Limitation of myocardial infarction by early infusion of recombinant tissue-type plasminogen activator.

abstract：BACKGROUND:Mesenchymal stem cells (MSCs) are bone marrow stromal cells that are in phase 1 clinical studies of cellular cardiomyoplasty. However, the electrophysiological effects of MSC transplantation have not been studied. Although improvement of ventricular function would represent a positive outcome of MSC transpla...

journal_title：Circulation

authors： Chang MG,Tung L,Sekar RB,Chang CY,Cysyk J,Dong P,Marbán E,Abraham MR

更新日期：2006-04-18 00:00:00

abstract：BACKGROUND:Familial polymorphic ventricular tachycardia (FPVT) is characterized by exercise-induced arrhythmias and sudden cardiac death due to missense mutations in the cardiac ryanodine receptor (RyR2), an intracellular Ca2+ release channel required for excitation-contraction coupling in the heart. METHODS AND RESUL...

journal_title：Circulation

authors： Lehnart SE,Wehrens XH,Laitinen PJ,Reiken SR,Deng SX,Cheng Z,Landry DW,Kontula K,Swan H,Marks AR

更新日期：2004-06-29 00:00:00

abstract：BACKGROUND:Studies have consistently shown that ventricular tachycardia (VT) and sudden cardiac death (SCD) complicate the long-term outcome after tetralogy of Fallot repair, yet the diagnostic and predictive value of electrophysiological testing in this population is uncertain. METHODS AND RESULTS:A multicenter cohor...

journal_title：Circulation

authors： Khairy P,Landzberg MJ,Gatzoulis MA,Lucron H,Lambert J,Marçon F,Alexander ME,Walsh EP

更新日期：2004-04-27 00:00:00

abstract：BACKGROUND:Thirteen of 14 epidemiological studies have shown an increased risk of approximately 20% for coronary heart disease (CHD) for never-smokers exposed to environmental tobacco smoke (ETS), but this association remains controversial. If true, ETS might account for an estimated 35,000 to 40,000 heart disease deat...

journal_title：Circulation

authors： Steenland K,Thun M,Lally C,Heath C Jr

更新日期：1996-08-15 00:00:00

abstract：:Analysis of the Framingham Heart Study experience between 1958 and 1970 showed a progressive increase in the rate of treatment and control of hypertension. With cross-sectional criteria to define diastolic hypertension, the treatment rate rose from 35% in 1958 through 1960 to 69% in 1968 through 1970 (p less than .001...

journal_title：Circulation

authors： Shea S,Cook EF,Kannel WB,Goldman L

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND:Endothelium-derived nitric oxide is an important modulator of resting vascular tone in animals and humans. However, the contribution of nitric oxide to exercise-induced vasodilation is unknown. METHODS AND RESULTS:The effect of NG-monomethyl-L-arginine (L-NMMA), an inhibitor of nitric oxide synthesis, on ex...

journal_title：Circulation

authors： Gilligan DM,Panza JA,Kilcoyne CM,Waclawiw MA,Casino PR,Quyyumi AA

更新日期：1994-12-01 00:00:00

abstract：BACKGROUND:Echocardiographically determined left ventricular hypertrophy (LVH) has a well-demonstrated association with cardiovascular morbidity and mortality. However, whether or not there is a sex differential in the impact of LVH on mortality has never been systematically explored. METHODS AND RESULTS:This study en...

journal_title：Circulation

authors： Liao Y,Cooper RS,Mensah GA,McGee DL

更新日期：1995-08-15 00:00:00

abstract：:We report noninvasive and invasive studies designed to clarify the mechanism of the third heart sound (S3) in humans. The noninvasive observations were made using a miniature accelerometer attached to the skin surface at the cardiac apex. In subjects with no S3, the tracings were either flat or showed very low undulat...

journal_title：Circulation

authors： Ozawa Y,Smith D,Craige E

更新日期：1983-02-01 00:00:00

abstract：BACKGROUND:Abnormalities of arterial pulse and limb growth after retrograde femoral arterial catheterization have been well documented. However, the magnitude of such complications after transfemoral artery balloon dilatation has not been thoroughly investigated. This study sought to evaluate the prevalence of these ab...

journal_title：Circulation

authors： Lee HY,Reddy SC,Rao PS

更新日期：1997-02-18 00:00:00

abstract：BACKGROUND:Fingolimod, a sphingosine-1-phosphate receptor agonist, is used for the treatment of multiple sclerosis and exerts antiapoptotic properties. We hypothesized that sphingosine-1-phosphate receptor activation with fingolimod during acute myocardial infarction (MI) inhibits apoptosis, leading to increased myocar...

journal_title：Circulation

authors： Santos-Gallego CG,Vahl TP,Goliasch G,Picatoste B,Arias T,Ishikawa K,Njerve IU,Sanz J,Narula J,Sengupta PP,Hajjar RJ,Fuster V,Badimon JJ

更新日期：2016-03-08 00:00:00

abstract：BACKGROUND:We developed a computer model to predict lysis rates of thrombi for intravenous thrombolytic regimens based on the convective/diffusive penetration of reacting and adsorbing fibrinolytic species from the circulation into the proximal face of a dissolving clot. METHODS AND RESULTS:Solution of a one-compartme...

