Pulmonary artery index. A nonpredictor of operative survival in patients undergoing modified Fontan repair.


:The importance of pulmonary artery size and the value of a standardized pulmonary artery index (PAI) in predicting outcome after Fontan's repair have previously been reported and questioned. We retrospectively reviewed 29 patients undergoing modified Fontan repair at The Children's Hospital of Philadelphia to examine the relation between preoperative PAI (determined echocardiographically) and operative mortality. Twenty-four of these 29 patients underwent pulmonary artery augmentation at the time of Fontan repair. PAIs ranged from 48 to 541 mm2/m2. Operative mortality was 21%. PAI ranged from 68 to 233 mm2/m2 in nonsurvivors and from 48 to 541 mm2/m2 in survivors. There was no statistically significant difference in PAI between survivors and nonsurvivors; the lowest PAI associated with survival (48 mm2/m2) was one fourth of the lowest PAI value previously reported. There was a trend, not statistically significant, toward increased survival in those with larger PAIs. We conclude that patients should not be excluded from consideration for Fontan's repair solely on the basis of pulmonary artery size.






Bridges ND,Farrell PE Jr,Pigott JD 3rd,Norwood WI,Chin AJ


Has Abstract


1989-09-01 00:00:00




3 Pt 1








  • Nitroglycerin improves functional recovery of neonatal lamb hearts after 2 hours of cold ischemia.

    abstract:BACKGROUND:Vascular events during initial reperfusion after a period of hypothermic cardioplegic ischemia may play an important role in the recovery of mechanical function. Prior studies have shown (1) that dysfunction of the postischemic myocardium after normothermic ischemia can be ameliorated by vasodilation and (2)...


    pub_type: 杂志文章


    authors: Kawata H,Aoki M,Mayer JE Jr

    更新日期:1993-11-01 00:00:00

  • Fractional Flow Reserve and Cardiac Events in Coronary Artery Disease: Data From a Prospective IRIS-FFR Registry (Interventional Cardiology Research Incooperation Society Fractional Flow Reserve).

    abstract:BACKGROUND:We evaluated the prognosis of deferred and revascularized coronary stenoses after fractional flow reserve (FFR) measurement to assess its revascularization threshold in clinical practice. METHODS:The IRIS-FFR registry (Interventional Cardiology Research In-cooperation Society Fractional Flow Reserve) prospe...


    pub_type: 杂志文章,多中心研究


    authors: Ahn JM,Park DW,Shin ES,Koo BK,Nam CW,Doh JH,Kim JH,Chae IH,Yoon JH,Her SH,Seung KB,Chung WY,Yoo SY,Lee JB,Choi SW,Park K,Hong TJ,Lee SY,Han M,Lee PH,Kang SJ,Lee SW,Kim YH,Lee CW,Park SW,Park SJ,IRIS-FF

    更新日期:2017-06-06 00:00:00

  • Cardiomyogenic potential of C-kit(+)-expressing cells derived from neonatal and adult mouse hearts.

    abstract:BACKGROUND:C-kit is a receptor tyrosine kinase family member expressed in hematopoietic stem cells. C-kit is also transiently expressed in cardiomyocyte precursors during development and in a rare cell population in the normal adult heart. In the present study, the cardiomyogenic potential of c-kit(+) cells isolated fr...


    pub_type: 杂志文章


    authors: Zaruba MM,Soonpaa M,Reuter S,Field LJ

    更新日期:2010-05-11 00:00:00

  • The epidemiology of plasma high-density lipoprotein cholesterol levels. The Lipid Research Clinics Program Prevalence Study. Summary.

    abstract::Correlates of high-density lipoprotein (HDL) cholesterol levels were studied in 4756 white males and females ages 20-59 years examined during a population survey conducted by 10 North American Lipid Research Clinics. Multivariable analysis was used to assess the relation of social, demographic, physical and behavioral...


    pub_type: 杂志文章


    authors: Heiss G,Johnson NJ,Reiland S,Davis CE,Tyroler HA

    更新日期:1980-11-01 00:00:00

  • Improvement in coronary flow reserve determined by positron emission tomography after 6 months of cholesterol-lowering therapy in patients with early stages of coronary atherosclerosis.

