Quantification of myocardial infarct size by thallium-201 single-photon emission computed tomography: experimental validation in the dog.

abstract：BACKGROUND:We investigated the feasibility and efficacy of polyethylenimine (PEI) based human vascular endothelial growth factor-165 (hVEGF165) gene transfer into human skeletal myoblasts (HSM) for cell based delivery to the infarcted myocardium. METHODS AND RESULTS:Based on optimized transfection procedure using enha...

journal_title：Circulation

authors： Ye L,Haider HKh,Tan R,Toh W,Law PK,Tan W,Su L,Zhang W,Ge R,Zhang Y,Lim Y,Sim EK

更新日期：2007-09-11 00:00:00

abstract：BACKGROUND:We conducted a 10-year follow-up of the 11 712 patients with acute myocardial infarction randomized in the Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto-1 study, the first large trial assessing thrombolytic therapy. METHODS AND RESULTS:Information on survival at 10 years was obtained for th...

journal_title：Circulation

authors： Franzosi MG,Santoro E,De Vita C,Geraci E,Lotto A,Maggioni AP,Mauri F,Rovelli F,Santoro L,Tavazzi L,Tognoni G

更新日期：1998-12-15 00:00:00

abstract：BACKGROUND:Although metabolomic profiling offers promise for the prediction of coronary heart disease (CHD), and metabolic risk factors are more strongly associated with CHD in women than men, limited data are available for women. METHODS:We applied a liquid chromatography-tandem mass spectrometry metabolomics platfor...

journal_title：Circulation

authors： Paynter NP,Balasubramanian R,Giulianini F,Wang DD,Tinker LF,Gopal S,Deik AA,Bullock K,Pierce KA,Scott J,Martínez-González MA,Estruch R,Manson JE,Cook NR,Albert CM,Clish CB,Rexrode KM

更新日期：2018-02-20 00:00:00

abstract：BACKGROUND:The pathophysiology of mental stress-induced myocardial ischemia, which occurs at lower heart rates than during physical stress, is not well understood. METHODS AND RESULTS:The Psychophysiological Investigations of Myocardial Ischemia Study (PIMI) evaluated the physiological and neuroendocrine functioning i...

journal_title：Circulation

authors： Goldberg AD,Becker LC,Bonsall R,Cohen JD,Ketterer MW,Kaufman PG,Krantz DS,Light KC,McMahon RP,Noreuil T,Pepine CJ,Raczynski J,Stone PH,Strother D,Taylor H,Sheps DS

更新日期：1996-11-15 00:00:00

abstract：BACKGROUND:Although prospective studies, systematic reviews, and meta-analyses have documented an association between depression and increased morbidity and mortality in a variety of cardiac populations, depression has not yet achieved formal recognition as a risk factor for poor prognosis in patients with acute corona...

journal_title：Circulation

authors： Lichtman JH,Froelicher ES,Blumenthal JA,Carney RM,Doering LV,Frasure-Smith N,Freedland KE,Jaffe AS,Leifheit-Limson EC,Sheps DS,Vaccarino V,Wulsin L,American Heart Association Statistics Committee of the Council on Epidemiology an

更新日期：2014-03-25 00:00:00

abstract：BACKGROUND:Obstruction to left ventricular outflow can be seen after surgical repair of congenital heart disease in which a ventricular septal defect (VSD) is closed by means of a baffle to the systemic great artery arising from the right ventricle (Rastelli operation, intraventricular repair, for conotruncal anomaly)....

journal_title：Circulation

authors： Rychik J,Jacobs ML,Norwood WI

更新日期：1994-11-01 00:00:00

abstract：BACKGROUND:The specific role of apoptosis in human atherosclerosis remains unknown. During apoptotic cell death, phosphatidylserine exposure on the cell surface confers a high tissue-factor (TF)-dependent procoagulant activity. METHODS AND RESULTS:In this study, we examined the role of apoptotic cell death in the prom...

