Contribution of myocardium responsible for ventricular tachycardia to abnormalities detected by analysis of signal-averaged ECGs.

abstract：BACKGROUND:Arteriogenesis serves as an efficient mechanism for flow restoration after arterial occlusion. This process is associated with inflammatory mediators such as tumor necrosis factor-alpha (TNF-alpha), although their role in arteriogenesis remains unclear. We hypothesized that arteriogenesis is reduced in mice ...

journal_title：Circulation

authors： Hoefer IE,van Royen N,Rectenwald JE,Bray EJ,Abouhamze Z,Moldawer LL,Voskuil M,Piek JJ,Buschmann IR,Ozaki CK

更新日期：2002-04-09 00:00:00

abstract：BACKGROUND:Growth factors such as platelet-derived growth factor (PDGF) have been postulated to be important mediators of neointimal formation in balloon-injured artery. Binding of growth factors to their receptors activates intrinsic receptor tyrosine kinase, resulting in tyrosine phosphorylation of receptors themselv...

journal_title：Circulation

authors： Abe J,Deguchi J,Matsumoto T,Takuwa N,Noda M,Ohno M,Makuuchi M,Kurokawa K,Takuwa Y

更新日期：1997-09-16 00:00:00

abstract：BACKGROUND:The application of iloprost, a stable prostacyclin analogue, by inhalation has been shown to improve hemodynamic variables in patients with primary pulmonary hypertension. However, repetitive inhalations are required due to its short-term effects. One potential approach to prolong and increase the vasorelaxa...

journal_title：Circulation

authors： Wilkens H,Guth A,König J,Forestier N,Cremers B,Hennen B,Böhm M,Sybrecht GW

更新日期：2001-09-11 00:00:00

abstract：BACKGROUND:Older coronary patients are at high risk of cardiac disability. Exercise conditioning programs have been demonstrated to improve functional capacity, particularly in younger coronary patients. In this study, the effects of aerobic conditioning on submaximal and maximal indicators of exercise performance were...

journal_title：Circulation

authors： Ades PA,Waldmann ML,Poehlman ET,Gray P,Horton ED,Horton ES,LeWinter MM

更新日期：1993-08-01 00:00:00

abstract：BACKGROUND:Lifetime risk for atherosclerotic cardiovascular disease (CVD) has not previously been estimated, and the effect of risk factor burden on lifetime risk is unknown. METHODS AND RESULTS:We included all Framingham Heart Study participants who were free of CVD (myocardial infarction, coronary insufficiency, ang...

journal_title：Circulation

authors： Lloyd-Jones DM,Leip EP,Larson MG,D'Agostino RB,Beiser A,Wilson PW,Wolf PA,Levy D

更新日期：2006-02-14 00:00:00

abstract：:Using a high-pressure liquid chromatographic assay, we measured serum amiodarone concentrations serially in 122 patients treated with amiodarone for 1.5-53 months (mean 9.3 months) for control of refractory symptomatic atrial or symptomatic and life-threatening ventricular tachyarrhythmias. The atrial tachyarrhythmias...

journal_title：Circulation

authors： Haffajee CI,Love JC,Canada AT,Lesko LJ,Asdourian G,Alpert JS

更新日期：1983-06-01 00:00:00

abstract：BACKGROUND:Randomized trials that studied clinical outcomes after percutaneous coronary intervention (PCI) with bare metal stenting versus coronary artery bypass grafting (CABG) are underpowered to properly assess safety end points like death, stroke, and myocardial infarction. Pooling data from randomized controlled t...

journal_title：Circulation

authors： Daemen J,Boersma E,Flather M,Booth J,Stables R,Rodriguez A,Rodriguez-Granillo G,Hueb WA,Lemos PA,Serruys PW

