Complete isolation of left atrium surrounding the pulmonary veins: new insights from the double-Lasso technique in paroxysmal atrial fibrillation.


BACKGROUND:Paroxysmal atrial fibrillation (PAF) can be eliminated with continuous circular lesions (CCLs) around the pulmonary veins (PVs), but it is unclear whether all PVs are completely isolated. METHODS AND RESULTS:Forty-one patients with symptomatic PAF underwent 3D mapping, and all PV ostia were marked on the 3D map based on venography. Irrigated radiofrequency energy was applied at a distance from the PV ostia guided by 2 Lasso catheters placed within the ipsilateral superior and inferior PVs. The mean radiofrequency duration was 1550+/-511 seconds for left-sided PVs and 1512+/-506 seconds for right-sided PVs. After isolation, automatic activity was observed in the right-sided PVs in 87.8% and in the left-sided PVs in 80.5%. During the procedure, a spontaneous or induced PV tachycardia (PVT) with a cycle length of 189+/-29 ms was observed in 19 patients. During a mean follow-up of 6 months, atrial tachyarrhythmias recurred in 10 patients. Nine patients underwent a repeat procedure. Conduction gaps in the left CCL in 9 patients and in the right CCL in 2 patients were closed during the second procedure. A spontaneous PVT with a cycle length of 212+/-44 ms was demonstrated in 7 of 9 patients, even though no PVT had been observed in 6 of these 7 patients during the first procedure. No AF recurred in 39 patients after PV isolation during follow-up. CONCLUSIONS:Automatic activity and fast tachycardia within the PVs could reflect an arrhythmogenic substrate in patients with PAF, which could be eliminated by isolating all PVs with CCLs guided by 3D mapping and the double-Lasso technique in the majority of patients.






Ouyang F,Bänsch D,Ernst S,Schaumann A,Hachiya H,Chen M,Chun J,Falk P,Khanedani A,Antz M,Kuck KH




Has Abstract


2004-10-12 00:00:00














  • Effect of coronary surgery on survival in asymptomatic and minimally symptomatic patients.

    abstract::The effect of aortocoronary saphenous bypass graft surgery on survival of functional class I and II patients was studied in 619 patients entered in the Seattle Heart Watch when they had coronary arteriography. Cox's regression analysis was used to correct for differences in baseline characteristics that occur as a res...


    pub_type: 杂志文章


    authors: Hammermeister KE,DeRouen TA,Dodge HT

    更新日期:1980-08-01 00:00:00

  • Increased activity of endogenous endothelin in patients with type II diabetes mellitus.

    abstract:BACKGROUND:Endothelial dysfunction may contribute to the risk of premature atherosclerosis in patients with diabetes. Endothelin (ET-1) may be involved in this process by activating smooth muscle cell mitogenesis and leukocyte adhesion. We sought to assess the activity of endogenous ET-1 in a group of patients with typ...


    pub_type: 临床试验,杂志文章


    authors: Cardillo C,Campia U,Bryant MB,Panza JA

    更新日期:2002-10-01 00:00:00

  • Cytomegalovirus infection with interleukin-6 response predicts cardiac mortality in patients with coronary artery disease.

    abstract:BACKGROUND:Prospective data relating previous exposure to cytomegalovirus (CMV) to the risk of cardiac mortality are controversial. We investigated the effect of previous exposure to CMV infection on the risk of future cardiac disease-related death in relation to an underlying inflammatory response. METHODS AND RESULT...


    pub_type: 临床试验,杂志文章


    authors: Blankenberg S,Rupprecht HJ,Bickel C,Espinola-Klein C,Rippin G,Hafner G,Ossendorf M,Steinhagen K,Meyer J

    更新日期:2001-06-19 00:00:00

  • A history of the American Heart Association's Council on Clinical Cardiology.

    abstract::This essay reviews the founding and early history of the Council on Clinical Cardiology of the American Heart Association (AHA), the largest of the AHA's 14 councils. Based on archival research, it stresses the factors that led to the council's formation and shaped its agenda. The council was established in the contex...


