Cyclooxygenase-2 inhibitor treatment improves left ventricular function and mortality in a murine model of doxorubicin-induced heart failure.

abstract：BACKGROUND:Oxidative stress activates endothelial innate immunity and disrupts endothelial functions, including endothelial nitric oxide synthase-derived nitric oxide bioavailability. Here, we postulated that oxidative stress induces sterol regulatory element-binding protein 2 (SREBP2) and microRNA-92a (miR-92a), which...

journal_title：Circulation

authors： Chen Z,Wen L,Martin M,Hsu CY,Fang L,Lin FM,Lin TY,Geary MJ,Geary GG,Zhao Y,Johnson DA,Chen JW,Lin SJ,Chien S,Huang HD,Miller YI,Huang PH,Shyy JY

更新日期：2015-03-03 00:00:00

abstract：BACKGROUND:AL amyloidosis with heart failure is associated with decreased longitudinal myocardial contraction measured by pulsed tissue Doppler imaging. We sought to clarify whether new modalities of myocardial strain Doppler (change in length per unit length) or strain rate (the temporal derivative of strain) were mor...

journal_title：Circulation

authors： Koyama J,Ray-Sequin PA,Falk RH

更新日期：2003-05-20 00:00:00

abstract：BACKGROUND:The relative anti-aggregatory effects of currently prescribed platelet glycoprotein IIb/IIIa receptor antagonists during and after percutaneous coronary intervention for acute coronary syndromes have not been established. METHODS AND RESULTS:We randomized 70 acute coronary syndrome patients undergoing percu...

journal_title：Circulation

authors： Batchelor WB,Tolleson TR,Huang Y,Larsen RL,Mantell RM,Dillard P,Davidian M,Zhang D,Cantor WJ,Sketch MH Jr,Ohman EM,Zidar JP,Gretler D,DiBattiste PM,Tcheng JE,Califf RM,Harrington RA

更新日期：2002-09-17 00:00:00

abstract：BACKGROUND:There is compelling experimental evidence that autologous skeletal muscle (SM) cell transplantation improves postinfarction cardiac function. This study assessed whether this benefit is still manifested in the clinically relevant setting of a treatment by ACE inhibitors. METHODS AND RESULTS:A myocardial inf...

journal_title：Circulation

authors： Pouzet B,Ghostine S,Vilquin JT,Garcin I,Scorsin M,Hagège AA,Duboc D,Schwartz K,Menasché P

更新日期：2001-09-18 00:00:00

abstract：BACKGROUND:Previous experimental studies have shown that the effect of serotonin on a coronary stenosis depends on whether that stenosis is compliant or fixed. However, the relation between coronary stenosis morphology and the response to serotonin in patients with angina is not known. METHODS AND RESULTS:Using comput...

journal_title：Circulation

authors： Tousoulis D,Davies G,McFadden E,Clarke J,Kaski JC,Maseri A

更新日期：1993-10-01 00:00:00

abstract：BACKGROUND:Mutations in the gene G4.5 result in a wide spectrum of severe infantile cardiomyopathic phenotypes, including isolated left ventricular noncompaction (LVNC), as well as Barth syndrome (BTHS) with dilated cardiomyopathy (DCM). The purpose of this study was to investigate patients with LVNC or BTHS for mutati...

journal_title：Circulation

authors： Ichida F,Tsubata S,Bowles KR,Haneda N,Uese K,Miyawaki T,Dreyer WJ,Messina J,Li H,Bowles NE,Towbin JA

更新日期：2001-03-06 00:00:00

abstract：BACKGROUND:Human cardiac troponin I is known to be phosphorylated at multiple amino acid residues by several kinases. Advances in mass spectrometry allow sensitive detection of known and novel phosphorylation sites and measurement of the level of phosphorylation simultaneously at each site in myocardial samples. METHO...