    abstract:BACKGROUND:Early stages of coronary atherosclerosis are characterized by a mainly functional impairment of coronary vasodilator capacity under the impact of such risk factors as hypercholesterolemia. The goal of this study was to determine whether 6-month cholesterol-lowering therapy improves coronary flow reserve in p...


    pub_type: 临床试验,杂志文章


    authors: Baller D,Notohamiprodjo G,Gleichmann U,Holzinger J,Weise R,Lehmann J

    更新日期:1999-06-08 00:00:00

  • Platelet activation by emotional stress in patients with coronary artery disease.

    abstract::We studied the effects of experimentally induced emotional stress (mental arithmetic) on different hemodynamic parameters, catecholamine levels, and serum and platelet function tests in 25 postinfarction patients and in 10 apparently healthy, age-matched control subjects. Mental stress (10 minutes) induced significant...


    pub_type: 杂志文章


    authors: Grignani G,Soffiantino F,Zucchella M,Pacchiarini L,Tacconi F,Bonomi E,Pastoris A,Sbaffi A,Fratino P,Tavazzi L

    更新日期:1991-04-01 00:00:00

  • Protection of endothelium in vessel segments excised for grafting.

    abstract::Contracture and collapse often complicate dissection and excision of blood vessels for grafting. Subsequent forceful redilatation and leak checking with cold saline almost always lead to partial or total denudation of endothelium, which increases the risk of early occlusion by thrombi or late occlusion by fibrocellula...


    pub_type: 杂志文章


    authors: Haudenschild C,Gould KE,Quist WC,LoGerfo FW

    更新日期:1981-08-01 00:00:00

  • Coronary artery surgery study (CASS): a randomized trial of coronary bypass surgery. Eight years follow-up and survival in patients with reduced ejection fraction.

    abstract::Survival data after 8 years of follow-up for all patients and after 7 years for certain subgroups are reported from CASS, a randomized trial of surgical or medical treatment assignment in patients with coronary artery disease who have less than severe angina or are asymptomatic after myocardial infarction. After 8 yea...


    pub_type: 临床试验,杂志文章


    authors: Killip T,Passamani E,Davis K

    更新日期:1985-12-01 00:00:00

  • Double-blind placebo-controlled trial of digoxin in symptomatic paroxysmal atrial fibrillation.

    abstract:BACKGROUND:Digoxin is commonly prescribed in symptomatic paroxysmal atrial fibrillation (AF) but has never been evaluated in this condition. METHODS AND RESULTS:From a multicenter registry, 43 representative patients with frequent symptomatic AF episodes were recruited into a randomized, double-blind crossover compari...


    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Murgatroyd FD,Gibson SM,Baiyan X,O'Nunain S,Poloniecki JD,Ward DE,Malik M,Camm AJ

    更新日期:1999-06-01 00:00:00

  • Carotid intima-media thickness is associated with premature parental coronary heart disease: the Framingham Heart Study.

    abstract:BACKGROUND:A family history of coronary heart disease (CHD) is an independent risk factor for cardiovascular events. However, the mechanisms underlying this susceptibility have not been fully elucidated. We hypothesized that an important mediator of the familial predisposition to CHD is subclinical atherosclerosis, whi...


    pub_type: 杂志文章


    authors: Wang TJ,Nam BH,D'Agostino RB,Wolf PA,Lloyd-Jones DM,MacRae CA,Wilson PW,Polak JF,O'Donnell CJ

    更新日期:2003-08-05 00:00:00

  • Pace mapping using body surface potential maps to guide catheter ablation of accessory pathways in patients with Wolff-Parkinson-White syndrome.

    abstract::BACKGROUND. A pace mapping technique using body surface potential maps (BSPMs) was developed to guide the positioning of an ablation catheter at the ventricular insertion point of accessory pathways (AP) in patients with the Wolff-Parkinson-White syndrome (WPW). METHODS AND RESULTS. The study was performed on 30 WPW p...


