Relations between enzymatically estimated myocardial infarct size and early ventricular dysrhythmia.

abstract：:The nature, prevalence, functional significance, and indeed existence of myocardial disease in progressive systemic sclerosis (PSS) has been debated. In this study the clinical and pathological features of 52 autopsied patients were analyzed in an attempt to resolve these questions. A distinctive focal myocardial lesi...

journal_title：Circulation

authors： Bulkley BH,Ridolfi RL,Salyer WR,Hutchins GM

更新日期：1976-03-01 00:00:00

abstract：:There is now evidence that under resting conditions coronary vasodilator reserve exists even in the presence of myocardial ischemia. Therefore, we tested the hypothesis that a vasodilator reserve may exist during exercise so that during exercise-induced ischemia a reduction in coronary constrictor tone can be produced...

journal_title：Circulation

authors： Heusch G,Guth BD,Seitelberger R,Ross J Jr

更新日期：1987-02-01 00:00:00

abstract：BACKGROUND:The CAPRICORN trial has shown that carvedilol improved outcome in patients with left ventricular dysfunction after acute myocardial infarction treated with ACE inhibitors. The aim of this substudy was to determine the effects of carvedilol on left ventricular remodeling in this patient group. METHODS AND RE...

journal_title：Circulation

authors： Doughty RN,Whalley GA,Walsh HA,Gamble GD,López-Sendón J,Sharpe N,CAPRICORN Echo Substudy Investigators.

更新日期：2004-01-20 00:00:00

abstract：BACKGROUND:Peripheral arterial disease (PAD) is associated with an impairment in exercise performance and muscle function that is not fully explained by the reduced leg blood flow during exercise. This study characterized the effects of PAD on muscle function, histology, and metabolism. METHODS AND RESULTS:Twenty-six ...

journal_title：Circulation

authors： Regensteiner JG,Wolfel EE,Brass EP,Carry MR,Ringel SP,Hargarten ME,Stamm ER,Hiatt WR

更新日期：1993-02-01 00:00:00

abstract：BACKGROUND:A recent study has shown that the implantable atrial defibrillator can restore sinus rhythm in patients with recurrent atrial fibrillation when therapy was delivered under physician observation. The objective of this study was to evaluate the safety and efficacy of ambulatory use of the implantable atrial de...

journal_title：Circulation

authors： Daoud EG,Timmermans C,Fellows C,Hoyt R,Lemery R,Dawson K,Ayers GM

更新日期：2000-09-19 00:00:00

abstract：:Between July 1985 and September 1987, 25 patients underwent 26 carotid endarterectomies based on an abnormal duplex scan (B-mode ultrasonography and pulsed-Doppler sound spectral analysis) indicative of severe stenosis or ulceration. Arteriography was not performed because of severe unstable angina requiring coronary ...

journal_title：Circulation

authors： Marshall WG Jr,Kouchoukos NT,Murphy SF,Pelate C

更新日期：1988-09-01 00:00:00

abstract：BACKGROUND:The introduction of limited approaches to the heart and the avoidance of cardiopulmonary bypass (CPB) aim to reduce the invasiveness of CABG by decreasing the systemic release of inflammatory cytokines, such as tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and IL-8, as well as the anti-inflammatory ...

journal_title：Circulation

authors： Diegeler A,Doll N,Rauch T,Haberer D,Walther T,Falk V,Gummert J,Autschbach R,Mohr FW

更新日期：2000-11-07 00:00:00

abstract：BACKGROUND:The effects of lysophosphatidylcholine (LPC) on electrophysiological activities and intracellular Ca2+ concentration ([Ca2+]i) were investigated in coronary arterial smooth muscle cells (CASMCs). METHODS AND RESULTS:The patch clamp techniques and Ca2+ measurements were applied to cultured rabbit CASMCs. The...

