Outcome after the single-stage, nonfenestrated Fontan procedure.

Abstract:

BACKGROUND:A completed Fontan circulation is the goal in the management of patients with single-ventricle physiology. To achieve this end, a two-stage rather than a single-stage approach is carried out routinely at many centers. Some groups have advocated baffle fenestration for virtually all patients to minimize post-Fontan complications. Other centers perform single-stage Fontan operations and do not fenestrate. Thus controversies have arisen regarding the indications for the staged procedure versus single stage and for fenestration versus no fenestration. METHODS AND RESULTS:The preoperative risk factors and postoperative course were characterized in 61 consecutive patients (median age, 3.3 years) undergoing a single-stage, nonfenestrated Fontan. The patients were followed for 3.5+/-1.9 years. The relationship between preoperative risk factors and mortality and morbidity was assessed. Preoperative risk factors assessed included age <2 years (n=18), branch pulmonary artery stenosis (n=20), elevated mean pulmonary artery pressure >15 mm Hg (n=16), atrioventricular valve regurgitation (n=5), and decreased ventricular function (n=2). Total caval pulmonary anastomosis was performed in 53 patients. Additional surgery was required at the time of the Fontan in 25 patients (41%). The median duration of mechanical ventilation was 1 day; median chest tube drainage was 5.5 days (range, 1 to 35). Oxygen saturation rose significantly postoperatively, from 83% to 95%. Early mortality was 4.9%; one patient died from pacemaker failure 9 months postoperatively, and one patient underwent successful heart transplant 4 months post-Fontan. One- and 5-year actuarial survival was 93%. No preoperative risk factor was associated with a failed Fontan or significant effusions. CONCLUSIONS:A single-stage, nonfenestrated Fontan was performed in a large group of patients with excellent surgical results and intermediate outcome. There is no evidence that a two-stage approach and/or baffle fenestration is required for a large cohort of patients who are candidates for a Fontan operation.

journal_name

Circulation

journal_title

Circulation

authors

Hsu DT,Quaegebeur JM,Ing FF,Selber EJ,Lamour JM,Gersony WM

subject

Has Abstract

pub_date

1997-11-04 00:00:00

pages

II-335-40

issue

9 Suppl

eissn

0009-7322

issn

1524-4539

journal_volume

96

pub_type

杂志文章
  • Peroxisome proliferator-activated receptor gamma plays a critical role in inhibition of cardiac hypertrophy in vitro and in vivo.

    abstract:BACKGROUND:Peroxisome proliferator-activated receptors (PPARs) are transcription factors of the nuclear receptor superfamily. It has been reported that the thiazolidinediones, which are antidiabetic agents and high-affinity ligands for PPARgamma, regulate growth of vascular cells. In the present study, we examined the ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/hc1002.105225

    authors: Asakawa M,Takano H,Nagai T,Uozumi H,Hasegawa H,Kubota N,Saito T,Masuda Y,Kadowaki T,Komuro I

    更新日期:2002-03-12 00:00:00

  • Relation between left ventricular oxygen consumption and pressure-volume area in conscious dogs.

    abstract:BACKGROUND:The relation between left ventricular (LV) oxygen consumption (MVO2) and pressure-volume area (PVA) developed in isolated hearts provides a powerful method to understand cardiac energetics. We investigated application of this relation to the intact circulation, determining its response to steady-state and tr...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.89.2.810

    authors: Nozawa T,Cheng CP,Noda T,Little WC

    更新日期:1994-02-01 00:00:00

  • Inherited Thoracic Aortic Disease: New Insights and Translational Targets.

    abstract::Inherited thoracic aortopathies denote a group of congenital conditions that predispose to disease of the thoracic aorta. Aortic wall weakness and abnormal aortic hemodynamic profiles predispose these patients to dilatation of the thoracic aorta, which is generally silent but can precipitate aortic dissection or ruptu...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.119.043756

    authors: Fletcher AJ,Syed MBJ,Aitman TJ,Newby DE,Walker NL

    更新日期:2020-05-12 00:00:00

  • Elastin stabilizes an infarct and preserves ventricular function.

