Abstract:
BACKGROUND:Primum atrial septal defect (ASD) is a defect that is usually associated with few symptoms and can be electively repaired with good results. A review of our experience with primum ASD identified a subset of patients characterized by presentation with congestive heart failure (CHF) in the first months of life and a requirement for early operation. Echocardiograms, catheterizations, operative reports, and clinical data were reviewed and compared with that on all other patients with primum ASD. Patients with transitional or complete atrioventricular (AV) canal defects were excluded. METHODS AND RESULTS:From January 1984 to December 1992, significant CHF was present in the first year of life in 11 patients (10.5%) with primum ASD who were managed surgically among 105 total patients undergoing repair of primum ASD. This early CHF group had a higher incidence of hypoplastic left-sided cardiac structures (9 of 11 patients) compared with other primum ASD patients (5 of 94, P < .001), including patients with coarctation (CoA) (n = 9), abnormal mitral valve (n = 7), left ventricular hypoplasia (n = 5), and subaortic stenosis (subAS) (n = 7). Other differentiators from patients without early CHF included incidence of Downs syndrome (0% versus 19%), elevated pulmonary artery pressures (72% versus 33% systemic, P < .001), earlier mean age at operation (8 months versus 5.4 years), greater incidence of reoperation after initial ASD closure (5 of 8 patients, 12 operations [5 subAS, 3 mitral valve, 3 CoA, 1 pacemaker] versus 4 of 93 patients, P < .001), and higher mortality (36% versus 1%, P < .001). CONCLUSIONS:Left-sided obstructive lesions must be sought in children with primum ASD presenting with CHF in the first year of life. The presence of these lesions alters prognosis and surgical management and mandates close follow-up, with particular attention to late appearance or progression of subaortic stenosis or deterioration of mitral valve function.
journal_name
Circulationjournal_title
Circulationauthors
Manning PB,Mayer JE Jr,Sanders SP,Coleman EA,Jonas RA,Keane JF,VanPraagh S,Castañeda ARsubject
Has Abstractpub_date
1994-11-01 00:00:00pages
II30-5issue
5 Pt 2eissn
0009-7322issn
1524-4539journal_volume
90pub_type
杂志文章相关文献
CIRCULATION文献大全abstract::Seven of 214 patients (3%) with acute myocardial infarction (120 inferior and 94 anterior) developed atrial fibrillation within 3 hr of the onset of chest pain. All seven patients had an inferior infarction and in all seven the left circumflex artery was occluded proximal to the origin of its left atrial circumflex br...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.75.1.146
更新日期:1987-01-01 00:00:00
abstract:BACKGROUND:Monitoring implantable cardiac device function and patient condition is important. The Lumos-T Safely Reduces Routine Office Device Follow-Up (TRUST) trial tested the hypothesis that remote home monitoring with automatic daily surveillance (HM) is safe and effective for implantable cardioverter-defibrillator...
journal_title:Circulation
pub_type: 杂志文章,随机对照试验
doi:10.1161/CIRCULATIONAHA.110.937409
更新日期:2010-07-27 00:00:00
abstract:BACKGROUND:In this study, we both investigated coronary flow velocity in hypertrophic obstructive cardiomyopathy (HOCM) and tested the hypothesis of differing coronary flow reserve (CFR) of coronary arteries perfusing left ventricular regions with nonuniform myocardial hypertrophy by measuring the relative CFR. METHOD...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.96.3.834
更新日期:1997-08-05 00:00:00
abstract:BACKGROUND:Thrombus regression in heparin-treated, acute deep venous thrombosis of the lower extremity is poorly documented in the literature; different rates of thrombus resolution and recanalization are reported. METHODS AND RESULTS:In a prospective follow-up study, duplex scanning was used to evaluate the thrombus ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.86.2.414
更新日期:1992-08-01 00:00:00
abstract:BACKGROUND:Aspirin is effective for the primary prevention of cardiovascular events, but it remains unclear for which subgroups of individuals aspirin is beneficial. We assessed the cost-effectiveness of aspirin separately for men and women of different ages with various levels of cardiovascular disease risk. METHODS ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.107.735340
更新日期:2008-06-03 00:00:00
abstract:BACKGROUND:approximately half of patients with heart failure die suddenly as a result of ventricular arrhythmias. Although abnormal Ca(2+) release from the sarcoplasmic reticulum through ryanodine receptors (RyR2) has been linked to arrhythmogenesis, the molecular mechanisms triggering release of arrhythmogenic Ca(2+) ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.110.982298
更新日期:2010-12-21 00:00:00
abstract::Reperfusion of the previously ischemic myocardium is associated with the production of oxygen free radicals and their metabolites, which contribute to the ultimate extent of irreversible myocardial injury. The relative importance of polymorphonuclear leukocytes vs intracellular-derived oxygen metabolites has remained ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.73.5.1077
更新日期:1986-05-01 00:00:00
abstract:BACKGROUND:Current consensus statements maintain that endoscopic vein harvesting (EVH) should be standard care in coronary artery bypass graft surgery, but vein quality and clinical outcomes have been questioned. The VICO trial (Vein Integrity and Clinical Outcomes) was designed to assess the impact of different vein h...