journal_title：Circulation

authors： Mallat Z,Hugel B,Ohan J,Lesèche G,Freyssinet JM,Tedgui A

更新日期：1999-01-26 00:00:00

abstract：BACKGROUND:Although several prospective cohort studies have found an inverse association between fish consumption and risk of coronary heart disease (CHD) or sudden cardiac death in the general population, limited data are available among diabetic patients. METHODS AND RESULTS:We examined prospectively the association...

journal_title：Circulation

authors： Hu FB,Cho E,Rexrode KM,Albert CM,Manson JE

更新日期：2003-04-15 00:00:00

abstract：BACKGROUND:The identification of sites of dominant activation frequency during atrial fibrillation (AF) in humans and the effect of ablation at these sites have not been reported. METHODS AND RESULTS:Thirty-two patients undergoing AF ablation (19 paroxysmal, 13 permanent) during ongoing arrhythmia were studied. Electr...

journal_title：Circulation

authors： Sanders P,Berenfeld O,Hocini M,Jaïs P,Vaidyanathan R,Hsu LF,Garrigue S,Takahashi Y,Rotter M,Sacher F,Scavée C,Ploutz-Snyder R,Jalife J,Haïssaguerre M

更新日期：2005-08-09 00:00:00

abstract：BACKGROUND:C-reactive protein (CRP) may have proatherogenic but also vasoprotective properties. We tested the hypothesis that the configuration of CRP (pentameric, or native [nCRP], versus monomeric, or modified [mCRP]) determines these different characteristics in an in vivo model. METHODS AND RESULTS:We investigated...

journal_title：Circulation

authors： Schwedler SB,Amann K,Wernicke K,Krebs A,Nauck M,Wanner C,Potempa LA,Galle J

更新日期：2005-08-16 00:00:00

abstract：BACKGROUND:Proto-oncogenes have been implicated in the pathogenesis of gene-mediated myocardial remodeling. In the human heart, however, it has not been clarified whether these proto-oncogenes are related to contractile impairment and structural alteration of the myocardium. The present study is designed to investigate...

journal_title：Circulation

authors： Taketani S,Sawa Y,Taniguchi K,Mitsuno M,Kawaguchi N,Onishi S,Matsuda H

更新日期：1997-11-04 00:00:00

abstract：BACKGROUND:The safety and efficacy of percutaneous coronary intervention of de novo lesions in unprotected left main coronary arteries remains an unresolved issue. METHODS AND RESULTS:We analyzed 67 consecutive patients treated with the following devices: 39 with stents, 12 with rotational atherectomy plus stents, 13 ...

journal_title：Circulation

authors： Takagi T,Stankovic G,Finci L,Toutouzas K,Chieffo A,Spanos V,Liistro F,Briguori C,Corvaja N,Albero R,Sivieri G,Paloschi R,Di Mario C,Colombo A

更新日期：2002-08-06 00:00:00

abstract：BACKGROUND:Therapy with racemic compounds produces effects that can be attributed to both (S)- and (R)-enantiomers. Here we have tested the hypothesis that an enantiomer-enantiomer interaction would modulate the effects of treatment with a racemate, the antiarrhythmic propafenone. Previous studies have shown that while...

journal_title：Circulation

authors： Kroemer HK,Fromm MF,Bühl K,Terefe H,Blaschke G,Eichelbaum M

更新日期：1994-05-01 00:00:00

abstract：BACKGROUND:Analyses from randomized controlled trials suggest that bleeding in patients with acute myocardial infarction is associated with poor outcomes. Because these data are not generalizable to all patients with acute myocardial infarction, we sought to better understand the scope of this problem in a "real-world"...

journal_title：Circulation

authors： Spencer FA,Moscucci M,Granger CB,Gore JM,Goldberg RJ,Steg PG,Goodman SG,Budaj A,FitzGerald G,Fox KA,GRACE Investigators.