    abstract:BACKGROUND:After a myocardial infarction, the injured region becomes fibrotic and the myocardial scar may expand if the ventricular wall lacks elasticity. Cardiac dilatation may precipitate the vicious cycle of progressive heart failure. The present study evaluated the functional benefits of increasing elastin within a...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.CIRCULATIONAHA.105.523795

    authors: Mizuno T,Yau TM,Weisel RD,Kiani CG,Li RK

    更新日期:2005-08-30 00:00:00

  • Effects of calcium, inorganic phosphate, and pH on isometric force in single skinned cardiomyocytes from donor and failing human hearts.

    abstract:BACKGROUND:During ischemia, the intracellular calcium and inorganic phosphate (P(i)) concentrations rise and pH falls. We investigated the effects of these changes on force development in donor and failing human hearts to determine if altered contractile protein composition during heart failure changes the myocardial r...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/hc3501.095485

    authors: van Der Velden J,Klein LJ,Zaremba R,Boontje NM,Huybregts MA,Stooker W,Eijsman L,de Jong JW,Visser CA,Visser FC,Stienen GJ

    更新日期:2001-09-04 00:00:00

  • The relationship of cardiac output and arterial pressure control.

    abstract::Many basic concepts of cardiac output and arterial pressure control have changed considerably in the past few years. In general, each tissue controls its own local resistance and blood flow regardless of the level of arterial pressure; the sum of the local flows then determines the venous return and cardiac output. Ho...

    journal_title:Circulation

    pub_type: 杂志文章,评审

    doi:10.1161/01.cir.64.6.1079

    authors: Guyton AC

    更新日期:1981-12-01 00:00:00

  • The cardioprotective effects of ischemic 'preconditioning' are not mediated by adenosine receptors in rat hearts.

    abstract:BACKGROUND:Adenosine receptor activation has been proposed to explain the cardioprotective effect of ischemic preconditioning in rabbit hearts. We tested this hypothesis in a rat model by assessing whether administration of an adenosine antagonist could block the protective effect of preconditioning and whether adenosi...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.87.5.1642

    authors: Li Y,Kloner RA

    更新日期:1993-05-01 00:00:00

  • Elevated matrix metalloproteinase-9 associated with stroke or cardiovascular death in patients with carotid stenosis.

    abstract:BACKGROUND:Matrix metalloproteinase-9 could exhibit an important role in the destabilization of atherosclerotic carotid plaques. We hypothesized that in patients with carotid stenosis, elevated levels of plasma matrix metalloproteinase-9 are associated with ipsilateral stroke or cardiovascular death. METHODS AND RESUL...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.105.593483

    authors: Eldrup N,Grønholdt ML,Sillesen H,Nordestgaard BG

    更新日期:2006-10-24 00:00:00

  • Vacuolar H(+)-ATPase plays a crucial role in growth and phenotypic modulation of myofibroblasts in cultured human saphenous vein.

    abstract:BACKGROUND:The molecular mechanism of neointimal hyperplasia after vein graft surgery remains elusive. Vacuolar H(+)-ATPase (V-ATPase) is involved in intracellular trafficking and may play a crucial role in neointimal cell growth. METHODS AND RESULTS:Cultured human saphenous vein segments developed neointimal formatio...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.102.suppl_3.iii-269

    authors: Otani H,Yamamura T,Nakao Y,Hattori R,Fujii H,Ninomiya H,Kido M,Kawaguchi H,Osako M,Imamura H,Ohta T,Ohkuma S

    更新日期:2000-11-07 00:00:00

  • Cyclooxygenase-1 and -2-dependent prostacyclin formation in patients with atherosclerosis.

    abstract:BACKGROUND:The formation of prostacyclin (PGI(2)), thromboxane (TX) A(2), and isoprostanes is markedly enhanced in atherosclerosis. We examined the relative contribution of cyclooxygenase (COX)-1 and -2 to the generation of these eicosanoids in patients with atherosclerosis. METHODS AND RESULTS:The study population co...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1161/01.cir.102.8.840

    authors: Belton O,Byrne D,Kearney D,Leahy A,Fitzgerald DJ

    更新日期:2000-08-22 00:00:00

  • Comparative effects of calcium entry-blocking drugs, beta-blocking drugs, and their combination in patients with chronic stable angina.

