Ventricular aneurysms complicating coxsackievirus group B, types 1 and 4 murine myocarditis.


:Suckling Swiss Webster mice were inoculated with 10(4)TCD50 of coxsackieviruses, group B types 1 or 4. Virulent necrotizing myocarditis resulted in 185 infected mice. Of the latter group, three (14.3%) nurslings on the 17th and 23rd day after inoculations had left ventricular aneurysms postmortem. None of 61 concurrently matched control mice developed aneurysms. Ventricular aneurysm is a suggested but previously undocumented complication of murine, and possibly human necrotizing transmural coxsackievirus myocarditis.






El-Khatib MR,Chason JL,Lerner AM




Has Abstract


1979-02-01 00:00:00












  • The impending crisis awaiting cardiac transplantation. Modeling a solution based on selection.

    abstract:BACKGROUND:Each month, the number of transplant candidates added to the waiting list exceeds the number of transplantations performed, and many outpatients deteriorate to require transplantation urgently. The current list of 2400 candidates and the average wait of 8 months continue to increase. METHODS AND RESULTS:To ...


    pub_type: 杂志文章


    authors: Stevenson LW,Warner SL,Steimle AE,Fonarow GC,Hamilton MA,Moriguchi JD,Kobashigawa JA,Tillisch JH,Drinkwater DC,Laks H

    更新日期:1994-01-01 00:00:00

  • Inositol 1, 4, 5-trisphosphate receptors and human left ventricular myocytes.

    abstract:BACKGROUND:Little is known about the function of inositol 1,4,5-trisphosphate receptors (IP3Rs) in the adult heart experimentally. Moreover, whether these Ca(2+) release channels are present and play a critical role in human cardiomyocytes remains to be defined. IP3Rs may be activated after Gαq-protein-coupled receptor...


    pub_type: 杂志文章


    authors: Signore S,Sorrentino A,Ferreira-Martins J,Kannappan R,Shafaie M,Del Ben F,Isobe K,Arranto C,Wybieralska E,Webster A,Sanada F,Ogórek B,Zheng H,Liu X,Del Monte F,D'Alessandro DA,Wunimenghe O,Michler RE,Hosoda T,Goichb

    更新日期:2013-09-17 00:00:00

  • Cytomegalovirus infection with interleukin-6 response predicts cardiac mortality in patients with coronary artery disease.

    abstract:BACKGROUND:Prospective data relating previous exposure to cytomegalovirus (CMV) to the risk of cardiac mortality are controversial. We investigated the effect of previous exposure to CMV infection on the risk of future cardiac disease-related death in relation to an underlying inflammatory response. METHODS AND RESULT...


    pub_type: 临床试验,杂志文章


    authors: Blankenberg S,Rupprecht HJ,Bickel C,Espinola-Klein C,Rippin G,Hafner G,Ossendorf M,Steinhagen K,Meyer J

    更新日期:2001-06-19 00:00:00

  • Cardiovascular responses to the isoprostanes iPF(2alpha)-III and iPE(2)-III are mediated via the thromboxane A(2) receptor in vivo.

    abstract:BACKGROUND:Isoprostanes (iPs) are free radical-catalyzed products of arachidonic acid that reflect lipid peroxidation in vivo. Several iPs exert biological effects in vitro and may contribute to the functional consequences of oxidant stress. For example, iPF(2alpha)-III (8-iso PGF(2alpha)) and iPE(2)-III modulate plate...


    pub_type: 杂志文章


    authors: Audoly LP,Rocca B,Fabre JE,Koller BH,Thomas D,Loeb AL,Coffman TM,FitzGerald GA

    更新日期:2000-06-20 00:00:00

  • Assessment of the treatment effect of enoxaparin for unstable angina/non-Q-wave myocardial infarction. TIMI 11B-ESSENCE meta-analysis.

    abstract:BACKGROUND:Two phase III trials of enoxaparin for unstable angina/non-Q-wave myocardial infarction have shown it to be superior to unfractionated heparin for preventing a composite of death and cardiac ischemic events. A prospectively planned meta-analysis was performed to provide a more precise estimate of the effects...


