Left ventricular hypertrophy has a greater impact on survival in women than in men.

abstract：BACKGROUND:Fe2+ released from tissue iron stores may accelerate lipid peroxidation by virtue of its pro-oxidant properties and thus promote early atherogenesis. METHODS AND RESULTS:The present prospective survey addresses the potential association between serum ferritin concentrations and the 5-year progression of car...

journal_title：Circulation

authors： Kiechl S,Willeit J,Egger G,Poewe W,Oberhollenzer F

更新日期：1997-11-18 00:00:00

abstract：BACKGROUND:Heparin-induced thrombocytopenia (HIT) is an immune-mediated syndrome caused by heparin. Complications range from thrombocytopenia to thrombocytopenia with thrombosis. We report a prospective, historical- controlled study evaluating the efficacy and safety of argatroban, a direct thrombin inhibitor, as antic...

journal_title：Circulation

authors： Lewis BE,Wallis DE,Berkowitz SD,Matthai WH,Fareed J,Walenga JM,Bartholomew J,Sham R,Lerner RG,Zeigler ZR,Rustagi PK,Jang IK,Rifkin SD,Moran J,Hursting MJ,Kelton JG,ARG-911 Study Investigators.

更新日期：2001-04-10 00:00:00

abstract：:We reviewed 35 patients undergoing resection of a chronic postinfarction left ventricular aneurysm. There was 5.7% operative mortality. Of the long-term survivors, 80% are functional class I or II. Ten patients had postoperative left ventriculograms studied by means of a computerized analysis of endocardial motion usi...

journal_title：Circulation

authors： Shaw RC,Connors JP,Hieb BR,Ludbrook PA,Krone R,Kleiger RE,Ferguson TB,Weldon CS

更新日期：1977-09-01 00:00:00

abstract：BACKGROUND:Although both 201Tl scintigraphy and low-dose dobutamine echocardiography (LDDE) have been proposed as effective methods of assessing myocardial viability, their relative efficacies are unknown. The aim of the present study was to compare the two imaging techniques in the prediction of improvement of regiona...

journal_title：Circulation

authors： Arnese M,Cornel JH,Salustri A,Maat A,Elhendy A,Reijs AE,Ten Cate FJ,Keane D,Balk AH,Roelandt JR

更新日期：1995-06-01 00:00:00

abstract：BACKGROUND:Interleukin-8 (IL-8) secreted from endothelial cells is a powerful neutrophil chemoattractant and activator. We hypothesized that human endothelial cells deprived of oxygen would secrete IL-8, which might translate into elevated IL-8 production after cardiac ischemia. Furthermore, we hypothesized that corona...

journal_title：Circulation

authors： Oz MC,Liao H,Naka Y,Seldomridge A,Becker DN,Michler RE,Smith CR,Rose EA,Stern DM,Pinsky DJ

更新日期：1995-11-01 00:00:00

abstract：:Echocardiography and Doppler ultrasound are useful in evaluating a variety of pathological conditions affecting the pericardium. Cardiac tamponade results in right atrial collapse and right ventricular diastolic collapse detectable by echocardiography. These echocardiographic signs have a high degree of sensitivity an...

journal_title：Circulation

authors： Chandraratna PA

更新日期：1991-09-01 00:00:00

abstract：BACKGROUND:Mechanisms favoring the occurrence of paroxysmal atrial fibrillation (PAF) are complex and poorly defined. This study was designed to analyze dynamic changes in autonomic tone preceding the onset of PAF in a large group of patients. METHODS AND RESULTS:Holter tapes from 77 unselected consecutive patients (6...

journal_title：Circulation

authors： Bettoni M,Zimmermann M

更新日期：2002-06-11 00:00:00

abstract：BACKGROUND:We investigated the effects of candesartan (an angiotensin II antagonist) alone, enalapril alone, and their combination on exercise tolerance, ventricular function, quality of life (QOL), neurohormone levels, and tolerability in congestive heart failure (CHF). METHODS AND RESULTS:Seven hundred sixty-eight p...