    pub_type: 历史文章,杂志文章


    authors: Fye WB

    更新日期:1993-03-01 00:00:00

  • Downregulation of immunodetectable connexin43 and decreased gap junction size in the pathogenesis of chronic hibernation in the human left ventricle.

    abstract:BACKGROUND:The regional wall motion impairment and predisposition to arrhythmias in human ventricular hibernation may plausibly result from abnormal intercellular propagation of the depolarizing wave front. This study investigated the hypothesis that altered patterns of expression of connexin43, the principal gap junct...


    pub_type: 杂志文章


    authors: Kaprielian RR,Gunning M,Dupont E,Sheppard MN,Rothery SM,Underwood R,Pennell DJ,Fox K,Pepper J,Poole-Wilson PA,Severs NJ

    更新日期:1998-02-24 00:00:00

  • Epidemiological and genetic associations of activated factor XII concentration with factor VII activity, fibrinopeptide A concentration, and risk of coronary heart disease in men.

    abstract:BACKGROUND:The relations of plasma activated factor XII (FXIIa) concentration and a common polymorphism (C46T) of the factor XII gene with hemostatic status and risk of coronary heart disease (CHD) were examined by prospective surveillance. METHODS AND RESULTS:Genotyping for the C46T variant was performed in 2624 men ...


    pub_type: 杂志文章


    authors: Zito F,Drummond F,Bujac SR,Esnouf MP,Morrissey JH,Humphries SE,Miller GJ

    更新日期:2000-10-24 00:00:00

  • Overexpression of eotaxin and the CCR3 receptor in human atherosclerosis: using genomic technology to identify a potential novel pathway of vascular inflammation.

    abstract:BACKGROUND:Unstable atherosclerotic lesions typically have an abundant inflammatory cell infiltrate, including activated T cells, macrophages, and mast cells, which may decrease plaque stability. The pathophysiology of inflammatory cell recruitment and activation in the human atheroma is incompletely described. METHOD...


    pub_type: 杂志文章


    authors: Haley KJ,Lilly CM,Yang JH,Feng Y,Kennedy SP,Turi TG,Thompson JF,Sukhova GH,Libby P,Lee RT

    更新日期:2000-10-31 00:00:00

  • Recent progress in understanding apolipoprotein B.

    abstract::For the past 5 years, investigators from many different laboratories have contributed to a greatly increased understanding of two very important lipid-carrying proteins in plasma--apo B-100 and apo B-48. Apo B-100, an extremely large protein composed of 4,536 amino acids, is synthesized by the liver and is crucial for...


    pub_type: 杂志文章,评审


    authors: Young SG

    更新日期:1990-11-01 00:00:00

  • Intra-arterial stenting in the atherosclerotic rabbit.

    abstract::The major problem associated with percutaneous transluminal coronary angioplasty is recurrence of the stenotic lesion. Balloon catheter-mounted intracoronary stent devices may reduce restenosis by improving luminal morphology and flow characteristics. This study assessed the effects of a stainless steel wire, interdig...


    pub_type: 杂志文章


    authors: Robinson KA,Roubin GS,Siegel RJ,Black AJ,Apkarian RP,King SB 3rd

    更新日期:1988-09-01 00:00:00

  • Vasodilatation to arachidonic acid in humans. An insight into endogenous prostanoids and effects of aspirin.

    abstract:BACKGROUND:Human endothelial and vascular smooth muscle cells synthesize prostanoids. Several of these have been implicated in the physiological and pathophysiological regulation of vascular tone; however, there is no direct evidence that human blood vessels synthesize sufficient prostanoid to alter vessel tone. METHO...


    pub_type: 杂志文章


    authors: Bhagat K,Collier J,Vallance P

    更新日期:1995-10-15 00:00:00

  • External beam radiation to prevent restenosis after superficial femoral artery balloon angioplasty.

    abstract:BACKGROUND:Femoropopliteal percutaneous transluminal angioplasty (PTA) remains limited by restenosis. Although vascular brachytherapy may be effective in reducing restenosis, external beam radiation would be more practical to administer after PTA. METHODS AND RESULTS:After femoropopliteal PTA without stent placement, ...


