Abstract:
BACKGROUND:Paroxysmal atrial fibrillation (PAF) can be eliminated with continuous circular lesions (CCLs) around the pulmonary veins (PVs), but it is unclear whether all PVs are completely isolated. METHODS AND RESULTS:Forty-one patients with symptomatic PAF underwent 3D mapping, and all PV ostia were marked on the 3D map based on venography. Irrigated radiofrequency energy was applied at a distance from the PV ostia guided by 2 Lasso catheters placed within the ipsilateral superior and inferior PVs. The mean radiofrequency duration was 1550+/-511 seconds for left-sided PVs and 1512+/-506 seconds for right-sided PVs. After isolation, automatic activity was observed in the right-sided PVs in 87.8% and in the left-sided PVs in 80.5%. During the procedure, a spontaneous or induced PV tachycardia (PVT) with a cycle length of 189+/-29 ms was observed in 19 patients. During a mean follow-up of 6 months, atrial tachyarrhythmias recurred in 10 patients. Nine patients underwent a repeat procedure. Conduction gaps in the left CCL in 9 patients and in the right CCL in 2 patients were closed during the second procedure. A spontaneous PVT with a cycle length of 212+/-44 ms was demonstrated in 7 of 9 patients, even though no PVT had been observed in 6 of these 7 patients during the first procedure. No AF recurred in 39 patients after PV isolation during follow-up. CONCLUSIONS:Automatic activity and fast tachycardia within the PVs could reflect an arrhythmogenic substrate in patients with PAF, which could be eliminated by isolating all PVs with CCLs guided by 3D mapping and the double-Lasso technique in the majority of patients.
journal_name
Circulationjournal_title
Circulationauthors
Ouyang F,Bänsch D,Ernst S,Schaumann A,Hachiya H,Chen M,Chun J,Falk P,Khanedani A,Antz M,Kuck KHdoi
10.1161/01.CIR.0000144459.37455.EEsubject
Has Abstractpub_date
2004-10-12 00:00:00pages
2090-6issue
15eissn
0009-7322issn
1524-4539pii
01.CIR.0000144459.37455.EEjournal_volume
110pub_type
杂志文章相关文献
CIRCULATION文献大全abstract::This study examined quantitative regional myocardial perfusion (RMP) measured by the washout of 133Xe at rest and after an isoproterenol challenge in 50 patients (group I) studied 8 to 14 days after they underwent saphenous vein bypass grafting to the left coronary artery, and compared this with RMP measured in the na...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.71.4.767
更新日期:1985-04-01 00:00:00
abstract::To evaluate possible occult myocardial disease in 18 patients whose only major manifestation of heart disease was spontaneous ventricular tachycardia or fibrillation, right ventricular endomyocardial biopsies were performed. None of the patients had symptoms of ischemic or congestive heart disease, and at catheterizat...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.68.6.1171
更新日期:1983-12-01 00:00:00
abstract:BACKGROUND:Myocardial uptake of either 201Tl or 99mTc-sestamibi (sestamibi) is known to plateau at high coronary flow rates. However, few direct comparisons have been made between these tracers to determine what effect differences in the uptake plateau for the two tracers may have on the detection of coronary stenoses ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.91.3.813
更新日期:1995-02-01 00:00:00
abstract:BACKGROUND:Factor Xa plays a central role in the generation of thrombin, making it a novel target for treatment of arterial thrombosis. Fondaparinux is a synthetic factor Xa inhibitor that has been shown to be superior to standard therapies for the prevention of venous thrombosis. We performed a randomized trial to det...
