当前位置： SCI文献检索 > CIRCULATION期刊下所有文献 > Prognostic significance of atrial fibrillation in advanced heart failure. A study of 390 patients.

Prognostic significance of atrial fibrillation in advanced heart failure. A study of 390 patients.

Abstract：

BACKGROUND:Atrial fibrillation is common in advanced heart failure, but its prognostic significance is controversial. METHODS AND RESULTS:We evaluated the relation of atrial rhythm to overall survival and sudden death in 390 consecutive advanced heart failure patients. Etiology of heart failure was coronary artery disease in 177 patients (45%) and nonischemic cardiomyopathy or valvular heart disease in 213 patients (55%). Mean left ventricular ejection fraction was 0.19 +/- 0.07. Seventy-five patients (19%) had paroxysmal (26 patients) or chronic (49 patients) atrial fibrillation. Compared with patients with sinus rhythm, patients with atrial fibrillation did not differ in etiology of heart failure, mean pulmonary capillary wedge pressure on therapy, or embolic events but were more likely to be receiving warfarin and antiarrhythmic drugs and had a slightly higher left ventricular ejection fraction. After a mean follow-up of 236 +/- 303 days, 98 patients died: 56 (57%) died suddenly, and 36 (37%) died of progressive heart failure. Actuarial 1-year overall survival was 68%, and sudden death-free survival was 79%. Actuarial survival was significantly worse for atrial fibrillation than for sinus rhythm patients (52% versus 71%, p = 0.0013). Similarly, sudden death-free survival was significantly worse for atrial fibrillation than for sinus rhythm patients (69% versus 82%, p = 0.0013). By Cox proportional hazards model, pulmonary capillary wedge pressure on therapy, left ventricular ejection fraction, coronary artery disease, and atrial fibrillation were independent risk factors for total mortality and sudden death. For patients who had pulmonary capillary wedge pressure of less than 16 mm Hg on therapy, atrial fibrillation was associated with poorer 1-year survival (44% versus 83%, p = 0.00001); however, in the high pulmonary capillary wedge pressure group, atrial fibrillation did not confer an increased risk (58% versus 57%). CONCLUSIONS:Atrial fibrillation is a marker for increased risk of death, especially in heart failure patients who have lower filling pressures on vasodilator and diuretic therapy. Whether aggressive attempts to maintain sinus rhythm will reduce this risk is unknown.

journal_name

Circulation

journal_title

Circulation

authors

Middlekauff HR,Stevenson WG,Stevenson LW

doi

10.1161/01.cir.84.1.40

subject

Has Abstract

pub_date

1991-07-01 00:00:00

pages

40-8

issue

1

eissn

0009-7322

issn

1524-4539

journal_volume

84

pub_type

杂志文章

相关文献

CIRCULATION文献大全
  • Epidemiological study of the electrocardiographic diagnosis of left ventricular hypertrophy.

    abstract：:Electrocardiograms from 5,129 examined persons, 2,449 men and 2,680 women, 16 years of age or older, were classified according to the Minnesota code of Blackburn and associates. The R wave amplitude criteria for possible left ventricular hypertrophy were fulfilled in 193 tracings from 135 men and 58 women. Age and sex...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/01.cir.33.2.270

    authors： Ostrander LD Jr

    更新日期：1966-02-01 00:00:00

  • Passage of inhaled particles into the blood circulation in humans.

    abstract：BACKGROUND:Pollution by particulates has been consistently associated with increased cardiovascular morbidity and mortality. However, the mechanisms responsible for these effects are not well-elucidated. METHODS AND RESULTS:To assess to what extent and how rapidly inhaled pollutant particles pass into the systemic cir...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/hc0402.104118

    authors： Nemmar A,Hoet PH,Vanquickenborne B,Dinsdale D,Thomeer M,Hoylaerts MF,Vanbilloen H,Mortelmans L,Nemery B

    更新日期：2002-01-29 00:00:00

  • Elevated levels of shed membrane microparticles with procoagulant potential in the peripheral circulating blood of patients with acute coronary syndromes.

    abstract：BACKGROUND:Apoptotic microparticles are responsible for almost all tissue factor activity of the plaque lipid core. We hypothesized that elevated levels of procoagulant microparticles could also circulate in the peripheral blood of patients with recent clinical signs of plaque disruption and thrombosis. METHODS AND RE...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/01.cir.101.8.841

    authors： Mallat Z,Benamer H,Hugel B,Benessiano J,Steg PG,Freyssinet JM,Tedgui A

    更新日期：2000-02-29 00:00:00

  • Assessing myocardial viability and infarct transmurality with left ventricular electromechanical mapping in patients with stable coronary artery disease: validation by delayed-enhancement magnetic resonance imaging.