    pub_type: 杂志文章,随机对照试验


    authors: Therasse E,Donath D,Lespérance J,Tardif JC,Guertin MC,Oliva VL,Soulez G

    更新日期:2005-06-21 00:00:00

  • Overexpression of heat shock protein 72 in transgenic mice decreases infarct size in vivo.

    abstract:BACKGROUND:Previous studies have demonstrated that induction of heat shock protein (HSP) 72 by whole-body hyperthermia reduces infarct size in an in vivo model of ischemia and reperfusion. Furthermore, hearts obtained from transgenic mice that overexpress HSP72 demonstrate improved functional recovery and decreased inf...


    pub_type: 杂志文章


    authors: Hutter JJ,Mestril R,Tam EK,Sievers RE,Dillmann WH,Wolfe CL

    更新日期:1996-09-15 00:00:00

  • Vascular signal transducer and activator of transcription-3 promotes angiogenesis and neuroplasticity long-term after stroke.

    abstract:BACKGROUND:Poststroke angiogenesis contributes to long-term recovery after stroke. Signal transducer and activator of transcription-3 (Stat3) is a key regulator for various inflammatory signals and angiogenesis. It was the aim of this study to determine its function in poststroke outcome. METHODS AND RESULTS:We genera...


    pub_type: 杂志文章


    authors: Hoffmann CJ,Harms U,Rex A,Szulzewsky F,Wolf SA,Grittner U,Lättig-Tünnemann G,Sendtner M,Kettenmann H,Dirnagl U,Endres M,Harms C

    更新日期:2015-05-19 00:00:00

  • Hemodynamic evaluation of the heart with a nonfluoroscopic electromechanical mapping technique.

    abstract:BACKGROUND:Clinical cardiac volumetric measurement techniques are essential for assessing cardiac performance but produce significant inaccuracies in extrapolation of the volume of a three-dimensional (3D) object from two-dimensional images and lack the ability to associate cardiac electrical and mechanical activities....


    pub_type: 杂志文章


    authors: Gepstein L,Hayam G,Shpun S,Ben-Haim SA

    更新日期:1997-11-18 00:00:00

  • Protective function of transcription factor TR3 orphan receptor in atherogenesis: decreased lesion formation in carotid artery ligation model in TR3 transgenic mice.

    abstract:BACKGROUND:Smooth muscle cells (SMCs) play a key role in intimal thickening in atherosclerosis and restenosis. The precise signaling pathways by which the proliferation of SMCs is regulated are largely unknown. The TR3 orphan receptor, the mitogen-induced nuclear orphan receptor (MINOR), and the nuclear receptor of T c...


    pub_type: 杂志文章


    authors: Arkenbout EK,de Waard V,van Bragt M,van Achterberg TA,Grimbergen JM,Pichon B,Pannekoek H,de Vries CJ

    更新日期:2002-09-17 00:00:00

  • Clinical and hemodynamic results of mitral valve replacement with autologous fascia lata grafts. Studies in patients with competent prostheses.

    abstract::Nine patients with severe mitral disease were studied before and six months after mitral valve replacement with a three-cusp stented prosthesis using fresh autologous fascia lata tissue. Only patients in whom there was no auscultatory and angiographic evidence of incompetence of the replaced valve were selected for re...


    pub_type: 杂志文章


    authors: Taylor SH,Galvin MC,Pakrashi BC,Tulpule AT,Ionescu MI,Whitaker W

    更新日期:1975-11-01 00:00:00

  • Participation of tyrosine phosphorylation in cytoskeletal reorganization, alpha(IIb)beta(3) integrin receptor activation, and aspirin-insensitive mechanisms of thrombin-stimulated human platelets.

    abstract:BACKGROUND:Fibrinogen binding to the active conformation of the alpha(IIb)beta(3) integrin receptor (glycoprotein IIb/IIIa) and cytoskeletal reorganization are important events in platelet function. Tyrosine phosphorylation of platelet proteins plays an essential role in platelet signal transduction pathways. We studie...


    pub_type: 杂志文章


    authors: Santos MT,Moscardó A,Vallés J,Martínez M,Piñón M,Aznar J,Broekman MJ,Marcus AJ

