Pulmonary artery index. A nonpredictor of operative survival in patients undergoing modified Fontan repair.


:The importance of pulmonary artery size and the value of a standardized pulmonary artery index (PAI) in predicting outcome after Fontan's repair have previously been reported and questioned. We retrospectively reviewed 29 patients undergoing modified Fontan repair at The Children's Hospital of Philadelphia to examine the relation between preoperative PAI (determined echocardiographically) and operative mortality. Twenty-four of these 29 patients underwent pulmonary artery augmentation at the time of Fontan repair. PAIs ranged from 48 to 541 mm2/m2. Operative mortality was 21%. PAI ranged from 68 to 233 mm2/m2 in nonsurvivors and from 48 to 541 mm2/m2 in survivors. There was no statistically significant difference in PAI between survivors and nonsurvivors; the lowest PAI associated with survival (48 mm2/m2) was one fourth of the lowest PAI value previously reported. There was a trend, not statistically significant, toward increased survival in those with larger PAIs. We conclude that patients should not be excluded from consideration for Fontan's repair solely on the basis of pulmonary artery size.






Bridges ND,Farrell PE Jr,Pigott JD 3rd,Norwood WI,Chin AJ


Has Abstract


1989-09-01 00:00:00




3 Pt 1








  • Iron therapy, advanced oxidation protein products, and carotid artery intima-media thickness in end-stage renal disease.

    abstract:BACKGROUND:Increased common carotid artery intima-media thickness (CCA-IMT) is a marker of early atherosclerosis. Low-grade inflammation is associated with the pathogenesis of atherosclerosis. Low-grade inflammation and increased CCA-IMT are observed in end-stage renal disease (ESRD). Oxidative stress is involved in ur...


    pub_type: 杂志文章


    authors: Drüeke T,Witko-Sarsat V,Massy Z,Descamps-Latscha B,Guerin AP,Marchais SJ,Gausson V,London GM

    更新日期:2002-10-22 00:00:00

  • Morphological predictors of restenosis after coronary stenting in humans.

    abstract:BACKGROUND:Experimental studies suggest that arterial injury and inflammation lead to increased neointimal growth after stenting. Despite the increased use of coronary stents in humans, there are only limited pathological data on the morphological features of in-stent restenosis. METHODS AND RESULTS:Detailed histology...


    pub_type: 杂志文章


    authors: Farb A,Weber DK,Kolodgie FD,Burke AP,Virmani R

    更新日期:2002-06-25 00:00:00

  • Exercise training in patients with chronic heart failure delays ventilatory anaerobic threshold and improves submaximal exercise performance.

    abstract::We have recently demonstrated that exercise training can induce important hemodynamic and metabolic adaptations in patients with chronic heart failure due to severe left ventricular dysfunction. This study examines the accompanying changes in submaximal exercise performance and the ventilatory response to exercise in ...


    pub_type: 杂志文章


    authors: Sullivan MJ,Higginbotham MB,Cobb FR

    更新日期:1989-02-01 00:00:00

  • Use of direct angioplasty for treatment of patients with acute myocardial infarction in hospitals with and without on-site cardiac surgery. The Myocardial Infarction, Triage, and Intervention Project Investigators.

    abstract:BACKGROUND:In the Myocardial Infarction, Triage, and Intervention (MITI) registry of acute myocardial infarction, 441 (12%) of 3750 patients had direct angioplasty as initial treatment. Approximately half (233) were performed in hospitals with no on-site surgery. METHODS AND RESULTS:Procedure success rates, use of eme...


    pub_type: 杂志文章


    authors: Weaver WD,Litwin PE,Martin JS

    更新日期:1993-11-01 00:00:00

  • Plasma adenosine levels increase in patients with chronic heart failure.