journal_title:Circulation
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1161/01.CIR.0000158485.70761.67
更新日期:2005-03-22 00:00:00
abstract:BACKGROUND:Proliferation of smooth muscle cells (SMCs) plays an important role in vascular pathobiology, being involved in the development of coronary restenosis and atherosclerosis. The activation of nuclear proto-oncogenes appears to be a final common pathway onto which various mitogenic signals coverage. Accordingly...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.88.3.1190
更新日期:1993-09-01 00:00:00
abstract:BACKGROUND:In hypertrophic cardiomyopathy, a spectrum of mitral leaflet abnormalities has been related to the mechanism of mitral systolic anterior motion (SAM), which causes both subaortic obstruction and mitral regurgitation. In the individual patient, SAM and regurgitation vary in parallel; clinically, however, grea...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.98.9.856
更新日期:1998-09-01 00:00:00
abstract:BACKGROUND:Acetylsalicylic acid (ASA), or aspirin, plus clopidogrel is becoming the standard antithrombotic treatment in people with coronary disease. Novel approaches such as the use of platelet-selective nitric oxide (NO) donors may provide additional protection against thrombosis. We evaluated the antithrombotic pro...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.CIR.0000142296.19558.99
更新日期:2004-09-21 00:00:00
abstract:BACKGROUND:Children stable at home with dilated cardiomyopathy remain at risk of death; there is evidence of survival benefit for transplantation out to 4 years postoperatively. The limited supply of donor organs makes risk stratification imperative, but although cardiopulmonary exercise test is well established as a p...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.111.035956
更新日期:2011-10-18 00:00:00
abstract:BACKGROUND:This study was designed to evaluate the effect of arglabin on the NLRP3 inflammasome inhibition and atherosclerotic lesion in ApoE2Ki mice fed a high-fat Western-type diet. METHODS AND RESULTS:Arglabin was purified, and its chemical identity was confirmed by mass spectrometry. It inhibited, in a concentrati...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.114.013730
更新日期:2015-03-24 00:00:00
abstract:BACKGROUND:-Recent studies have suggested that testosterone has a protective effect in the arterial vascular system. However, little is known about the molecular aspects of the mechanism(s) involved in these processes. The aim of the present study was to investigate the effect of testosterone on neointimal plaque devel...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.103.10.1382
更新日期:2001-03-13 00:00:00
abstract:BACKGROUND:We studied the growth-promoting effects of 2 sodium pump-selective cardiotonic steroids, ouabain and marinobufagenin, on cultured cells from vascular smooth muscle (VSMCs) from human umbilical vein and a rat VSMC line, A7r5. METHODS AND RESULTS:Both ouabain and marinobufagenin activated proliferation of the...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.CIR.0000101919.00548.86
更新日期:2003-12-16 00:00:00
abstract:BACKGROUND:The striated preferentially expressed gene (Speg) generates 4 different isoforms through alternative promoter use and tissue-specific splicing. Depending on the cell type, Speg isoforms may serve as markers of striated or smooth muscle differentiation. METHODS AND RESULTS:To elucidate function of Speg gene ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.108.799536
更新日期:2009-01-20 00:00:00
abstract:BACKGROUND:Vascular events during initial reperfusion after a period of hypothermic cardioplegic ischemia may play an important role in the recovery of mechanical function. Prior studies have shown (1) that dysfunction of the postischemic myocardium after normothermic ischemia can be ameliorated by vasodilation and (2)...
journal_title:Circulation
pub_type: 杂志文章
doi:
更新日期:1993-11-01 00:00:00
abstract::We performed transventricular pulmonary valvotomy as initial surgery in 22 consecutive patients with pulmonary atresia and intact ventricular septum who had a patent infundibulum. Nineteen patients also had placement of a central aortopulmonary shunt. All patients survived surgery, and 16 patients have had preoperativ...
journal_title:Circulation
pub_type: 杂志文章
doi:
更新日期:1990-11-01 00:00:00
abstract::The endothelin (ET) system is comprised of 4 active ETs, with ET-1 being the predominant isoform in the cardiovascular system. Because of the potent vasoconstricting and mitogenic effects of ET-1 and its involvement in various cardiovascular diseases, blockade of the ET receptor has received considerable attention. ET...
journal_title:Circulation
pub_type: 杂志文章,评审
doi:10.1161/01.CIR.0000094397.19932.78
更新日期:2003-11-04 00:00:00
abstract::Cerebral neurons can tolerate at least 20 min of normothermic ischemic anoxia. Cerebral recovery from more than 5 min of cardiac arrest is hampered by complex secondary derangements of multiple organ systems after reperfusion. There is increasing support of our hypothesis that this "postresuscitation syndrome" include...
journal_title:Circulation
pub_type: 杂志文章,评审
doi:
更新日期:1986-12-01 00:00:00
abstract:BACKGROUND:Left ventricular remodeling after myocardial infarction (MI) involves the hypertrophic growth of cardiomyocytes and the accumulation of fibrillar collagen in the interstitial space. We evaluated the role of kinins in postinfarction ventricular remodeling and their potential contribution to the antiremodeling...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.95.7.1910
更新日期:1997-04-01 00:00:00
abstract:BACKGROUND:Recent studies have shown that improved myocardial salvage after heat-shock pretreatment correlates with the amount of induced cardiac heat-shock protein (HSP)72. However, heat shock also induces myocardial catalase activity, potentially reducing free radical-mediated ischemic injury. The aim of the present ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.92.11.3318
更新日期:1995-12-01 00:00:00
abstract::High-density lipoprotein (HDL) cholesterol distributions were compared among 191 black and 1341 white males and 233 black and 1088 white females, ages 5-44 years, examined in five of the Lipid Research Clinic (LRC) population-based surveys. Mean HDL cholesterol was higher in blacks than whites in each 5-year age group...
