteriograms (microvascular angina pectoris) is not known. We examined whether supplementation with L-arginine, a precursor of endothelium-derived nitric oxide, improves endothelium-dependent coron...

journal_title：Circulation

authors： Egashira K,Hirooka Y,Kuga T,Mohri M,Takeshita A

更新日期：1996-07-15 00:00:00

abstract：BACKGROUND:Cellular electrophysiological alterations may contribute to arrhythmogenesis in cardiac hypertrophy. An L-like current occurs in left ventricular myocytes (LVMs) isolated from the hypertrophied heart of old spontaneously hypertensive rats (SHR). Factors that influence L occurrence during development of cardi...

journal_title：Circulation

authors： Cerbai E,Barbieri M,Mugelli A

更新日期：1996-10-01 00:00:00

abstract：BACKGROUND:Previous investigators have shown that systemic markers of inflammation may be increased in patients with acute ischemic syndromes or after percutaneous coronary revascularization and that persistent elevation in these markers is predictive of excess risk of subsequent adverse cardiac events. By virtue of it...

journal_title：Circulation

authors： Lincoff AM,Kereiakes DJ,Mascelli MA,Deckelbaum LI,Barnathan ES,Patel KK,Frederick B,Nakada MT,Topol EJ

更新日期：2001-07-10 00:00:00

abstract：BACKGROUND:The use of bipolar endocardial electrogram characteristics to guide radiofrequency (RF) current catheter ablation of accessory pathways (APs) has been advocated by several investigators. However, the influences of a varying anatomy of the AP and the atrioventricular groove, of different ablative approaches, ...

journal_title：Circulation

authors： Cappato R,Schlüter M,Mont L,Kuck KH

更新日期：1994-08-01 00:00:00

abstract：:The first stage of a repair of pulmonary atresia with intact ventricular septum (type I) was attempted in a 2-day-old infant. At surgery, decompression of the hypertensive small right ventricle was followed by a sudden loss of myocardial contractility and death. Postmortem examination revealed a fistula with a large o...

journal_title：Circulation

authors： O'Connor WN,Cottrill CM,Johnson GL,Noonan JA,Todd EP

更新日期：1982-04-01 00:00:00

abstract：BACKGROUND:Observational studies suggest that there are differences in adherence to antihypertensive medications in different classes. Our objective was to quantify the association between antihypertensive drug class and adherence in clinical settings. METHODS AND RESULTS:Studies were identified through a systematic s...

journal_title：Circulation

authors： Kronish IM,Woodward M,Sergie Z,Ogedegbe G,Falzon L,Mann DM

更新日期：2011-04-19 00:00:00

abstract：BACKGROUND:To explore roles of endogenous atrial natriuretic peptide (ANP) in blood pressure and volume regulation, we examined the effects of a newly developed ANP antagonist, HS-142-1 (HS) in deoxycorticosterone acetate (DOCA)-salt hypertensive rats. METHODS AND RESULTS:We examined 1) the effects of HS on ANP- or br...

journal_title：Circulation

authors： Hirata Y,Matsuoka H,Suzuki E,Hayakawa H,Sugimoto T,Matsuda Y,Morishita Y,Kangawa K,Minamino N,Matsuo H

更新日期：1993-02-01 00:00:00

abstract：BACKGROUND:Paroxysmal atrial fibrillation (PAF) can be eliminated with continuous circular lesions (CCLs) around the pulmonary veins (PVs), but it is unclear whether all PVs are completely isolated. METHODS AND RESULTS:Forty-one patients with symptomatic PAF underwent 3D mapping, and all PV ostia were marked on the 3D...

journal_title：Circulation

authors： Ouyang F,Bänsch D,Ernst S,Schaumann A,Hachiya H,Chen M,Chun J,Falk P,Khanedani A,Antz M,Kuck KH

更新日期：2004-10-12 00:00:00

abstract：BACKGROUND:With MRI, an index of myocardial perfusion reserve (MPRI) can be determined. We assessed the value of this technique for the noninvasive detection of coronary artery disease (CAD) in patients with suspected CAD. METHODS AND RESULTS:Eighty-four patients referred for a primary diagnostic coronary angiography ...

journal_title：Circulation

authors： Nagel E,Klein C,Paetsch I,Hettwer S,Schnackenburg B,Wegscheider K,Fleck E