    pub_type: 临床试验,杂志文章,meta分析,多中心研究


    authors: Antman EM,Cohen M,Radley D,McCabe C,Rush J,Premmereur J,Braunwald E

    更新日期:1999-10-12 00:00:00

  • Benefits and risks of corticosteroid prophylaxis in adult cardiac surgery: a dose-response meta-analysis.

    abstract:BACKGROUND:Cardiopulmonary bypass and cardiac surgery are associated with a significant systemic inflammatory response that may increase postoperative complications. This meta-analysis assessed whether the benefits and risks of corticosteroid use were dose dependent in adult cardiac surgery. METHODS AND RESULTS:Random...


    pub_type: 杂志文章,meta分析


    authors: Ho KM,Tan JA

    更新日期:2009-04-14 00:00:00

  • Uric acid and survival in chronic heart failure: validation and application in metabolic, functional, and hemodynamic staging.

    abstract:BACKGROUND:Serum uric acid (UA) could be a valid prognostic marker and useful for metabolic, hemodynamic, and functional (MFH) staging in chronic heart failure (CHF). METHODS AND RESULTS:For the derivation study, 112 patients with CHF (age 59+/-12 years, peak oxygen consumption [Vo2] 17+/-7 mL/kg per minute) were recr...


    pub_type: 杂志文章


    authors: Anker SD,Doehner W,Rauchhaus M,Sharma R,Francis D,Knosalla C,Davos CH,Cicoira M,Shamim W,Kemp M,Segal R,Osterziel KJ,Leyva F,Hetzer R,Ponikowski P,Coats AJ

    更新日期:2003-04-22 00:00:00

  • Clinical features, management, and outcome of children with fetal and postnatal diagnoses of isomerism syndromes.

    abstract:BACKGROUND:Isomerism is associated with a complex spectrum of anomalies. There is paucity of data on prenatally detected cases. METHODS AND RESULTS:Between January 1990 and February 2004, 83 of 166 cases (50%) had a prenatal diagnosis of left isomerism (LAI; 52 of 97) or right isomerism (RAI; 31 of 69) at our institut...


    pub_type: 杂志文章


    authors: Lim JS,McCrindle BW,Smallhorn JF,Golding F,Caldarone CA,Taketazu M,Jaeggi ET

    更新日期:2005-10-18 00:00:00

  • Mitral anulus motion. Relation to pulmonary venous and transmitral flows in normal subjects and in patients with dilated cardiomyopathy.

    abstract::The dynamics between mitral anulus motion, and, thus, motion of the base of the heart, and filling of the left atrium and ventricle were studied by Doppler echocardiography in 12 normal subjects and 28 patients with dilated cardiomyopathy. The normal motion of the mitral anulus is associated with two phases of inflow ...


    pub_type: 杂志文章


    authors: Keren G,Sonnenblick EH,LeJemtel TH

    更新日期:1988-09-01 00:00:00

  • Targeted molecular probes for imaging atherosclerotic lesions with magnetic resonance using antibodies that recognize oxidation-specific epitopes.

    abstract:BACKGROUND:Oxidized low-density lipoprotein plays a key role in the initiation, progression, and destabilization of atherosclerotic plaques and is present in macrophages and the lipid pool. The aim of this study was to assess the feasibility of magnetic resonance imaging of atherosclerotic lesions in mice using micelle...


    pub_type: 杂志文章


    authors: Briley-Saebo KC,Shaw PX,Mulder WJ,Choi SH,Vucic E,Aguinaldo JG,Witztum JL,Fuster V,Tsimikas S,Fayad ZA

    更新日期:2008-06-24 00:00:00

  • Beta-adrenergic receptor subtypes differentially affect apoptosis in adult rat ventricular myocytes.

