Abstract:
BACKGROUND:Airborne particulate matter has been linked to excess morbidity and mortality. Recent attention has focused on the effects of particulate exposure on cardiac autonomic control. Inhaled particulates may affect the autonomic nervous system either directly, by eliciting a sympathetic stress response, or indirectly, through inflammatory cytokines produced in the lungs and released into the circulation. METHODS AND RESULTS:This longitudinal study examined the association of particulates =2.5 microm in diameter (PM(2.5)) with heart rate variability (HRV) in an occupational cohort (N=40). Continuous monitoring of exposure and HR was performed during and away from work. PM(2.5) levels were higher than ambient levels typically reported in Boston, 0.167+/-3.205 mg/m(3) (geometric mean+/-geometric SD). We found a 2.66% decrease (95% CI, -3.75% to -1.58%) in the 5-minute SD of normal RR intervals (SDNN) for every 1 mg/m(3) increase in the 4-hour moving PM(2.5) average and a 1.02% increase (95% CI, 0.59% to 1.46%) in HR after adjusting for potential confounding factors. The decrease in SDNN became larger as the averaging interval increased. CONCLUSIONS:Workers experienced altered cardiac autonomic control after exposure to occupational and environmental PM(2.5). There appears to be either a long-acting (several hours) and a short-acting (several minutes) component to the mechanism of action that may be related to the production of cytokines and the sympathetic stress response, respectively, or a cumulative effect that begins shortly after exposure begins. The clinical significance of these effects in a healthy working population is unclear.
journal_name
Circulationjournal_title
Circulationauthors
Magari SR,Hauser R,Schwartz J,Williams PL,Smith TJ,Christiani DCdoi
10.1161/hc3401.095038subject
Has Abstractpub_date
2001-08-28 00:00:00pages
986-91issue
9eissn
0009-7322issn
1524-4539journal_volume
104pub_type
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