Elevated matrix metalloproteinase-9 associated with stroke or cardiovascular death in patients with carotid stenosis.

abstract：BACKGROUND:Coronary artery disease is the major cause of late cardiac allograft failure. However, few data exist regarding the natural history of changes in intimal and external elastic membrane (EEM) areas after heart transplantation. METHODS AND RESULTS:In 38 transplant recipients, serial intravascular ultrasound ex...

journal_title：Circulation

authors： Tsutsui H,Ziada KM,Schoenhagen P,Iyisoy A,Magyar WA,Crowe TD,Klingensmith JD,Vince DG,Rincon G,Hobbs RE,Yamagishi M,Nissen SE,Tuzcu EM

更新日期：2001-08-07 00:00:00

abstract：:Cardiac allograft vasculopathy (CAV) remains a troublesome long-term complication of heart transplantation. It is manifested by a unique and unusually accelerated form of coronary disease affecting both intramural and epicardial coronary arteries and veins.CAV is characterized by vascular injury induced by a variety o...

journal_title：Circulation

authors： Weis M,von Scheidt W

更新日期：1997-09-16 00:00:00

abstract：BACKGROUND:A paucity of literature is available on the effects of age and coronary artery bypass grafting (CABG) on the outcomes of patients undergoing mitral valve (MV) repair versus replacement. METHODS AND RESULTS:A matched study was performed using prospectively collected data from the Emory cardiovascular databas...

journal_title：Circulation

authors： Thourani VH,Weintraub WS,Guyton RA,Jones EL,Williams WH,Elkabbani S,Craver JM

更新日期：2003-07-22 00:00:00

abstract：BACKGROUND:Endogenous nitric oxide (NO) has been reported to inhibit oxygen consumption in the normal heart, so that nonselective inhibition of NO synthase (NOS) caused an increase of myocardial oxygen consumption (MVO2). Although endothelial NOS responses are depressed in congestive heart failure (CHF), inducible NOS ...

journal_title：Circulation

authors： Chen Y,Traverse JH,Du R,Hou M,Bache RJ

更新日期：2002-07-09 00:00:00

abstract：:Cross-sectional echocardiographic studies of the aortic arch and proximal descending aorta were performed in 18 patients with coarctation of the aorta and 20 normal subjects. In normals the aortic arch and proximal descending aorta appeared as an arcuate, echo-free structure curving across the plane of the scan. There...

journal_title：Circulation

authors： Weyman AE,Caldwell RL,Hurwitz RA,Girod DA,Dillon JC,Feigenbaum H,Green D

更新日期：1978-03-01 00:00:00

abstract：:The relation between left atrial size and atrial fibrillation was examined in 37 patients who had left ventriculomyotomy and myectomy at the National Heart and Lung Institute. Atrial fibrillation was present in 11 of 27 (41%) patients with an echocardiographically measured left atrial dimension greater than 45 mm. No ...

journal_title：Circulation

authors： Watson DC,Henry WL,Epstein SE,Morrow AG

更新日期：1977-01-01 00:00:00

abstract：BACKGROUND:The regulation of the cardiac neutral endopeptidase (EC 24.10, NEP) that degrades bradykinin and natriuretic peptides has been investigated in human cardiac hypertrophy and heart failure. Methods and Results- NEP mRNA was quantitated by real-time polymerase chain reaction (PCR) in left ventricular biopsies f...

journal_title：Circulation

authors： Fielitz J,Dendorfer A,Pregla R,Ehler E,Zurbrügg HR,Bartunek J,Hetzer R,Regitz-Zagrosek V

更新日期：2002-01-22 00:00:00

abstract：BACKGROUND:Percutaneous transluminal coronary angioplasty (PTCA) of the infarct-related artery was performed within 42 days of recombinant tissue-type plasminogen activator (rt-PA) administration in 1,414 of the 3,534 patients who participated in the Thrombolysis In Myocardial Infarction (TIMI) II study. Primary angiog...

journal_title：Circulation

authors： Baim DS,Diver DJ,Feit F,Greenberg MA,Holmes DR,Weiner BH,Williams DO,Schweiger MJ,Brown BG,Frederick MM

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:This study compared the efficacy of ischemic preconditioning (IPC) and sodium-hydrogen exchanger (NHE)-1 inhibition to reduce infarct size (IS) induced by a 90-minute ischemic insult and examined the interaction between NHE-1 inhibition and IPC. METHODS AND RESULTS:In a canine infarct model, either IPC, pro...

journal_title：Circulation

authors： Gumina RJ,Buerger E,Eickmeier C,Moore J,Daemmgen J,Gross GJ

更新日期：1999-12-21 00:00:00

abstract：BACKGROUND:Regular exercise in patients with stable coronary artery disease has been shown to improve myocardial perfusion and to retard disease progression. We therefore conducted a randomized study to compare the effects of exercise training versus standard percutaneous coronary intervention (PCI) with stenting on cl...

journal_title：Circulation

authors： Hambrecht R,Walther C,Möbius-Winkler S,Gielen S,Linke A,Conradi K,Erbs S,Kluge R,Kendziorra K,Sabri O,Sick P,Schuler G