journal_title：Circulation

authors： Zhang P,Kirk JA,Ji W,dos Remedios CG,Kass DA,Van Eyk JE,Murphy AM

更新日期：2012-10-09 00:00:00

abstract：BACKGROUND:Conflicting results from recent observational studies have raised questions concerning the benefit of β-blockers for patients undergoing coronary artery bypass grafting (CABG). Furthermore, the efficacy of long-term β-blocker therapy in CABG patients after hospital discharge is uncertain. METHODS AND RESULT...

journal_title：Circulation

authors： Zhang H,Yuan X,Zhang H,Chen S,Zhao Y,Hua K,Rao C,Wang W,Sun H,Hu S,Zheng Z

更新日期：2015-06-23 00:00:00

abstract：BACKGROUND:A subgroup of patients with hypertrophic obstructive cardiomyopathy remain severely symptomatic despite optimal medical therapy. Septal myectomy reduces or eliminates left ventricular outflow obstruction and produces marked symptomatic improvement. With the recent advent of alternative methods for treatment ...

journal_title：Circulation

authors： McCully RB,Nishimura RA,Tajik AJ,Schaff HV,Danielson GK

更新日期：1996-08-01 00:00:00

abstract：BACKGROUND:Coronary blood flow occurs mainly during the diastolic phase of each cardiac cycle and is mainly dependent on diastolic driving pressure, especially in the left anterior descending coronary artery (LAD). We hypothesized that calculation of the ratio of the diastolic driving pressure of a stenotic LAD to its ...

journal_title：Circulation

authors： Abe M,Tomiyama H,Yoshida H,Doba N

更新日期：2000-11-07 00:00:00

abstract：BACKGROUND:We hypothesized that cytomegalovirus (CMV) may contribute to the vasculopathy observed in cardiac allograft recipients by impairing the endothelial nitric oxide synthase pathway. We focused on asymmetric dimethylarginine (ADMA, the endogenous inhibitor of nitric oxide synthase) as a potential mediator of the...

journal_title：Circulation

authors： Weis M,Kledal TN,Lin KY,Panchal SN,Gao SZ,Valantine HA,Mocarski ES,Cooke JP

更新日期：2004-02-03 00:00:00

abstract：BACKGROUND:CD4+CD28null T cells are present in increased numbers in the peripheral blood of patients with acute coronary syndrome (ACS) compared with patients with chronic stable angina (CSA). The triggers of activation and expansion of these cells to date remain unclear. METHODS AND RESULTS:Twenty-one patients with A...

journal_title：Circulation

authors： Zal B,Kaski JC,Arno G,Akiyu JP,Xu Q,Cole D,Whelan M,Russell N,Madrigal JA,Dodi IA,Baboonian C

更新日期：2004-03-16 00:00:00

abstract：BACKGROUND:An effect of diet in determining blood pressure is suggested by epidemiological studies, but the role of specific nutrients is still unsettled. METHODS AND RESULTS:The relation of various nutritional factors with hypertension was examined prospectively among 30,681 predominantly white US male health profess...

journal_title：Circulation

authors： Ascherio A,Rimm EB,Giovannucci EL,Colditz GA,Rosner B,Willett WC,Sacks F,Stampfer MJ

更新日期：1992-11-01 00:00:00

abstract：BACKGROUND:Few data are available on the prevalence of hypertension in Mexico. METHODS AND RESULTS:We compared the prevalence of mild hypertension (systolic blood pressure > or = 140 mm Hg and/or diastolic blood pressure > or = 90 mm Hg and/or use of antihypertensive medications) in 1500 low-income Mexican Americans w...

journal_title：Circulation

authors： Haffner S,González Villalpando C,Hazuda HP,Valdez R,Mykkänen L,Stern M

更新日期：1994-09-01 00:00:00

abstract：BACKGROUND:A prior diagnosis of diabetes mellitus is associated with adverse outcomes after acute myocardial infarction (MI), but the risk associated with a new diagnosis of diabetes in this setting has not been well defined. METHODS AND RESULTS:We assessed the risk of death and major cardiovascular events associated ...