journal_title：Circulation

authors： Terasawa K,Nakajima T,Iida H,Iwasawa K,Oonuma H,Jo T,Morita T,Nakamura F,Fujimori Y,Toyo-oka T,Nagai R

更新日期：2002-12-10 00:00:00

abstract：:Genetic analysis can be performed to identify the molecular substrate of inherited arrhythmogenic diseases; however, the role of this information in helping the management of patients is still debated. Here, we support the view that the practical value of genetic analysis is different in the various inherited conditio...

journal_title：Circulation

authors： Priori SG,Napolitano C

更新日期：2006-02-28 00:00:00

abstract：BACKGROUND:Biomarkers that predict response to cardiac resynchronization therapy (CRT) in heart failure patients with dyssynchrony (HFDYS) would be clinically important. Circulating extracellular microRNAs (miRNAs) have emerged as novel biomarkers that may also play important functional roles, but their relevance as ma...

journal_title：Circulation

authors： Melman YF,Shah R,Danielson K,Xiao J,Simonson B,Barth A,Chakir K,Lewis GD,Lavender Z,Truong QA,Kleber A,Das R,Rosenzweig A,Wang Y,Kass D,Singh JP,Das S

更新日期：2015-06-23 00:00:00

abstract：BACKGROUND:Hypercholesterolemia is associated with endothelial dysfunction. On the basis of the hypothesis that high plasma cholesterol per se may be a sufficient stimulus to upregulate endothelial adhesiveness and that this phenomenon might be reversible, soluble endothelial leukocyte adhesion molecules (sELAMs) were ...

journal_title：Circulation

authors： Sampietro T,Tuoni M,Ferdeghini M,Ciardi A,Marraccini P,Prontera C,Sassi G,Taddei M,Bionda A

更新日期：1997-09-02 00:00:00

abstract：:Several conditions that contribute to drowning and near drowning must be considered in the treatment of near-drowned victims. Regardless of the cause, mechanical ventilation should begin as soon as possible and closed-chest cardiac massage should be administered when there is any question about the adequacy of cardiac...

journal_title：Circulation

authors： Modell JH

更新日期：1986-12-01 00:00:00

abstract：:Amiloride, a widely used diuretic, has multiple pharmacological actions, including inhibition of the sodium-hydronium ion and the sodium-calcium exchanger in heart. In terms of cardiac electrophysiology, amiloride prolongs action potential duration without alteration in upstroke velocity of phase 0 in Purkinje fibers....

journal_title：Circulation

authors： Duff HJ,Lester WM,Rahmberg M

更新日期：1988-12-01 00:00:00

abstract：BACKGROUND:The characteristics of transmembrane potential (TMP) at the core of functional reentry in the atrium are not well understood. METHODS AND RESULTS:In protocol 1 (11 dogs), isolated perfused canine right atria were mapped from the endocardial surface while simultaneous TMPs were recorded from the epicardial s...

journal_title：Circulation

authors： Athill CA,Ikeda T,Kim YH,Wu TJ,Fishbein MC,Karagueuzian HS,Chen PS

更新日期：1998-10-13 00:00:00

abstract：BACKGROUND:Factor Xa plays a central role in the generation of thrombin, making it a novel target for treatment of arterial thrombosis. Fondaparinux is a synthetic factor Xa inhibitor that has been shown to be superior to standard therapies for the prevention of venous thrombosis. We performed a randomized trial to det...

journal_title：Circulation

authors： Mehta SR,Steg PG,Granger CB,Bassand JP,Faxon DP,Weitz JI,Afzal R,Rush B,Peters RJ,Natarajan MK,Velianou JL,Goodhart DM,Labinaz M,Tanguay JF,Fox KA,Yusuf S,ASPIRE Investigators.