    abstract：BACKGROUND:This study was designed to define myocardial viability and establish practical cut-off values for differentiating normal myocardial tissue from subendocardial and transmural scar tissue by using electromechanical mapping (EMM). We validated our results by delayed-enhancement cardiac MRI (DE-MRI). METHODS AN...

    journal_title：Circulation

    pub_type： 临床试验,杂志文章

    doi：10.1161/01.cir.0000026394.01888.18

    authors： Perin EC,Silva GV,Sarmento-Leite R,Sousa AL,Howell M,Muthupillai R,Lambert B,Vaughn WK,Flamm SD

    更新日期：2002-08-20 00:00:00

  • Posterior mitral leaflet motion in mitral stenosis.

    abstract：:A reduced rate of diastolic closure of the anterior mitral leaflet has been shown to occur in mitral stenosis, primary pulmonary hypertension, and in cases with reduced left ventricular compliance. Posterior notion of the posterior mitral leaflet in diastole has been the distinguishing feature to rule out the diagnosi...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/01.cir.51.3.511

    authors： Levisman JA,Abbasi AS,Pearce ML

    更新日期：1975-03-01 00:00:00

  • Inhibition of prolyl hydroxylase domain proteins promotes therapeutic revascularization.

    abstract：BACKGROUND:The hypoxia-inducible transcription factor (HIF) subunits are destabilized via the O(2)-dependent prolyl hydroxylase domain proteins (PHD1, PHD2, and PHD3). We investigated whether inhibition of PHDs via upregulating HIF might promote postischemic neovascularization. METHODS AND RESULTS:Mice with right femo...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/CIRCULATIONAHA.108.813303

    authors： Loinard C,Ginouvès A,Vilar J,Cochain C,Zouggari Y,Recalde A,Duriez M,Lévy BI,Pouysségur J,Berra E,Silvestre JS

    更新日期：2009-07-07 00:00:00

  • Myocardial thallium-201 kinetics in normal and ischemic myocardium.

    abstract：:The initial myocardial uptake of thallium-201 depends on myocardial blood flow distribution. The phenomenon of delayed thallium redistribution after transiently or chronically altered myocardial perfusion has been described. The net myocardial accumulation of thallium-201 after injection depends upon the net balance b...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/01.cir.64.3.610

    authors： Grunwald AM,Watson DD,Holzgrefe HH Jr,Irving JF,Beller GA

    更新日期：1981-09-01 00:00:00

  • Downregulation of c-myc expression by antisense oligonucleotides inhibits proliferation of human smooth muscle cells.

    abstract：BACKGROUND:Proliferation of smooth muscle cells (SMCs) plays an important role in vascular pathobiology, being involved in the development of coronary restenosis and atherosclerosis. The activation of nuclear proto-oncogenes appears to be a final common pathway onto which various mitogenic signals coverage. Accordingly...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/01.cir.88.3.1190

    authors： Shi Y,Hutchinson HG,Hall DJ,Zalewski A

    更新日期：1993-09-01 00:00:00

  • Two-dimensional echocardiographic findings in atrial septal defect.

    abstract：:Two-dimensional echocardiographic findings in a group of 24 patients with atrial septal defects were correlated with findings obtained by cardiac catheterization and M-mode echocardiography. The prevalence of mitral prolapse was 95% by two-dimensional echocardiography and 59% by angiography in patients with secundum a...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/01.cir.56.3.447

    authors： Lieppe W,Scallion R,Behar VS,Kisslo JA

    更新日期：1977-09-01 00:00:00

  • Impact of nonoperative therapy on the clinical management of peripheral arterial disease.

    abstract：:Nonoperative therapy includes conservative noninterventional modalities and the endovascular interventional modalities of percutaneous transluminal angioplasty and a variety of laser systems and atherectomy devices. The role and impact of all nonoperative treatments are considered in the perspectives of the natural hi...

    journal_title：Circulation

    pub_type： 杂志文章,评审

    doi：

    authors： Veith FJ,Gupta SK,Wengerter KR,Rivers SP,Bakal CW

    更新日期：1991-02-01 00:00:00

  • Increased preferential absorption in human atherosclerotic plaque with oral beta carotene. Implications for laser endarterectomy.

