Matrix-dependent mechanism of neutrophil-mediated release and activation of matrix metalloproteinase 9 in myocardial ischemia/reperfusion.

abstract：:Coronary occlusion in the dog results in irreversible myocardial cell injury which develops first in subendocardial areas of severe ischemica and subsequently spreads into mid and subepicardial areas of moderate ischemia. The effect of propranolol on this progression of ischemic injury was evaluated. Three groups of d...

journal_title：Circulation

authors： Rasmussen MM,Reimer KA,Kloner RA,Jennings RB

更新日期：1977-11-01 00:00:00

abstract：:Diabetes mellitus increases the risk of heart failure independently of underlying coronary artery disease, and many believe that diabetes leads to cardiomyopathy. The underlying pathogenesis is partially understood. Several factors may contribute to the development of cardiac dysfunction in the absence of coronary art...

journal_title：Circulation

authors： Boudina S,Abel ED

更新日期：2007-06-26 00:00:00

abstract：:The hypothesis tested in this study was that despite the presence of severe postischemic myocardial dysfunction ("stunning"), the extraction and subsequent intracellular washout of thallium 201 should be preserved as long as irreversible sarcolemmal membrane injury was avoided. To produce myocardial stunning, 19 open-...

journal_title：Circulation

authors： Moore CA,Cannon J,Watson DD,Kaul S,Beller GA

更新日期：1990-05-01 00:00:00

abstract：:Blood pressure and heart rate of 15 male shift workers were measured every 15 minutes for 24 hours during three work shifts: morning, 4:00 AM to noon; afternoon, noon to 8:00 PM; and night, 8:00 PM to 4:00 AM. For each shift, 24-hour systolic and diastolic blood pressure showed a large "trough" (the low pressure span)...

journal_title：Circulation

authors： Chau NP,Mallion JM,de Gaudemaris R,Ruche E,Siche JP,Pelen O,Mathern G

更新日期：1989-08-01 00:00:00

abstract：BACKGROUND:Exercise stimulates the vascular response in pathological conditions, including ischemia; however, the molecular mechanisms by which exercise improves the impaired hypoxia-induced factor (HIF)-1 alpha-mediated response to hypoxia associated with aging are poorly understood. Here, we report that swimming trai...

journal_title：Circulation

authors： Cheng XW,Kuzuya M,Kim W,Song H,Hu L,Inoue A,Nakamura K,Di Q,Sasaki T,Tsuzuki M,Shi GP,Okumura K,Murohara T

更新日期：2010-08-17 00:00:00

abstract：:To determine whether multiple lead precordial electrocardiographic recordings offer an improved index for noninvasive estimation of left ventricular hemodynamic function and segmental dyssynergy, precordial mapping was performed in patients with anterior myocardial infarction, and the number of pathologic Q waves (gre...

journal_title：Circulation

authors： Awan NA,Miller RR,Vera Z,Janzen DA,Amsterdam EA,Mason DT

更新日期：1977-06-01 00:00:00

abstract：:This essay reviews the founding and early history of the Council on Clinical Cardiology of the American Heart Association (AHA), the largest of the AHA's 14 councils. Based on archival research, it stresses the factors that led to the council's formation and shaped its agenda. The council was established in the contex...

journal_title：Circulation

authors： Fye WB

更新日期：1993-03-01 00:00:00

abstract：:Disorders associated with the overproduction or delayed clearance of beta-very low density lipoprotein and low density lipoprotein (LDL) are strikingly related to premature coronary artery disease. There are five recognized classes of LDL-lowering drugs, each acting through different basic mechanisms. The increased pr...

journal_title：Circulation

authors： Levy RI,Troendle AJ,Fattu JM

更新日期：1993-04-01 00:00:00

abstract：BACKGROUND:The maternal circulatory system and hormone balance both change dynamically during pregnancy, delivery, and the postpartum period. Although atrial natriuretic peptides and brain natriuretic peptides produced in the heart control circulatory homeostasis through their common receptor, NPR1, the physiologic and...

journal_title：Circulation

authors： Otani K,Tokudome T,Kamiya CA,Mao Y,Nishimura H,Hasegawa T,Arai Y,Kaneko M,Shioi G,Ishida J,Fukamizu A,Osaki T,Nagai-Okatani C,Minamino N,Ensho T,Hino J,Murata S,Takegami M,Nishimura K,Kishimoto I,Miyazato M,Hara

更新日期：2020-02-18 00:00:00

abstract：:In this double-blind randomized study, 19 patients with acute transmural myocardial infarction were treated with methylprednisolone administered 4.4 +/- 0.7 hours (+/- SEM) after the onset of chest pain, and were compared with 21 patients who received placebo 4.5 +/- 0.4 hours after the start of clinical symptoms. The...

journal_title：Circulation

authors： Madias JE,Hood WB Jr

更新日期：1982-06-01 00:00:00

abstract：BACKGROUND:Cell-mediated autoimmunity has been strongly implicated in the pathogenesis of viral myocarditis. METHODS AND RESULTS:Using a murine model of acute myocarditis caused by coxsackievirus B3, we analyzed the phenotypes and morphology of the infiltrating cells in the hearts by immunofluorescence and electron mi...

