Adverse intrauterine conditions diminish the fetal defense against acute hypoxia by increasing nitric oxide activity.

abstract：BACKGROUND:The mechanism through which ischemic preconditioning causes cardioprotection is unknown. The present study investigated the role of stunning in preconditioning. METHODS AND RESULTS:We studied three different protocols of preconditioning: two cycles of 2-minute ischemia separated by 5-minute reperfusion (2'P...

journal_title：Circulation

authors： Miura T,Goto M,Urabe K,Endoh A,Shimamoto K,Iimura O

更新日期：1991-12-01 00:00:00

abstract：BACKGROUND:Adipocyte-derived hormones may represent a mechanism linking insulin resistance to cardiovascular disease. In the present study, we evaluated the direct effects of resistin, a novel adipocyte-derived hormone, on endothelial activation. METHODS AND RESULTS:Endothelial cells (ECs) were incubated with human re...

journal_title：Circulation

authors： Verma S,Li SH,Wang CH,Fedak PW,Li RK,Weisel RD,Mickle DA

更新日期：2003-08-12 00:00:00

abstract：:The current dispute over the effects of "low" vs "high" doses of aspirin should take into consideration the pharmacokinetics of this drug. In fact, different pharmaceutical formulations of aspirin may deliver little or no aspirin to the systemic blood. This was the case, for instance, in healthy volunteers taking 320 ...

journal_title：Circulation

authors： de Gaetano G,Cerletti C,Dejana E,Latini R

更新日期：1985-12-01 00:00:00

abstract：:Minoxidil, a potent predominant arterial dilator, improves hemodynamics over the short term in patients with heart failure. In random double-blind fashion 17 patients with chronic left heart failure were given minoxidil (nine patients) or placebo (eight patients) in addition to digoxin and diuretics for 3 months. Card...

journal_title：Circulation

authors： Franciosa JA,Jordan RA,Wilen MM,Leddy CL

更新日期：1984-07-01 00:00:00

abstract：:The indications for biventricular versus left ventricular mechanical circulatory support as a bridge to cardiac transplantation are not well established. In this study, 27 potential heart transplant candidates who were in imminent risk of dying before donor heart procurement were implanted with Thoratec prosthetic ven...

journal_title：Circulation

authors： Farrar DJ,Hill JD,Gray LA Jr,Galbraith TA,Chow E,Hershon JJ

更新日期：1989-11-01 00:00:00

abstract：BACKGROUND:Little is known about the function of inositol 1,4,5-trisphosphate receptors (IP3Rs) in the adult heart experimentally. Moreover, whether these Ca(2+) release channels are present and play a critical role in human cardiomyocytes remains to be defined. IP3Rs may be activated after Gαq-protein-coupled receptor...

journal_title：Circulation

authors： Signore S,Sorrentino A,Ferreira-Martins J,Kannappan R,Shafaie M,Del Ben F,Isobe K,Arranto C,Wybieralska E,Webster A,Sanada F,Ogórek B,Zheng H,Liu X,Del Monte F,D'Alessandro DA,Wunimenghe O,Michler RE,Hosoda T,Goichb

更新日期：2013-09-17 00:00:00

abstract：:The formula for survival in resuscitation describes educational efficiency and local implementation as key determinants in survival after cardiac arrest. Current educational offerings in the form of standardized online and face-to-face courses are falling short, with providers demonstrating a decay of skills over time...

journal_title：Circulation

authors： Cheng A,Nadkarni VM,Mancini MB,Hunt EA,Sinz EH,Merchant RM,Donoghue A,Duff JP,Eppich W,Auerbach M,Bigham BL,Blewer AL,Chan PS,Bhanji F,American Heart Association Education Science Investigators; and on behalf of the American

更新日期：2018-08-07 00:00:00

abstract：BACKGROUND:The pathophysiology of mental stress-induced myocardial ischemia, which occurs at lower heart rates than during physical stress, is not well understood. METHODS AND RESULTS:The Psychophysiological Investigations of Myocardial Ischemia Study (PIMI) evaluated the physiological and neuroendocrine functioning i...