    abstract：:Patients undergoing carotid endarterectomy were pretreated with low-dose, oral beta carotene to determine whether the carotenoid content of plaque could be increased in vivo. Beta carotene-treated patients had a 50-fold increase in their plaque beta carotene level from 0.066 to 3.3 micrograms beta carotene/g plaque. M...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/01.cir.78.2.338

    authors： Prince MR,LaMuraglia GM,MacNichol EF Jr

    更新日期：1988-08-01 00:00:00

  • Prediction of lifetime risk for cardiovascular disease by risk factor burden at 50 years of age.

    abstract：BACKGROUND:Lifetime risk for atherosclerotic cardiovascular disease (CVD) has not previously been estimated, and the effect of risk factor burden on lifetime risk is unknown. METHODS AND RESULTS:We included all Framingham Heart Study participants who were free of CVD (myocardial infarction, coronary insufficiency, ang...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/CIRCULATIONAHA.105.548206

    authors： Lloyd-Jones DM,Leip EP,Larson MG,D'Agostino RB,Beiser A,Wilson PW,Wolf PA,Levy D

    更新日期：2006-02-14 00:00:00

  • Differential clinical outcomes associated with hypoglycemia and hyperglycemia in acute myocardial infarction.

    abstract：BACKGROUND:In patients with acute myocardial infarction (AMI), hyperglycemia predicts death, but the prognostic significance of hypoglycemia is controversial. METHODS AND RESULTS:We evaluated the prognostic significance of hypoglycemia and hyperglycemia in 30 536 AMI patients in a post hoc analysis of 2 large trials o...

    journal_title：Circulation

    pub_type： 杂志文章,随机对照试验

    doi：10.1161/CIRCULATIONAHA.108.837765

    authors： Goyal A,Mehta SR,Díaz R,Gerstein HC,Afzal R,Xavier D,Liu L,Pais P,Yusuf S

    更新日期：2009-12-15 00:00:00

  • Anthracycline cardiomyopathy is mediated by depletion of the cardiac stem cell pool and is rescued by restoration of progenitor cell function.

    abstract：BACKGROUND:Anthracyclines are the most effective drugs available in the treatment of neoplastic diseases; however, they have profound consequences on the structure and function of the heart, which over time cause a cardiomyopathy that leads to congestive heart failure. METHODS AND RESULTS:Administration of doxorubicin...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/CIRCULATIONAHA.109.895771

    authors： De Angelis A,Piegari E,Cappetta D,Marino L,Filippelli A,Berrino L,Ferreira-Martins J,Zheng H,Hosoda T,Rota M,Urbanek K,Kajstura J,Leri A,Rossi F,Anversa P

    更新日期：2010-01-19 00:00:00

  • In vivo molecular imaging of acute and subacute thrombosis using a fibrin-binding magnetic resonance imaging contrast agent.

    abstract：BACKGROUND:Plaque rupture with subsequent thrombosis is recognized as the underlying pathophysiology of most acute coronary syndromes and stroke. Thus, direct thrombus visualization may be beneficial for both diagnosis and guidance of therapy. We sought to test the feasibility of direct imaging of acute and subacute th...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/01.CIR.0000127034.50006.C0

    authors： Botnar RM,Perez AS,Witte S,Wiethoff AJ,Laredo J,Hamilton J,Quist W,Parsons EC Jr,Vaidya A,Kolodziej A,Barrett JA,Graham PB,Weisskoff RM,Manning WJ,Johnstone MT

    更新日期：2004-04-27 00:00:00

  • Noninvasive evaluation of intrarenal oxygenation with BOLD MRI.

    abstract：BACKGROUND:The countercurrent arrangement of capillary blood flow in the medulla of mammalian kidneys generates a gradient of oxygen tension between the renal cortex and the papillary tip that results in a state of relative hypoxia within the renal medulla. Exploration of the pathophysiological implications of medullar...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/01.cir.94.12.3271

    authors： Prasad PV,Edelman RR,Epstein FH

    更新日期：1996-12-15 00:00:00

  • Limitation of myocardial infarction by early infusion of recombinant tissue-type plasminogen activator.

    abstract：:In a double-blind randomized trial involving five Sydney hospitals and the city ambulance paramedical service, 145 patients with a first evolving myocardial infarction and with onset of pain less than 2.5 (mean 1.9 +/- 0.5 [SD]) hr previously were allocated to intravenous infusion of 100 mg recombinant tissue-type pla...

    journal_title：Circulation

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1161/01.cir.77.6.1311

    authors： O'Rourke M,Baron D,Keogh A,Kelly R,Nelson G,Barnes C,Raftos J,Graham K,Hillman K,Newman H

    更新日期：1988-06-01 00:00:00

  • Ablation Versus Amiodarone for Treatment of Persistent Atrial Fibrillation in Patients With Congestive Heart Failure and an Implanted Device: Results From the AATAC Multicenter Randomized Trial.