    abstract::BACKGROUND-Catecholamine-induced apoptosis is mediated by activation of the beta-adrenergic signaling pathway. We tested the hypothesis that beta(1)- and beta(2)-adrenergic receptor (AR) subtypes differentially affect apoptosis in adult rat ventricular myocytes in vitro. METHODS AND RESULTS-Myocytes were first exposed...


    pub_type: 杂志文章


    authors: Zaugg M,Xu W,Lucchinetti E,Shafiq SA,Jamali NZ,Siddiqui MA

    更新日期:2000-07-18 00:00:00

  • Temporal response and localization of integrins beta1 and beta3 in the heart after myocardial infarction: regulation by cytokines.

    abstract:BACKGROUND:Integrins are involved in structural remodeling and tissue repair. This study aimed to elucidate the role of the beta-integrins in cardiac remodeling after myocardial infarction (MI). METHODS AND RESULTS:The MI model was created by ligation of the left anterior descending coronary artery in rats. We detecte...


    pub_type: 杂志文章


    authors: Sun M,Opavsky MA,Stewart DJ,Rabinovitch M,Dawood F,Wen WH,Liu PP

    更新日期:2003-02-25 00:00:00

  • Cerebral resuscitation after cardiac arrest: a review.

    abstract::Cerebral neurons can tolerate at least 20 min of normothermic ischemic anoxia. Cerebral recovery from more than 5 min of cardiac arrest is hampered by complex secondary derangements of multiple organ systems after reperfusion. There is increasing support of our hypothesis that this "postresuscitation syndrome" include...


    pub_type: 杂志文章,评审


    authors: Safar P

    更新日期:1986-12-01 00:00:00

  • Effects of nifedipine on systemic and regional oxygen transport and metabolism at rest and during exercise.

    abstract::In a placebo-controlled, randomized, cross-over, double-blind study of 12 patients with stable exertional angina, we measured at rest and during bicycle exercise the effects of 20 mg of nifedipine administered sublingually on hemodynamics and systemic and regional oxygen extraction and metabolism. Nifedipine decreased...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Choong CY,Roubin GS,Shen WF,Harris PJ,Kelly DT

    更新日期:1985-04-01 00:00:00

  • Global burden of cardiovascular diseases: part I: general considerations, the epidemiologic transition, risk factors, and impact of urbanization.

    abstract::This two-part article provides an overview of the global burden of atherothrombotic cardiovascular disease. Part I initially discusses the epidemiologic transition which has resulted in a decrease in deaths in childhood due to infections, with a concomitant increase in cardiovascular and other chronic diseases; and th...


    pub_type: 杂志文章,评审


    authors: Yusuf S,Reddy S,Ounpuu S,Anand S

    更新日期:2001-11-27 00:00:00

  • Induction of meandering functional reentrant wave front in isolated human atrial tissues.

    abstract:BACKGROUND:The purpose of this study was to test the hypothesis that a single meandering functional reentrant wave front can result in rapid and irregular electrogram activity in human atrial tissues. METHODS AND RESULTS:The study used the explanted hearts of five human cardiac transplant recipients. Three right and t...


    pub_type: 杂志文章


    authors: Ikeda T,Czer L,Trento A,Hwang C,Ong JJ,Hough D,Fishbein MC,Mandel WJ,Karagueuzian HS,Chen PS

    更新日期:1997-11-04 00:00:00

  • Rapid ventricular induction of brain natriuretic peptide gene expression in experimental acute myocardial infarction.

    abstract:BACKGROUND:We have demonstrated that brain natriuretic peptide (BNP) is a cardiac hormone predominantly synthesized in and secreted from the ventricle. We have also reported that, compared with atrial natriuretic peptide (ANP), the plasma concentration of BNP is increased to a greater degree in patients with congestive...


    pub_type: 杂志文章


    authors: Hama N,Itoh H,Shirakami G,Nakagawa O,Suga S,Ogawa Y,Masuda I,Nakanishi K,Yoshimasa T,Hashimoto Y

    更新日期:1995-09-15 00:00:00

  • Enhanced inflammatory response to coronary angioplasty in patients with severe unstable angina.