journal_title：Circulation

authors： Seko Y,Shinkai Y,Kawasaki A,Yagita H,Okumura K,Takaku F,Yazaki Y

更新日期：1991-08-01 00:00:00

abstract：:Defibrillation/cardioversion thresholds were measured in 33 patients undergoing defibrillator implants. Each patient had a 12 cm2 patch placed near the left ventricular apex via a thoracotomy and a 10 cm2 spring lead placed pervenously at the right atrial-superior vena caval junction. Ventricular tachycardia of stable...

journal_title：Circulation

authors： Winkle RA,Stinson EB,Bach SM Jr,Echt DS,Oyer P,Armstrong K

更新日期：1984-04-01 00:00:00

abstract：:Experimental studies demonstrate that short-term regional perfusion-contraction matching, in which the energy demands of regional myocardial contraction are reduced to match the diminished myocardial substrate supply, occurs during states of low coronary blood flow under resting conditions and during exercise-induced ...

journal_title：Circulation

authors： Ross J Jr

更新日期：1991-03-01 00:00:00

abstract：:There is now evidence that under resting conditions coronary vasodilator reserve exists even in the presence of myocardial ischemia. Therefore, we tested the hypothesis that a vasodilator reserve may exist during exercise so that during exercise-induced ischemia a reduction in coronary constrictor tone can be produced...

journal_title：Circulation

authors： Heusch G,Guth BD,Seitelberger R,Ross J Jr

更新日期：1987-02-01 00:00:00

abstract：BACKGROUND:Human salusins, related bioactive polypeptides with mitogenic effects on vascular smooth muscle cells and fibroblasts and roles in hemodynamic homeostasis, may be involved in the origin of coronary atherosclerosis. Macrophage foam cell formation, characterized by cholesterol ester accumulation, is modulated ...

journal_title：Circulation

authors： Watanabe T,Nishio K,Kanome T,Matsuyama TA,Koba S,Sakai T,Sato K,Hongo S,Nose K,Ota H,Kobayashi Y,Katagiri T,Shichiri M,Miyazaki A

更新日期：2008-02-05 00:00:00

abstract：:This is a report of a 10-year-old child who underwent surgery for complex congenital heart disease consisting of corrected transposition of the great vessels, ventricular septal defect, patent ductus arterisus, severe left-sided atrioventricular (AV) valve insuffieicney (Ebstein's deformity) and Wolff-Parkinson-White ...

journal_title：Circulation

authors： Benson DW Jr,Gallagher JJ,Oldham HN,Sealy WC,Sterba R,Spach MS

更新日期：1980-06-01 00:00:00

abstract：BACKGROUND:Tumor necrosis factor alpha (TNF-alpha) increases in patients with severe congestive heart failure (CHF) and cachexia. Two naturally occurring modulators of TNF-alpha activity have been identified in human serum. These two soluble proteins are the extracellular domains of the TNF receptors (sTNF-RI and sTNF-...

journal_title：Circulation

authors： Ferrari R,Bachetti T,Confortini R,Opasich C,Febo O,Corti A,Cassani G,Visioli O

更新日期：1995-09-15 00:00:00

abstract：BACKGROUND:Epidemiological studies aimed at correlating coronary heart disease (CHD) with serum ferritin levels have thus far yielded inconsistent results. We hypothesized that a labile iron component associated with non-transferrin-bound iron (NTBI) that appears in individuals with overt or cryptic iron overload might...

journal_title：Circulation

authors： van der A DL,Marx JJ,Grobbee DE,Kamphuis MH,Georgiou NA,van Kats-Renaud JH,Breuer W,Cabantchik ZI,Roest M,Voorbij HA,van der Schouw YT

更新日期：2006-04-25 00:00:00

abstract：:In 61 patients sinus node function was tested by programmed (sinoatrial conduction time, SACT) and overdrive atrial pacing (sinus node recovery time, SRT). In the control group (N = 20), mean sinus cycle length was 773 +/- 140.2 msec, mean absolute SRT 1044 +/- 215.8 msec [corrected SRT (CSRT) 270 +/- 112.5 msec; mean...

journal_title：Circulation

authors： Breithardt G,Seipel L,Loogen F

更新日期：1977-07-01 00:00:00

abstract：BACKGROUND:Health-related quality-of-life instruments have become important measures of early health outcomes after cardiac surgery. The relationship between quality of life after recovery from surgery and subsequent long-term survival has not previously been explored. Our objective was to determine whether the Duke Ac...

journal_title：Circulation

authors： Koch CG,Li L,Lauer M,Sabik J,Starr NJ,Blackstone EH

更新日期：2007-02-13 00:00:00

abstract：BACKGROUND:Peripheral adiposity confers protection against diabetes and atherosclerosis in elderly women. The underlying mechanisms, however, remain to be elucidated. METHODS AND RESULTS:On the basis on dual-energy X-ray absorptiometry measurements of central fat mass (CFM) and peripheral fat mass (PFM), we identified...