    abstract：BACKGROUND:Whether catheter ablation (CA) is superior to amiodarone (AMIO) for the treatment of persistent atrial fibrillation (AF) in patients with heart failure is unknown. METHODS AND RESULTS:This was an open-label, randomized, parallel-group, multicenter study. Patients with persistent AF, dual-chamber implantable...

    journal_title：Circulation

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1161/CIRCULATIONAHA.115.019406

    authors： Di Biase L,Mohanty P,Mohanty S,Santangeli P,Trivedi C,Lakkireddy D,Reddy M,Jais P,Themistoclakis S,Dello Russo A,Casella M,Pelargonio G,Narducci ML,Schweikert R,Neuzil P,Sanchez J,Horton R,Beheiry S,Hongo R,Hao S,

    更新日期：2016-04-26 00:00:00

  • Metabolic Predictors of Incident Coronary Heart Disease in Women.

    abstract：BACKGROUND:Although metabolomic profiling offers promise for the prediction of coronary heart disease (CHD), and metabolic risk factors are more strongly associated with CHD in women than men, limited data are available for women. METHODS:We applied a liquid chromatography-tandem mass spectrometry metabolomics platfor...

    journal_title：Circulation

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1161/CIRCULATIONAHA.117.029468

    authors： Paynter NP,Balasubramanian R,Giulianini F,Wang DD,Tinker LF,Gopal S,Deik AA,Bullock K,Pierce KA,Scott J,Martínez-González MA,Estruch R,Manson JE,Cook NR,Albert CM,Clish CB,Rexrode KM

    更新日期：2018-02-20 00:00:00

  • Inducible nitric oxide synthase mediates delayed myocardial protection induced by activation of adenosine A(1) receptors: evidence from gene-knockout mice.

    abstract：BACKGROUND:The mechanism of delayed preconditioning induced by activation of adenosine A(1) receptors (A(1)ARs) is not fully understood. We determined the role of inducible nitric oxide synthase (iNOS) in mediating adenosine-induced late cardioprotection using pharmacological inhibitors and iNOS gene-knockout mice. ME...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/01.cir.102.8.902

    authors： Zhao T,Xi L,Chelliah J,Levasseur JE,Kukreja RC

    更新日期：2000-08-22 00:00:00

  • Unique features and prognosis of primum ASD presenting in the first year of life.

    abstract：BACKGROUND:Primum atrial septal defect (ASD) is a defect that is usually associated with few symptoms and can be electively repaired with good results. A review of our experience with primum ASD identified a subset of patients characterized by presentation with congestive heart failure (CHF) in the first months of life...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：

    authors： Manning PB,Mayer JE Jr,Sanders SP,Coleman EA,Jonas RA,Keane JF,VanPraagh S,Castañeda AR

    更新日期：1994-11-01 00:00:00

  • Effect of torcetrapib on glucose, insulin, and hemoglobin A1c in subjects in the Investigation of Lipid Level Management to Understand its Impact in Atherosclerotic Events (ILLUMINATE) trial.

    abstract：BACKGROUND:High-density lipoproteins have antidiabetic properties in vitro. Furthermore, elevated high-density lipoprotein levels accompanying a genetic deficiency of cholesteryl ester transfer protein are associated with decreased levels of plasma glucose. We now investigate effects on glucose homeostasis of inhibitin...

    journal_title：Circulation

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1161/CIRCULATIONAHA.111.018259

    authors： Barter PJ,Rye KA,Tardif JC,Waters DD,Boekholdt SM,Breazna A,Kastelein JJ

    更新日期：2011-08-02 00:00:00

  • Lumen loss in transplant coronary artery disease is a biphasic process involving early intimal thickening and late constrictive remodeling: results from a 5-year serial intravascular ultrasound study.

    abstract：BACKGROUND:Coronary artery disease is the major cause of late cardiac allograft failure. However, few data exist regarding the natural history of changes in intimal and external elastic membrane (EEM) areas after heart transplantation. METHODS AND RESULTS:In 38 transplant recipients, serial intravascular ultrasound ex...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/hc3101.093867

    authors： Tsutsui H,Ziada KM,Schoenhagen P,Iyisoy A,Magyar WA,Crowe TD,Klingensmith JD,Vince DG,Rincon G,Hobbs RE,Yamagishi M,Nissen SE,Tuzcu EM

    更新日期：2001-08-07 00:00:00

  • Plasma cholesterol regulates soluble cell adhesion molecule expression in familial hypercholesterolemia.