更新日期：2003-07-29 00:00:00

abstract：BACKGROUND:We examined the relationship between hypertension subtype and cardiovascular disease incidence and mortality in Chinese adults. METHODS AND RESULTS:We conducted a prospective cohort study in a nationally representative sample of 169 871 Chinese men and women aged >or=40 years. Data on systolic (SBP) and dia...

journal_title：Circulation

authors： Kelly TN,Gu D,Chen J,Huang JF,Chen JC,Duan X,Wu X,Yau CL,Whelton PK,He J

更新日期：2008-10-07 00:00:00

abstract：:The effects of verapamil (0.02-0.2 mg/kg) on contractility in normal and partially ischemic myocardium were compared with the changes following propranolol (0.01-1.0 mg/kg). Regional contractile function was studied in open-chest dogs with ultrasonic crystals and ischemia was controlled by graded occlusion of a caroti...

journal_title：Circulation

authors： Smith HJ,Goldstein RA,Griffith JM,Kent KM,Epstein SE

更新日期：1976-10-01 00:00:00

abstract：BACKGROUND:Genetic testing for long-QT syndrome (LQTS) has diagnostic, prognostic, and therapeutic implications. Hundreds of causative mutations in 12 known LQTS-susceptibility genes have been identified. Genetic testing that includes the 3 most commonly mutated genes is available clinically. Distinguishing pathogenic ...

journal_title：Circulation

authors： Kapa S,Tester DJ,Salisbury BA,Harris-Kerr C,Pungliya MS,Alders M,Wilde AA,Ackerman MJ

更新日期：2009-11-03 00:00:00

abstract：:To evaluate the potential advantages of thallium-201 (201T1) single-photon emission computerized tomography (SPECT) to assess myocardial infarct size in the experimental animal, six normal dogs and 14 dogs with 6 to 8 hr closed-chest coronary occlusion (eight left anterior descending and six left circumflex) were stud...

journal_title：Circulation

authors： Prigent F,Maddahi J,Garcia EV,Satoh Y,Van Train K,Berman DS

更新日期：1986-10-01 00:00:00

abstract：:We studied six patients who suffered from angina pectoris but had angiographically patent major coronary arteries. Two of the patients suffered also from congestive heart failure. Three patients had supraventricular tachyarrhythmias. Three patients had conduction disturbances. During coronary angiography the patients ...

journal_title：Circulation

authors： Mosseri M,Yarom R,Gotsman MS,Hasin Y

更新日期：1986-11-01 00:00:00

abstract：:Direct examination of the aortic orifice at the level of the aortic valves (aortic valvular orifice area, AVOA) in the short-axis plane was performed with a 3 MHz two-dimensional pulsed Doppler echocardiographic apparatus. The AVOA was mapped with the Doppler gate to detect or rule out the presence of a regurgitant ao...

journal_title：Circulation

authors： Veyrat C,Lessana A,Abitbol G,Ameur A,Benaim R,Kalmanson D

更新日期：1983-11-01 00:00:00

abstract：:Although ST-segment abnormalities during acute myocardial infarction are clinically important, the total thoracic distribution of these repolarization potentials has not been reported. To provide this information, 24 patients with acute myocardial infarction were studied. Isopotential body surface maps were constructe...

journal_title：Circulation

authors： Mirvis DM

更新日期：1980-10-01 00:00:00

abstract：BACKGROUND:More than 300 000 out-of-hospital cardiac arrests (OHCA) occur each year in the United States. The relationship between time of day and OHCA outcomes in the prehospital setting is unknown. Any such association may have important implications for emergency medical services resource allocation. METHODS AND RE...

journal_title：Circulation

authors： Wallace SK,Abella BS,Shofer FS,Leary M,Agarwal AK,Mechem CC,Gaieski DF,Becker LB,Neumar RW,Band RA

更新日期：2013-04-16 00:00:00

abstract：BACKGROUND:Epidemiological studies and animal experiments have provided evidence supporting the role of lipid peroxidation in atherogenesis and cardiovascular diseases. Direct evidence linking lipid oxidation to atherosclerotic progression in humans, however, has been lacking. We investigated the association of lipid o...

journal_title：Circulation

authors： Salonen JT,Nyyssönen K,Salonen R,Porkkala-Sarataho E,Tuomainen TP,Diczfalusy U,Björkhem I

