Effect of testosterone on plaque development and androgen receptor expression in the arterial vessel wall.

abstract：BACKGROUND:Whether passively collected data can substitute for adjudicated outcomes to reproduce the magnitude and direction of treatment effect observed in cardiovascular clinical trials is not well known. METHODS:We linked adults ≥65 years of age in the HiR (US CoreValve Pivotal High Risk) and SURTAVI trials (Surgic...

journal_title：Circulation

authors： Strom JB,Faridi KF,Butala NM,Zhao Y,Tamez H,Valsdottir LR,Brennan JM,Shen C,Popma JJ,Kazi DS,Yeh RW

更新日期：2020-07-21 00:00:00

abstract：BACKGROUND:The majority of infrarenal abdominal aortic aneurysm (AAA) repairs in the United States are performed with endovascular methods. Baseline aortoiliac arterial anatomic characteristics are fundamental criteria for appropriate patient selection for endovascular aortic repair (EVAR) and key determinants of long-...

journal_title：Circulation

authors： Schanzer A,Greenberg RK,Hevelone N,Robinson WP,Eslami MH,Goldberg RJ,Messina L

更新日期：2011-06-21 00:00:00

abstract：BACKGROUND:Platelet deposition and aggregation are central to the pathogenesis of ischemic complications of acute coronary syndromes (ACS). Pharmacodynamic effects of the platelet glycoprotein IIb/IIIa antagonist eptifibatide have been delineated in healthy subjects but not in patients with ACS. We assessed effects of ...

journal_title：Circulation

authors： Tardiff BE,Jennings LK,Harrington RA,Gretler D,Potthoff RF,Vorchheimer DA,Eisenberg PR,Lincoff AM,Labinaz M,Joseph DM,McDougal MF,Kleiman NS,PERIGEE Investigators.

更新日期：2001-07-24 00:00:00

abstract：:BACKGROUND. A pace mapping technique using body surface potential maps (BSPMs) was developed to guide the positioning of an ablation catheter at the ventricular insertion point of accessory pathways (AP) in patients with the Wolff-Parkinson-White syndrome (WPW). METHODS AND RESULTS. The study was performed on 30 WPW p...

journal_title：Circulation

authors： Dubuc M,Nadeau R,Tremblay G,Kus T,Molin F,Savard P

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:Experimental models suggest that brain natriuretic peptide (BNP) can modify left ventricular diastolic performance. The aim of this study was to evaluate the effects of BNP on resting and exercise hemodynamics and neurohormones in patients with isolated diastolic heart failure. METHODS AND RESULTS:Six patie...

journal_title：Circulation

authors： Clarkson PB,Wheeldon NM,MacFadyen RJ,Pringle SD,MacDonald TM

更新日期：1996-06-01 00:00:00

abstract：:Cardiac allograft vasculopathy (CAV) remains a troublesome long-term complication of heart transplantation. It is manifested by a unique and unusually accelerated form of coronary disease affecting both intramural and epicardial coronary arteries and veins.CAV is characterized by vascular injury induced by a variety o...

journal_title：Circulation

authors： Weis M,von Scheidt W

更新日期：1997-09-16 00:00:00

abstract：:A mathematical model to measure infarct size from serial estimates of CPK has been developed by Shell et al. Norris et al. have recently introduced a modification of this method by calculating an individualized disappearance rate parameter (Kd) from the uniformly monoexponential portion of the CPK vs time curve. This ...

journal_title：Circulation

authors： Slutsky AS

更新日期：1977-10-01 00:00:00

abstract：BACKGROUND:During the 1980s, mortality from coronary artery disease (CAD) decreased markedly in the United States. This raises the question of whether a parallel decrease occurred in excess mortality due to CAD in patients undergoing surgical correction of valvular regurgitation. METHODS AND RESULTS:Survival of 752 pa...

journal_title：Circulation

authors： Tribouilloy CM,Enriquez-Sarano M,Schaff HV,Orszulak TA,Fett SL,Bailey KR,Tajik AJ,Frye RL

更新日期：1998-11-10 00:00:00

abstract：BACKGROUND:The role of infections and inflammation in the pathophysiology of coronary heart disease is emerging. We studied the independent and joint effects of these 2 components on coronary risk. METHODS AND RESULTS:We measured baseline levels of C-reactive protein (CRP) and antibodies to adenovirus, enterovirus, cy...

journal_title：Circulation

authors： Roivainen M,Viik-Kajander M,Palosuo T,Toivanen P,Leinonen M,Saikku P,Tenkanen L,Manninen V,Hovi T,Mänttäri M

更新日期：2000-01-25 00:00:00

abstract：:A quantitative analysis of adventitial inflammation of the coronary artery with intimal lesions is described in 12 patients who suffered coronary death and had had unstable angina (crescendo angina) at rest (group 1). After autopsy in these patients we examined epon-embedded cross sections by light and electron micros...