journal_title：Circulation

authors： Goldberg AD,Becker LC,Bonsall R,Cohen JD,Ketterer MW,Kaufman PG,Krantz DS,Light KC,McMahon RP,Noreuil T,Pepine CJ,Raczynski J,Stone PH,Strother D,Taylor H,Sheps DS

更新日期：1996-11-15 00:00:00

abstract：BACKGROUND:Coronary spastic angina (CSA) is a common disease among East Asians, including Japanese. The prevalence of alcohol flushing syndrome associated with deficient activity of the variant aldehyde dehydrogenase 2 (ALDH2*2) genotype is prevalent among East Asians. We examined whether CSA is associated with the ALD...

journal_title：Circulation

authors： Mizuno Y,Harada E,Morita S,Kinoshita K,Hayashida M,Shono M,Morikawa Y,Murohara T,Nakayama M,Yoshimura M,Yasue H

更新日期：2015-05-12 00:00:00

abstract：:From November 1981 to November 1982, intra-aortic balloon pumping (IABP) was used after surgery in eight patients who were from 6 weeks to 6 years old and who weighed from 4.2 to 16.2 kg. In seven patients, specially constructed intra-aortic balloons with 2.5 and 5.0 ml volumes mounted on No. 5F catheters were used. I...

journal_title：Circulation

authors： Veasy LG,Blalock RC,Orth JL,Boucek MM

更新日期：1983-11-01 00:00:00

abstract：BACKGROUND:High-sensitivity cardiac troponin assays can help to identify patients who are at low risk of myocardial infarction in the emergency department. We aimed to determine whether the addition of clinical risk scores would improve the safety of early rule-out pathways for myocardial infarction. METHODS:In 1935 p...

journal_title：Circulation

authors： Chapman AR,Hesse K,Andrews J,Lee KK,Anand A,Shah ASV,Sandeman D,Ferry AV,Jameson J,Piya S,Stewart S,Marshall L,Strachan FE,Gray A,Newby DE,Mills NL

更新日期：2018-10-16 00:00:00

abstract：:For monotherapy, beta-blockers and calcium-entry blockers are effective and safe antianginal medications. For prophylaxis of myocardial ischemia, a different mechanism of action for each class of drugs is reflected by the different heart rate and rate-pressure product during exercise. In patients who continue to have ...

journal_title：Circulation

authors： Kostuk WJ,Pflugfelder P

更新日期：1987-06-01 00:00:00

abstract：BACKGROUND:Cardiopulmonary bypass and cardiac surgery are associated with a significant systemic inflammatory response that may increase postoperative complications. This meta-analysis assessed whether the benefits and risks of corticosteroid use were dose dependent in adult cardiac surgery. METHODS AND RESULTS:Random...

journal_title：Circulation

authors： Ho KM,Tan JA

更新日期：2009-04-14 00:00:00

abstract：BACKGROUND:Unlike the Western world, valvular disease ranks among the major cardiovascular afflictions in Africa. Acute rheumatic fever and chronic rheumatic valvular disease in their most virulent form are still commonly encountered and impose a huge burden on limited healthcare resources. METHODS AND RESULTS:We perf...

journal_title：Circulation

authors： Essop MR,Nkomo VT

更新日期：2005-12-06 00:00:00

abstract：BACKGROUND:Myocardial necrosis can occur during percutaneous coronary intervention (PCI) despite optimal adjunctive pharmacology and careful technique. We investigated the mechanisms of procedural infarction using angiographic analysis, intravascular ultrasound, and delayed-enhancement magnetic resonance imaging. METH...

journal_title：Circulation

authors： Porto I,Selvanayagam JB,Van Gaal WJ,Prati F,Cheng A,Channon K,Neubauer S,Banning AP