    abstract:BACKGROUND:Adenosine is believed to be cardioprotective; however, it has not been elucidated whether the plasma adenosine level is increased in chronic heart failure. METHODS AND RESULTS:Seventy-one patients attending a specialized heart failure clinic during a 6-month period were grouped according to the cause of chr...


    pub_type: 杂志文章


    authors: Funaya H,Kitakaze M,Node K,Minamino T,Komamura K,Hori M

    更新日期:1997-03-18 00:00:00

  • Temporal trends in event rates after Q-wave myocardial infarction: the Framingham Heart Study.

    abstract:BACKGROUND:Short-term (<30 day) mortality after Q-wave myocardial infarction (MI) has declined over the decades, but it is unclear if rates of long-term sequelae after Q-wave MI have improved. METHODS AND RESULTS:In 546 Framingham Heart Study subjects (388 men with a mean age of 60 years; 158 women with a mean age of ...


    pub_type: 临床试验,杂志文章


    authors: Guidry UC,Evans JC,Larson MG,Wilson PW,Murabito JM,Levy D

    更新日期:1999-11-16 00:00:00

  • Late dysrhythmias and disturbances of conduction following Mustard operation for complete transposition of the great arteries.

    abstract::Between 1964 and 1971, 49 patients were discharged from hospital following atrial baffle repair for transposition of the great arteries. Electrocardiograms of 47 of these patients were available for review seven months to eight and a half years (average 31 months) after operation. Of the 46 patients in sinus rhythm pr...


    pub_type: 杂志文章


    authors: Clarkson PM,Barratt-Boyles BG,Neutze JM

    更新日期:1976-03-01 00:00:00

  • Determinants of severity of coronary artery disease in Australian men and women.

    abstract:BACKGROUND:Factors predicting the occurrence of premature coronary artery disease (CAD) may not be quantitatively the same as those predicting CAD severity, particularly in women, in whom there have been few studies. METHODS AND RESULTS:To determine factors predictive of severity of CAD and of angina pectoris, we docu...


    pub_type: 杂志文章


    authors: Wang XL,Tam C,McCredie RM,Wilcken DE

    更新日期:1994-05-01 00:00:00

  • The prognostic implications of acute myocardial infarct scintigraphy with 99mTc-pyrophosphate.

    abstract::The predictive value of the myocardial scintigraphy with 99mTc-pyrophosphate was studied in 100 patients admitted to the coronary care unit with suspected acute myocardial infarction. None of the 21 patients with normal scintigrams had acute myocardial infraction by other criteria. Fifty-five percent of patients with ...


    pub_type: 杂志文章


    authors: Holman BL,Chisholm RJ,Braunwald E

    更新日期:1978-02-01 00:00:00

  • National Trends in the Use of Cardiac Resynchronization Therapy With or Without Implantable Cardioverter-Defibrillator.

    abstract:BACKGROUND:Candidates for cardiac resynchronization therapy (CRT) receive either a biventricular pacemaker or a biventricular pacemaker with an implantable cardioverter-defibrillator (CRT-D). Optimal device selection remains challenging because the benefit of implantable cardioverter-defibrillator therapy may not be un...


    pub_type: 杂志文章


    authors: Lindvall C,Chatterjee NA,Chang Y,Chernack B,Jackson VA,Singh JP,Metlay JP

    更新日期:2016-01-19 00:00:00

  • Call to Action to Prevent Venous Thromboembolism in Hospitalized Patients: A Policy Statement From the American Heart Association.

    abstract::Venous thromboembolism (VTE) is a major preventable disease that affects hospitalized inpatients. Risk stratification and prophylactic measures have good evidence supporting their use, but multiple reasons exist that prevent full adoption, compliance, and efficacy that may underlie the persistence of VTE over the past...


    pub_type: 杂志文章


    authors: Henke PK,Kahn SR,Pannucci CJ,Secemksy EA,Evans NS,Khorana AA,Creager MA,Pradhan AD,American Heart Association Advocacy Coordinating Committee.