    abstract:BACKGROUND:Systemic markers of inflammation have been found in unstable angina. Disruption of culprit coronary stenoses may cause a greater inflammatory response in patients with unstable than those with stable angina. We assessed the time course of C-reactive protein (CRP), serum amyloid A protein (SAA), and interleuk...


    pub_type: 临床试验,杂志文章


    authors: Liuzzo G,Buffon A,Biasucci LM,Gallimore JR,Caligiuri G,Vitelli A,Altamura S,Ciliberto G,Rebuzzi AG,Crea F,Pepys MB,Maseri A

    更新日期:1998-12-01 00:00:00

  • Genesis of high frequency notching of QRS complexes in an in vivo cardiac model.

    abstract::High frequency notching of the QRS complex is associated with transmural infarction, cardiomyopathies, and ventricular hypertrophy from any cause. The mechanism producing notching is unknown; but the presence of a discrete anatomic lesion is not an essential feature. The hypothesis that notching was produced by activa...


    pub_type: 杂志文章


    authors: Vanderark CR,Reynolds EW

    更新日期:1975-02-01 00:00:00

  • High prevalence of viral genomes and multiple viral infections in the myocardium of adults with "idiopathic" left ventricular dysfunction.

    abstract:BACKGROUND:For a long time, enteroviruses have been considered to be the most common cause of acute viral myocarditis (MC), with possible transition from MC to dilated cardiomyopathy (DCM). Recent investigations have shown, however, that other viruses are also frequently encountered in MC patients, suggesting that pers...


    pub_type: 杂志文章


    authors: Kühl U,Pauschinger M,Noutsias M,Seeberg B,Bock T,Lassner D,Poller W,Kandolf R,Schultheiss HP

    更新日期:2005-02-22 00:00:00

  • Sudden death in patients evaluated for ischemic heart disease.

    abstract::Data from 981 patients evaluated for ischemic heart disease with coronary angiography were reviewed to identify variables predictive of sudden death and duration from onset of symptoms to death. During the period of follow-up, 113 patients died. Of these deaths, 99 were classified as cardiovascular. Forty percent occu...


    pub_type: 杂志文章


    authors: Oberman A,Ray M,Turner ME,Barnes G,Grooms C

    更新日期:1975-12-01 00:00:00

  • Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.

    abstract:BACKGROUND:Oxidized LDLs (oxLDLs) and matrix metalloproteinases (MMPs) are present in atherosclerotic lesions. OxLDLs activate various signaling pathways potentially involved in atherogenesis. OxLDLs induce smooth muscle cell (SMC) proliferation mediated by the activation of the sphingomyelin/ceramide pathway and tyros...


    pub_type: 杂志文章


    authors: Augé N,Maupas-Schwalm F,Elbaz M,Thiers JC,Waysbort A,Itohara S,Krell HW,Salvayre R,Nègre-Salvayre A

    更新日期:2004-08-03 00:00:00

  • Experimental model of single ventricle. Influence of carbon dioxide on pulmonary vascular dynamics.

    abstract:BACKGROUND:Important in the postoperative management of neonates with single-ventricle complexes, such as hypoplastic left heart syndrome and pulmonary atresia with intact ventricular septum, is the fact that the pulmonary circulation is connected to the systemic circulation via a shunt. The distribution of flow to the...


    pub_type: 杂志文章


    authors: Mora GA,Pizarro C,Jacobs ML,Norwood WI

    更新日期:1994-11-01 00:00:00

  • Atherosclerosis and late closure of aortocoronary saphenous vein grafts: sequential angiographic studies at 2 weeks, 1 year, 5 to 7 years, and 10 to 12 years after surgery.

    abstract::Sequential control angiographic examinations were performed at 2 weeks, 1 year, 5 to 7 years, and 10 to 12 years after aortocoronary saphenous vein bypass surgery in 82 unselected patients. Graft modifications consisting of wall irregularities and obstructive lesions of various severity and shapes that were found to d...