更新日期：2006-08-15 00:00:00

abstract：BACKGROUND:Ventricular tachyarrhythmias are the major clinical manifestation of arrhythmogenic right ventricular disease. Although antiarrhythmic therapy has been widely advocated, there is only limited information available on the efficacy of antiarrhythmic drugs in these patients. METHODS AND RESULTS:The short- and ...

journal_title：Circulation

authors： Wichter T,Borggrefe M,Haverkamp W,Chen X,Breithardt G

更新日期：1992-07-01 00:00:00

abstract：:We examined the cardiopulmonary effects of maximum bicycle ergometer exercise in seven patients with implanted Intermedics Nova MR pacemakers for three types of pacing in a randomized sequence: VVI or AAI at 70 beats/min (SSI 70), rate-adaptive temperature-controlled pacing with the implanted Nova MR, and rate-adaptiv...

journal_title：Circulation

authors： Alt E,Völker R,Högl B,MacCarter D

更新日期：1988-11-01 00:00:00

abstract：BACKGROUND:The Jun family of activator protein 1 (AP-1) transcription factors (c-Jun, JunB, and JunD) is involved in fundamental biological processes such as proliferation, apoptosis, tumor angiogenesis, and hypertrophy. The role of individual AP-1 transcription factors in the stressed heart is not clear. In the presen...

journal_title：Circulation

authors： Hilfiker-Kleiner D,Hilfiker A,Kaminski K,Schaefer A,Park JK,Michel K,Quint A,Yaniv M,Weitzman JB,Drexler H

更新日期：2005-09-06 00:00:00

abstract：BACKGROUND:Left ventricular (LV) mechanical dyssynchrony (LVMD) has emerged as a therapeutic target using cardiac resynchronization therapy (CRT) in selected patients with chronic heart failure. Current methods used to evaluate LVMD are technically difficult and do not assess LVMD of the whole LV simultaneously. We dev...

journal_title：Circulation

authors： Kapetanakis S,Kearney MT,Siva A,Gall N,Cooklin M,Monaghan MJ

更新日期：2005-08-16 00:00:00

abstract：BACKGROUND:Lung hypoplasia and persistent pulmonary hypertension of the newborn limit survival in congenital diaphragmatic hernia (CDH). Unlike other diseases resulting in persistent pulmonary hypertension of the newborn, infants with CDH are refractory to inhaled nitric oxide (NO). Nitric oxide mediates pulmonary vaso...

journal_title：Circulation

authors： Luong C,Rey-Perra J,Vadivel A,Gilmour G,Sauve Y,Koonen D,Walker D,Todd KG,Gressens P,Kassiri Z,Nadeem K,Morgan B,Eaton F,Dyck JR,Archer SL,Thébaud B

更新日期：2011-05-17 00:00:00

abstract：BACKGROUND:Clinical and experimental studies have demonstrated a major role of the renin-angiotensin system in the functional and structural changes of the large arteries in hypertension. Because genetic studies may help us to understand the mechanisms underlying the involvement of this system in arterial regulation, t...

journal_title：Circulation

authors： Benetos A,Gautier S,Ricard S,Topouchian J,Asmar R,Poirier O,Larosa E,Guize L,Safar M,Soubrier F,Cambien F

更新日期：1996-08-15 00:00:00

abstract：:A patient who had disabling supraventricular tachycardia showed electrophysiologic evidence of coexistent right and left Kent bundles. The supraventricular tachycardia was accelerated by sequential antegrade and retrograde conduction over the right and left Kent bundles, respectively. Spontaneous blocking of the condu...

journal_title：Circulation

authors： Cinca J,Valle V,Gutierrez L,Figueras J,Rius J

更新日期：1980-09-01 00:00:00

abstract：BACKGROUND:Echocardiographically determined left ventricular hypertrophy (LVH) has a well-demonstrated association with cardiovascular morbidity and mortality. However, whether or not there is a sex differential in the impact of LVH on mortality has never been systematically explored. METHODS AND RESULTS:This study en...