更新日期：2007-12-11 00:00:00

abstract：BACKGROUND:Myocardial salvage is most likely to occur when thrombolytic therapy is administered within 4 to 6 hours of the onset of symptoms of myocardial infarction. The impact of delays within this early time period on final myocardial infarct size are unknown. The purpose of this study was to quantitate the relation...

journal_title：Circulation

authors： Raitt MH,Maynard C,Wagner GS,Cerqueira MD,Selvester RH,Weaver WD

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND:Although autonomic imbalance is known to be characteristics of patients with clinically overt symptomatic congestive heart failure, it is currently unknown whether this autonomic response arises early in the course of left ventricular dysfunction or is restricted to the later stages of circulatory failure. ...

journal_title：Circulation

authors： Eaton GM,Cody RJ,Nunziata E,Binkley PF

更新日期：1995-08-01 00:00:00

abstract：BACKGROUND:Extracorporeal circulation with circuits coated with surface-bound heparin has allowed reduced levels of systemic heparinization. Clinical benefits have included reduced postoperative bleeding and less homologous blood usage. However, the effects on the hemostatic and fibrinolytic systems have remained in pa...

journal_title：Circulation

authors： Ovrum E,Brosstad F,Am Holen E,Tangen G,Abdelnoor M

更新日期：1995-11-01 00:00:00

abstract：:Considerable variability was observed among recruitment sources and centers in the proportion of first protocol visits proceeding to entry. Some of the reasons for these differences are explored. Several characteristics of the participants were also analyzed to determine whether significant variability existed among r...

journal_title：Circulation

authors： Hunninghake DB,Knoke J,LaDouceur M,Peterson F

更新日期：1982-12-01 00:00:00

abstract：:From November 1981 to November 1982, intra-aortic balloon pumping (IABP) was used after surgery in eight patients who were from 6 weeks to 6 years old and who weighed from 4.2 to 16.2 kg. In seven patients, specially constructed intra-aortic balloons with 2.5 and 5.0 ml volumes mounted on No. 5F catheters were used. I...

journal_title：Circulation

authors： Veasy LG,Blalock RC,Orth JL,Boucek MM

更新日期：1983-11-01 00:00:00

abstract：:The reduced responsiveness of the renin-angiotensin system to hemodynamic changes in patients with congestive heart failure (CHF) could be due to a defect of the juxtaglomerular apparatus. To test this hypothesis, the responses to viprostol, an analog of prostaglandin E2 (PGE2) that is known to stimulate both the macu...

journal_title：Circulation

authors： Olivari MT,Levine TB,Cohn JN

更新日期：1986-12-01 00:00:00

abstract：BACKGROUND:Patients with chronic granulomatous disease (CGD) experience immunodeficiency because of defects in the phagocyte NADPH oxidase and the concomitant reduction in reactive oxygen intermediates. This may result in a reduction in atherosclerotic injury. METHODS AND RESULTS:We prospectively assessed the prevalen...

journal_title：Circulation

authors： Sibley CT,Estwick T,Zavodni A,Huang CY,Kwan AC,Soule BP,Long Priel DA,Remaley AT,Rudman Spergel AK,Turkbey EB,Kuhns DB,Holland SM,Malech HL,Zarember KA,Bluemke DA,Gallin JI

更新日期：2014-12-02 00:00:00

abstract：BACKGROUND:Heart failure is a growing cause of morbidity and mortality worldwide. Transforming growth factor beta (TGF-β1) promotes cardiac fibrosis, but also activates counterregulatory pathways that serve to regulate TGF-β1 activity in heart failure. Bone morphogenetic protein 9 (BMP9) is a member of the TGFβ family ...

journal_title：Circulation

authors： Morine KJ,Qiao X,York S,Natov PS,Paruchuri V,Zhang Y,Aronovitz MJ,Karas RH,Kapur NK

