Abstract:
:Endocardial catheter mapping was performed in 15 patients in sinus rhythm who had no evidence of structural heart disease and normal left ventricles. Mapping was performed with the use of 10 mm interelectrode distance from various left ventricular endocardial sites. In 10 patients a quantitative analysis of electrographic amplitude, duration, and amplitude/duration ratio was performed. The normal left ventricular bipolar electrograms had an amplitude of greater than 3 mV, a duration of less than 70 msec, and an amplitude/duration ratio of greater than 0.045. Local activation times were also assessed in the 15 patients. This analysis revealed two endocardial breakthrough sites, one on the midinferior septum and a second on the anterior wall near the insertion of the anterior papillary muscle. We therefore have defined normal quantitative characteristics of left ventricular bipolar electrograms and the normal left ventricular activation sequence in the intact normal human left ventricle.
journal_name
Circulationjournal_title
Circulationauthors
Cassidy DM,Vassallo JA,Marchlinski FE,Buxton AE,Untereker WJ,Josephson MEdoi
10.1161/01.cir.70.1.37subject
Has Abstractpub_date
1984-07-01 00:00:00pages
37-42issue
1eissn
0009-7322issn
1524-4539journal_volume
70pub_type
杂志文章相关文献
CIRCULATION文献大全abstract:BACKGROUND:Adverse cardiovascular events associated with thrombotic occlusion occur in 4% to 12.8% of patients after coronary angioplasty. Recently, potent antiplatelet agents have been used to reduce those thrombotic complications. Tirofiban is a highly selective, short-acting inhibitor of fibrinogen binding to platel...
journal_title:Circulation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.cir.96.5.1445
更新日期:1997-09-02 00:00:00
abstract:BACKGROUND:Catheter-based intrapericardial (IPC) delivery of therapeutic agents has recently been demonstrated. Paclitaxel is known to inhibit vascular smooth muscle cell proliferation. This study examined the effect of IPC instillation of paclitaxel on neointimal proliferation after balloon overstretch of porcine coro...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.102.13.1575
更新日期:2000-09-26 00:00:00
abstract::Using a mechanical sector-scanner, two-dimensional echocardiograms were obtained from 28 normal subjects, 15 patients with tetralogy of Fallot, 11 patients with complete transposition of the great arteries and six patients with double outlet right ventricle. The image obtained perpendicular to the long axis of the lef...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.56.2.267
更新日期:1977-08-01 00:00:00
abstract:BACKGROUND:We investigated the effects of candesartan (an angiotensin II antagonist) alone, enalapril alone, and their combination on exercise tolerance, ventricular function, quality of life (QOL), neurohormone levels, and tolerability in congestive heart failure (CHF). METHODS AND RESULTS:Seven hundred sixty-eight p...
journal_title:Circulation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.cir.100.10.1056
更新日期:1999-09-07 00:00:00
abstract:BACKGROUND:Most survival prediction models for coronary artery bypass grafting surgery are limited to in-hospital or 30-day end points. We estimate a long-term survival model using data from the Society of Thoracic Surgeons Adult Cardiac Surgery Database and Centers for Medicare and Medicaid Services. METHODS AND RESU...
journal_title:Circulation
pub_type: 杂志文章,多中心研究
doi:10.1161/CIRCULATIONAHA.111.066902
更新日期:2012-03-27 00:00:00
abstract::We evaluated high-energy phosphate (HEP) levels and the ability to perform work in rat hearts preserved by standard techniques (0.9% NaCl arrest and storage at 4 degrees C) and by continuous coronary perfusion at 22 degrees C, pH 7.25, and 55 mm Hg for 4 or 8 hr with Krebs-Henseleit buffer (KHB), modified Morgan's sol...