journal_title:Circulation
pub_type: 杂志文章,随机对照试验
doi:10.1161/CIRCULATIONAHA.117.028261
更新日期:2017-10-31 00:00:00
abstract:BACKGROUND:Cardiac Na/K-ATPase (NKA) regulates intracellular Na ([Na](i)), which in turn affects intracellular Ca and thus contractility via Na/Ca exchange. Recent evidence shows that phosphorylation of the NKA-associated small transmembrane protein phospholemman (PLM) mediates beta-adrenergic-induced NKA stimulation. ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.107.754051
更新日期:2008-04-08 00:00:00
abstract:BACKGROUND:The purposes of this study were to evaluate the comparative accuracy of dobutamine echocardiography and quantitative rest-redistribution 201Tl tomography in the prediction of recovery of function after revascularization and to assess the relation of contractile reserve to thallium uptake. METHODS AND RESULT...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.95.3.626
更新日期:1997-02-04 00:00:00
abstract::The electrophysiologic effects of amiodarone were examined in 13 dogs that received 30 g amiodarone orally during 3 weeks and compared with 13 control dogs that did not receive amiodarone. Longitudinal and transverse epicardial conduction velocities were estimated with a square array of 64 closely spaced electrodes an...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.79.4.948
更新日期:1989-04-01 00:00:00
abstract:BACKGROUND:Patients with anorexia nervosa exhibit abnormal myocardial repolarization and are susceptible to sudden cardiac death. Exercise testing is useful in unmasking QT prolongation in disorders associated with abnormal repolarization. We characterized QT adaptation during exercise in anorexia. METHODS AND RESULTS...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.115.016697
更新日期:2016-02-09 00:00:00
abstract:BACKGROUND:After a myocardial infarction, the injured region becomes fibrotic and the myocardial scar may expand if the ventricular wall lacks elasticity. Cardiac dilatation may precipitate the vicious cycle of progressive heart failure. The present study evaluated the functional benefits of increasing elastin within a...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.CIRCULATIONAHA.105.523795
更新日期:2005-08-30 00:00:00
abstract::Intermittent restoration of coronary flow during ischemia reduced myocardial damage and improved recovery of function. The mechanisms of the protective effects of intermittent perfusion were investigated in isolated rat hearts. Ventricular function was assessed as the product of developed pressure (left ventricular sy...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.82.2.536
更新日期:1990-08-01 00:00:00
abstract:BACKGROUND:Limited information exists on the intermediate-term graft patency and 5-year clinical outcomes of patients receiving saphenous vein grafts with multiple (m-SVG) versus single distal targets (s-SVG) during coronary artery bypass graft (CABG) surgery in the current era. METHODS AND RESULTS:We studied the asso...
journal_title:Circulation
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1161/CIRCULATIONAHA.110.991299
更新日期:2011-07-19 00:00:00
abstract::Using an isolated rat heart preparation under both aerobic and ischemic conditions we have characterized the temperature dependency of the slow calcium channel-blocking drug verapamil. In the first series of studies, isolated working rat hearts were subjected to global ischemia at 37 degrees, 34 degrees, 31 degrees, 2...
journal_title:Circulation
pub_type: 杂志文章
doi:
更新日期:1984-09-01 00:00:00
abstract:BACKGROUND:A growing body of evidence from animal studies supports the hypothesis that oxidative stress-mediated mechanisms play a central role in early atherogenesis. In contrast, clinical trials with antioxidant vitamins have not produced consistent results in humans with established atherosclerosis. METHODS AND RES...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.0000055186.40785.c4
更新日期:2003-02-04 00:00:00
abstract:BACKGROUND:Functional benefit in heart failure due to idiopathic dilated cardiomyopathy has been observed after beta-blockade, but improvement in survival has not been established in a large-scale randomized trial. This was the main objective of the Cardiac Insufficiency Bisoprolol Study (CIBIS). METHODS AND RESULTS:S...
journal_title:Circulation
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1161/01.cir.90.4.1765
更新日期:1994-10-01 00:00:00
abstract:BACKGROUND:Atherosclerosis is complicated by cardiovascular events such as myocardial infarction, stroke, or peripheral arterial occlusive disease. Inflammation and pathological neovascularization are thought to precipitate plaque rupture or erosion, both causes of arterial thrombosis and cardiovascular events. We test...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.CIR.0000146787.16297.E8
更新日期:2004-11-02 00:00:00
abstract::The purpose of this study was to examine high density lipoprotein cholesterol (HDL-C) levels in a sample of community-living women and men who consumed 1 drink of alcohol/day or less. Self-reports of alcohol consumption and clinical assessments of plasma lipid and lipoprotein levels were obtained twice, at 12 months a...