journal_title：Circulation

authors： Kohchi K,Takebayashi S,Hiroki T,Nobuyoshi M

更新日期：1985-04-01 00:00:00

abstract：:One hundred eighty-eight patients with acute myocardial infarction were studied prospectively from August 1980 to September 1982. One hundred thirty-six of these patients were entered into a intracoronary streptokinase study after informed consent was obtained. The remaining 52 patients, who either met exclusion crite...

journal_title：Circulation

authors： Smalling RW,Fuentes F,Matthews MW,Freund GC,Hicks CH,Reduto LA,Walker WE,Sterling RP,Gould KL

更新日期：1983-07-01 00:00:00

abstract：BACKGROUND:Trends in cardiovascular mortality across Europe demonstrate significant geographical variation, and an understanding of these trends has a central role in global public health. METHODS AND RESULTS:Ischemic heart disease and cerebrovascular disease age-standardized death rates (as per International Classifi...

journal_title：Circulation

authors： Hartley A,Marshall DC,Salciccioli JD,Sikkel MB,Maruthappu M,Shalhoub J

更新日期：2016-05-17 00:00:00

abstract：BACKGROUND:To assess the long-term results of the edge-to-edge mitral repair performed without annuloplasty in degenerative mitral regurgitation (MR). METHODS AND RESULTS:From 1993 to 2002, 61 patients with degenerative MR were treated with an isolated edge-to-edge suture without any annuloplasty. Annuloplasty was omi...

journal_title：Circulation

authors： De Bonis M,Lapenna E,Maisano F,Barili F,La Canna G,Buzzatti N,Pappalardo F,Calabrese M,Nisi T,Alfieri O

更新日期：2014-09-09 00:00:00

abstract：:Optimal electrode position for long-term transvenous cardiac pacing is in the apex of the right ventricle. Intracardiac electrograms, surface electrocardiograms, frontal fluoroscopy, lateral roentgenograms, and pacing threshold levels were studied in two groups of patients: One group was comprised of five patients wit...

journal_title：Circulation

authors： Gulotta SJ

更新日期：1970-10-01 00:00:00

abstract：BACKGROUND:Factors leading differentially to the development of isolated diastolic (IDH), systolic-diastolic (SDH), and isolated systolic (ISH) hypertension are poorly understood. We examined the relations of blood pressure (BP) and clinical risk factors to the new onset of the 3 forms of hypertension. METHODS AND RES...

journal_title：Circulation

authors： Franklin SS,Pio JR,Wong ND,Larson MG,Leip EP,Vasan RS,Levy D

更新日期：2005-03-08 00:00:00

abstract：BACKGROUND:Coronary flow reserve has been considered an important diagnostic index of the functional significance of coronary artery stenosis. With Doppler technique, it has been assessed as the ratio of hyperemic to basal coronary flow velocity (coronary flow velocity reserve [CFVR]) by invasive or semiinvasive method...

journal_title：Circulation

authors： Hozumi T,Yoshida K,Ogata Y,Akasaka T,Asami Y,Takagi T,Morioka S

更新日期：1998-04-28 00:00:00

abstract：BACKGROUND:Brain natriuretic peptide is a novel natriuretic peptide that is secreted predominantly from the ventricles, and its plasma levels have been shown to be markedly increased in patients with chronic congestive heart failure. This study was designed to examine the plasma levels of brain natriuretic peptide as w...

journal_title：Circulation

authors： Morita E,Yasue H,Yoshimura M,Ogawa H,Jougasaki M,Matsumura T,Mukoyama M,Nakao K

更新日期：1993-07-01 00:00:00

abstract：BACKGROUND:Proprotein convertase subtilisin kexin type 9 (PCSK9) promotes the degradation of the low-density lipoprotein (LDL) receptor (LDLR), and its deficiency in humans results in low plasma LDL cholesterol and protection against coronary heart disease. Recent evidence indicates that PCSK9 also modulates the metabo...

journal_title：Circulation

authors： Rashid S,Tavori H,Brown PE,Linton MF,He J,Giunzioni I,Fazio S

更新日期：2014-07-29 00:00:00

abstract：:Digital vasospastic phenomena have been reported to result from use of nonselective and cardioselective beta-adrenoreceptor-blocking drugs. The effects of 80 mg/day propranolol and 100 mg/day metoprolol on finger hemodynamics and clinical responses were compared with those of placebo in 16 patients with Raynaud's phen...

journal_title：Circulation

authors： Coffman JD,Rasmussen HM

更新日期：1985-09-01 00:00:00

abstract：:The anatomy of 58 specimens of aortic outflow tract atresia was studied. All cases had situs solitus and levocardia, 37 had atrioventricular (AV) concordance, two had common inlet to a right ventricle and 19 had mitral atresia. The great arteries were normally interrelated in all cases. Fifty-one cases had an intact v...

journal_title：Circulation

authors： Thiene G,Gallucci V,Macartney FJ,Del Torso S,Pellegrino PA,Anderson RH

更新日期：1979-01-01 00:00:00

abstract：BACKGROUND:The mainstay of treatment for atrial fibrillation (AF) remains pharmacological; however, catheter ablation has increasingly been used over the last decade. The relative merits of each strategy have not been extensively studied. METHODS AND RESULTS:We conducted a randomized multicenter comparison of these 2 ...