    更新日期:2020-06-16 00:00:00

  • Inherited Thoracic Aortic Disease: New Insights and Translational Targets.

    abstract::Inherited thoracic aortopathies denote a group of congenital conditions that predispose to disease of the thoracic aorta. Aortic wall weakness and abnormal aortic hemodynamic profiles predispose these patients to dilatation of the thoracic aorta, which is generally silent but can precipitate aortic dissection or ruptu...


    pub_type: 杂志文章


    authors: Fletcher AJ,Syed MBJ,Aitman TJ,Newby DE,Walker NL

    更新日期:2020-05-12 00:00:00

  • Dynamics of pulmonary gas exchange.

    abstract::Power outputs that are below the anaerobic threshold (theta an) may be sustained for prolonged durations, whereas power outputs that are greater than theta an result in a significant reduction in the tolerable duration to fatigue. The theta an may therefore be considered to demarcate exercise intensity into moderate (...


    pub_type: 杂志文章,评审


    authors: Whipp BJ

    更新日期:1987-12-01 00:00:00

  • Decreased myocyte tension development and calcium responsiveness in rat right ventricular pressure overload.

    abstract:BACKGROUND:The contractile dysfunction observed in end-stage myocardial hypertrophy has at its base an abnormality in myocyte function. However, whether depressed contractile function is related to an alteration in contractile protein function is presently unknown. METHODS AND RESULTS:Contractile force, tension, and c...


    pub_type: 杂志文章


    authors: Fan D,Wannenburg T,de Tombe PP

    更新日期:1997-05-06 00:00:00

  • Improved vascular endothelial function after oral B vitamins: An effect mediated through reduced concentrations of free plasma homocysteine.

    abstract:BACKGROUND:Hyperhomocysteinemia is an independent risk factor for coronary heart disease (CHD). Dietary supplementation with B vitamins lowers plasma homocysteine by up to 30%. However, little is known about the potential beneficial effects of homocysteine lowering on vascular function in patients with CHD. METHODS AN...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Chambers JC,Ueland PM,Obeid OA,Wrigley J,Refsum H,Kooner JS

    更新日期:2000-11-14 00:00:00

  • Trends in Mortality From Ischemic Heart Disease and Cerebrovascular Disease in Europe: 1980 to 2009.

    abstract:BACKGROUND:Trends in cardiovascular mortality across Europe demonstrate significant geographical variation, and an understanding of these trends has a central role in global public health. METHODS AND RESULTS:Ischemic heart disease and cerebrovascular disease age-standardized death rates (as per International Classifi...


    pub_type: 杂志文章


    authors: Hartley A,Marshall DC,Salciccioli JD,Sikkel MB,Maruthappu M,Shalhoub J

    更新日期:2016-05-17 00:00:00

  • Cyclosporine may affect improvement of cognitive brain function after successful cardiac transplantation.

    abstract:BACKGROUND:The effects of cardiac transplantation on cognitive brain function are uncertain. METHODS AND RESULTS:We measured cognitive brain function and quality of life in out-of-hospital cardiac transplant candidates (n = 55; ejection fraction, 19.9%; age, 54.8 years [means]). After transplantation, the patients wer...


    pub_type: 杂志文章


    authors: Grimm M,Yeganehfar W,Laufer G,Madl C,Kramer L,Eisenhuber E,Simon P,Kupilik N,Schreiner W,Pacher R,Bunzel B,Wolner E,Grimm G

    更新日期:1996-09-15 00:00:00

  • Epigenetic Reader BRD4 (Bromodomain-Containing Protein 4) Governs Nucleus-Encoded Mitochondrial Transcriptome to Regulate Cardiac Function.

    abstract:BACKGROUND:BET (bromodomain and extraterminal) epigenetic reader proteins, in particular BRD4 (bromodomain-containing protein 4), have emerged as potential therapeutic targets in a number of pathological conditions, including cancer and cardiovascular disease. Small-molecule BET protein inhibitors such as JQ1 have demo...