journal_title：Circulation

authors： Liao Y,Cooper RS,Mensah GA,McGee DL

更新日期：1995-08-15 00:00:00

abstract：BACKGROUND:Peroxisome proliferator-activated receptor gamma (PPARgamma) activators, such as troglitazone (Tro), not only improve insulin resistance but also suppress the neointimal formation after balloon injury. However, the precise mechanisms have not been determined. Angiotensin II (Ang II) plays crucial roles in th...

journal_title：Circulation

authors： Takeda K,Ichiki T,Tokunou T,Funakoshi Y,Iino N,Hirano K,Kanaide H,Takeshita A

更新日期：2000-10-10 00:00:00

abstract：BACKGROUND:Tenascin is a large extracellular matrix glycoprotein generally found in adult tissues undergoing active remodeling such as healing wounds and tumors. To determine the potential role of tenascin-C (TN-C) in the pathophysiology of atherosclerosis, we investigated the pattern of expression of TN-C in human cor...

journal_title：Circulation

authors： Wallner K,Li C,Shah PK,Fishbein MC,Forrester JS,Kaul S,Sharifi BG

更新日期：1999-03-16 00:00:00

abstract：:The effects of abrupt withdrawal or continuation of beta-blockade therapy during acute myocardial infarction were evaluated in 326 patients participating in the Multicenter Investigation of the Limitation of Infarct Size (MILIS). Thirty-nine patients previously receiving a beta-blocker and randomly selected for withdr...

journal_title：Circulation

authors： Croft CH,Rude RE,Gustafson N,Stone PH,Poole WK,Roberts R,Strauss HW,Raabe DS Jr,Thomas LJ,Jaffe AS

更新日期：1986-06-01 00:00:00

abstract：BACKGROUND:Pulmonary hypertension (PH) is a life-threatening disorder characterized by increased pulmonary artery pressure, remodeling of the pulmonary vasculature, and right ventricular failure. Loss of endothelium-derived nitric oxide (NO) and prostacyclin contributes to PH pathogenesis, and current therapies are tar...

journal_title：Circulation

authors： Bubb KJ,Trinder SL,Baliga RS,Patel J,Clapp LH,MacAllister RJ,Hobbs AJ

更新日期：2014-08-05 00:00:00

abstract：BACKGROUND:This multicenter trial was conducted to determine the efficacy and safety of pimobendan, an inotropic agent with calcium-sensitizing properties and activity as a phosphodiesterase inhibitor, in patients with heart failure. METHODS AND RESULTS:One hundred ninety-eight ambulatory patients with symptoms of mod...

journal_title：Circulation

authors： Kubo SH,Gollub S,Bourge R,Rahko P,Cobb F,Jessup M,Brozena S,Brodsky M,Kirlin P,Shanes J

更新日期：1992-03-01 00:00:00

abstract：BACKGROUND:Circulatory arrest (CA), which provides a bloodless field and good visualization without the need of aortic cross-clamp, is commonly used to facilitate repair of aortic lesions. However, extended periods of CA may impair cerebral metabolism and cause ischemic injury. Studies were performed to evaluate the ef...

journal_title：Circulation

authors： Lin PJ,Chang CH,Tan PP,Chang CN,Lee ST,Wang CC,Chang JP,Liu DW,Chu JJ,Tsai KT,Kao CL,Hsieh MJ,Hua MS

更新日期：1996-11-01 00:00:00

abstract：BACKGROUND:In vivo testing of novel antiplatelet agents requires informative biomarkers. By genetically modifying mouse von Willebrand factor (VWF(R1326H)), we have developed a small animal model that supports human but not mouse platelet-mediated thrombosis. Here, we evaluate the use of this biological platform as a p...

journal_title：Circulation

authors： Magallon J,Chen J,Rabbani L,Dangas G,Yang J,Bussel J,Diacovo T

更新日期：2011-01-25 00:00:00