journal_title:Circulation
pub_type: 杂志文章
doi:
更新日期:1980-11-01 00:00:00
abstract::Between July 1980 and November 1982, there were 935 coronary angioplasties attempted at Emory University Hospital. Of these patients, 20 developed acute occlusion. Of these 20, 19 presented within 3 hr of surgery or within 3 hr after stopping a continuous heparin infusion. Five patients required emergency surgery, but...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.68.4.725
更新日期:1983-10-01 00:00:00
abstract:BACKGROUND:Current two-dimensional echocardiographic measures of right ventricular volume are limited by the asymmetrical and crescentic shape of the ventricle and by difficulty in obtaining standardized views. Three-dimensional echocardiographic reconstruction, which does not require geometric assumptions or standardi...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.89.5.2342
更新日期:1994-05-01 00:00:00
abstract:BACKGROUND:A positive association was previously reported between angiotensin-converting enzyme (ACE) gene polymorphism and several cardiovascular diseases, such as myocardial infarction, left ventricular hypertrophy, and restenosis after percutaneous transluminal coronary angioplasty. Plasma ACE activity and carotid-w...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.91.4.951
更新日期:1995-02-15 00:00:00
abstract:BACKGROUND:There are no reported studies on the safety and efficacy of low-dose aspirin with low-intensity oral anticoagulation in patients with heart valve replacement. In this study, we compared the use of 100 mg/d aspirin with 650 mg/d aspirin in the prevention of systemic embolism and vascular death in patients wit...
journal_title:Circulation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.cir.94.9.2113
更新日期:1996-11-01 00:00:00
abstract:BACKGROUND:Endothelin (ET), a coronary vasoconstrictor, mediates its activity through the specific receptors ET-A and ET-B, which may demonstrate different activity under pathophysiological conditions. Thoracic inferior vena cava constriction (TIVCC) is an experimental model of congestive heart failure that is characte...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.93.4.646
更新日期:1996-02-15 00:00:00
abstract:BACKGROUND:Airborne particulate matter has been linked to excess morbidity and mortality. Recent attention has focused on the effects of particulate exposure on cardiac autonomic control. Inhaled particulates may affect the autonomic nervous system either directly, by eliciting a sympathetic stress response, or indirec...
journal_title:Circulation
pub_type: 临床试验,杂志文章
doi:10.1161/hc3401.095038
更新日期:2001-08-28 00:00:00
abstract:BACKGROUND:Two different techniques have been developed for radiofrequency catheter ablation of typical atrioventricular nodal reentry (AVNRT). Lesions made anteriorly near the apex of the triangle of Koch usually eliminate fast pathway function, whereas lesions made posteriorly near the ostium of the coronary sinus se...
journal_title:Circulation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.cir.87.5.1551
更新日期:1993-05-01 00:00:00
abstract::The effect of bretylium tosylate (BT) was determined in 27 consecutive cases of resistant ventricular fibrillation (VF) encountered by a hospital cardiac arrest team. The VF was sustained and completely resistant to multiple injections of lidocaine, sequential DC shocks at 400 watt-sec and one or a combination of intr...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.55.3.541
更新日期:1977-03-01 00:00:00
abstract:BACKGROUND:The uptake of oxidized low-density lipoprotein (OxLDL) by macrophage scavenger receptors is thought to be a key process in the formation of foam cells, the hallmark of early atherosclerotic lesions. CXCL16/scavenger receptor for phosphatidylserine and OxLDL is a multifunctional chemokine that exhibits scaven...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.105.540583
更新日期:2006-08-08 00:00:00
abstract::In experimental animals, the calcium channel-blocking agents lessen the arrhythmogenic, ionic, metabolic, and electrical changes that occur during acute myocardial ischemia. To date, these effects have been studied separately, and the effects of these agents on local activation have not been correlated with ionic or m...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.73.4.837
更新日期:1986-04-01 00:00:00
abstract::The purpose of this study was to examine high density lipoprotein cholesterol (HDL-C) levels in a sample of community-living women and men who consumed 1 drink of alcohol/day or less. Self-reports of alcohol consumption and clinical assessments of plasma lipid and lipoprotein levels were obtained twice, at 12 months a...
journal_title:Circulation
pub_type: 临床试验,杂志文章
doi:10.1161/01.cir.83.1.176
更新日期:1991-01-01 00:00:00