更新日期：1997-02-18 00:00:00

abstract：BACKGROUND:Microvascular dysfunction in hypertrophic cardiomyopathy (HCM) may create an ischemic substrate conducive to sudden death, but it remains unknown whether the extent of hypertrophy is associated with proportionally poorer perfusion reserve. Comparisons between magnitude of hypertrophy, impairment of perfusion...

journal_title：Circulation

authors： Petersen SE,Jerosch-Herold M,Hudsmith LE,Robson MD,Francis JM,Doll HA,Selvanayagam JB,Neubauer S,Watkins H

更新日期：2007-05-08 00:00:00

abstract：BACKGROUND:Platelet-thrombus formation is a complication of arterial wall deep injury by balloon angioplasty that may lead to acute arterial occlusion and may contribute to restenosis. METHODS AND RESULTS:Because common platelet-inhibitor drugs with a heparin bolus (100 units/kg) may be effective in inhibiting platele...

journal_title：Circulation

authors： Lam JY,Chesebro JH,Steele PM,Heras M,Webster MW,Badimon L,Fuster V

更新日期：1991-08-01 00:00:00

abstract：BACKGROUND:Elevated lipoprotein (Lp) (a) concentrations are associated with coronary artery disease and myocardial infarction. Lp(a) is structurally related to proteins involved in lipid transport, fibrinolysis, coagulation, and cellular mitogenesis and is known to have important physiological interactions with the coa...

journal_title：Circulation

authors： Desmarais RL,Sarembock IJ,Ayers CR,Vernon SM,Powers ER,Gimple LW

更新日期：1995-03-01 00:00:00

abstract：BACKGROUND:Myocardial perfusion reflects the macro- and microvascular coronary circulation. Recent quantitation developments using cardiovascular magnetic resonance perfusion permit automated measurement clinically. We explored the prognostic significance of stress myocardial blood flow (MBF) and myocardial perfusion r...

journal_title：Circulation

authors： Knott KD,Seraphim A,Augusto JB,Xue H,Chacko L,Aung N,Petersen SE,Cooper JA,Manisty C,Bhuva AN,Kotecha T,Bourantas CV,Davies RH,Brown LAE,Plein S,Fontana M,Kellman P,Moon JC

更新日期：2020-04-21 00:00:00

abstract：BACKGROUND:Aging is associated with increased cardiovascular risk and endothelial dysfunction. Since exercise can improve endothelium-dependent vasodilation, in the present study we tested whether long-term physical activity could prevent aging-related endothelial dysfunction. METHODS AND RESULTS:In 12 young and elder...

journal_title：Circulation

authors： Taddei S,Galetta F,Virdis A,Ghiadoni L,Salvetti G,Franzoni F,Giusti C,Salvetti A

更新日期：2000-06-27 00:00:00

abstract：BACKGROUND:The association of anticardiolipin (aCL) antibodies with coronary artery disease has been shown in several studies but remains controversial. We evaluated the association of aCL and anti-beta(2)-glycoprotein I (abeta(2)GPI) antibodies with the risk of recurrent cardiac events in postinfarction patients. MET...

journal_title：Circulation

authors： Bili A,Moss AJ,Francis CW,Zareba W,Watelet LF,Sanz I

更新日期：2000-09-12 00:00:00

abstract：:To determine the effects of coronary angioplasty on coronary flow reserve (CFR), we studied 32 patients before and immediately after single-vessel coronary angioplasty and 31 patients evaluated late after angioplasty (7.5 +/- 1.2 months, mean +/- SEM). The geometry (percent area stenosis and minimal cross-sectional ar...

journal_title：Circulation

authors： Wilson RF,Johnson MR,Marcus ML,Aylward PE,Skorton DJ,Collins S,White CW

更新日期：1988-04-01 00:00:00

abstract：BACKGROUND:Associations between left ventricular (LV) geometry and the insulin resistance syndrome have been found, mostly in small studies of middle-aged hypertensives. The purpose of this study was to elucidate these associations through the use of a large sample of elderly men. METHODS AND RESULTS:We investigated 4...

journal_title：Circulation

authors： Sundström J,Lind L,Nyström N,Zethelius B,Andrén B,Hales CN,Lithell HO

更新日期：2000-06-06 00:00:00