journal_title：Circulation

authors： Tankó LB,Bruun JM,Alexandersen P,Bagger YZ,Richelsen B,Christiansen C,Larsen PJ

更新日期：2004-10-12 00:00:00

abstract：:To determine whether alteration of intrinsic myocardial stiffness is responsible for the reduction of left ventricular filling pressure and volume by nifedipine in patients with impaired baseline ventricular function, we evaluated the hemodynamic responses in 32 patients undergoing diagnostic cardiac catheterization. ...

journal_title：Circulation

authors： Kurnik PB,Courtois MR,Ludbrook PA

更新日期：1986-07-01 00:00:00

abstract：BACKGROUND:The renin-angiotensin system (RAS) is a key player in the progression of heart failure. Angiotensin-(1-7) is thought to modulate the activity of the RAS. Furthermore, this peptide may play a part in the beneficial effects of angiotensin-converting enzyme inhibitors in cardiovascular disease. We assessed the ...

journal_title：Circulation

authors： Loot AE,Roks AJ,Henning RH,Tio RA,Suurmeijer AJ,Boomsma F,van Gilst WH

更新日期：2002-04-02 00:00:00

abstract：BACKGROUND:The mechanism of ECG changes and arrhythmogenesis in Brugada syndrome (BS) patients is unknown. METHODS AND RESULTS:A BS patient without clinically detected cardiac structural abnormalities underwent cardiac transplantation for intolerable numbers of implantable cardioverter/defibrillator discharges. The pa...

journal_title：Circulation

authors： Coronel R,Casini S,Koopmann TT,Wilms-Schopman FJ,Verkerk AO,de Groot JR,Bhuiyan Z,Bezzina CR,Veldkamp MW,Linnenbank AC,van der Wal AC,Tan HL,Brugada P,Wilde AA,de Bakker JM

更新日期：2005-11-01 00:00:00

abstract：:The incidence and prevalence of most cardiovascular disorders increase with age, and cardiovascular disease is the leading cause of death and major disability in adults ≥75 years of age; however, despite the large impact of cardiovascular disease on quality of life, morbidity, and mortality in older adults, patients a...

journal_title：Circulation

authors： Rich MW,Chyun DA,Skolnick AH,Alexander KP,Forman DE,Kitzman DW,Maurer MS,McClurken JB,Resnick BM,Shen WK,Tirschwell DL,American Heart Association Older Populations Committee of the Council on Clinical Cardiology, Council on Cardiov

更新日期：2016-05-24 00:00:00

abstract：:Acute cardiac rejection, syndrome X, and arterial hypertension can induce small vessel damage and, therefore, restriction of coronary reserve in the presence of normal epicardial coronary arteries. A characteristic response pattern to dipyridamole (DIP) infusion has been previously described in syndrome X and arterial...

journal_title：Circulation

authors： Picano E,De Pieri G,Salerno JA,Arbustini E,Distante A,Martinelli L,Pucci A,Montemartini C,Viganò M,Donato L

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND:Coronary heart disease (CHD) mortality is rising in many developing countries. We examined how much of the increase in CHD mortality in Beijing, China, between 1984 and 1999 could be attributed to changes in major cardiovascular risk factors and assessed the impact of medical and surgical treatments. METHOD...

journal_title：Circulation

authors： Critchley J,Liu J,Zhao D,Wei W,Capewell S

更新日期：2004-09-07 00:00:00

abstract：BACKGROUND:The renin-angiotensin-aldosterone system is involved in the pathogenesis of atherosclerosis, partially because of its pro-oxidative properties. We questioned the effect and mechanisms of action of administration of aldosterone to apolipoprotein E-deficient (E(0)) mice on their macrophages and aorta oxidative...

journal_title：Circulation

authors： Keidar S,Kaplan M,Pavlotzky E,Coleman R,Hayek T,Hamoud S,Aviram M

更新日期：2004-05-11 00:00:00

abstract：BACKGROUND:Cardiac allograft arteriosclerosis is a complex process of alloimmune response, chronic inflammation, and smooth muscle cell proliferation that includes cross talk between cytokines and growth factors. METHODS AND RESULTS:Our results in rat cardiac allografts established alloimmune response as an alternativ...

journal_title：Circulation

authors： Lemström KB,Krebs R,Nykänen AI,Tikkanen JM,Sihvola RK,Aaltola EM,Häyry PJ,Wood J,Alitalo K,Ylä-Herttuala S,Koskinen PK

更新日期：2002-05-28 00:00:00

abstract：BACKGROUND:Right ventricular (RV) dilatation that occurs as a consequence of RV infarction is thought to produce hemodynamic instability by reducing left ventricular (LV) preload and compliance. We hypothesized that these geometric changes may also adversely affect LV systolic performance. METHODS AND RESULTS:Twelve 4...

journal_title：Circulation

authors： Brookes C,Ravn H,White P,Moeldrup U,Oldershaw P,Redington A

更新日期：1999-08-17 00:00:00