journal_title:Circulation
pub_type: 杂志文章
doi:
更新日期:1986-11-01 00:00:00
abstract:BACKGROUND:A subgroup of patients with hypertrophic obstructive cardiomyopathy remain severely symptomatic despite optimal medical therapy. Septal myectomy reduces or eliminates left ventricular outflow obstruction and produces marked symptomatic improvement. With the recent advent of alternative methods for treatment ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.94.3.467
更新日期:1996-08-01 00:00:00
abstract:BACKGROUND:Previous studies suggest that the antifibrillatory action of class I and III drugs is due to prolongation of the atrial wavelength. The aim of the present study was to directly evaluate the electrophysiological action of antifibrillatory drugs in a goat model of chronic atrial fibrillation (AF). METHODS AND...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.102.2.260
更新日期:2000-07-11 00:00:00
abstract:BACKGROUND:Vascular endothelial growth factor (VEGF) is an endothelial cell-specific mitogen that is angiogenic in vitro and in vivo. It has been hypothesized that VEGF plays a role in myocardial collateral formation; however, the effects of VEGF on collateral flow to ischemic myocardium are unknown. METHODS AND RESUL...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.89.5.2183
更新日期:1994-05-01 00:00:00
abstract:BACKGROUND:Disease-associated electrophysiological alterations may contribute to the increased predisposition to arrhythmias of the hypertrophied or failing myocardium. An I(f)-like current is expressed in rat left ventricular myocytes (LVMs), its amplitude being linearly related to the severity of cardiac hypertrophy....
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.95.3.568
更新日期:1997-02-04 00:00:00
abstract:BACKGROUND:The purpose of this study was to test the hypothesis that a single meandering functional reentrant wave front can result in rapid and irregular electrogram activity in human atrial tissues. METHODS AND RESULTS:The study used the explanted hearts of five human cardiac transplant recipients. Three right and t...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.96.9.3013
更新日期:1997-11-04 00:00:00
abstract:BACKGROUND:Brain natriuretic peptide (BNP) and N-terminal (NT)-proBNP have recently emerged as promising parameters for risk assessment in acute pulmonary embolism (PE). However, their positive predictive value is low, and the prognostic implications of NT-proBNP or troponin elevation alone are questionable. METHODS A...
journal_title:Circulation
pub_type: 杂志文章,多中心研究
doi:10.1161/CIRCULATIONAHA.105.552216
更新日期:2005-09-13 00:00:00
abstract::There is strong evidence that revascularization does not prevent myocardial infarction in patients with stable coronary artery disease (CAD). The anatomic basis for this counterintuitive conclusion seems to be that most myocardial infarctions occur at sites that did not previously exhibit an angiographically significa...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.96.4.1360
更新日期:1997-08-19 00:00:00
abstract:BACKGROUND:Atherosclerosis is associated with immune responses to oxidized lipoproteins and certain microorganisms, but the role of specific immunity has remained unclear. METHODS AND RESULTS:To study the role of immunity in atherosclerosis, we crossed atherosclerosis-prone apoE(-/-) mice with immunodeficient scid/sci...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.102.24.2919
更新日期:2000-12-12 00:00:00
abstract::A patient is described in whom a large congenital aneurysm or diverticulum of the right atrium caused repeated attacks of supraventricular arrhythmia and a strikingly reduced cardiac output. The aneurysm, which contained a large thrombus, was demonstrated by preoperative angiographic examinations. At the time of opera...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.38.1.124
更新日期:1968-07-01 00:00:00
abstract:BACKGROUND:The effect of isoproterenol on increasing the peak amplitude of the L-type calcium current is reduced in myocytes dispersed from the epicardial border zone (EBZ) of the 5-day infarcted canine heart when compared with control cells from noninfarcted hearts. This suggests that specific alterations in the beta-...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.91.11.2824
更新日期:1995-06-01 00:00:00
abstract::Reperfusion of ischemic myocardium may accelerate necrosis of injured myocytes. To determine the role of neutrophil leukocytes in this process, we examined whether neutrophil depletion during reperfusion could modify infarct size in anesthetized dogs. The proximal circumflex coronary artery was occluded for 90 minutes...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.80.6.1816
更新日期:1989-12-01 00:00:00
abstract::The importance of pulmonary artery size and the value of a standardized pulmonary artery index (PAI) in predicting outcome after Fontan's repair have previously been reported and questioned. We retrospectively reviewed 29 patients undergoing modified Fontan repair at The Children's Hospital of Philadelphia to examine ...
journal_title:Circulation
pub_type: 杂志文章
doi:
更新日期:1989-09-01 00:00:00
abstract:BACKGROUND:Increasingly, the diagnostic codes from administrative claims data are being used as clinical outcomes. METHODS AND RESULTS:Data from the Cardiovascular Health Study (CHS) were used to compare event rates and risk factor associations between adjudicated hospitalized cardiovascular events and claims-based me...