    abstract：BACKGROUND:Hypercholesterolemia is associated with endothelial dysfunction. On the basis of the hypothesis that high plasma cholesterol per se may be a sufficient stimulus to upregulate endothelial adhesiveness and that this phenomenon might be reversible, soluble endothelial leukocyte adhesion molecules (sELAMs) were ...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/01.cir.96.5.1381

    authors： Sampietro T,Tuoni M,Ferdeghini M,Ciardi A,Marraccini P,Prontera C,Sassi G,Taddei M,Bionda A

    更新日期：1997-09-02 00:00:00

  • Stabilization of atherosclerotic plaques by blockade of macrophage migration inhibitory factor after vascular injury in apolipoprotein E-deficient mice.

    abstract：BACKGROUND:Macrophage migration inhibitory factor (MIF), a cytokine that controls cell-mediated inflammatory responses, is upregulated in atherogenesis; however, its functional contribution to lesion development has not been evaluated. METHODS AND RESULTS:We studied the role of MIF on neointima lesion formation after ...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/01.CIR.0000109201.72441.09

    authors： Schober A,Bernhagen J,Thiele M,Zeiffer U,Knarren S,Roller M,Bucala R,Weber C

    更新日期：2004-01-27 00:00:00

  • Short- and intermediate-term clinical outcomes from direct myocardial laser revascularization guided by biosense left ventricular electromechanical mapping.

    abstract：BACKGROUND:Direct myocardial revascularization (DMR) has been examined as an alternative treatment for patients with chronic refractory myocardial ischemic syndromes who are not candidates for conventional coronary revascularization. Methods and Results-We used left ventricular electromagnetic guidance in 77 patients w...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/01.cir.102.10.1120

    authors： Kornowski R,Baim DS,Moses JW,Hong MK,Laham RJ,Fuchs S,Hendel RC,Wallace D,Cohen DJ,Bonow RO,Kuntz RE,Leon MB

    更新日期：2000-09-05 00:00:00

  • Low operative mortality with implantation of a continuous-flow left ventricular assist device and impact of concurrent cardiac procedures.

    abstract：BACKGROUND:The objective of this study was to determine the impact of concurrent cardiac procedures (CCP) on patient outcomes after HeartMate II (HMII) left ventricular assist device implantation. METHODS AND RESULTS:Two hundred eighty-one patients underwent implantation of a HMII as a bridge to transplantation from M...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/CIRCULATIONAHA.108.844274

    authors： Pal JD,Klodell CT,John R,Pagani FD,Rogers JG,Farrar DJ,Milano CA,HeartMate II Clinical Investigators.

    更新日期：2009-09-15 00:00:00

  • Mechanism of acceleration of functional reentry in the ventricle: effects of ATP-sensitive potassium channel opener.

    abstract：BACKGROUND:The effect of effective refractory period (ERP) shortening on the vulnerability and characteristics of induced functional reentry in the ventricle remain poorly defined. We hypothesized that ERP shortening increases ventricular vulnerability to reentry and accelerates its rate, as is the case in the atrium. ...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/01.cir.99.5.704

    authors： Uchida T,Yashima M,Gotoh M,Qu Z,Garfinkel A,Weiss JN,Fishbein MC,Mandel WJ,Chen PS,Karagueuzian HS

    更新日期：1999-02-09 00:00:00

  • Mechanism of atrial sounds in atrial fibrillation. Phonoechocardiographic correlation. Report of a case.

    abstract：:Audible atrial sounds were noted in a patient with congestive cardiomyopathy and atrial fibrillation with slow ventricular rate. Oscillatory motion of similar periodicity as fibrillation waves in the ECG and the sounds in the phonocardiogram was demonstrated in aortic and left ventricular walls, mitral, tricuspid and ...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/01.cir.53.3.569

    authors： Bamrah VS,Hughes CV,Tristani FE

    更新日期：1976-03-01 00:00:00

  • Prognostic implications of myocardial perfusion single-photon emission computed tomography in the elderly.

    abstract：BACKGROUND:The goal of this study was to assess the clinical value of stress myocardial perfusion scintigraphy (MPS) in elderly patients (> or =75 years of age). METHODS AND RESULTS:We followed up 5200 elderly patients (41% exercise) after dual-isotope MPS over 2.8+/-1.7 years (362 cardiac deaths [CDs], 7.0%, 2.6%/y) ...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/CIRCULATIONAHA.108.817387

    authors： Hachamovitch R,Kang X,Amanullah AM,Abidov A,Hayes SW,Friedman JD,Cohen I,Thomson LE,Germano G,Berman DS

    更新日期：2009-12-01 00:00:00