更新日期：2005-03-22 00:00:00

abstract：:Congestive heart failure is often preceded by a latent or preclinical phase in which patients are relatively asymptomatic. During this period, there is neuroendocrine activation, left ventricular dysfunction, and remodeling of the heart. The extent to which these activities are interrelated is unclear, but it appears ...

journal_title：Circulation

authors： Francis GS,McDonald KM,Cohn JN

更新日期：1993-05-01 00:00:00

abstract：BACKGROUND:The Jun family of activator protein 1 (AP-1) transcription factors (c-Jun, JunB, and JunD) is involved in fundamental biological processes such as proliferation, apoptosis, tumor angiogenesis, and hypertrophy. The role of individual AP-1 transcription factors in the stressed heart is not clear. In the presen...

journal_title：Circulation

authors： Hilfiker-Kleiner D,Hilfiker A,Kaminski K,Schaefer A,Park JK,Michel K,Quint A,Yaniv M,Weitzman JB,Drexler H

更新日期：2005-09-06 00:00:00

abstract：BACKGROUND:Macrophages in human atherosclerotic plaques produce a family of matrix metalloproteinases (MMPs), which may influence vascular remodeling and plaque disruption. Because oxidized LDL (ox-LDL) is implicated in many proatherogenic events, we hypothesized that ox-LDL would regulate expression of MMP-9 and tissu...

journal_title：Circulation

authors： Xu XP,Meisel SR,Ong JM,Kaul S,Cercek B,Rajavashisth TB,Sharifi B,Shah PK

更新日期：1999-03-02 00:00:00

abstract：BACKGROUND:Adverse cardiovascular events associated with thrombotic occlusion occur in 4% to 12.8% of patients after coronary angioplasty. Recently, potent antiplatelet agents have been used to reduce those thrombotic complications. Tirofiban is a highly selective, short-acting inhibitor of fibrinogen binding to platel...

journal_title：Circulation

authors：

更新日期：1997-09-02 00:00:00

abstract：BACKGROUND:Female sex is an independent risk factor for torsade de pointes in long-QT syndrome. In women, QT interval and torsade de pointes risk fluctuate dynamically during the menstrual cycle and pregnancy. Accumulating clinical evidence suggests a role for progesterone; however, the effect of progesterone on cardia...

journal_title：Circulation

authors： Nakamura H,Kurokawa J,Bai CX,Asada K,Xu J,Oren RV,Zhu ZI,Clancy CE,Isobe M,Furukawa T

更新日期：2007-12-18 00:00:00

abstract：BACKGROUND:This study sought to evaluate the clinical impact of angiographic complete revascularization (CR) after drug-eluting stent implantation or coronary artery bypass graft surgery for multivessel coronary disease. METHODS AND RESULTS:A total of 1914 consecutive patients with multivessel coronary disease undergo...

journal_title：Circulation

authors： Kim YH,Park DW,Lee JY,Kim WJ,Yun SC,Ahn JM,Song HG,Oh JH,Park JS,Kang SJ,Lee SW,Lee CW,Park SW,Park SJ

更新日期：2011-05-31 00:00:00

abstract：BACKGROUND:Endothelin-1 (ET-1) is a potent positive inotrope in vitro, but its physiological effects on intrinsic myocardial contractile function in humans in vivo are unknown. Plasma ET-1 levels are elevated in heart failure, and ET-1 may be involved in the pathophysiology of this condition. However, its effects on co...

journal_title：Circulation

authors： MacCarthy PA,Grocott-Mason R,Prendergast BD,Shah AM

更新日期：2000-01-18 00:00:00

abstract：BACKGROUND:Autosomal dominant hypercholesterolemia (ADH) is characterized by elevated low-density lipoprotein cholesterol levels and premature cardiovascular disease. Mutations in the genes encoding for low-density lipoprotein receptor (LDLR), apolipoprotein B (APOB), and proprotein convertase subtilisin/kexin 9 (PCSK9...

journal_title：Circulation

authors： van der Graaf A,Avis HJ,Kusters DM,Vissers MN,Hutten BA,Defesche JC,Huijgen R,Fouchier SW,Wijburg FA,Kastelein JJ,Wiegman A