    abstract::For monotherapy, beta-blockers and calcium-entry blockers are effective and safe antianginal medications. For prophylaxis of myocardial ischemia, a different mechanism of action for each class of drugs is reflected by the different heart rate and rate-pressure product during exercise. In patients who continue to have ...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章

    doi:

    authors: Kostuk WJ,Pflugfelder P

    更新日期:1987-06-01 00:00:00

  • Results of reoperation for unsuccessful coronary artery bypass surgery.

    abstract::Twenty-one reoperations for relief of angina have been performed at Stanford Medical Center in patients who had had previously unsuccessful direct coronary artery surgery. Complete releif of angina was obtained in seven (33%), improvement of angina in six (29%), and no change in angina in eight (38%) after these opera...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:

    authors:

    更新日期:1975-08-01 00:00:00

  • Arterial oxygenation and arterial oxygen transport in chronic myocardial failure at rest, during exercise and after hydralazine treatment.

    abstract::Arterial oxygen transport (cardiac output x arterial oxygen content) may be decreased in heart failure. We studied the determinants of arterial oxygen transport in 15 patients with chronic, severe myocardial failure at rest and during cycle ergometry. During control therapy at rest, arterial oxygen tension was normal ...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.66.1.143

    authors: Rubin SA,Brown HV,Swan HJ

    更新日期:1982-07-01 00:00:00

  • A randomized trial of beta-blockade in heart failure. The Cardiac Insufficiency Bisoprolol Study (CIBIS). CIBIS Investigators and Committees.

    abstract:BACKGROUND:Functional benefit in heart failure due to idiopathic dilated cardiomyopathy has been observed after beta-blockade, but improvement in survival has not been established in a large-scale randomized trial. This was the main objective of the Cardiac Insufficiency Bisoprolol Study (CIBIS). METHODS AND RESULTS:S...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1161/01.cir.90.4.1765

    authors:

    更新日期:1994-10-01 00:00:00

  • Quantification of extracellular and intracellular adenosine production: understanding the transmembranous concentration gradient.

    abstract:BACKGROUND:Inhibitors of adenosine membrane transport cause vasodilation and enhance the plasma adenosine concentration. However, it is unclear why the plasma adenosine concentration rises rather than falls when membrane transport is inhibited. We tested the hypothesis that the cytosolic adenosine concentration exceeds...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.99.15.2041

    authors: Deussen A,Stappert M,Schäfer S,Kelm M

    更新日期:1999-04-20 00:00:00

  • Epinephrine increases the severity of postresuscitation myocardial dysfunction.

    abstract:BACKGROUND:Epinephrine has been the mainstay for cardiac resuscitation for more than 30 years. Its vasopressor effect by which it increases coronary perfusion pressure is likely to favor initial resuscitation. Its beta-adrenergic action, however, may have detrimental effects on postresuscitation myocardial function whe...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.92.10.3089

    authors: Tang W,Weil MH,Sun S,Noc M,Yang L,Gazmuri RJ

    更新日期:1995-11-15 00:00:00

  • Benefits and risks of corticosteroid prophylaxis in adult cardiac surgery: a dose-response meta-analysis.

    abstract:BACKGROUND:Cardiopulmonary bypass and cardiac surgery are associated with a significant systemic inflammatory response that may increase postoperative complications. This meta-analysis assessed whether the benefits and risks of corticosteroid use were dose dependent in adult cardiac surgery. METHODS AND RESULTS:Random...

    journal_title:Circulation

    pub_type: 杂志文章,meta分析

    doi:10.1161/CIRCULATIONAHA.108.848218

    authors: Ho KM,Tan JA

    更新日期:2009-04-14 00:00:00

  • Proprotein convertase subtilisin kexin type 9 promotes intestinal overproduction of triglyceride-rich apolipoprotein B lipoproteins through both low-density lipoprotein receptor-dependent and -independent mechanisms.