    pub_type: 杂志文章


    authors: Campeau L,Enjalbert M,Lespérance J,Vaislic C,Grondin CM,Bourassa MG

    更新日期:1983-09-01 00:00:00

  • Clinical, genetic, and biophysical characterization of SCN5A mutations associated with atrioventricular conduction block.

    abstract:BACKGROUND:Three distinct cardiac arrhythmia disorders, the long-QT syndrome, Brugada syndrome, and conduction system disease, have been associated with heterozygous mutations in the cardiac voltage-gated sodium channel alpha-subunit gene (SCN5A). We present clinical, genetic, and biophysical features of 2 new SCN5A mu...


    pub_type: 杂志文章


    authors: Wang DW,Viswanathan PC,Balser JR,George AL Jr,Benson DW

    更新日期:2002-01-22 00:00:00

  • Atrium-selective sodium channel block as a strategy for suppression of atrial fibrillation: differences in sodium channel inactivation between atria and ventricles and the role of ranolazine.

    abstract:BACKGROUND:The development of selective atrial antiarrhythmic agents is a current strategy for suppression of atrial fibrillation (AF). METHODS AND RESULTS:Whole-cell patch clamp techniques were used to evaluate inactivation of peak sodium channel current (I(Na)) in myocytes isolated from canine atria and ventricles. ...


    pub_type: 杂志文章


    authors: Burashnikov A,Di Diego JM,Zygmunt AC,Belardinelli L,Antzelevitch C

    更新日期:2007-09-25 00:00:00

  • Vitamins C and E inhibit O2- production in the pig coronary artery.

    abstract:BACKGROUND:We previously found in a pig coronary balloon injury model that vitamins C and E as well as probucol had beneficial effects on the vessel response to injury measured by morphometry These effects correlated with an inhibition in the ability to oxidize LDLs ex vivo, suggesting that the morphological response w...


    pub_type: 杂志文章


    authors: Nunes GL,Robinson K,Kalynych A,King SB 3rd,Sgoutas DS,Berk BC

    更新日期:1997-11-18 00:00:00

  • Acute cardiovascular effects of fetal surgery in the human.

    abstract:BACKGROUND:Prenatal surgery for congenital anomalies can prevent fetal demise or alter the course of organ development, resulting in a more favorable condition at birth. The indications for fetal surgery continue to expand, yet little is known about the acute sequelae of fetal surgery on the human cardiovascular system...


    pub_type: 杂志文章,评审


    authors: Rychik J,Tian Z,Cohen MS,Ewing SG,Cohen D,Howell LJ,Wilson RD,Johnson MP,Hedrick HL,Flake AW,Crombleholme TM,Adzick NS

    更新日期:2004-09-21 00:00:00

  • Hirulog in the treatment of unstable angina. Results of the Thrombin Inhibition in Myocardial Ischemia (TIMI) 7 trial.

    abstract:BACKGROUND:Direct thrombin inhibitors are a new class of drugs that may offer a more effective and potentially simpler alternative to heparin. Hirulog is a synthetic peptide based on the leech-derived compound hirudin and, like hirudin, is a highly specific, direct inhibitor of free and clot-bound thrombin. METHODS AN...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Fuchs J,Cannon CP

    更新日期:1995-08-15 00:00:00

  • Defibrillator Versus beta-Blockers for Unexplained Death in Thailand (DEBUT): a randomized clinical trial.

    abstract:BACKGROUND:Sudden Unexplained Death Syndrome (SUDS) is the leading cause of death in young, healthy, Southeast Asian men. The role of an implantable cardioverter defibrillator (ICD) for mortality reduction in these patients remains unclear. METHODS AND RESULTS:The Defibrillator Versus beta-Blockers for Unexplained Dea...


    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Nademanee K,Veerakul G,Mower M,Likittanasombat K,Krittayapong R,Bhuripanyo K,Sitthisook S,Chaothawee L,Lai MY,Azen SP

    更新日期:2003-05-06 00:00:00