journal_title：Circulation

authors： Jaïs P,Cauchemez B,Macle L,Daoud E,Khairy P,Subbiah R,Hocini M,Extramiana F,Sacher F,Bordachar P,Klein G,Weerasooriya R,Clémenty J,Haïssaguerre M

更新日期：2008-12-09 00:00:00

abstract：:Prognostic stratification was carried out on 518 patients less than or equal to 65 years of age who were discharged from the hospital following a definite or probable acute myocardial infarction and followed for four months. The total population was made up of 272 patients hospitalzed in 1973 and 246 patients hospital...

journal_title：Circulation

authors： Moss AJ,DeCamilla J,Davis H,Bayer L

更新日期：1976-07-01 00:00:00

abstract：BACKGROUND:We tested the hypothesis that real-time magnetic resonance imaging (MRI) can guide coronary artery catheterization in swine via a percutaneous femoral artery approach. METHODS AND RESULTS:In 12 pigs, we accessed femoral arteries percutaneously. We used 6- or 7-French coronary Judkins catheters filled with d...

journal_title：Circulation

authors： Omary RA,Green JD,Schirf BE,Li Y,Finn JP,Li D

更新日期：2003-06-03 00:00:00

abstract：BACKGROUND:Adrenomedullin (AM) is a vasodilating peptide involved in the regulation of circulatory homeostasis and in the pathophysiology of certain cardiovascular diseases. To determine the extent to which chronic AM overproduction affects circulatory physiology under normal and pathological conditions, we used a prep...

journal_title：Circulation

authors： Shindo T,Kurihara H,Maemura K,Kurihara Y,Kuwaki T,Izumida T,Minamino N,Ju KH,Morita H,Oh-hashi Y,Kumada M,Kangawa K,Nagai R,Yazaki Y

更新日期：2000-05-16 00:00:00

abstract：BACKGROUND:In PTCA patients with multivessel coronary artery disease, incomplete revascularization (IR) is the result of both pre-PTCA strategy and initial lesion outcome. The unique contribution of these components on long-term patient outcome is uncertain. METHODS AND RESULTS:From the Bypass Angioplasty Revasculariz...

journal_title：Circulation

authors： Kip KE,Bourassa MG,Jacobs AK,Schwartz L,Feit F,Alderman EL,Weiner BH,Weiss MB,Kellett MA Jr,Sharaf BL,Dimas AP,Jones RH,Sopko G,Detre KM

更新日期：1999-08-31 00:00:00

abstract：:As part of two Department of Veterans Affairs Cooperative Trials, we obtained angiographic patency data for internal mammary artery (IMA) and saphenous vein grafts to the left anterior descending (LAD) coronary artery at 1 year after coronary artery bypass surgery. Patients received either aspirin 325 mg q.d., aspirin...

journal_title：Circulation

authors： Goldman S,Copeland J,Moritz T,Henderson W,Zadina K,Ovitt T,Kern KB,Sethi G,Sharma GV,Khuri S

更新日期：1990-11-01 00:00:00

abstract：BACKGROUND:Adenosine can initiate ischemic preconditioning, and mitochondrial ATP-sensitive potassium (K(ATP)) channels have emerged as the likely effectors. We sought to determine the mechanistic interactions between these 2 observations. METHODS AND RESULTS:The mitochondrial flavoprotein oxidation induced by diazoxi...

journal_title：Circulation

authors： Sato T,Sasaki N,O'Rourke B,Marbán E

更新日期：2000-08-15 00:00:00

abstract：BACKGROUND:Chemokines play an essential role in regulating the infiltration of leukocytes into allografts in experimental models. Little is known of their expression or function after human cardiac transplantation. METHODS AND RESULTS:We analyzed 169 sequential human endomyocardial biopsies by immunocytochemistry for ...

journal_title：Circulation

authors： Melter M,Exeni A,Reinders ME,Fang JC,McMahon G,Ganz P,Hancock WW,Briscoe DM

更新日期：2001-11-20 00:00:00

abstract：BACKGROUND:Macrophages contribute to the progression and acute complications of atherosclerosis. Macrophage imaging may serve as a biomarker to identify subclinical inflamed lesions, to predict future risk, and to aid in the assessment of novel therapies. METHODS AND RESULTS:To test the hypothesis that nanoparticle-en...

journal_title：Circulation

authors： Morishige K,Kacher DF,Libby P,Josephson L,Ganz P,Weissleder R,Aikawa M

更新日期：2010-10-26 00:00:00

abstract：BACKGROUND:Major gender-based differences in the incidence of ventricular tachyarrhythmia after myocardial infarction have been shown in humans. Although the underlying mechanisms are unclear, earlier studies suggest that estrogen receptor-mediated effects play a major role in this process. METHODS AND RESULTS:We exam...

journal_title：Circulation

authors： Korte T,Fuchs M,Arkudas A,Geertz S,Meyer R,Gardiwal A,Klein G,Niehaus M,Krust A,Chambon P,Drexler H,Fink K,Grohé C

更新日期：2005-05-10 00:00:00