journal_title：Circulation

authors： McKelvie RS,Yusuf S,Pericak D,Avezum A,Burns RJ,Probstfield J,Tsuyuki RT,White M,Rouleau J,Latini R,Maggioni A,Young J,Pogue J

更新日期：1999-09-07 00:00:00

abstract：BACKGROUND:Cardiac hypertrophy is a common response to circulatory or neurohumoral stressors as a mechanism to augment contractility. When the heart is under sustained stress, the hypertrophic response can evolve into decompensated heart failure, although the mechanism(s) underlying this transition remain largely unkno...

journal_title：Circulation

authors： Warren SA,Briggs LE,Zeng H,Chuang J,Chang EI,Terada R,Li M,Swanson MS,Lecker SH,Willis MS,Spinale FG,Maupin-Furlowe J,McMullen JR,Moss RL,Kasahara H

更新日期：2012-11-27 00:00:00

abstract：BACKGROUND:Aldosterone and angiotensin (Ang) II both may cause organ damage. Circulating aldosterone is produced in the adrenals; however, local cardiac synthesis has been reported. Aldosterone concentrations depend on the activity of aldosterone synthase (CYP11B2). We tested the hypothesis that reducing aldosterone by...

journal_title：Circulation

authors： Fiebeler A,Nussberger J,Shagdarsuren E,Rong S,Hilfenhaus G,Al-Saadi N,Dechend R,Wellner M,Meiners S,Maser-Gluth C,Jeng AY,Webb RL,Luft FC,Muller DN

更新日期：2005-06-14 00:00:00

abstract：BACKGROUND:Ventricular septal defect (VSD) complicating acute myocardial infarction has been studied primarily in small, prethrombolytic-era trials. Our goal was to determine clinical predictors and angiographic and clinical outcomes of this complication in the thrombolytic era. METHODS AND RESULTS:We compared enrollm...

journal_title：Circulation

authors： Crenshaw BS,Granger CB,Birnbaum Y,Pieper KS,Morris DC,Kleiman NS,Vahanian A,Califf RM,Topol EJ

更新日期：2000-01-04 00:00:00

abstract：BACKGROUND:The high cardiovascular morbidity and mortality in patients with end-stage kidney disease could be partially caused by extensive cardiovascular calcification. SNF472, intravenous myo-inositol hexaphosphate, selectively inhibits the formation and growth of hydroxyapatite. METHODS:This double-blind, placebo-c...

journal_title：Circulation

authors： Raggi P,Bellasi A,Bushinsky D,Bover J,Rodriguez M,Ketteler M,Sinha S,Salcedo C,Gillotti K,Padgett C,Garg R,Gold A,Perelló J,Chertow GM

更新日期：2020-03-03 00:00:00

abstract：:The clinical and pathologic features of 18 consecutive patients with peripartum cardiomyopathy at The Johns Hopkins Hospital were examined in an attempt to define the incidence of myocarditis and to determine its response to immunosuppressive agents. In addition to routine studies, patients were evaluated with echocar...

journal_title：Circulation

authors： Midei MG,DeMent SH,Feldman AM,Hutchins GM,Baughman KL

更新日期：1990-03-01 00:00:00

abstract：:We quantitated the growth patterns of the normal fetal heart and the right and left ventricles from postmortem hearts obtained from 55 spontaneously aborted human fetuses from the completion of cardiogenesis to term. Fetal gestational age was assessed by menstrual history of the mother, crown-rump length, head circumf...

journal_title：Circulation

authors： St John Sutton MG,Raichlen JS,Reichek N,Huff DS

更新日期：1984-12-01 00:00:00

abstract：BACKGROUND:Apoptosis in human atherosclerotic coronary plaques possibly causes plaque destabilization by contributing to the weakening and breaking down of the fibrous cap. We tested the hypothesis that apoptosis is quantitatively increased in unstable atherosclerotic plaques. METHODS AND RESULTS:We analyzed the expre...