    更新日期:2000-10-17 00:00:00

  • Ventricular septal defects.

    abstract::Ventricular septal defects are the most common congenital heart defect. They vary greatly in location, clinical presentation, associated lesions, and natural history. The present article describes the clinical aspects of ventricular septal defects and current management strategies. ...


    pub_type: 杂志文章,评审


    authors: Minette MS,Sahn DJ

    更新日期:2006-11-14 00:00:00

  • Cardiac troponin I is associated with impaired hemodynamics, progressive left ventricular dysfunction, and increased mortality rates in advanced heart failure.

    abstract:BACKGROUND:Cardiac troponin I (cTnI), a sensitive and specific marker of myocardial cell injury, is useful in diagnosing and assessing prognosis in acute coronary syndromes. Small studies report that cTnI is elevated in severe heart failure (HF) and may predict adverse outcomes. METHODS AND RESULTS:The present study e...


    pub_type: 杂志文章


    authors: Horwich TB,Patel J,MacLellan WR,Fonarow GC

    更新日期:2003-08-19 00:00:00

  • Knowledge Gaps in Cardiovascular Care of the Older Adult Population: A Scientific Statement From the American Heart Association, American College of Cardiology, and American Geriatrics Society.

    abstract::The incidence and prevalence of most cardiovascular disorders increase with age, and cardiovascular disease is the leading cause of death and major disability in adults ≥75 years of age; however, despite the large impact of cardiovascular disease on quality of life, morbidity, and mortality in older adults, patients a...


    pub_type: 杂志文章


    authors: Rich MW,Chyun DA,Skolnick AH,Alexander KP,Forman DE,Kitzman DW,Maurer MS,McClurken JB,Resnick BM,Shen WK,Tirschwell DL,American Heart Association Older Populations Committee of the Council on Clinical Cardiology, Council on Cardiov

    更新日期:2016-05-24 00:00:00

  • Noninvasive evaluation of intrarenal oxygenation with BOLD MRI.

    abstract:BACKGROUND:The countercurrent arrangement of capillary blood flow in the medulla of mammalian kidneys generates a gradient of oxygen tension between the renal cortex and the papillary tip that results in a state of relative hypoxia within the renal medulla. Exploration of the pathophysiological implications of medullar...


    pub_type: 杂志文章


    authors: Prasad PV,Edelman RR,Epstein FH

    更新日期:1996-12-15 00:00:00

  • Coagulant activities of platelets in coronary artery disease.

    abstract::Platelets have been implicated in the pathogenesis of coronary artery disease, and a number of studies have examined platelet function and coagulation parameters in such patients. We have examined platelet coagulant activities, volumes, and aggregate ratios in 23 patients with chest pain, seven of whom had normal coro...


    pub_type: 杂志文章


    authors: Rao AK,Mintz PD,Lavine SJ,Bove AA,McDonough MT,Spann JF,Walsh PN

    更新日期:1984-01-01 00:00:00

  • Cardiac allograft vasculopathy: a review.

    abstract::Cardiac allograft vasculopathy (CAV) remains a troublesome long-term complication of heart transplantation. It is manifested by a unique and unusually accelerated form of coronary disease affecting both intramural and epicardial coronary arteries and veins.CAV is characterized by vascular injury induced by a variety o...


    pub_type: 杂志文章,评审


    authors: Weis M,von Scheidt W

    更新日期:1997-09-16 00:00:00

  • Noninvasive assessment of significant left anterior descending coronary artery stenosis by coronary flow velocity reserve with transthoracic color Doppler echocardiography.

    abstract:BACKGROUND:Coronary flow reserve has been considered an important diagnostic index of the functional significance of coronary artery stenosis. With Doppler technique, it has been assessed as the ratio of hyperemic to basal coronary flow velocity (coronary flow velocity reserve [CFVR]) by invasive or semiinvasive method...


    pub_type: 杂志文章


    authors: Hozumi T,Yoshida K,Ogata Y,Akasaka T,Asami Y,Takagi T,Morioka S

    更新日期:1998-04-28 00:00:00

  • Quantification of myocardial infarct size by thallium-201 single-photon emission computed tomography: experimental validation in the dog.