journal_title：Circulation

authors： Aguilar D,Solomon SD,Køber L,Rouleau JL,Skali H,McMurray JJ,Francis GS,Henis M,O'Connor CM,Diaz R,Belenkov YN,Varshavsky S,Leimberger JD,Velazquez EJ,Califf RM,Pfeffer MA

更新日期：2004-09-21 00:00:00

abstract：:The thienopyridines ticlopidine and clopidogrel are inhibitors of platelet function in vivo. Their mode of action has not been defined, but it appears that they require conversion to as yet unidentified metabolites that are noncompetitive antagonists of the platelet ADP receptor. Inhibition of platelet aggregation wit...

journal_title：Circulation

authors： Quinn MJ,Fitzgerald DJ

更新日期：1999-10-12 00:00:00

abstract：BACKGROUND:Passive ventricular constraint provides external cardiac support to reduce left ventricular (LV) wall stress and myocardial stretch, which are primary determinants of LV remodeling. Altered wall strain results in cytokine and reactive oxygen species production, which, in turn, stimulates apoptosis and extrac...

journal_title：Circulation

authors： Cheng A,Nguyen TC,Malinowski M,Langer F,Liang D,Daughters GT,Ingels NB Jr,Miller DC

更新日期：2006-07-04 00:00:00

abstract：:To determine the long-term efficacy of apical left ventricular to aortic conduits in palliating complex left ventricular outflow obstruction, we reviewed our entire experience of 20 pediatric patients who underwent placement of a composite porcine valve-bearing conduit from the left ventricular apex to the aorta from ...

journal_title：Circulation

authors： Frommelt PC,Rocchini AP,Bove EL

更新日期：1991-11-01 00:00:00

abstract：:We assessed the reversibility of functional and morphological changes of arterialized vein segments by returning them to the venous circulation. Thirteen dogs underwent right carotid and femoral veno-arterial grafting. After 12 weeks, veno-arterial grafts were removed for contractility (norepinephrine [NE] and 5-hydro...

journal_title：Circulation

authors： Fann JI,Sokoloff MH,Sarris GE,Yun KL,Kosek JC,Miller DC

更新日期：1990-11-01 00:00:00

abstract：BACKGROUND:The diagnosis of infective endocarditis (IE) in prosthetic valves and intracardiac devices is challenging because both the modified Duke criteria (DC) and echocardiography have limitations in this population. The added value of (18)F-fluorodeoxyglucose ((18)F-FDG) positron emission tomography (PET)/computed ...

journal_title：Circulation

authors： Pizzi MN,Roque A,Fernández-Hidalgo N,Cuéllar-Calabria H,Ferreira-González I,Gonzàlez-Alujas MT,Oristrell G,Gracia-Sánchez L,González JJ,Rodríguez-Palomares J,Galiñanes M,Maisterra-Santos O,Garcia-Dorado D,Castell-Conesa J,Alm

更新日期：2015-09-22 00:00:00

abstract：BACKGROUND:One or more brief episodes of coronary artery occlusion protect or "precondition" the myocardium perfused by that artery from a subsequent episode of sustained ischemia. We sought to determine whether ischemic preconditioning protects only those myocytes subjected to brief coronary occlusion or whether brief...

journal_title：Circulation

authors： Przyklenk K,Bauer B,Ovize M,Kloner RA,Whittaker P

更新日期：1993-03-01 00:00:00

abstract：BACKGROUND:Cardiac troponin and B-type natriuretic peptide (BNP) concentrations are associated with adverse cardiovascular outcome in primary prevention populations. Whether statin therapy modifies this association is poorly understood. METHODS AND RESULTS:We measured high-sensitivity cardiac troponin I (hsTnI) in 12 ...

journal_title：Circulation

authors： Everett BM,Zeller T,Glynn RJ,Ridker PM,Blankenberg S

更新日期：2015-05-26 00:00:00

abstract：BACKGROUND:We investigated whether electrical stimulation (STIM) of efferent vagus nerves may suppress nuclear factor (NF)-kappaB activation and the inflammatory cascade in hemorrhagic (Hem) shock. METHODS AND RESULTS:Rats were subjected to bilateral cervical vagotomy (VGX) or sham surgical procedures. Hem shock was i...

