Autonomic tone variations before the onset of paroxysmal atrial fibrillation.

abstract：BACKGROUND:Membrane contact sites are fundamental for transmission and translation of signals in multicellular organisms. The junctional membrane complexes in the cardiac dyads, where transverse (T) tubules are juxtaposed to the sarcoplasmic reticulum, are a prime example. T-tubule uncoupling and remodeling are well-kn...

journal_title：Circulation

authors： Liu C,Spinozzi S,Chen JY,Fang X,Feng W,Perkins G,Cattaneo P,Guimarães-Camboa N,Dalton ND,Peterson KL,Wu T,Ouyang K,Fu XD,Evans SM,Chen J

更新日期：2019-07-02 00:00:00

abstract：BACKGROUND:A key component of reperfusion of myocardial infarction is an immediate inflammatory response, which enhances tissue repair. Matrix turnover is crucial to tissue repair, and matrix metalloproteinases (MMPs) are key enzymes involved in matrix degradation. The hypothesis tested is that one inflammation-based e...

journal_title：Circulation

authors： Lindsey M,Wedin K,Brown MD,Keller C,Evans AJ,Smolen J,Burns AR,Rossen RD,Michael L,Entman M

更新日期：2001-05-01 00:00:00

abstract：BACKGROUND:The clinical profiles and outcomes of patients treated surgically for acute type B aortic dissection (ABAD) are often reported for those in small series or for those cared for at a single institution over a long time period, during which a continuous evolution in techniques has occurred. Accordingly, we soug...

journal_title：Circulation

authors： Trimarchi S,Nienaber CA,Rampoldi V,Myrmel T,Suzuki T,Bossone E,Tolva V,Deeb MG,Upchurch GR Jr,Cooper JV,Fang J,Isselbacher EM,Sundt TM 3rd,Eagle KA,IRAD Investigators.

更新日期：2006-07-04 00:00:00

abstract：BACKGROUND:Right ventricular function may be an important determinant of exercise capacity, peak oxygen consumption (VO2), and the ventilatory response to carbon dioxide production (VE/VCO2 relation) in patients with chronic heart failure (CHF). METHODS AND RESULTS:We studied the role of right ventricular function in ...

journal_title：Circulation

authors： Clark AL,Swan JW,Laney R,Connelly M,Somerville J,Coats AJ

更新日期：1994-05-01 00:00:00

abstract：BACKGROUND:Cardiac Na/K-ATPase (NKA) regulates intracellular Na ([Na](i)), which in turn affects intracellular Ca and thus contractility via Na/Ca exchange. Recent evidence shows that phosphorylation of the NKA-associated small transmembrane protein phospholemman (PLM) mediates beta-adrenergic-induced NKA stimulation. ...

journal_title：Circulation

authors： Despa S,Tucker AL,Bers DM

更新日期：2008-04-08 00:00:00

abstract：BACKGROUND:Reduced renal function is associated with a poorer prognosis and increased bleeding risk in patients with acute coronary syndromes and may therefore alter the risk-benefit ratio with antiplatelet therapies. In the Platelet Inhibition and Patient Outcomes (PLATO) trial, ticagrelor compared with clopidogrel re...

journal_title：Circulation

authors： James S,Budaj A,Aylward P,Buck KK,Cannon CP,Cornel JH,Harrington RA,Horrow J,Katus H,Keltai M,Lewis BS,Parikh K,Storey RF,Szummer K,Wojdyla D,Wallentin L

更新日期：2010-09-14 00:00:00

abstract：:Statins (HMG-CoA reductase inhibitors) are used widely for the treatment of hypercholesterolemia. They inhibit HMG-CoA reductase competitively, reduce LDL levels more than other cholesterol-lowering drugs, and lower triglyceride levels in hypertriglyceridemic patients. Statins are well tolerated and have an excellent ...

journal_title：Circulation

authors： Maron DJ,Fazio S,Linton MF

更新日期：2000-01-18 00:00:00

abstract：BACKGROUND:Since Mexican Americans have adverse patterns of risk factors for myocardial infarction relative to non-Hispanic whites, the incidence of myocardial infarction should be greater among Mexican Americans than among non-Hispanic whites. This expectation conflicts with reports generated from death certificate re...

journal_title：Circulation

authors： Goff DC,Nichaman MZ,Chan W,Ramsey DJ,Labarthe DR,Ortiz C

更新日期：1997-03-18 00:00:00

abstract：:Several conditions that contribute to drowning and near drowning must be considered in the treatment of near-drowned victims. Regardless of the cause, mechanical ventilation should begin as soon as possible and closed-chest cardiac massage should be administered when there is any question about the adequacy of cardiac...

journal_title：Circulation

authors： Modell JH

更新日期：1986-12-01 00:00:00

abstract：BACKGROUND:Increased expression of osteopontin (OPN), fibroblast growth factors (FGFs), and their type-1 receptor (FGFR-1) is associated with neointima formation and atherosclerosis. This study tested the hypothesis that ligand activation of FGFR-1 stimulates OPN expression in rat aortic smooth muscle cells (RASMCs), e...