    pub_type: 杂志文章


    authors: Dubuc M,Nadeau R,Tremblay G,Kus T,Molin F,Savard P

    更新日期:1993-01-01 00:00:00

  • Contribution of exercise-induced mitral regurgitation to exercise stroke volume and exercise capacity in patients with left ventricular systolic dysfunction.

    abstract:BACKGROUND:Functional mitral regurgitation (MR) is common in patients with heart failure and left ventricular (LV) dysfunction, and its severity may vary over time, depending primarily on the loading conditions. Because dynamic changes in the severity of functional MR may affect forward stroke volume, we hypothesized t...


    pub_type: 杂志文章


    authors: Lapu-Bula R,Robert A,Van Craeynest D,D'Hondt AM,Gerber BL,Pasquet A,Melin JA,De Kock M,Vanoverschelde JL

    更新日期:2002-09-10 00:00:00

  • Vascular signal transducer and activator of transcription-3 promotes angiogenesis and neuroplasticity long-term after stroke.

    abstract:BACKGROUND:Poststroke angiogenesis contributes to long-term recovery after stroke. Signal transducer and activator of transcription-3 (Stat3) is a key regulator for various inflammatory signals and angiogenesis. It was the aim of this study to determine its function in poststroke outcome. METHODS AND RESULTS:We genera...


    pub_type: 杂志文章


    authors: Hoffmann CJ,Harms U,Rex A,Szulzewsky F,Wolf SA,Grittner U,Lättig-Tünnemann G,Sendtner M,Kettenmann H,Dirnagl U,Endres M,Harms C

    更新日期:2015-05-19 00:00:00

  • Amplification of flecainide-induced ventricular conduction slowing by exercise. A potentially significant clinical consequence of use-dependent sodium channel blockade.

    abstract::Proarrhythmic effects of flecainide acetate have been reported during exercise, but the mechanism for the arrhythmogenic interaction between flecainide and exercise is unknown. We hypothesized that the sinus tachycardia of exercise may enhance flecainide-induced conduction slowing by increasing use-dependent sodium ch...


    pub_type: 杂志文章


    authors: Ranger S,Talajic M,Lemery R,Roy D,Nattel S

    更新日期:1989-05-01 00:00:00

  • Cost-effectiveness of prasugrel versus clopidogrel in patients with acute coronary syndromes and planned percutaneous coronary intervention: results from the trial to assess improvement in therapeutic outcomes by optimizing platelet inhibition with Prasug

    abstract:BACKGROUND:In patients with acute coronary syndromes and planned percutaneous coronary intervention, the Trial to Assess Improvement in Therapeutic Outcomes by Optimizing Platelet Inhibition With Prasugrel-Thrombolysis in Myocardial Infarction 38 (TRITON-TIMI 38) demonstrated that treatment with prasugrel versus clopid...


    pub_type: 杂志文章


    authors: Mahoney EM,Wang K,Arnold SV,Proskorovsky I,Wiviott S,Antman E,Braunwald E,Cohen DJ

    更新日期:2010-01-05 00:00:00

  • Influence of pre-PTCA strategy and initial PTCA result in patients with multivessel disease: the Bypass Angioplasty Revascularization Investigation (BARI).

    abstract:BACKGROUND:In PTCA patients with multivessel coronary artery disease, incomplete revascularization (IR) is the result of both pre-PTCA strategy and initial lesion outcome. The unique contribution of these components on long-term patient outcome is uncertain. METHODS AND RESULTS:From the Bypass Angioplasty Revasculariz...


    pub_type: 杂志文章


    authors: Kip KE,Bourassa MG,Jacobs AK,Schwartz L,Feit F,Alderman EL,Weiner BH,Weiss MB,Kellett MA Jr,Sharaf BL,Dimas AP,Jones RH,Sopko G,Detre KM

    更新日期:1999-08-31 00:00:00

  • Thallium 201 kinetics in stunned myocardium characterized by severe postischemic systolic dysfunction.

    abstract::The hypothesis tested in this study was that despite the presence of severe postischemic myocardial dysfunction ("stunning"), the extraction and subsequent intracellular washout of thallium 201 should be preserved as long as irreversible sarcolemmal membrane injury was avoided. To produce myocardial stunning, 19 open-...