    abstract:BACKGROUND:Proprotein convertase subtilisin kexin type 9 (PCSK9) promotes the degradation of the low-density lipoprotein (LDL) receptor (LDLR), and its deficiency in humans results in low plasma LDL cholesterol and protection against coronary heart disease. Recent evidence indicates that PCSK9 also modulates the metabo...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.113.006720

    authors: Rashid S,Tavori H,Brown PE,Linton MF,He J,Giunzioni I,Fazio S

    更新日期:2014-07-29 00:00:00

  • Sympathoinhibitory effects of atrial natriuretic factor in normal humans.

    abstract::In rats, atrial natriuretic factor (ANF) reduces sympathetic nerve activity (SNA) reflexively by sensitizing cardiac mechanoreceptors with inhibitory vagal afferents. We performed three series of experiments in 26 normal young men to document whether ANF inhibits SNA in humans and if so, to determine potential mechani...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.81.6.1860

    authors: Floras JS

    更新日期:1990-06-01 00:00:00

  • Meta-analysis of wine and beer consumption in relation to vascular risk.

    abstract:BACKGROUND:Many epidemiological studies have evaluated whether different alcoholic beverages protect against cardiovascular disease. We performed a meta-analysis of 26 studies on the relationship between wine or beer consumption and vascular risk. Methods and Results- General variance-based method and fitting models we...

    journal_title:Circulation

    pub_type: 杂志文章,meta分析

    doi:10.1161/01.cir.0000018653.19696.01

    authors: Di Castelnuovo A,Rotondo S,Iacoviello L,Donati MB,De Gaetano G

    更新日期:2002-06-18 00:00:00

  • Human internal thoracic artery reactivity to dopaminergic agents.

    abstract:BACKGROUND:Vasospasm of the internal thoracic artery (ITA) is common. The purpose of this study was to characterize the vascular reactivity of human ITA to dopaminergic agents used in patients undergoing coronary bypass surgery (CBS): dopamine, dobutamine, and dopexamine. METHODS AND RESULTS:Segments of the distal ITA...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:

    authors: Myers ML,Li GH,Yaghi A,McCormack D

    更新日期:1993-11-01 00:00:00

  • A randomized trial of recombinant staphylokinase versus alteplase for coronary artery patency in acute myocardial infarction. The STAR Trial Group.

    abstract:BACKGROUND:Recombinant staphylokinase (STAR) was shown recently to offer promise for coronary arterial thrombolysis in patients with evolving myocardial infarction. The present multicenter randomized open trial was designed to assess the thrombolytic efficacy, safety, and fibrin specificity of STAR relative to accelera...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1161/01.cir.92.8.2044

    authors: Vanderschueren S,Barrios L,Kerdsinchai P,Van den Heuvel P,Hermans L,Vrolix M,De Man F,Benit E,Muyldermans L,Collen D

    更新日期:1995-10-15 00:00:00

  • Subclinical coronary atherosclerosis in asymptomatic Filipino and white women.

    abstract:BACKGROUND:Coronary heart disease (CHD) is the leading cause of morbidity and mortality in persons with type 2 diabetes mellitus (T2DM). Electron-beam computed tomography (EBCT) detects coronary artery calcium (CAC), a marker of atherosclerotic plaque. Few studies have described EBCT-defined CHD among ethnic minorities...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.CIR.0000146377.15057.CC

    authors: Araneta MR,Barrett-Connor E

    更新日期:2004-11-02 00:00:00

  • Autologous culture-modified mononuclear cells confer vascular protection after arterial injury.

    abstract:BACKGROUND:Bone marrow-derived cells have been shown to contribute to endothelial replacement after vascular injury. In vitro culture of peripheral blood mononuclear cells produces cells with phenotypic characteristics of endothelium. To test the hypothesis that delivery of autologous culture-modified mononuclear cells...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.CIR.0000089084.48655.49

    authors: Gulati R,Jevremovic D,Peterson TE,Witt TA,Kleppe LS,Mueske CS,Lerman A,Vile RG,Simari RD

    更新日期:2003-09-23 00:00:00

  • Angiographic determination of arterial patency after percutaneous catheterization in infants and small children.

