Beneficial hemodynamic and renal effects of adrenomedullin in an ovine model of heart failure.

abstract：:With the advent of reliable prosthetic valves, the number of aortic valvuloplastic procedures performed in adults has decreased significantly. This is in contradistinction to patients with congenital aortic stenosis, in whom aortic valvuloplasty remains the primary approach. Although only a 25% to 50% incidence of lon...

journal_title：Circulation

authors： Mindich BP,Guarino T,Goldman ME

更新日期：1986-09-01 00:00:00

abstract：:Cerebral neurons can tolerate at least 20 min of normothermic ischemic anoxia. Cerebral recovery from more than 5 min of cardiac arrest is hampered by complex secondary derangements of multiple organ systems after reperfusion. There is increasing support of our hypothesis that this "postresuscitation syndrome" include...

journal_title：Circulation

authors： Safar P

更新日期：1986-12-01 00:00:00

abstract：:Certain clinical and morphologic observations are described in 27 patients with severe isolated angina pectoris of either the stable (five patients) or the unstable form (22 patients). Twenty-four patients died during or shortly after cardiac operations designed to relieve angina pectoris and three died during cardiac...

journal_title：Circulation

authors： Roberts WC

更新日期：1976-09-01 00:00:00

abstract：BACKGROUND:Many clinical trials use composite end points to reduce sample size, but the relative importance of each individual end point within the composite may differ between patients and researchers. METHODS AND RESULTS:We asked 785 cardiovascular patients and 164 clinical trial authors to assign 25 "spending weigh...

journal_title：Circulation

authors： Stolker JM,Spertus JA,Cohen DJ,Jones PG,Jain KK,Bamberger E,Lonergan BB,Chan PS

更新日期：2014-10-07 00:00:00

abstract：BACKGROUND:Although molecular biological studies suggest a pathogenic link between enterovirus infection and dilated cardiomyopathy (DCM), the frequency of detection of enteroviral RNA is not consistently high in myocardial tissue from patients with DCM. A recent study has suggested that hepatitis C virus (HCV) may als...

journal_title：Circulation

authors： Okabe M,Fukuda K,Arakawa K,Kikuchi M

更新日期：1997-07-01 00:00:00

abstract：BACKGROUND:The aims of this study were to identify hibernating myocardium (hypocontractile, hypoperfused viable myocardium that regains contractility after revascularization) in the clinical setting and to predict functional outcome in patients with coronary artery disease after coronary revascularization. METHODS AND...

journal_title：Circulation

authors： Shivalkar B,Maes A,Borgers M,Ausma J,Scheys I,Nuyts J,Mortelmans L,Flameng W

更新日期：1996-08-01 00:00:00

abstract：:A transvenous lead system for implantable defibrillators would obviate a surgical thoracotomy and reduce the morbidity and mortality associated with implantation. We evaluated the clinical performance of a new nonthoracotomy lead system that included a defibrillation lead in the coronary sinus. At the time of defibril...

journal_title：Circulation

authors： Yee R,Klein GJ,Leitch JW,Guiraudon GM,Guiraudon CM,Jones DL,Norris C

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:Fibrinogen binding to the active conformation of the alpha(IIb)beta(3) integrin receptor (glycoprotein IIb/IIIa) and cytoskeletal reorganization are important events in platelet function. Tyrosine phosphorylation of platelet proteins plays an essential role in platelet signal transduction pathways. We studie...

journal_title：Circulation

authors： Santos MT,Moscardó A,Vallés J,Martínez M,Piñón M,Aznar J,Broekman MJ,Marcus AJ

更新日期：2000-10-17 00:00:00

abstract：:To determine the contribution of disopyramide's suggested opposing direct depressant and indirect acceleratory actions on sinus node function, we studied the effects of disopyramide, 1 x 10(-7) to 1 x 10(-4) M, on isolated rabbit sinus node preparations using standard microelectrode techniques. Transmembrane potential...

journal_title：Circulation

authors： Katoh T,Karagueuzian HS,Jordan J,Mandel WJ

更新日期：1982-12-01 00:00:00

abstract：BACKGROUND:The vascular remodeling responsible for pulmonary arterial hypertension (PAH) involves predominantly the accumulation of α-smooth muscle actin-expressing mesenchymal-like cells in obstructive pulmonary vascular lesions. Endothelial-to-mesenchymal transition (EndoMT) may be a source of those α-smooth muscle a...

journal_title：Circulation

authors： Ranchoux B,Antigny F,Rucker-Martin C,Hautefort A,Péchoux C,Bogaard HJ,Dorfmüller P,Remy S,Lecerf F,Planté S,Chat S,Fadel E,Houssaini A,Anegon I,Adnot S,Simonneau G,Humbert M,Cohen-Kaminsky S,Perros F

更新日期：2015-03-17 00:00:00

abstract：BACKGROUND:Administration of aprotinin during extracorporeal circulation reduces blood loss and improves platelet function. METHODS AND RESULTS:To evaluate the protective effect of aprotinin on platelets, 50 patients undergoing cardiopulmonary bypass were randomized before surgery to one of three groups. Seventeen pat...