更新日期：2008-09-09 00:00:00

abstract：BACKGROUND:Adriamycin (ADR) is an anticancer drug known to cause severe cardiac toxicity by generating free radicals. We investigated the role of a redox-regulating molecule, thioredoxin-1 (TRX1), in ADR-induced cardiotoxicity. METHODS AND RESULTS:The in vitro study showed that TRX1 was dose-dependently increased conc...

journal_title：Circulation

authors： Shioji K,Kishimoto C,Nakamura H,Masutani H,Yuan Z,Oka S,Yodoi J

更新日期：2002-09-10 00:00:00

abstract：:Recent reports of selected observational studies and a meta-analysis have stirred controversy and have become the impetus for calls to abandon recommendations for reduced sodium intake by the US general population. A detailed review of these studies documents substantial methodological concerns that limit the usefulne...

journal_title：Circulation

authors： Whelton PK,Appel LJ,Sacco RL,Anderson CA,Antman EM,Campbell N,Dunbar SB,Frohlich ED,Hall JE,Jessup M,Labarthe DR,MacGregor GA,Sacks FM,Stamler J,Vafiadis DK,Van Horn LV

更新日期：2012-12-11 00:00:00

abstract：BACKGROUND:Matrix metalloproteinases (MMPs) in inflamed atherosclerotic plaques may contribute to extracellular matrix remodeling and the onset of acute thrombotic complications. METHODS AND RESULTS:To test the hypothesis that optical molecular imaging with the use of an activatable near-infrared fluorescence (NIRF) p...

journal_title：Circulation

authors： Deguchi JO,Aikawa M,Tung CH,Aikawa E,Kim DE,Ntziachristos V,Weissleder R,Libby P

更新日期：2006-07-04 00:00:00

abstract：BACKGROUND:Several nonatherosclerotic animal models of restenosis exist and are used for the evaluation of the vascular response to angioplasty-induced injury. However, few studies have evaluated the response of an atherosclerotic vessel to angioplasty. The present study examined the radiographic, histological, immunoh...

journal_title：Circulation

authors： Wilensky RL,March KL,Gradus-Pizlo I,Sandusky G,Fineberg N,Hathaway DR

更新日期：1995-11-15 00:00:00

abstract：:Aortocoronary vein bypass surgery might not restore normal maximal coronary flow reserve to bypassed coronary vessels because residual diffuse coronary atherosclerosis might limit maximal hyperemia. To investigate the effect of diffuse atherosclerosis and a focal stenosis at the graft-coronary anastomosis, we measured...

journal_title：Circulation

authors： Wilson RF,White CW

更新日期：1987-09-01 00:00:00

abstract：BACKGROUND:Defining the arrhythmogenic substrate is essential for successful ablation of scar-related ventricular tachycardia. The visual characteristics of endocardial ischemic scar have not been described in vivo. The goal of this study was (1) to quantify the visual characteristics of normal tissue, scar border zone...

journal_title：Circulation

authors： Betensky BP,Jauregui M,Campos B,Michele J,Marchlinski FE,Oley L,Wylie B,Robinson D,Gerstenfeld EP

更新日期：2012-10-23 00:00:00

abstract：BACKGROUND:Heart rate (HR) variability is a marker of tonic cardiac autonomic activity and contributes in assessing risk for sudden death after myocardial infarction. Recent clinical observations have indicated that attenuation of HR variability, which occurs after myocardial infarction, may be transient. This study ad...

journal_title：Circulation

authors： Adamson PB,Huang MH,Vanoli E,Foreman RD,Schwartz PJ,Hull SS Jr

更新日期：1994-08-01 00:00:00

abstract：BACKGROUND:The causes of metabolic syndrome (MS), which may be a precursor of coronary disease, are uncertain. We hypothesize that disturbances in neuroendocrine and cardiac autonomic activity (CAA) contribute to development of MS. We examine reversibility and the power of psychosocial and behavioral factors to explain...