更新日期：2018-07-31 00:00:00

abstract：BACKGROUND:Inducible nitric oxide synthase (iNOS, or NOS2) reduces the severity of accelerated graft arteriosclerosis (AGA) in transplanted organs, although the precise mechanism is unclear. METHODS AND RESULTS:We transplanted wild-type murine hearts into either wild-type or NOS2-null recipient mice; we then measured ...

journal_title：Circulation

authors： Qian Z,Gelzer-Bell R,Yang Sx SX,Cao W,Ohnishi T,Wasowska BA,Hruban RH,Rodriguez ER,Baldwin WM 3rd,Lowenstein CJ

更新日期：2001-11-06 00:00:00

abstract：BACKGROUND:A low ankle-arm index (AAI) is a strong predictor of mortality and cardiovascular events. A high AAI also appears to be associated with higher mortality risk in select populations. However, mortality and cardiovascular risk across the AAI spectrum have not been described in a more broadly defined population....

journal_title：Circulation

authors： O'Hare AM,Katz R,Shlipak MG,Cushman M,Newman AB

更新日期：2006-01-24 00:00:00

abstract：:Exercise trials in cardiology are often hindered by inconsistent approaches to exercise testing. These inconsistencies include the choice of exercise protocol, exercise end points, points of analysis, and absence or misuse of gas exchange data. Gas exchange techniques greatly enhance the accuracy with which cardiopulm...

journal_title：Circulation

authors： Myers J,Froelicher VF

更新日期：1990-11-01 00:00:00

abstract：BACKGROUND:Prosthetic valve thrombosis during pregnancy is life-threatening for mother and fetus, and the treatment of this complication is unclear. Cardiac surgery in pregnancy is associated with very high maternal and fetal mortality and morbidity. Thrombolytic therapy has rarely been used in these patients. The aim ...

journal_title：Circulation

authors： Özkan M,Çakal B,Karakoyun S,Gürsoy OM,Çevik C,Kalçık M,Oğuz AE,Gündüz S,Astarcioglu MA,Aykan AÇ,Bayram Z,Biteker M,Kaynak E,Kahveci G,Duran NE,Yıldız M

更新日期：2013-07-30 00:00:00

abstract：BACKGROUND:Several of the theories on the pathogenesis of atherosclerosis may be integrated into a single multifactorial one. According to this theory, the most likely sequence of events involved in early atherosclerosis is vascular dysfunction and/or injury, monocyte recruitment and macrophage formation, lipid deposit...

journal_title：Circulation

authors： Badimon JJ,Fuster V,Chesebro JH,Badimon L

更新日期：1993-03-01 00:00:00

abstract：BACKGROUND:Single premature beats were introduced in the reentrant circuit during stable atrial flutter in the canine sterile pericarditis model to test the hypotheses that (1) despite the fact that the reentrant circuit is functionally determined, there is a fully excitable gap; (2) the excitable gap in the reentrant ...

journal_title：Circulation

authors： Niwano S,Ortiz J,Abe H,Gonzalez X,Rudy Y,Waldo AL

更新日期：1994-10-01 00:00:00

abstract：:Genetic analysis can be performed to identify the molecular substrate of inherited arrhythmogenic diseases; however, the role of this information in helping the management of patients is still debated. Here, we support the view that the practical value of genetic analysis is different in the various inherited conditio...

journal_title：Circulation

authors： Priori SG,Napolitano C

更新日期：2006-02-28 00:00:00

abstract：BACKGROUND:Depression is an independent risk factor for myocardial infarction (MI). Selective serotonin reuptake inhibitors (SSRIs) may reduce this risk through attenuation of serotonin-mediated platelet activation in addition to treatment of depression itself. METHODS AND RESULTS:case-control study of first MI in smo...

journal_title：Circulation

authors： Sauer WH,Berlin JA,Kimmel SE

更新日期：2001-10-16 00:00:00