更新日期：2004-03-23 00:00:00

abstract：:Although the resting hemodynamic effects of captopril in congestive heart failure are known, little information is available about the hemodynamic response to captopril during exercise or about changes in noninvasive measurements of the size and function of both ventricles. In this study, 14 stable New York Heart Asso...

journal_title：Circulation

authors： Massie B,Kramer BL,Topic N,Henderson SG

更新日期：1982-06-01 00:00:00

abstract：BACKGROUND:The substitution variants K35A,E38A,K74A, E75A,R77A (SakSTAR.M38) and K74A,E75A,R77A,E80A, D82A (SakSTAR.M89) of recombinant staphylokinase (SakSTAR) with reduced antibody reactivity were assayed for thrombolytic potency and antibody induction in animal models and in patients. METHODS AND RESULTS:In a 125I-...

journal_title：Circulation

authors： Collen D,Moreau H,Stockx L,Vanderschueren S

更新日期：1996-07-15 00:00:00

abstract：BACKGROUND:Guidelines for the management of patients with suspected coronary artery disease (CAD) rely on the age, sex, and angina typicality-based pretest probabilities of angiographically significant CAD derived from invasive coronary angiography (guideline probabilities). Reliability of guideline probabilities has n...

journal_title：Circulation

authors： Cheng VY,Berman DS,Rozanski A,Dunning AM,Achenbach S,Al-Mallah M,Budoff MJ,Cademartiri F,Callister TQ,Chang HJ,Chinnaiyan K,Chow BJ,Delago A,Gomez M,Hadamitzky M,Hausleiter J,Karlsberg RP,Kaufmann P,Lin FY,Maffei E

更新日期：2011-11-29 00:00:00

abstract：:Endocardial catheter mapping was performed in 15 patients in sinus rhythm who had no evidence of structural heart disease and normal left ventricles. Mapping was performed with the use of 10 mm interelectrode distance from various left ventricular endocardial sites. In 10 patients a quantitative analysis of electrogra...

journal_title：Circulation

authors： Cassidy DM,Vassallo JA,Marchlinski FE,Buxton AE,Untereker WJ,Josephson ME

更新日期：1984-07-01 00:00:00

abstract：BACKGROUND:Microvascular dysfunction in hypertrophic cardiomyopathy (HCM) may create an ischemic substrate conducive to sudden death, but it remains unknown whether the extent of hypertrophy is associated with proportionally poorer perfusion reserve. Comparisons between magnitude of hypertrophy, impairment of perfusion...

journal_title：Circulation

authors： Petersen SE,Jerosch-Herold M,Hudsmith LE,Robson MD,Francis JM,Doll HA,Selvanayagam JB,Neubauer S,Watkins H

更新日期：2007-05-08 00:00:00

abstract：BACKGROUND:Soluble stem cell factor (SCF) has been shown to mobilize bone marrow stem cells and improve cardiac repair after myocardial infarction (MI). However, the effect of membrane-associated SCF on cardiac remodeling after MI is not known. The present study investigated the effects of cardiomyocyte-specific overex...

journal_title：Circulation

authors： Xiang FL,Lu X,Hammoud L,Zhu P,Chidiac P,Robbins J,Feng Q

更新日期：2009-09-22 00:00:00

abstract：:We have recently demonstrated that exercise training can induce important hemodynamic and metabolic adaptations in patients with chronic heart failure due to severe left ventricular dysfunction. This study examines the accompanying changes in submaximal exercise performance and the ventilatory response to exercise in ...

journal_title：Circulation

authors： Sullivan MJ,Higginbotham MB,Cobb FR

更新日期：1989-02-01 00:00:00

abstract：:A reduced rate of diastolic closure of the anterior mitral leaflet has been shown to occur in mitral stenosis, primary pulmonary hypertension, and in cases with reduced left ventricular compliance. Posterior notion of the posterior mitral leaflet in diastole has been the distinguishing feature to rule out the diagnosi...

journal_title：Circulation

authors： Levisman JA,Abbasi AS,Pearce ML

更新日期：1975-03-01 00:00:00

abstract：:For the past 5 years, investigators from many different laboratories have contributed to a greatly increased understanding of two very important lipid-carrying proteins in plasma--apo B-100 and apo B-48. Apo B-100, an extremely large protein composed of 4,536 amino acids, is synthesized by the liver and is crucial for...

journal_title：Circulation

authors： Young SG

更新日期：1990-11-01 00:00:00

abstract：:It is generally agreed that the conditions leading to myocardial ischemia occur when the oxygen demands of the myocardium exceed the oxygen supply. The major limitations of oxygen supply to the myocardium are atherogenic disease and vasospasm of the coronary arteries. The major hemodynamic determinants of myocardial o...

journal_title：Circulation

authors： Frishman WH

更新日期：1983-06-01 00:00:00

abstract：BACKGROUND:Titin is a giant elastic protein that spans the half-sarcomere from Z-disk to M-band. It acts as a molecular spring and mechanosensor and has been linked to striated muscle disease. The pathways that govern titin-dependent cardiac growth and contribute to disease are diverse and difficult to dissect. METHOD...