journal_title：Circulation

authors： Brunner EJ,Hemingway H,Walker BR,Page M,Clarke P,Juneja M,Shipley MJ,Kumari M,Andrew R,Seckl JR,Papadopoulos A,Checkley S,Rumley A,Lowe GD,Stansfeld SA,Marmot MG

更新日期：2002-11-19 00:00:00

abstract：BACKGROUND:The mechanistic target of rapamycin (mTOR) comprises 2 structurally distinct multiprotein complexes, mTOR complexes 1 and 2 (mTORC1 and mTORC2). Deregulation of mTOR signaling occurs during and contributes to the severity of myocardial damage from ischemic heart disease. However, the relative roles of mTORC1...

journal_title：Circulation

authors： Völkers M,Konstandin MH,Doroudgar S,Toko H,Quijada P,Din S,Joyo A,Ornelas L,Samse K,Thuerauf DJ,Gude N,Glembotski CC,Sussman MA

更新日期：2013-11-05 00:00:00

abstract：:A group of 916 apparently healthy men between the ages of 27 and 55 years (mean 37) were followed up with serial medical and exercise test evaluations for a period of 8 to 15 years (mean 12.7) to determine (1) the prevalence and specific types of new coronary events observed in subjects with and without abnormal ST se...

journal_title：Circulation

authors： McHenry PL,O'Donnell J,Morris SN,Jordan JJ

更新日期：1984-10-01 00:00:00

abstract：:Long-term tocainide therapy has been evaluated in 17 patients with ventricular arrhythmias. Ventricular tachycardia and/or fibrillation was recurrent and sustained in nine patients, and symptomatic but unsustained in three others. Five patients had frequent but only mildly symptomatic ventricular irritability. In all ...

journal_title：Circulation

authors： Winkle RA,Meffin PJ,Harrison DC

更新日期：1978-05-01 00:00:00

abstract：:We quantitated the growth patterns of the normal fetal heart and the right and left ventricles from postmortem hearts obtained from 55 spontaneously aborted human fetuses from the completion of cardiogenesis to term. Fetal gestational age was assessed by menstrual history of the mother, crown-rump length, head circumf...

journal_title：Circulation

authors： St John Sutton MG,Raichlen JS,Reichek N,Huff DS

更新日期：1984-12-01 00:00:00

abstract：BACKGROUND:A key component of reperfusion of myocardial infarction is an immediate inflammatory response, which enhances tissue repair. Matrix turnover is crucial to tissue repair, and matrix metalloproteinases (MMPs) are key enzymes involved in matrix degradation. The hypothesis tested is that one inflammation-based e...

journal_title：Circulation

authors： Lindsey M,Wedin K,Brown MD,Keller C,Evans AJ,Smolen J,Burns AR,Rossen RD,Michael L,Entman M

更新日期：2001-05-01 00:00:00

abstract：BACKGROUND:Oxidized low-density lipoprotein plays a key role in the initiation, progression, and destabilization of atherosclerotic plaques and is present in macrophages and the lipid pool. The aim of this study was to assess the feasibility of magnetic resonance imaging of atherosclerotic lesions in mice using micelle...

journal_title：Circulation

authors： Briley-Saebo KC,Shaw PX,Mulder WJ,Choi SH,Vucic E,Aguinaldo JG,Witztum JL,Fuster V,Tsimikas S,Fayad ZA

更新日期：2008-06-24 00:00:00

abstract：BACKGROUND:Little information is available regarding the occurrence of perioperative and late cardiac events in women with vascular disease. The current study was performed to examine whether sex-specific differences exist in these outcomes in a large population of vascular surgery patients and to determine the value o...

journal_title：Circulation

authors： Hendel RC,Chen MH,L'Italien GJ,Newell JB,Paul SD,Eagle KA,Leppo JA

更新日期：1995-02-15 00:00:00

abstract：BACKGROUND:Graft survival after skeletal myoblast transplantation is affected by various pathological processes caused by environmental stress. Heat shock is known to afford protection of several aspects of cell metabolism and function. We hypothesized that prior heat shock treatment of graft cells would improve their ...