journal_title:Circulation
pub_type: 杂志文章,多中心研究
doi:10.1161/CIRCULATIONAHA.115.018610
更新日期:2016-01-12 00:00:00
abstract::This review discusses the role of growth factors on the proliferation of smooth muscle cells (SMCs) in injured arteries. We have used a variety of procedures to injure rat carotid arteries and noted that removal of endothelium followed by platelet adherence does not always initiate SMC replication. Furthermore, thromb...
journal_title:Circulation
pub_type: 杂志文章,评审
doi:
更新日期:1992-12-01 00:00:00
abstract::Analysis of the Framingham Heart Study experience between 1958 and 1970 showed a progressive increase in the rate of treatment and control of hypertension. With cross-sectional criteria to define diastolic hypertension, the treatment rate rose from 35% in 1958 through 1960 to 69% in 1968 through 1970 (p less than .001...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.71.1.22
更新日期:1985-01-01 00:00:00
abstract:BACKGROUND:Surviving cells in the postinfarction border zone are subjected to intense fluctuations of their microenvironment. Recently, border zone cardiomyocytes have been specifically implicated in cardiac regeneration. Here, we defined their unique transcriptional and regulatory properties, and comprehensively valid...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.118.038944
更新日期:2019-09-09 00:00:00
abstract:BACKGROUND:Biventricular direct cardiac compression (DCC) can potentially support the failing heart without the complications associated with a blood/device interface. The effect of uniform DCC on left and right ventricular performance was evaluated in 7 isolated canine heart preparations. METHODS AND RESULTS:A comput...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.99.16.2177
更新日期:1999-04-27 00:00:00
abstract:BACKGROUND:Albumin microbubbles that are used for contrast echocardiography persist within the myocardial microcirculation after ischemia/reperfusion (I-R). The mechanism responsible for this phenomenon is unknown. METHODS AND RESULTS:Intravital microscopy of the microcirculation of exteriorized cremaster muscle was p...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.101.6.668
更新日期:2000-02-15 00:00:00
abstract:BACKGROUND:In the last decades, interest has increased in the potential deleterious atherogenic effects of some cellular elastase activities. The results of experimental and clinical investigations were inconsistent. In this report, we assessed the associations of serum elastase activity and serum elastase inhibitors w...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.0000017329.51160.ef
更新日期:2002-06-04 00:00:00
abstract:BACKGROUND:Intracoronary stents may be effective when used as "bail-out" devices for acute complications after percutaneous transluminal coronary angioplasty. Furthermore, preliminary reports have demonstrated some promising results with stents with regard to the reduction of restenosis. Several stent devices are avail...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.83.5.1788
更新日期:1991-05-01 00:00:00
abstract:BACKGROUND:Repeated brief episodes of myocardial ischemia performed by mechanical clamping of a coronary artery "precondition" the heart and reduce infarct size after a subsequent sustained ischemia. It is not known, however, whether spontaneous episodes of transient ischemia caused by formation of platelet thrombi, wh...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.85.2.779
更新日期:1992-02-01 00:00:00
abstract:BACKGROUND:Atherosclerosis is an inflammatory disease in which interferon (IFN)-gamma, the signature cytokine of Th1 cells, plays a central role. We investigated whether interleukin (IL)-17, the signature cytokine of Th17 cells, is also associated with human coronary atherosclerosis. METHODS AND RESULTS:Circulating IL...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.108.827618
更新日期:2009-03-17 00:00:00
abstract:BACKGROUND:In the twin-to-twin transfusion syndrome (TTTS), pressure rather than volume overload is increasingly considered as a key factor in the pathogenesis of the cardiomyopathy of the recipient twin. If this is the case, cardiac dysfunction should be among the first signs observed with TTTS. The objective of this ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.CIR.0000146896.20317.59
更新日期:2004-11-09 00:00:00
abstract:BACKGROUND:For decades, the coronary heart disease (CHD) mortality rate has been four or more times higher in Finland than in France despite comparable intakes of dietary cholesterol and saturated fat. A potential answer to this paradox is provided by this study of 40 countries and the analyses of other nutrients in th...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.88.6.2771
更新日期:1993-12-01 00:00:00