journal_title:Circulation
pub_type: 临床试验,杂志文章
doi:10.1161/01.cir.83.1.176
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND:Weight loss in obese insulin-resistant but not in insulin-sensitive persons reduces coronary heart disease risk. To what extent changes in gene expression are related to atherosclerosis and cardiovascular function is unknown. METHODS AND RESULTS:We studied the effect of diet restriction-induced weight loss ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.CIR.0000147614.85888.7A
更新日期:2004-11-16 00:00:00
abstract::Since the discovery that neuregulin-1 (NRG-1)/ErbB signaling is indispensable in cardiac development, evidence has shown that this system also plays a crucial role in the adult heart. In patients, an inhibitory ErbB2 antibody, trastuzumab, used in the treatment of mammary carcinomas, increases the risk for the develop...
journal_title:Circulation
pub_type: 杂志文章,评审
doi:10.1161/CIRCULATIONAHA.107.690487
更新日期:2007-08-21 00:00:00
abstract:BACKGROUND:Although both 201Tl scintigraphy and low-dose dobutamine echocardiography (LDDE) have been proposed as effective methods of assessing myocardial viability, their relative efficacies are unknown. The aim of the present study was to compare the two imaging techniques in the prediction of improvement of regiona...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.91.11.2748
更新日期:1995-06-01 00:00:00
abstract:BACKGROUND:The clinical significance of pericardial biopsy is controversial. The aim of this study was to assess the feasibility and diagnostic value of 3 approaches to pericardial biopsy: fluoroscopic control and standard sampling, pericardioscopy guidance with standard sampling, and pericardioscopy guidance with exte...
journal_title:Circulation
pub_type: 临床试验,杂志文章
doi:10.1161/01.cir.0000051366.97361.ea
更新日期:2003-02-25 00:00:00
abstract:BACKGROUND:The mechanisms of thrombosis on plaque erosion are poorly understood. We examined the potential role of endothelial apoptosis in endothelial erosion and vessel thrombosis. METHODS AND RESULTS:Segments of New Zealand White rabbit femoral arteries were temporarily isolated in vivo. One artery was incubated wi...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.CIR.0000130172.62481.90
更新日期:2004-06-01 00:00:00
abstract:BACKGROUND:Research published in Circulation has shown that cardiac mortality is highest during December and January. We investigated whether some of this spike could be ascribed to the Christmas/New Year's holidays rather than to climatic factors. METHODS AND RESULTS:We fitted a locally weighted polynomial regression...
journal_title:Circulation
pub_type: 杂志文章,评审
doi:10.1161/01.CIR.0000151424.02045.F7
更新日期:2004-12-21 00:00:00
abstract:BACKGROUND:In the monocrotaline (MCT)-treated rat, there is marked stimulation of DNA synthesis and megalocytosis of pulmonary arterial endothelial cells (PAECs) within 3 to 4 days, followed by pulmonary hypertension (PH) 10 to 14 days later. Growing evidence implicates caveolin-1 (cav-1) in plasma membrane rafts as a ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.CIR.0000141576.39579.23
更新日期:2004-09-14 00:00:00
abstract::Correlates of high-density lipoprotein (HDL) cholesterol levels were studied in 4756 white males and females ages 20-59 years examined during a population survey conducted by 10 North American Lipid Research Clinics. Multivariable analysis was used to assess the relation of social, demographic, physical and behavioral...
journal_title:Circulation
pub_type: 杂志文章
doi:
更新日期:1980-11-01 00:00:00
abstract::The goals of electrocardiographic (ECG) monitoring in hospital settings have expanded from simple heart rate and basic rhythm determination to the diagnosis of complex arrhythmias, myocardial ischemia, and prolonged QT interval. Whereas computerized arrhythmia analysis is automatic in cardiac monitoring systems, compu...
journal_title:Circulation
pub_type: 指南,杂志文章,实务指引
doi:10.1161/01.CIR.0000145144.56673.59
更新日期:2004-10-26 00:00:00
abstract:BACKGROUND:Cardiac tissue engineering offers the prospect of a novel treatment for acquired or congenital heart defects. We have created vascularized pieces of beating cardiac muscle in the rat that are as thick as the adult rat right ventricle wall. METHOD AND RESULTS:Neonatal rat cardiomyocytes in Matrigel were impl...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.106.657379
更新日期:2007-01-23 00:00:00