journal_title：Circulation

authors： Li G,Oparil S,Kelpke SS,Chen YF,Thompson JA

更新日期：2002-08-13 00:00:00

abstract：BACKGROUND:Chagas heart disease is a frequent cause of morbidity and mortality in Latin America. Echocardiography provides useful diagnostic and prognostic information and is an important tool in the management of patients with Chagas disease. METHODS AND RESULTS:A search for relevant publications was obtained from ME...

journal_title：Circulation

authors： Acquatella H

更新日期：2007-03-06 00:00:00

abstract：BACKGROUND:To assess the reliability of pediatric echocardiographic measurements, we compared local measurements with those made at a central facility. METHODS AND RESULTS:The comparison was based on the first echocardiographic recording obtained on 735 children of HIV-infected mothers at 10 clinical sites focusing on...

journal_title：Circulation

authors： Lipshultz SE,Easley KA,Orav EJ,Kaplan S,Starc TJ,Bricker JT,Lai WW,Moodie DS,Sopko G,Schluchter MD,Colan SD

更新日期：2001-07-17 00:00:00

abstract：BACKGROUND:Current methods of signal-averaged ECG analysis interrogate the terminal 40 msec of the QRS complex and/or the ST segment and have a low positive-predictive accuracy for detecting vulnerability to sustained ventricular tachycardia (VT). The extent to which abnormalities detected during these ECG intervals ar...

journal_title：Circulation

authors： Hood MA,Pogwizd SM,Peirick J,Cain ME

更新日期：1992-12-01 00:00:00

abstract：BACKGROUND:Previous studies have demonstrated that induction of heat shock protein (HSP) 72 by whole-body hyperthermia reduces infarct size in an in vivo model of ischemia and reperfusion. Furthermore, hearts obtained from transgenic mice that overexpress HSP72 demonstrate improved functional recovery and decreased inf...

journal_title：Circulation

authors： Hutter JJ,Mestril R,Tam EK,Sievers RE,Dillmann WH,Wolfe CL

更新日期：1996-09-15 00:00:00

abstract：BACKGROUND:Inotropic drugs are often used to treat acute, severe heart failure resulting from acute myocardial infarction and other unstable coronary artery syndromes. However, catecholamine inotropic agents may potentiate coronary thrombosis via a platelet alpha2-adrenergic mechanism, thus exacerbating the original pr...

journal_title：Circulation

authors： Sill JC,Bertha B,Berger I,Uhl C,Nugent M,Folts J

更新日期：1997-09-02 00:00:00

abstract：:These types of studies lay the foundation for understanding the human apolipoproteins at the genetic level. In addition, through a few specific examples, we have already shown evidence at the DNA level that lesions in apolipoprotein genes can play a role in human atherosclerosis. This work is in its infancy, but we ho...

journal_title：Circulation

authors： Breslow JL

更新日期：1984-06-01 00:00:00

abstract：BACKGROUND:Endothelin (ET)-1 and norepinephrine (NE) are involved in myocardial ischemia/reperfusion injury. We investigated the role of ET-1 in ischemia/reperfusion-induced NE overflow and cardiac dysfunction using a selective ET(A) receptor antagonist (ABT-627), a selective ET(B) receptor antagonist (A-192621), and t...

journal_title：Circulation

authors： Yamamoto S,Matsumoto N,Kanazawa M,Fujita M,Takaoka M,Gariepy CE,Yanagisawa M,Matsumura Y

更新日期：2005-01-25 00:00:00

abstract：BACKGROUND:In patients with acute minor ischemic stroke or high-risk transient ischemic attack enrolled in the POINT trial (Platelet-Oriented Inhibition in New TIA and Minor Ischemic Stroke [POINT] Trial), the combination of clopidogrel and aspirin for 90 days reduced major ischemic events but increased major hemorrhag...

journal_title：Circulation

authors： Johnston SC,Elm JJ,Easton JD,Farrant M,Barsan WG,Kim AS,Lindblad AS,Palesch YY,Zurita KG,Albers GW,Cucchiara BL,Kleindorfer DO,Lutsep HL,Pearson C,Sethi P,Vora N,POINT and Neurological Emergencies Treatment Trials Network

更新日期：2019-08-20 00:00:00

abstract：BACKGROUND:Extracorporeal circulation with circuits coated with surface-bound heparin has allowed reduced levels of systemic heparinization. Clinical benefits have included reduced postoperative bleeding and less homologous blood usage. However, the effects on the hemostatic and fibrinolytic systems have remained in pa...

journal_title：Circulation

authors： Ovrum E,Brosstad F,Am Holen E,Tangen G,Abdelnoor M

更新日期：1995-11-01 00:00:00

abstract：BACKGROUND:The incidence of perinatal morbidity arising from birth hypoxia or asphyxia has not changed significantly in recent years despite marked improvements in labor management. Perinatal mortality in these circumstances may therefore reflect antenatal compromise and subsequent alteration of the fetal capacity to r...