    abstract::To evaluate the potential advantages of thallium-201 (201T1) single-photon emission computerized tomography (SPECT) to assess myocardial infarct size in the experimental animal, six normal dogs and 14 dogs with 6 to 8 hr closed-chest coronary occlusion (eight left anterior descending and six left circumflex) were stud...


    pub_type: 杂志文章


    authors: Prigent F,Maddahi J,Garcia EV,Satoh Y,Van Train K,Berman DS

    更新日期:1986-10-01 00:00:00

  • Mortality and sudden death in pediatric left ventricular noncompaction in a tertiary referral center.

    abstract:BACKGROUND:Left ventricular noncompaction is a cardiomyopathy characterized by excessive trabeculation of the left ventricle, progressive myocardial dysfunction, and early mortality. Left ventricular noncompaction has a heterogeneous clinical presentation that includes arrhythmia and sudden cardiac death. METHODS AND ...


    pub_type: 杂志文章


    authors: Brescia ST,Rossano JW,Pignatelli R,Jefferies JL,Price JF,Decker JA,Denfield SW,Dreyer WJ,Smith O,Towbin JA,Kim JJ

    更新日期:2013-06-04 00:00:00

  • Ryanodine receptor phosphorylation by calcium/calmodulin-dependent protein kinase II promotes life-threatening ventricular arrhythmias in mice with heart failure.

    abstract:BACKGROUND:approximately half of patients with heart failure die suddenly as a result of ventricular arrhythmias. Although abnormal Ca(2+) release from the sarcoplasmic reticulum through ryanodine receptors (RyR2) has been linked to arrhythmogenesis, the molecular mechanisms triggering release of arrhythmogenic Ca(2+) ...


    pub_type: 杂志文章


    authors: van Oort RJ,McCauley MD,Dixit SS,Pereira L,Yang Y,Respress JL,Wang Q,De Almeida AC,Skapura DG,Anderson ME,Bers DM,Wehrens XH

    更新日期:2010-12-21 00:00:00

  • Downregulation of delayed rectifier K(+) currents in dogs with chronic complete atrioventricular block and acquired torsades de pointes.

    abstract:BACKGROUND:Acquired QT prolongation enhances the susceptibility to torsades de pointes (TdP). Clinical and experimental studies indicate ventricular action potential prolongation, increased regional dispersion of repolarization, and early afterdepolarizations as underlying factors. We examined whether K(+)-current alte...


    pub_type: 杂志文章


    authors: Volders PG,Sipido KR,Vos MA,Spätjens RL,Leunissen JD,Carmeliet E,Wellens HJ

    更新日期:1999-12-14 00:00:00

  • Assessment of left ventricular relaxation by Doppler echocardiography. Comparison of isovolumic relaxation time and transmitral flow velocities with time constant of isovolumic relaxation.

    abstract::Isovolumic relaxation time (IVRT) and events of early transmitral flow measured by Doppler echocardiography were validated against the time constant of left ventricular relaxation (tau) in open-chest dogs. During increased inotropy (by isoproterenol infusion) at constant preload, enhancement of relaxation was indicate...


    pub_type: 杂志文章


    authors: Myreng Y,Smiseth OA

    更新日期:1990-01-01 00:00:00

  • Intramural delivery of recombinant apolipoprotein A-IMilano/phospholipid complex (ETC-216) inhibits in-stent stenosis in porcine coronary arteries.

    abstract:BACKGROUND:We have previously demonstrated vasculoprotective effects after repeated intravenous administration of recombinant apolipoprotein A-IMilano (apoA-Im)/phospholipid complex. In this study, we sought to determine the effects of local recombinant apoA-Im/1-palmitoyl,2-oleoyl phosphatidylcholine complex (ETC-216)...


    pub_type: 杂志文章


    authors: Kaul S,Rukshin V,Santos R,Azarbal B,Bisgaier CL,Johansson J,Tsang VT,Chyu KY,Cercek B,Mirocha J,Shah PK

    更新日期:2003-05-27 00:00:00