journal_title：Circulation

authors： Radke MH,Polack C,Methawasin M,Fink C,Granzier HL,Gotthardt M

更新日期：2019-04-09 00:00:00

abstract：BACKGROUND:We tested prospectively the hypothesis that stroke development can be predicted by echolucency of carotid atherosclerotic plaques in previously symptomatic and asymptomatic patients. METHODS AND RESULTS:We followed incidence of ipsilateral ischemic strokes for 4.4 years in 111 asymptomatic and 135 symptomat...

journal_title：Circulation

authors： Grønholdt ML,Nordestgaard BG,Schroeder TV,Vorstrup S,Sillesen H

更新日期：2001-07-03 00:00:00

abstract：BACKGROUND:To date, the uptake of drugs into the human heart by transport proteins is poorly understood. A candidate protein is the organic cation transporter novel type 2 (OCTN2) (SLC22A5), physiologically acting as a sodium-dependent transport protein for carnitine. We investigated expression and localization of OCTN...

journal_title：Circulation

authors： Grube M,Meyer zu Schwabedissen HE,Präger D,Haney J,Möritz KU,Meissner K,Rosskopf D,Eckel L,Böhm M,Jedlitschky G,Kroemer HK

更新日期：2006-02-28 00:00:00

abstract：BACKGROUND:Because pulmonary artery size is considered by most investigators to be a major prognosticator of outcome in patients undergoing staged Fontan reconstruction, the objective of the present study was to determine the efficacy of noninvasive measures in determining pulmonary artery size. METHODS AND RESULTS:Th...

journal_title：Circulation

authors： Fogel MA,Donofrio MT,Ramaciotti C,Hubbard AM,Weinberg PM

更新日期：1994-12-01 00:00:00

abstract：BACKGROUND:Cystathionine γ-lyase (CSE) produces H2S via enzymatic conversion of L-cysteine and plays a critical role in cardiovascular homeostasis. We investigated the effects of genetic modulation of CSE and exogenous H2S therapy in the setting of pressure overload-induced heart failure. METHODS AND RESULTS:Transvers...

journal_title：Circulation

authors： Kondo K,Bhushan S,King AL,Prabhu SD,Hamid T,Koenig S,Murohara T,Predmore BL,Gojon G Sr,Gojon G Jr,Wang R,Karusula N,Nicholson CK,Calvert JW,Lefer DJ

更新日期：2013-03-12 00:00:00

abstract：:This 2020 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations for advanced life support includes updates on multiple advanced life support topics addressed with 3 different types of reviews. Topics were prioritized on the basis of both recen...

journal_title：Circulation

authors： Berg KM,Soar J,Andersen LW,Böttiger BW,Cacciola S,Callaway CW,Couper K,Cronberg T,D'Arrigo S,Deakin CD,Donnino MW,Drennan IR,Granfeldt A,Hoedemaekers CWE,Holmberg MJ,Hsu CH,Kamps M,Musiol S,Nation KJ,Neumar RW,Nic

更新日期：2020-10-20 00:00:00

abstract：BACKGROUND:Diffuse myocardial fibrosis is a final end point in most cardiac diseases. It is missed by the cardiovascular magnetic resonance (CMR) late gadolinium enhancement technique. Currently, quantifying diffuse myocardial fibrosis requires invasive biopsy, with inherent risk and sampling error. We have developed a...

journal_title：Circulation

authors： Flett AS,Hayward MP,Ashworth MT,Hansen MS,Taylor AM,Elliott PM,McGregor C,Moon JC

更新日期：2010-07-13 00:00:00

abstract：BACKGROUND:This study examines the cellular basis for the phenotypic appearance of broad-based T waves, increased transmural dispersion of repolarization (TDR), and torsade de pointes (TdP) induced by beta-adrenergic agonists under conditions mimicking the LQT1 form of the congenital long-QT syndrome. METHODS AND RESU...

journal_title：Circulation

authors： Shimizu W,Antzelevitch C

更新日期：1998-11-24 00:00:00

abstract：BACKGROUND:ST-segment depression during exercise testing is frequently observed in the absence of restenosis after coronary angioplasty. METHODS AND RESULTS:We studied the determinants of this phenomenon in 70 consecutive patients with unstable angina related to a single left anterior descending coronary artery lesion...

journal_title：Circulation

authors： Beregi JP,Bauters C,McFadden EP,Quandalle P,Bertrand ME,Lablanche JM

更新日期：1994-07-01 00:00:00

abstract：BACKGROUND:Despite the fact that nonsteroidal anti-inflammatory drugs (NSAIDs) are contraindicated among patients with established cardiovascular disease, many receive NSAID treatment for a short period of time. However, little is known about the association between NSAID treatment duration and risk of cardiovascular d...

journal_title：Circulation

authors： Schjerning Olsen AM,Fosbøl EL,Lindhardsen J,Folke F,Charlot M,Selmer C,Lamberts M,Bjerring Olesen J,Køber L,Hansen PR,Torp-Pedersen C,Gislason GH

更新日期：2011-05-24 00:00:00