    pub_type: 杂志文章


    authors: Moore CA,Cannon J,Watson DD,Kaul S,Beller GA

    更新日期:1990-05-01 00:00:00

  • Mechanisms responsible for inhibition of vein-graft arteriosclerosis by fish oil.

    abstract::Favorable changes in lipoproteins, inhibition of platelet aggregation, reduction of serum thromboxane (TX), altered plasma-membrane fluidity, and reduced production of growth factors (mitogens) have all been implicated as possibly being involved in the inhibition of arteriosclerosis by fish oil (FO), which is rich in ...


    pub_type: 杂志文章


    authors: Sarris GE,Fann JI,Sokoloff MH,Smith DL,Loveday M,Kosek JC,Stephens RJ,Cooper AD,May K,Willis AL

    更新日期:1989-09-01 00:00:00

  • Correlation of regional myocardial blood flow and function with myocardial infarct size during acute myocardial ischemia in the conscious pig.

    abstract::Regional myocardial function and blood flow were determined for 48 hours after permanent occlusion of the left circumflex coronary artery in conscious swine. Systolic wall thickening and end-diastolic wall thickness (EDWTh) were correlated with regional myocardial flow (RMBF) at 15 minutes, 24 and 48 hours after occlu...


    pub_type: 杂志文章


    authors: Savage RM,Guth B,White FC,Hagan AD,Bloor CM

    更新日期:1981-10-01 00:00:00

  • De subitaneis mortibus. XV. Hereditary stenosis of the His bundle in Pug dogs.

    abstract::Syncope and sudden death occurs in certain purebred Pug dogs which have been found to have intermittent sinus pauses and paroxysmal second degree heart block on electrocardiographic (ECG) study. We have established a colony of such dogs to study this problem and here report the results of histological examination of t...


    pub_type: 杂志文章


    authors: James TN,Robertson BT,Waldo AL,Branch CE

    更新日期:1975-12-01 00:00:00

  • Composite graft replacement for the treatment of aneurysms of the ascending aorta associated with aortic valvular disease.

    abstract::Composite graft replacement of the ascending aorta and aortic valve was performed in 78 patients over an 8 1/2-year period. Degenerative lesions of the aortic root in Marfan's syndrome (annuloaortic ectasia) was the indication for operation in 56 cases; the other 22 patients had other causes of aortic root dilatation ...


    pub_type: 杂志文章


    authors: Donaldson RM,Ross DN

    更新日期:1982-08-01 00:00:00

  • Cerebral protection during surgery for acute aortic dissection type A: results of the German Registry for Acute Aortic Dissection Type A (GERAADA).

    abstract:BACKGROUND:Cerebral protection during surgery for acute aortic dissection type A relies on hypothermic circulatory arrest, either alone or in conjunction with cerebral perfusion. METHODS AND RESULTS:The perioperative and intraoperative conditions of 1558 patients submitted from 44 cardiac surgery centers in German-spe...


    pub_type: 杂志文章


    authors: Krüger T,Weigang E,Hoffmann I,Blettner M,Aebert H,GERAADA Investigators.

    更新日期:2011-07-26 00:00:00

  • Resistin promotes endothelial cell activation: further evidence of adipokine-endothelial interaction.

    abstract:BACKGROUND:Adipocyte-derived hormones may represent a mechanism linking insulin resistance to cardiovascular disease. In the present study, we evaluated the direct effects of resistin, a novel adipocyte-derived hormone, on endothelial activation. METHODS AND RESULTS:Endothelial cells (ECs) were incubated with human re...


    pub_type: 杂志文章


    authors: Verma S,Li SH,Wang CH,Fedak PW,Li RK,Weisel RD,Mickle DA

    更新日期:2003-08-12 00:00:00

  • Limited exercise capacity in heterozygous manganese superoxide dismutase gene-knockout mice: roles of superoxide anion and nitric oxide.

    abstract:BACKGROUND:We have reported that there is a limitation of exercise capacity in mice with defects in the expression of endothelial nitric oxide (NO) synthase, which is associated with a greater increase in whole-body oxygen consumption (VO2). We hypothesized that in states in which superoxide anion (O2-) is increased, e...