    abstract::Patency of the femoral artery of infants and children who previously had percutaneous arterial catheterization at a weight of less than 25 kg was studied angiographically. During the study period, 118 patients had repeat arterial catheterization. 48 from the opposite leg. Femoral artery occlusion was found in four pat...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.56.1.102

    authors: Hurwitz RA,Franken EA Jr,Girod DA,Smith JA,Smith WL

    更新日期:1977-07-01 00:00:00

  • Dietary alpha-lipoic acid supplementation inhibits atherosclerotic lesion development in apolipoprotein E-deficient and apolipoprotein E/low-density lipoprotein receptor-deficient mice.

    abstract:BACKGROUND:Vascular inflammation and lipid deposition are prominent features of atherosclerotic lesion formation. We have shown previously that the dithiol compound alpha-lipoic acid (LA) exerts antiinflammatory effects by inhibiting tumor necrosis factor-alpha- and lipopolysaccharide-induced endothelial and monocyte a...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/CIRCULATIONAHA.107.725275

    authors: Zhang WJ,Bird KE,McMillen TS,LeBoeuf RC,Hagen TM,Frei B

    更新日期:2008-01-22 00:00:00

  • Plaque volume and occurrence and location of periprocedural myocardial necrosis after percutaneous coronary intervention: insights from delayed-enhancement magnetic resonance imaging, thrombolysis in myocardial infarction myocardial perfusion grade analys

    abstract:BACKGROUND:Myocardial necrosis can occur during percutaneous coronary intervention (PCI) despite optimal adjunctive pharmacology and careful technique. We investigated the mechanisms of procedural infarction using angiographic analysis, intravascular ultrasound, and delayed-enhancement magnetic resonance imaging. METH...

    journal_title:Circulation

    pub_type: 临床试验,杂志文章

    doi:10.1161/CIRCULATIONAHA.105.593210

    authors: Porto I,Selvanayagam JB,Van Gaal WJ,Prati F,Cheng A,Channon K,Neubauer S,Banning AP

    更新日期:2006-08-15 00:00:00

  • Pathological healing response of explanted MitraClip devices.

    abstract:BACKGROUND:The safety and effectiveness of the MitraClip device (Abbott Vascular, Menlo Park, CA) is being evaluated in the Endovascular Valve Edge-to-Edge Repair Study (EVEREST) clinical studies. The healing response after device implantation has not previously been characterized in humans. METHODS AND RESULTS:A tota...

    journal_title:Circulation

    pub_type: 杂志文章,随机对照试验

    doi:10.1161/CIRCULATIONAHA.110.978130

    authors: Ladich E,Michaels MB,Jones RM,McDermott E,Coleman L,Komtebedde J,Glower D,Argenziano M,Feldman T,Nakano M,Virmani R,Endovascular Valve Edge-to-Edge Repair Study (EVEREST) Investigators.

    更新日期:2011-04-05 00:00:00

  • Exercise conditioning in older coronary patients. Submaximal lactate response and endurance capacity.

    abstract:BACKGROUND:Older coronary patients are at high risk of cardiac disability. Exercise conditioning programs have been demonstrated to improve functional capacity, particularly in younger coronary patients. In this study, the effects of aerobic conditioning on submaximal and maximal indicators of exercise performance were...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.cir.88.2.572

    authors: Ades PA,Waldmann ML,Poehlman ET,Gray P,Horton ED,Horton ES,LeWinter MM

    更新日期:1993-08-01 00:00:00

  • Transgenic mouse model of ventricular preexcitation and atrioventricular reentrant tachycardia induced by an AMP-activated protein kinase loss-of-function mutation responsible for Wolff-Parkinson-White syndrome.

    abstract:BACKGROUND:We identified a gene (PRKAG2) that encodes the gamma-2 regulatory subunit of AMP-activated protein kinase (AMPK) with a mutation (Arg302Gln) responsible for familial Wolff-Parkinson-White (WPW) syndrome. The human phenotype consists of ventricular preexcitation, conduction abnormalities, and cardiac hypertro...

    journal_title:Circulation

    pub_type: 杂志文章

    doi:10.1161/01.CIR.0000151291.32974.D5

    authors: Sidhu JS,Rajawat YS,Rami TG,Gollob MH,Wang Z,Yuan R,Marian AJ,DeMayo FJ,Weilbacher D,Taffet GE,Davies JK,Carling D,Khoury DS,Roberts R

    更新日期:2005-01-04 00:00:00