journal_title：Circulation

authors： Anand S,Diamond SL

更新日期：1996-08-15 00:00:00

abstract：BACKGROUND:Prior small to modest-sized studies suggest a benefit of intravascular ultrasound (IVUS) guidance in noncomplex lesions. Whether IVUS guidance is associated with improved clinical outcomes after drug-eluting stent (DES) implantation in an unrestricted patient population is unknown. METHODS AND RESULTS:Asses...

journal_title：Circulation

authors： Witzenbichler B,Maehara A,Weisz G,Neumann FJ,Rinaldi MJ,Metzger DC,Henry TD,Cox DA,Duffy PL,Brodie BR,Stuckey TD,Mazzaferri EL Jr,Xu K,Parise H,Mehran R,Mintz GS,Stone GW

更新日期：2014-01-28 00:00:00

abstract：BACKGROUND:Little is known about the behavior with regard to restenosis of multiple lesions within the same patient treated with intracoronary stenting. Our objective was to test the hypothesis that there is an intrapatient dependence of restenosis between lesions. METHODS AND RESULTS:Quantitative analysis was carried...

journal_title：Circulation

authors： Kastrati A,Schömig A,Elezi S,Schühlen H,Wilhelm M,Dirschinger J

更新日期：1998-06-23 00:00:00

abstract：BACKGROUND:Receptor-mediated activation of myocardial Gq signaling is postulated as a biochemical mechanism transducing pressure-overload hypertrophy. The specific effects of Gq activation on the functional and morphological adaptations to pressure overload are not known. METHODS AND RESULTS:To determine the effects o...

journal_title：Circulation

authors： Sakata Y,Hoit BD,Liggett SB,Walsh RA,Dorn GW 2nd

更新日期：1998-04-21 00:00:00

abstract：BACKGROUND:Whether cardiac rehabilitation (CR) is effective in patients older than 75 years, who have been excluded from most trials, remains unclear. We enrolled patients 46 to 86 years old in a randomized trial and assessed the effects of 2 months of post-myocardial infarction (MI) CR on total work capacity (TWC, in ...

journal_title：Circulation

authors： Marchionni N,Fattirolli F,Fumagalli S,Oldridge N,Del Lungo F,Morosi L,Burgisser C,Masotti G

更新日期：2003-05-06 00:00:00

abstract：:The thienopyridines ticlopidine and clopidogrel are inhibitors of platelet function in vivo. Their mode of action has not been defined, but it appears that they require conversion to as yet unidentified metabolites that are noncompetitive antagonists of the platelet ADP receptor. Inhibition of platelet aggregation wit...

journal_title：Circulation

authors： Quinn MJ,Fitzgerald DJ

更新日期：1999-10-12 00:00:00

abstract：BACKGROUND:Mitral regurgitation (MR) generally accompanies inferobasal myocardial infarction (MI), with leaflet tethering by displaced papillary muscles. Mitral regurgitation is also reported with anteroapical MI without global dilatation or inferior wall motion abnormalities. We hypothesized that anteroapical MI exten...

journal_title：Circulation

authors： Yosefy C,Beeri R,Guerrero JL,Vaturi M,Scherrer-Crosbie M,Handschumacher MD,Levine RA

更新日期：2011-04-12 00:00:00

abstract：BACKGROUND:In the preterm newborn, a patent ductus arteriosus is in large part a result of the increased sensitivity of the immature ductus to prostaglandin E2 (PGE2). PGE2 acts through 3 G protein-coupled receptors (EP2, EP3, and EP4) that activate both adenyl cyclase and K(ATP) channels. We explored these pathways to...

journal_title：Circulation

authors： Waleh N,Kajino H,Marrache AM,Ginzinger D,Roman C,Seidner SR,Moss TJ,Fouron JC,Vazquez-Tello A,Chemtob S,Clyman RI

更新日期：2004-10-19 00:00:00

abstract：:Physiological studies of the type we have described, when performed in patients with the WPW syndrome, can yield diagnostic information regarding the mechanism of arrhythmia, demonstrate functional properties of therapeutic import, facilitate therapeutic decision-making about drug regimens and presumptively localize t...

journal_title：Circulation

authors： Gallagher JJ,Gilbert M,Svenson RH,Sealy WC,Kasell J,Wallace AG

更新日期：1975-05-01 00:00:00

abstract：BACKGROUND:Subclinical inflammation is associated with an increased risk of heart failure and with adverse prognosis in patients with established heart failure. Yet, treatments specifically directed at reducing inflammation in patients with heart failure have not yet shown improved clinical outcomes. We tested the hypo...

journal_title：Circulation

authors： Everett BM,Cornel JH,Lainscak M,Anker SD,Abbate A,Thuren T,Libby P,Glynn RJ,Ridker PM