journal_title：Circulation

authors： Mohr R,Goor DA,Lusky A,Lavee J

更新日期：1992-11-01 00:00:00

abstract：:Nine children ages 2--15 years have undergone mitral valve replacement (MVR) with Hancock porcine heterograft valves for severe mitral insufficiency. The etiology of the mitral valve disease was rheumatic in two patients, and congenital in seven. Porcine valve sizes ranged from 19--31 mm. Follow-up has been from 1.6 t...

journal_title：Circulation

authors： Kutsche LM,Oyer P,Shumway N,Baum D

更新日期：1979-08-01 00:00:00

abstract：:Suckling Swiss Webster mice were inoculated with 10(4)TCD50 of coxsackieviruses, group B types 1 or 4. Virulent necrotizing myocarditis resulted in 185 infected mice. Of the latter group, three (14.3%) nurslings on the 17th and 23rd day after inoculations had left ventricular aneurysms postmortem. None of 61 concurren...

journal_title：Circulation

authors： El-Khatib MR,Chason JL,Lerner AM

更新日期：1979-02-01 00:00:00

abstract：BACKGROUND:The molecular mechanism of neointimal hyperplasia after vein graft surgery remains elusive. Vacuolar H(+)-ATPase (V-ATPase) is involved in intracellular trafficking and may play a crucial role in neointimal cell growth. METHODS AND RESULTS:Cultured human saphenous vein segments developed neointimal formatio...

journal_title：Circulation

authors： Otani H,Yamamura T,Nakao Y,Hattori R,Fujii H,Ninomiya H,Kido M,Kawaguchi H,Osako M,Imamura H,Ohta T,Ohkuma S

更新日期：2000-11-07 00:00:00

abstract：BACKGROUND:Smooth muscle cell (SMC) migration and proliferation critically influence the clinical course of vascular disease. We tested the effect of the novel small leucine-rich repeat protein podocan on SMC migration and proliferation using a podocan-deficient mouse in combination with a model of arterial injury and ...

journal_title：Circulation

authors： Hutter R,Huang L,Speidl WS,Giannarelli C,Trubin P,Bauriedel G,Klotman ME,Fuster V,Badimon JJ,Klotman PE

更新日期：2013-11-26 00:00:00

abstract：BACKGROUND:The identification of high-risk patients who require early revascularization has become increasingly important with the present emphasis on reducing health care resources. This is particularly relevant to health care systems with prolonged waiting times for interventions. Myocardial viability imaging with th...

journal_title：Circulation

authors： Beanlands RS,Hendry PJ,Masters RG,deKemp RA,Woodend K,Ruddy TD

更新日期：1998-11-10 00:00:00

abstract：UNLABELLED:BACKGROUND- Reactive oxygen species serve signaling functions in the vasculature, and hypoxia has been associated with increased reactive oxygen species production. NADPH oxidase 4 (Nox4) is a reactive oxygen species-producing enzyme that is highly expressed in the endothelium, yet its specific role is unkno...

journal_title：Circulation

authors： Craige SM,Chen K,Pei Y,Li C,Huang X,Chen C,Shibata R,Sato K,Walsh K,Keaney JF Jr

更新日期：2011-08-09 00:00:00

abstract：:Correlates of high-density lipoprotein (HDL) cholesterol levels were studied in 4756 white males and females ages 20-59 years examined during a population survey conducted by 10 North American Lipid Research Clinics. Multivariable analysis was used to assess the relation of social, demographic, physical and behavioral...

journal_title：Circulation

authors： Heiss G,Johnson NJ,Reiland S,Davis CE,Tyroler HA

更新日期：1980-11-01 00:00:00

abstract：BACKGROUND:In cardiac arrest, use of percutaneous cardiopulmonary bypass support (PCPS) may lead to left ventricular loading, with deleterious effects on the myocardium, and is often accompanied by an increase in pulmonary artery pressure. The present study was designed to assess the potential of artificially induced p...

journal_title：Circulation

authors： Scholz KH,Figulla HR,Schröder T,Hering JP,Bock H,Ferrari M,Kreuzer H,Hellige G

更新日期：1995-05-15 00:00:00

abstract：:Six instances of sudden death were recorded by Holter monitoring, which showed ventricular fibrillation in five and a bradyarrhythmia in one. Complex ventricular ectopic activity preceded cardiac arrest in five patients, including the one with the bradyarrhythmic arrest. Two patients with chronic bifascicular block ar...

journal_title：Circulation

authors： Nikolic G,Bishop RL,Singh JB

更新日期：1982-07-01 00:00:00

abstract：:Dual antiplatelet therapy with aspirin and a thienopyridine has been shown to reduce cardiac events after coronary stenting. However, many patients and healthcare providers prematurely discontinue dual antiplatelet therapy, which greatly increases the risk of stent thrombosis, myocardial infarction, and death. This ad...