journal_title：Circulation

authors： Rossi ML,Marziliano N,Merlini PA,Bramucci E,Canosi U,Belli G,Parenti DZ,Mannucci PM,Ardissino D

更新日期：2004-09-28 00:00:00

abstract：BACKGROUND:Patients with prior atherosclerosis in 1 or more vascular territories (coronary, cerebrovascular, or peripheral arterial) who present with acute coronary syndromes have high cardiovascular risk and may benefit significantly from evidence-based therapies, yet whether these are used consistently is unknown. M...

journal_title：Circulation

authors： Brilakis ES,Hernandez AF,Dai D,Peterson ED,Banerjee S,Fonarow GC,Cannon CP,Bhatt DL

更新日期：2009-08-18 00:00:00

abstract：BACKGROUND:Traditional risk factors have been linked to atherosclerotic heart disease in women. However, the effect of risk factors and menopausal status on the mechanism of sudden coronary death is unknown. METHODS AND RESULTS:We examined 51 cases of sudden coronary death and 15 hearts from women who died of trauma. ...

journal_title：Circulation

authors： Burke AP,Farb A,Malcom GT,Liang Y,Smialek J,Virmani R

更新日期：1998-06-02 00:00:00

abstract：BACKGROUND:Previous studies have demonstrated that synchronized coronary venous retroperfusion (SRP) can restore blood flow to the ischemic myocardium, resulting in infarct size reduction and improvement of the left ventricular function. Despite the nutritive blood flow achieved by SRP being relatively limited, SRP has...

journal_title：Circulation

authors： Wakida Y,Nordlander R,Kobayashi S,Kar S,Haendchen R,Corday E

更新日期：1993-11-01 00:00:00

abstract：BACKGROUND:Outcomes for organ transplantation are constantly improving because of advances in organ preservation, surgical techniques, immune clinical monitoring, and immunosuppressive treatment preventing acute transplant rejection. However, chronic rejection including transplant vasculopathy still limits long-term pa...

journal_title：Circulation

authors： Galvani S,Trayssac M,Augé N,Thiers JC,Calise D,Krell HW,Sallusto F,Kamar N,Rostaing L,Thomsen M,Nègre-Salvayre A,Salvayre R

更新日期：2011-12-13 00:00:00

abstract：BACKGROUND:The long-term success of coronary bypass surgery is dependent on graft patency after surgery. This trial was designed to determine if aspirin improved saphenous vein graft or internal mammary artery (IMA) graft patency between 1 and 3 years after coronary artery bypass grafting (CABG). METHODS AND RESULTS:A...

journal_title：Circulation

authors： Goldman S,Copeland J,Moritz T,Henderson W,Zadina K,Ovitt T,Kern KB,Sethi G,Sharma GV,Khuri S

更新日期：1994-03-01 00:00:00

abstract：:In Phase I of the NHLBI trial of Thrombolysis in Myocardial Infarction (TIMI), 290 patients admitted within 7 hr after onset of acute infarction were randomly assigned to intravenous treatment with either streptokinase (SK) or recombinant tissue-type plasminogen activator (rt-PA). Left ventricular function was measure...

journal_title：Circulation

authors： Sheehan FH,Braunwald E,Canner P,Dodge HT,Gore J,Van Natta P,Passamani ER,Williams DO,Zaret B

更新日期：1987-04-01 00:00:00

abstract：BACKGROUND:Dynamic intraventricular flow velocities after valve replacement for aortic stenosis have been associated with high in-hospital morbidity and mortality. The aims of the present study were to determine the mechanisms and preoperative predictors of abnormal flow velocity (AFV) after valve replacement for aorti...