更新日期：2019-03-05 00:00:00

abstract：:Many vasodilators have been tried as antianginal agents, but the reflex increase in sympathetic tone produced by these drugs necessitate their use with caution in patients with angina. In the first part of this study, captopril was given to 14 patients with angina and systolic arterial pressures of greater than 120 mm...

journal_title：Circulation

authors： Daly P,Mettauer B,Rouleau JL,Cousineau D,Burgess JH

更新日期：1985-02-01 00:00:00

abstract：BACKGROUND:Atrial fibrillation is associated with increased risks of death, stroke/systemic embolism, and bleeding (incurred by antithrombotic therapy), which may occur early after diagnosis. METHODS:We assessed the risk of early events (death, stroke/systemic embolism, and major bleeding) over 12 months and their rel...

journal_title：Circulation

authors： Bassand JP,Virdone S,Goldhaber SZ,Camm AJ,Fitzmaurice DA,Fox KAA,Goto S,Haas S,Hacke W,Kayani G,Mantovani LG,Misselwitz F,Pieper KS,Turpie AGG,van Eickels M,Verheugt FWA,Kakkar AK

更新日期：2019-02-05 00:00:00

abstract：BACKGROUND:The striated preferentially expressed gene (Speg) generates 4 different isoforms through alternative promoter use and tissue-specific splicing. Depending on the cell type, Speg isoforms may serve as markers of striated or smooth muscle differentiation. METHODS AND RESULTS:To elucidate function of Speg gene ...

journal_title：Circulation

authors： Liu X,Ramjiganesh T,Chen YH,Chung SW,Hall SR,Schissel SL,Padera RF Jr,Liao R,Ackerman KG,Kajstura J,Leri A,Anversa P,Yet SF,Layne MD,Perrella MA

更新日期：2009-01-20 00:00:00

abstract：BACKGROUND:The novel anticoagulant fondaparinux proved to be effective and safe in the postoperative prevention of venous thrombosis. Current phase III trials with this synthetic selective factor Xa inhibitor focus on its use in the treatment of patients with venous and arterial thrombosis. As with any anticoagulant th...

journal_title：Circulation

authors： Bijsterveld NR,Moons AH,Boekholdt SM,van Aken BE,Fennema H,Peters RJ,Meijers JC,Büller HR,Levi M

更新日期：2002-11-12 00:00:00

abstract：:The electrophysiologic effects of amiodarone were examined in 13 dogs that received 30 g amiodarone orally during 3 weeks and compared with 13 control dogs that did not receive amiodarone. Longitudinal and transverse epicardial conduction velocities were estimated with a square array of 64 closely spaced electrodes an...

journal_title：Circulation

authors： Anderson KP,Walker R,Dustman T,Lux RL,Ershler PR,Kates RE,Urie PM

更新日期：1989-04-01 00:00:00

abstract：BACKGROUND:Conversion of chronic atrial fibrillation (AF) is associated with atrial stunning, but the short-term effect of a brief episode of AF on left atrial appendage (LAA) emptying velocity is unknown. The purpose of this study was to determine whether a short episode of AF affects left atrial function and whether ...

journal_title：Circulation

authors： Daoud EG,Marcovitz P,Knight BP,Goyal R,Man KC,Strickberger SA,Armstrong WF,Morady F

更新日期：1999-06-15 00:00:00

abstract：:Continuous retrograde coronary sinus cardioplegia (CSCP) has previously been carefully evaluated experimentally and shown to be efficacious during ischemia, even in the presence of coronary lesions and in the hypertrophied state. A new technique of retrograde cardioplegia delivery through the right atrium, using right...

journal_title：Circulation

authors： Salter DR,Goldstein JP,Abd-Elfattah A,Murphy CE,Brunsting LA,Wechsler AS

更新日期：1987-11-01 00:00:00

abstract：BACKGROUND:Elevated pulse pressure is associated strongly with adverse cardiovascular outcome; however, the genetic basis of this condition is unknown. This study examined whether genotypic variation in the extracellular matrix protein fibrillin-1, the Marfan gene, was associated with aortic stiffening and therefore co...

journal_title：Circulation

authors： Medley TL,Cole TJ,Gatzka CD,Wang WY,Dart AM,Kingwell BA

更新日期：2002-02-19 00:00:00

abstract：BACKGROUND:The purpose of the present study was to investigate plasma lipid-independent mechanisms for the sex difference in the development of atherosclerosis. METHODS AND RESULTS:In the first experiment, 20 male and 20 female rabbits were balloon-injured in the middle thoracic aorta and maintained at the same plasma...

journal_title：Circulation

authors： Holm P,Andersen HL,Arrøe G,Stender S

更新日期：1998-12-15 00:00:00

abstract：:To determine how survival and clinical status were related to left ventricular (LV) size and systolic function after mitral valve replacement, 104 patients (48 mitral regurgitation [MR], 33 mitral stenosis [MS], and 23 MS/MR) with isolated mitral valve replacement were evaluated before and after surgery. Preoperative ...

journal_title：Circulation

authors： Crawford MH,Souchek J,Oprian CA,Miller DC,Rahimtoola S,Giacomini JC,Sethi G,Hammermeister KE

更新日期：1990-04-01 00:00:00