journal_title：Circulation

authors： Suzuki K,Smolenski RT,Jayakumar J,Murtuza B,Brand NJ,Yacoub MH

更新日期：2000-11-07 00:00:00

abstract：BACKGROUND:Percutaneous transluminal coronary angioplasty of the infarct-related artery in stable survivors of acute myocardial infarction is often performed, even in patients without any symptoms or residual ischemia. Despite the lack of randomized studies, it is widely believed that this intervention will improve the...

journal_title：Circulation

authors： Zeymer U,Uebis R,Vogt A,Glunz HG,Vöhringer HF,Harmjanz D,Neuhaus KL,ALKK-Study Group.

更新日期：2003-09-16 00:00:00

abstract：BACKGROUND:Patients with transfusional iron overload may develop a life-limiting cardiomyopathy. The sensitivity of lipid-metabolizing enzymes to peroxidative injury, as well as the reported effects of arachidonic acid (AA) and metabolites on cardiac rhythm, led us to hypothesize that iron-overloaded cardiomyocytes dis...

journal_title：Circulation

authors： Mattera R,Stone GP,Bahhur N,Kuryshev YA

更新日期：2001-05-15 00:00:00

abstract：BACKGROUND:Hypoxia from birth in immature rabbits increases the tolerance of isolated hearts to ischemia compared with age-matched normoxic rabbits. We determined whether this increased tolerance to ischemia was due to an alteration in the ATP-sensitive potassium (KATP) channel and whether increased KATP channel activa...

journal_title：Circulation

authors： Baker JE,Curry BD,Olinger GN,Gross GJ

更新日期：1997-03-04 00:00:00

abstract：BACKGROUND:Clinical manifestations of acute myocarditis, with distinct onset, vary from asymptomatic to fatal. The predictors of the course of the disease in patients with acute myocarditis at initial presentation have not yet been established. In this study, we examined the predictive values of various parameters in t...

journal_title：Circulation

authors： Fuse K,Kodama M,Okura Y,Ito M,Hirono S,Kato K,Hanawa H,Aizawa Y

更新日期：2000-12-05 00:00:00

abstract：BACKGROUND:Signaling through protein tyrosine kinases (PTKs) is a major contributor to the transmission of mitogenic stimuli to the interior of the cell and nucleus. The present study was designed to determine the effect of the tyrphostin AG1295, a selective blocker of PDGF-receptor PTK, on the growth of porcine and hu...

journal_title：Circulation

authors： Banai S,Wolf Y,Golomb G,Pearle A,Waltenberger J,Fishbein I,Schneider A,Gazit A,Perez L,Huber R,Lazarovichi G,Rabinovich L,Levitzki A,Gertz SD

更新日期：1998-05-19 00:00:00

abstract：:We have compared casual indirect measurements of arterial pressure obtained 1) by the general practitioner (GP) and 2) in the outpatient clinic (OPC) with 24 hour continuous recording of direct arterial pressure in two selected group of unrestricted patients. 1) Eight asymptomatic, untreated patients with suspected hy...

journal_title：Circulation

authors： Littler WA,Honour AJ,Pugsley DJ,Sleight P

更新日期：1975-06-01 00:00:00

abstract：:Patients with lower-extremity peripheral artery disease (PAD) have greater functional impairment, faster functional decline, increased rates of mobility loss, and poorer quality of life than people without PAD. Supervised exercise therapy (SET) improves walking ability, overall functional status, and health-related qu...

journal_title：Circulation

authors： Treat-Jacobson D,McDermott MM,Beckman JA,Burt MA,Creager MA,Ehrman JK,Gardner AW,Mays RJ,Regensteiner JG,Salisbury DL,Schorr EN,Walsh ME,American Heart Association Council on Peripheral Vascular Disease; Council on Cardiovascular

更新日期：2019-09-24 00:00:00