journal_title：Circulation

authors： Bartunek J,Sys SU,Rodrigues AC,van Schuerbeeck E,Mortier L,de Bruyne B

更新日期：1996-02-15 00:00:00

abstract：BACKGROUND:Coronary perforation is a life-threatening complication of percutaneous interventions. In the past few years, the implantation of covered stents has emerged as a strategy for treatment when the traditional conservative approach (ie, prolonged balloon inflation and reversal of anticoagulation) fails. METHODS...

journal_title：Circulation

authors： Briguori C,Nishida T,Anzuini A,Di Mario C,Grube E,Colombo A

更新日期：2000-12-19 00:00:00

abstract：:Thirty patients with triple-vessel coronary artery disease proven by angiography, symptomatic angina and a positive ECG stress test were evaluated with thallium-201 (201TI) scintigraphy. Twenty patients also had aortocoronary saphenous vein bypass surgery; 15 of them had repeat noninvasive evaluation. Seventy percent ...

journal_title：Circulation

authors： Leppo J,Yipintsoi T,Blankstein R,Bontemps R,Freeman LM,Zohman L,Scheuer J

更新日期：1979-04-01 00:00:00

abstract：:The purpose of this investigation was to determine whether blood vessels could develop de novo between an extracardiac artery and a collateral-dependent zone of the heart and to quantify the nutritive blood flow afforded by the new vessels. We also adapted the preparation so that angiogenically active agents could be ...

journal_title：Circulation

authors： Unger EF,Sheffield CD,Epstein SE

更新日期：1990-10-01 00:00:00

abstract：BACKGROUND:Chronic heart failure is associated with endothelial dysfunction including impaired endothelium-mediated, flow-dependent dilation (FDD). Since endothelial function is thought to play an important role in coordinating tissue perfusion and modulating arterial compliance, interventions to improve endothelial dy...

journal_title：Circulation

authors： Hornig B,Maier V,Drexler H

更新日期：1996-01-15 00:00:00

abstract：:The widespread use of exercise testing for the detection of myocardial ischemia in patients suspected of having coronary artery disease led to the detection of ischemic changes in many subjects who subsequently were found to have angiographically normal epicardial vessels--the false positive response. Such a result is...

journal_title：Circulation

authors： Epstein SE,Cannon RO 3rd,Bonow RO

更新日期：1991-05-01 00:00:00

abstract：BACKGROUND:The pathophysiological mechanisms leading to acceleration of ventricular tachycardia (VT) are still unclear. METHODS AND RESULTS:High-resolution epicardial mapping was used to study the mechanisms of VT acceleration by programmed electrical stimulation (PES) in a model of sustained reentrant VT in Langendor...

journal_title：Circulation

authors： Brugada J,Brugada P,Boersma L,Mont L,Kirchhof C,Wellens HJ,Allessie MA

更新日期：1991-05-01 00:00:00

abstract：BACKGROUND:In patients with severe congestive heart failure (CHF), short-term administration of dobutamine exerts sustained clinical benefits that are partially mediated by a training-like effect on skeletal muscle. Recently, physical training has been shown to enhance endothelial function in the skeletal muscle vascul...

journal_title：Circulation

authors： Patel MB,Kaplan IV,Patni RN,Levy D,Strom JA,Shirani J,LeJemtel TH

更新日期：1999-01-05 00:00:00

abstract：BACKGROUND:Progression of heart failure after initial myocardial injury is mediated in part by various redundant inflammatory mediators, including the widely expressed cyclooxygenase-2 (COX-2). Because COX-2 inhibitors are useful in treating many inflammation-mediated diseases, we asked whether COX-2 inhibition can att...

journal_title：Circulation

authors： Delgado RM 3rd,Nawar MA,Zewail AM,Kar B,Vaughn WK,Wu KK,Aleksic N,Sivasubramanian N,McKay K,Mann DL,Willerson JT

更新日期：2004-03-23 00:00:00