    pub_type: 杂志文章


    authors: Kim SY,Zhang X,Schiattarella GG,Altamirano F,Ramos TAR,French KM,Jiang N,Szweda PA,Evers BM,May HI,Luo X,Li H,Szweda LI,Maracaja-Coutinho V,Lavandero S,Gillette TG,Hill JA

    更新日期:2020-12-15 00:00:00

  • SIRT2 Acts as a Cardioprotective Deacetylase in Pathological Cardiac Hypertrophy.

    abstract:BACKGROUND:Pathological cardiac hypertrophy induced by stresses such as aging and neurohumoral activation is an independent risk factor for heart failure and is considered a target for the treatment of heart failure. However, the mechanisms underlying pathological cardiac hypertrophy remain largely unknown. We aimed to...


    pub_type: 杂志文章


    authors: Tang X,Chen XF,Wang NY,Wang XM,Liang ST,Zheng W,Lu YB,Zhao X,Hao DL,Zhang ZQ,Zou MH,Liu DP,Chen HZ

    更新日期:2017-11-21 00:00:00

  • S-nitrosoglutathione reduces the rate of embolization in humans.

    abstract:BACKGROUND:Antiplatelet agents presently used in the secondary prevention of cardiovascular disease fail to prevent the majority of cases of recurrent stroke and systemic embolization. An evaluation of the efficacy of new agents is hampered by a lack of in vivo models in humans. Asymptomatic cerebral embolic signals (E...


    pub_type: 临床试验,杂志文章


    authors: Molloy J,Martin JF,Baskerville PA,Fraser SC,Markus HS

    更新日期:1998-10-06 00:00:00

  • Oxygen uptake kinetics are determined by cardiac function at onset of exercise rather than peak exercise in patients with prior myocardial infarction.

    abstract:BACKGROUND:Resting cardiac function does not necessarily affect exercise capacity. However, to determine whether it affects early dynamics of oxygen uptake (VO2) during exercise, we measured VO2 during a constant work rate and during incremental exercise testing in patients with a history of myocardial infarction. VO2 ...


    pub_type: 杂志文章


    authors: Koike A,Hiroe M,Adachi H,Yajima T,Yamauchi Y,Nogami A,Ito H,Miyahara Y,Korenaga M,Marumo F

    更新日期:1994-11-01 00:00:00

  • Costs and benefits of targeted screening for causes of sudden cardiac death in children and adolescents.

    abstract:BACKGROUND:Sudden cardiac death in children is a rare but devastating event. Experts have debated the merits of community-based screening programs using an ECG and targeting 2 potential high-risk groups: school-aged children initiating stimulant medications to treat attention-deficit/hyperactivity disorder and adolesce...


    pub_type: 杂志文章


    authors: Leslie LK,Cohen JT,Newburger JW,Alexander ME,Wong JB,Sherwin ED,Rodday AM,Parsons SK,Triedman JK

    更新日期:2012-05-29 00:00:00

  • Effects of quinidine and verapamil on human cardiovascular alpha1-adrenoceptors.

    abstract:BACKGROUND:The antiarrhythmic drugs quinidine and verapamil are known to block alpha1-adrenoceptors (alpha1ARs). Alpha1ARs are a heterogeneous family of three subtypes (alpha1A, alpha1B, and alpha1D), and little is known about the effects of quinidine and verapamil on the different human alpha1AR subtypes. METHODS AND...


    pub_type: 杂志文章


    authors: Shibata K,Hirasawa A,Foglar R,Ogawa S,Tsujimoto G

    更新日期:1998-04-07 00:00:00

  • National study of physician awareness and adherence to cardiovascular disease prevention guidelines.

    abstract:BACKGROUND:Few data have evaluated physician adherence to cardiovascular disease (CVD) prevention guidelines according to physician specialty or patient characteristics, particularly gender. METHODS AND RESULTS:An online study of 500 randomly selected physicians (300 primary care physicians, 100 obstetricians/gynecolo...