journal_title：Circulation

authors： Grines CL,Bonow RO,Casey DE Jr,Gardner TJ,Lockhart PB,Moliterno DJ,O'Gara P,Whitlow P,American Heart Association.,American College of Cardiology.,Society for Cardiovascular Angiography and Interventions.,American College of Surgeon

更新日期：2007-02-13 00:00:00

abstract：BACKGROUND:Heterogeneous electrophysiological properties, which may be due in part to autonomic innervation, are important in the maintenance of atrial fibrillation (AF). We hypothesized that heterogeneous sympathetic denervation with phenol would create a milieu for sustained AF. METHODS AND RESULTS:After the determi...

journal_title：Circulation

authors： Olgin JE,Sih HJ,Hanish S,Jayachandran JV,Wu J,Zheng QH,Winkle W,Mulholland GK,Zipes DP,Hutchins G

更新日期：1998-12-08 00:00:00

abstract：BACKGROUND:The renin-angiotensin system regulates blood pressure through its effects on vascular tone, renal hemodynamics, and renal sodium and fluid balance. METHODS AND RESULTS:Using data from a large population-based sample of 1488 siblings having a mean age of 14.8 years and belonging to the youngest generation of...

journal_title：Circulation

authors： Fornage M,Amos CI,Kardia S,Sing CF,Turner ST,Boerwinkle E

更新日期：1998-05-12 00:00:00

abstract：:Children with congenital aortic stenosis have "excessive" left ventricular hypertrophy with reduced resting systolic wall stress that allows for supernormal ejection performance. If aortic stenosis is uncorrected, this pattern persists until adulthood. The effect of removing the aortic pressure gradient on left ventri...

journal_title：Circulation

authors： Dorn GW 2nd,Donner R,Assey ME,Spann JF Jr,Wiles HB,Carabello BA

更新日期：1988-12-01 00:00:00

abstract：BACKGROUND:The coexistence of atrial fibrillation (AF) and atrial flutter (AFL) is well recognized. AF precedes the onset of AFL in almost all instances. We evaluated the effect of 2 ablation strategies in patients with paroxysmal AF (PAF) and AFL. METHODS AND RESULTS:Ninety-eight patients with PAF/AFL were prospectiv...

journal_title：Circulation

authors： Moreira W,Timmermans C,Wellens HJ,Mizusawa Y,Philippens S,Perez D,Rodriguez LM

更新日期：2007-12-11 00:00:00

abstract：BACKGROUND:The main goal of the initial treatment of ST-segment elevation myocardial infarction is prompt reperfusion of the infarct-related artery. The value of pretreatment with clopidogrel before primary percutaneous coronary intervention is currently unclear. METHODS AND RESULTS:Studies were retrieved through MEDL...

journal_title：Circulation

authors： Vlaar PJ,Svilaas T,Damman K,de Smet BJ,Tijssen JG,Hillege HL,Zijlstra F

更新日期：2008-10-28 00:00:00

abstract：:Various electrocardiographic and vectorcardiographic (ECG-VCG) patterns of ventricular conduction disturbances are inducible by premature right atrial stimulation (PRAS). These patterns are a consequence of different degrees of refractoriness in the specialized ventricular conduction system. We observed that the inter...

journal_title：Circulation

authors： Piccolo E,Raviele A,Delise P,Dainese F,Pascotto P,Totaro G,Sartori F,D'Este D

更新日期：1979-05-01 00:00:00

abstract：BACKGROUND:Mechanisms favoring the occurrence of paroxysmal atrial fibrillation (PAF) are complex and poorly defined. This study was designed to analyze dynamic changes in autonomic tone preceding the onset of PAF in a large group of patients. METHODS AND RESULTS:Holter tapes from 77 unselected consecutive patients (6...

journal_title：Circulation

authors： Bettoni M,Zimmermann M

更新日期：2002-06-11 00:00:00

abstract：BACKGROUND:Development and validation of novel imaging modalities to assess the composition of human atherosclerotic plaques will improve the understanding of atheroma evolution and could facilitate evaluation of therapeutic strategies for plaque modification. Surface MRI can characterize tissue content of carotid but ...

journal_title：Circulation

authors： Larose E,Yeghiazarians Y,Libby P,Yucel EK,Aikawa M,Kacher DF,Aikawa E,Kinlay S,Schoen FJ,Selwyn AP,Ganz P

更新日期：2005-10-11 00:00:00

abstract：BACKGROUND:Thrombus regression in heparin-treated, acute deep venous thrombosis of the lower extremity is poorly documented in the literature; different rates of thrombus resolution and recanalization are reported. METHODS AND RESULTS:In a prospective follow-up study, duplex scanning was used to evaluate the thrombus ...

journal_title：Circulation

authors： van Ramshorst B,van Bemmelen PS,Hoeneveld H,Faber JA,Eikelboom BC

更新日期：1992-08-01 00:00:00