journal_title：Circulation

authors： Guarini S,Altavilla D,Cainazzo MM,Giuliani D,Bigiani A,Marini H,Squadrito G,Minutoli L,Bertolini A,Marini R,Adamo EB,Venuti FS,Squadrito F

更新日期：2003-03-04 00:00:00

abstract：BACKGROUND:Although early intravenous beta-blocker therapy during acute myocardial infarction (AMI) reduces the incidence of fatal arrhythmias in patients not treated with thrombolytic agents, its antiarrhythmic effect in thrombolysed patients remains controversial. We investigated prospectively the arrhythmia incidenc...

journal_title：Circulation

authors： Heidbüchel H,Tack J,Vanneste L,Ballet A,Ector H,Van de Werf F

更新日期：1994-03-01 00:00:00

abstract：BACKGROUND:Several echocardiographic dyssynchrony indexes have been proposed to identify responders to cardiac resynchronization therapy using tissue velocity and strain. The present study aimed to compare tissue velocity-derived and strain-derived dyssynchrony indexes in patients with or without systolic dysfunction a...

journal_title：Circulation

authors： Miyazaki C,Powell BD,Bruce CJ,Espinosa RE,Redfield MM,Miller FA,Hayes DL,Cha YM,Oh JK

更新日期：2008-05-20 00:00:00

abstract：:We have recently demonstrated that exercise training can induce important hemodynamic and metabolic adaptations in patients with chronic heart failure due to severe left ventricular dysfunction. This study examines the accompanying changes in submaximal exercise performance and the ventilatory response to exercise in ...

journal_title：Circulation

authors： Sullivan MJ,Higginbotham MB,Cobb FR

更新日期：1989-02-01 00:00:00

abstract：:Electrophysiologic studies were performed in 28 patients with documented atrioventricular (AV) nodal reentrant supraventricular tachycardia (SVT) to investigate the presence of AV nodal tissue situated between the tachycardia circuit and both the atrium (upper common pathway, UCP) and the His bundle (lower common path...

journal_title：Circulation

authors： Miller JM,Rosenthal ME,Vassallo JA,Josephson ME

更新日期：1987-05-01 00:00:00

abstract：BACKGROUND:C-reactive protein (CRP) and interleukin (IL)-6 are important risk factors for atherosclerosis and coronary heart disease. In the present study, we examined serum levels of CRP and IL-6, IL-6 production by monocytes, and the effect of nasal continuous positive airway pressure (nCPAP) in patients with obstruc...

journal_title：Circulation

authors： Yokoe T,Minoguchi K,Matsuo H,Oda N,Minoguchi H,Yoshino G,Hirano T,Adachi M

更新日期：2003-03-04 00:00:00

abstract：BACKGROUND:Macrophages in human atherosclerotic plaques produce a family of matrix metalloproteinases (MMPs), which may influence vascular remodeling and plaque disruption. Because oxidized LDL (ox-LDL) is implicated in many proatherogenic events, we hypothesized that ox-LDL would regulate expression of MMP-9 and tissu...

journal_title：Circulation

authors： Xu XP,Meisel SR,Ong JM,Kaul S,Cercek B,Rajavashisth TB,Sharifi B,Shah PK

更新日期：1999-03-02 00:00:00

abstract：:Background: Vascular smooth muscle cells (VSMCs) show a remarkable phenotypic plasticity allowing acquisition of contractile or synthetic states but critical information is missing about the physiological signals, promoting formation and maintenance of contractile VSMCs in vivo. BMP9 and BMP10 are known to regulate en...

journal_title：Circulation

authors： Wang L,Rice M,Swist S,Kubin T,Wu F,Wang S,Kraut S,Weissmann N,Böttger T,Wheeler M,Schneider A,Braun T

更新日期：2020-12-18 00:00:00