journal_title：Circulation

authors： Gardner DS,Fowden AL,Giussani DA

更新日期：2002-10-22 00:00:00

abstract：BACKGROUND:Cardiac resynchronization therapy has emerged as an important therapy for advanced systolic heart failure. Among available cardiac resynchronization therapy pacing modes that restore ventricular synchrony, it is uncertain whether simultaneous biventricular (BiV), sequential BiV, or left ventricular (LV) paci...

journal_title：Circulation

authors： Rao RK,Kumar UN,Schafer J,Viloria E,De Lurgio D,Foster E

更新日期：2007-04-24 00:00:00

abstract：BACKGROUND:Considerable controversy exists on the association between coffee consumption and cardiovascular disease (CVD) risk. A meta-analysis was performed to assess the dose-response relationship of long-term coffee consumption with CVD risk. METHODS AND RESULTS:PubMed and EMBASE were searched for prospective cohor...

journal_title：Circulation

authors： Ding M,Bhupathiraju SN,Satija A,van Dam RM,Hu FB

更新日期：2014-02-11 00:00:00

abstract：BACKGROUND:Early graft failure after the use of less satisfactory autologous grafts (30% of all vein grafts) is caused primarily by the following problems: (1) suitable autologous transplants are limited; (2) biotechnology has not yet been able to produce reliable graft substitutes that are legally and ethically approv...

journal_title：Circulation

authors： Lamm P,Juchem G,Milz S,Schuffenhauer M,Reichart B

更新日期：2001-09-18 00:00:00

abstract：BACKGROUND:A subgroup of patients with hypertrophic obstructive cardiomyopathy remain severely symptomatic despite optimal medical therapy. Septal myectomy reduces or eliminates left ventricular outflow obstruction and produces marked symptomatic improvement. With the recent advent of alternative methods for treatment ...

journal_title：Circulation

authors： McCully RB,Nishimura RA,Tajik AJ,Schaff HV,Danielson GK

更新日期：1996-08-01 00:00:00

abstract：BACKGROUND:Intraoperative mapping studies suggest that an isthmus of myocardium between the mitral valve annulus and the border of inferior myocardial infarction may play a role in the genesis of ventricular tachycardia. We examined the frequency with which a slow conduction zone within the mitral isthmus was critical ...

journal_title：Circulation

authors： Wilber DJ,Kopp DE,Glascock DN,Kinder CA,Kall JG

更新日期：1995-12-15 00:00:00

abstract：BACKGROUND:In the preterm newborn, a patent ductus arteriosus is in large part a result of the increased sensitivity of the immature ductus to prostaglandin E2 (PGE2). PGE2 acts through 3 G protein-coupled receptors (EP2, EP3, and EP4) that activate both adenyl cyclase and K(ATP) channels. We explored these pathways to...

journal_title：Circulation

authors： Waleh N,Kajino H,Marrache AM,Ginzinger D,Roman C,Seidner SR,Moss TJ,Fouron JC,Vazquez-Tello A,Chemtob S,Clyman RI

更新日期：2004-10-19 00:00:00

abstract：:Of 22 children with congenital complete heart block (CCHB) available for study, 14 (63.6%) were born to 11 mothers with clinical or laboratory evidence of connective tissue disease, primarily lupus erythematosus (LE). Seven mothers had both clinical and laboratory evidence of disease while four had only positive labor...

journal_title：Circulation

authors： McCue CM,Mantakas ME,Tingelstad JB,Ruddy S

更新日期：1977-07-01 00:00:00

abstract：BACKGROUND:It is not known whether progression of aortic arch (AA) atheroma is associated with vascular events in patients with stroke or transient ischemic attack (TIA). METHODS AND RESULTS:AA atheroma was detected on baseline transesophageal echocardiogram in 167 consecutive patients who had prevalent stroke or TIA....

journal_title：Circulation

authors： Sen S,Hinderliter A,Sen PK,Simmons J,Beck J,Offenbacher S,Ohman EM,Oppenheimer SM

更新日期：2007-08-21 00:00:00

abstract：BACKGROUND:Atrial fibrillation is common in advanced heart failure, but its prognostic significance is controversial. METHODS AND RESULTS:We evaluated the relation of atrial rhythm to overall survival and sudden death in 390 consecutive advanced heart failure patients. Etiology of heart failure was coronary artery dis...

journal_title：Circulation

authors： Middlekauff HR,Stevenson WG,Stevenson LW

更新日期：1991-07-01 00:00:00

abstract：BACKGROUND:Iron overload has an increasing worldwide prevalence and is associated with significant cardiovascular morbidity and mortality. Elevated iron levels in the myocardium lead to impaired systolic and diastolic function and elevated oxidative stress. Taurine accounts for 25% to 50% of the amino acid pool in myoc...

journal_title：Circulation

authors： Oudit GY,Trivieri MG,Khaper N,Husain T,Wilson GJ,Liu P,Sole MJ,Backx PH

更新日期：2004-04-20 00:00:00