更新日期：2011-03-22 00:00:00

abstract：:The incidence and prevalence of most cardiovascular disorders increase with age, and cardiovascular disease is the leading cause of death and major disability in adults ≥75 years of age; however, despite the large impact of cardiovascular disease on quality of life, morbidity, and mortality in older adults, patients a...

journal_title：Circulation

authors： Rich MW,Chyun DA,Skolnick AH,Alexander KP,Forman DE,Kitzman DW,Maurer MS,McClurken JB,Resnick BM,Shen WK,Tirschwell DL,American Heart Association Older Populations Committee of the Council on Clinical Cardiology, Council on Cardiov

更新日期：2016-05-24 00:00:00

abstract：:Both the Veterans Administration Cooperative Study and the European Coronary Surgery Study have provided only brief accounts of graft patency rates in their surgically treated patients. In the Veterans Administration Cooperative Study, at an average of 1 year after operation, 69% of the grafts were patent among 208 pa...

journal_title：Circulation

authors： Bourassa MG,Fisher LD,Campeau L,Gillespie MJ,McConney M,Lespérance J

更新日期：1985-12-01 00:00:00

abstract：BACKGROUND:The alpha1-adrenergic receptors (alpha1-ARs) play a key role in cardiovascular homeostasis. However, the functional role of alpha1-AR subtypes in vivo is still unclear. The aim of this study was to evaluate the cardiovascular influences of alpha1b-AR. METHODS AND RESULTS:In transgenic mice lacking alpha1-AR...

journal_title：Circulation

authors： Vecchione C,Fratta L,Rizzoni D,Notte A,Poulet R,Porteri E,Frati G,Guelfi D,Trimarco V,Mulvany MJ,Agabiti-Rosei E,Trimarco B,Cotecchia S,Lembo G

更新日期：2002-04-09 00:00:00

abstract：:Paroxysmal supraventricular tachycardia (PSVT) is commonly caused by reentry within the atrioventricular (AV) node. This arrhythmia was abolished by operative dissection of the AV junction in a patient with disabling tachycardia that was not controlled by drugs. The operation was intended to create complete AV block, ...

journal_title：Circulation

authors： Pritchett EL,Anderson RW,Benditt DG,Kasell J,Harrison L,Wallace AG,Sealy WC,Gallagher JJ

更新日期：1979-08-01 00:00:00

abstract：BACKGROUND:Varicose veins are a common problem with no approved medical therapies. Although it is believed that varicose vein pathogenesis is multifactorial, there is limited understanding of the genetic and environmental factors that contribute to their formation. Large-scale studies of risk factors for varicose veins...

journal_title：Circulation

authors： Fukaya E,Flores AM,Lindholm D,Gustafsson S,Zanetti D,Ingelsson E,Leeper NJ

更新日期：2018-12-18 00:00:00

abstract：:Knowledge of the potential gradient field created by defibrillation electrodes is important for the understanding and improvement of defibrillation. To obtain this knowledge by direct measurements, potentials were recorded from 60 epicardial, eight septal, and 36 right ventricular transmural electrodes in six open-che...

journal_title：Circulation

authors： Chen PS,Wolf PD,Claydon FJ,Dixon EG,Vidaillet HJ Jr,Danieley ND,Pilkington TC,Ideker RE

更新日期：1986-09-01 00:00:00

abstract：BACKGROUND:A completed Fontan circulation is the goal in the management of patients with single-ventricle physiology. To achieve this end, a two-stage rather than a single-stage approach is carried out routinely at many centers. Some groups have advocated baffle fenestration for virtually all patients to minimize post-...

journal_title：Circulation

authors： Hsu DT,Quaegebeur JM,Ing FF,Selber EJ,Lamour JM,Gersony WM

更新日期：1997-11-04 00:00:00