    pub_type: 杂志文章


    authors: Kinugawa S,Wang Z,Kaminski PM,Wolin MS,Edwards JG,Kaley G,Hintze TH

    更新日期:2005-03-29 00:00:00

  • Electrocardiographic and hemodynamic changes in experimental right ventricular infarction.

    abstract::To investigate the electrocardiographic and hemodynamic changes in isolated right ventricular infarction, 0.25 ml or 0.5 ml of metallic mercury was injected into the right coronary artery of 14 closed-chest dogs. At autopsy, at least 60% of the right ventricle was necrotic in every dog. Hemodynamic observations were m...


    pub_type: 杂志文章


    authors: Chou TC,Fowler NO,Gabel M,van der Bel-Kahn J,Feltner EJ

    更新日期:1983-06-01 00:00:00

  • Peak oxygen uptake correlates with survival without clinical deterioration in ambulatory children with dilated cardiomyopathy.

    abstract:BACKGROUND:Children stable at home with dilated cardiomyopathy remain at risk of death; there is evidence of survival benefit for transplantation out to 4 years postoperatively. The limited supply of donor organs makes risk stratification imperative, but although cardiopulmonary exercise test is well established as a p...


    pub_type: 杂志文章


    authors: Giardini A,Fenton M,Andrews RE,Derrick G,Burch M

    更新日期:2011-10-18 00:00:00

  • Knowledge Gaps in Cardiovascular Care of the Older Adult Population: A Scientific Statement From the American Heart Association, American College of Cardiology, and American Geriatrics Society.

    abstract::The incidence and prevalence of most cardiovascular disorders increase with age, and cardiovascular disease is the leading cause of death and major disability in adults ≥75 years of age; however, despite the large impact of cardiovascular disease on quality of life, morbidity, and mortality in older adults, patients a...


    pub_type: 杂志文章


    authors: Rich MW,Chyun DA,Skolnick AH,Alexander KP,Forman DE,Kitzman DW,Maurer MS,McClurken JB,Resnick BM,Shen WK,Tirschwell DL,American Heart Association Older Populations Committee of the Council on Clinical Cardiology, Council on Cardiov

    更新日期:2016-05-24 00:00:00

  • Inhibition of growth of thrombus on fresh mural thrombus. Targeting optimal therapy.

    abstract:BACKGROUND:Residual mural thrombus on severely damaged arterial wall is very thrombogenic. We tested the hypothesis that direct thrombin inhibition will block thrombus growth on fresh thrombus better than indirect thrombin inhibition, cyclooxygenase inhibition, or both. METHODS AND RESULTS:A fresh mural thrombus was f...


    pub_type: 杂志文章


    authors: Meyer BJ,Badimon JJ,Mailhac A,Fernández-Ortiz A,Chesebro JH,Fuster V,Badimon L

    更新日期:1994-11-01 00:00:00

  • Cardiomyocyte-specific overexpression of human stem cell factor improves cardiac function and survival after myocardial infarction in mice.

    abstract:BACKGROUND:Soluble stem cell factor (SCF) has been shown to mobilize bone marrow stem cells and improve cardiac repair after myocardial infarction (MI). However, the effect of membrane-associated SCF on cardiac remodeling after MI is not known. The present study investigated the effects of cardiomyocyte-specific overex...


    pub_type: 杂志文章


    authors: Xiang FL,Lu X,Hammoud L,Zhu P,Chidiac P,Robbins J,Feng Q

    更新日期:2009-09-22 00:00:00

  • Mitral regurgitation after anteroapical myocardial infarction: new mechanistic insights.

    abstract:BACKGROUND:Mitral regurgitation (MR) generally accompanies inferobasal myocardial infarction (MI), with leaflet tethering by displaced papillary muscles. Mitral regurgitation is also reported with anteroapical MI without global dilatation or inferior wall motion abnormalities. We hypothesized that anteroapical MI exten...


    pub_type: 杂志文章


    authors: Yosefy C,Beeri R,Guerrero JL,Vaturi M,Scherrer-Crosbie M,Handschumacher MD,Levine RA

    更新日期:2011-04-12 00:00:00