    pub_type: 杂志文章


    authors: Mosca L,Linfante AH,Benjamin EJ,Berra K,Hayes SN,Walsh BW,Fabunmi RP,Kwan J,Mills T,Simpson SL

    更新日期:2005-02-01 00:00:00

  • Ischemia-related lesion characteristics in patients with stable or unstable angina. A study with intracoronary angioscopy and ultrasound.

    abstract:BACKGROUND:Postmortem-derived findings support the common beliefs that lipid-rich coronary plaques with a thin, fibrous cap are prone to rupture and that rupture and superimposed thrombosis are the primary mechanisms causing acute coronary syndromes. In vivo imaging with intracoronary techniques may disclose difference...


    pub_type: 杂志文章


    authors: de Feyter PJ,Ozaki Y,Baptista J,Escaned J,Di Mario C,de Jaegere PP,Serruys PW,Roelandt JR

    更新日期:1995-09-15 00:00:00

  • Arteriovenous carbon dioxide and pH gradients during cardiac arrest.

    abstract::In a porcine preparation of cardiac arrest, we demonstrated that there is a marked paradox of venous acidemia and arterial alkalemia. This paradox is related to decreased clearance of CO2 from the lungs when pulmonary blood flow is critically reduced. Accordingly, increased venous PCO2 rather than metabolic acidosis d...


    pub_type: 杂志文章


    authors: Grundler W,Weil MH,Rackow EC

    更新日期:1986-11-01 00:00:00

  • Clinical pharmacokinetics and efficacy of amiodarone for refractory tachyarrhythmias.

    abstract::Using a high-pressure liquid chromatographic assay, we measured serum amiodarone concentrations serially in 122 patients treated with amiodarone for 1.5-53 months (mean 9.3 months) for control of refractory symptomatic atrial or symptomatic and life-threatening ventricular tachyarrhythmias. The atrial tachyarrhythmias...


    pub_type: 杂志文章


    authors: Haffajee CI,Love JC,Canada AT,Lesko LJ,Asdourian G,Alpert JS

    更新日期:1983-06-01 00:00:00

  • Intrapericardial paclitaxel delivery inhibits neointimal proliferation and promotes arterial enlargement after porcine coronary overstretch.

    abstract:BACKGROUND:Catheter-based intrapericardial (IPC) delivery of therapeutic agents has recently been demonstrated. Paclitaxel is known to inhibit vascular smooth muscle cell proliferation. This study examined the effect of IPC instillation of paclitaxel on neointimal proliferation after balloon overstretch of porcine coro...


    pub_type: 杂志文章


    authors: Hou D,Rogers PI,Toleikis PM,Hunter W,March KL

    更新日期:2000-09-26 00:00:00

  • Q fever endocarditis in Queensland.

    abstract::Thirteen patients with proven Q fever endocarditis and three additional patients with probable endocarditis are reviewed. The most helpful diagnostic test is the demonstration of a high complement fixing antibody titre to Phase 1 antigen of Coxiella burneti. The macroscopic pathology of the aortic valve is described a...


    pub_type: 杂志文章


    authors: Wilson HG,Neilson GH,Galea EG,Stafford G,O'Brien MF

    更新日期:1976-04-01 00:00:00

  • Peripartum myocarditis and cardiomyopathy.

    abstract::The clinical and pathologic features of 18 consecutive patients with peripartum cardiomyopathy at The Johns Hopkins Hospital were examined in an attempt to define the incidence of myocarditis and to determine its response to immunosuppressive agents. In addition to routine studies, patients were evaluated with echocar...


    pub_type: 杂志文章


    authors: Midei MG,DeMent SH,Feldman AM,Hutchins GM,Baughman KL

    更新日期:1990-03-01 00:00:00