Novel gene mutations in patients with left ventricular noncompaction or Barth syndrome.

abstract：BACKGROUND:Ischemia reperfusion injury (IRI) predisposes to the formation of donor-specific antibodies, a factor contributing to chronic rejection and late allograft loss. METHODS:We describe a mechanism underlying the correlative association between IRI and donor-specific antibodies by using humanized models and pati...

journal_title：Circulation

authors： Liu L,Fang C,Fu W,Jiang B,Li G,Qin L,Rosenbluth J,Gong G,Xie CB,Yoo P,Tellides G,Pober JS,Jane-Wit D

更新日期：2020-02-11 00:00:00

abstract：BACKGROUND:Intentional weight loss is associated with lower risk of heart failure (HF) and atherosclerotic cardiovascular disease among patients with type 2 diabetes. However, the contribution of baseline measures and longitudinal changes in fat mass (FM), lean mass (LM), and waist circumference (WC) to the risk of HF ...

journal_title：Circulation

authors： Patel KV,Bahnson JL,Gaussoin SA,Johnson KC,Pi-Sunyer X,White U,Olson KL,Bertoni AG,Kitzman DW,Berry JD,Pandey A,Look AHEAD Research Group.

更新日期：2020-12-22 00:00:00

abstract：BACKGROUND:Lead V(1) directly faces the right ventricle and may exhibit ST elevation during an acute inferior myocardial infarction when the right ventricle is also involved. Leads V(1) and V(3) indirectly face the posterolateral left ventricle, and ST depression ("mirror-image" ST elevation) in V(1) through V(3) may r...

journal_title：Circulation

authors： Wong CK,Gao W,Stewart RA,French JK,Aylward PE,Benatar J,White HD,Hirulog and Early Reperfusion or Occlusion-2 Investigators.

更新日期：2010-08-03 00:00:00

abstract：BACKGROUND:Current guidelines recommend mitral valve surgery for asymptomatic patients with severe degenerative mitral regurgitation and preserved left ventricular systolic function when exercise pulmonary hypertension (PHT) is present. However, the determinants of exercise PHT have not been evaluated. The aim of this ...

journal_title：Circulation

authors： Magne J,Lancellotti P,Piérard LA

更新日期：2010-07-06 00:00:00

abstract：BACKGROUND:Coronary blood flow occurs mainly during the diastolic phase of each cardiac cycle and is mainly dependent on diastolic driving pressure, especially in the left anterior descending coronary artery (LAD). We hypothesized that calculation of the ratio of the diastolic driving pressure of a stenotic LAD to its ...

journal_title：Circulation

authors： Abe M,Tomiyama H,Yoshida H,Doba N

更新日期：2000-11-07 00:00:00

abstract：BACKGROUND:Flavone-8-acetic acid (FAA; [Flavonoid]), an adjuvant antitumor drug, inhibits ristocetin-induced aggregation of human platelets. The effect of FAA on platelet-dependent thrombosis was studied in vivo in the porcine carotid artery after deep arterial injury by balloon angioplasty. METHODS AND RESULTS:(111)I...

journal_title：Circulation

authors： Mruk JS,Webster MW,Heras M,Reid JM,Grill DE,Chesebro JH

更新日期：2000-01-25 00:00:00

abstract：BACKGROUND:Doppler echocardiography is frequently used to predict filling pressures in normal sinus rhythm, but it is unknown whether it can be applied in sinus tachycardia, with merging of E and A velocities. Tissue Doppler imaging (TDI) can record the mitral annular velocity. The early diastolic velocity (Ea) behaves...

journal_title：Circulation

authors： Nagueh SF,Mikati I,Kopelen HA,Middleton KJ,Quiñones MA,Zoghbi WA

更新日期：1998-10-20 00:00:00

abstract：BACKGROUND:Bolus thrombolytic therapy is a simplified means of administering thrombolysis that facilitates rapid time to treatment. TNK-tissue plasminogen activator (TNK-tPA) is a highly fibrin-specific single-bolus thrombolytic agent. METHODS AND RESULTS:In TIMI 10B, 886 patients with acute ST-elevation myocardial in...

journal_title：Circulation

authors： Cannon CP,Gibson CM,McCabe CH,Adgey AA,Schweiger MJ,Sequeira RF,Grollier G,Giugliano RP,Frey M,Mueller HS,Steingart RM,Weaver WD,Van de Werf F,Braunwald E

更新日期：1998-12-22 00:00:00

abstract：:Peripheral arterial disease is one manifestation of systemic atherosclerosis. The prevalence of peripheral arterial disease increases with the age of the population. It is important to remember the significant association of coincident coronary artery disease, which is the major cause of mortality in these patients. R...

journal_title：Circulation

authors： White CJ,Gray WA

更新日期：2007-11-06 00:00:00

abstract：:To estimate the extent of myocardial infarction after coronary artery reperfusion, serum levels of cardiac myosin light chain (LC) I and creatine kinase (CK) were determined serially in 49 patients with acute myocardial infarction. Intracoronary thrombolysis was successful in 25 patients (reperfusion group), and 24 pa...

journal_title：Circulation

authors： Isobe M,Nagai R,Ueda S,Tsuchimochi H,Nakaoka H,Takaku F,Yamaguchi T,Machii K,Nobuyoshi M,Yazaki Y

更新日期：1987-12-01 00:00:00

abstract：BACKGROUND:Patients with atrial fibrillation (AF) often take multiple medications. METHODS AND RESULTS:We examined characteristics and compared adjusted outcomes between rivaroxaban and warfarin according to number of concomitant baseline medications and the presence of combined cytochrome P450 3A4 and P-glycoprotein ...

journal_title：Circulation

authors： Piccini JP,Hellkamp AS,Washam JB,Becker RC,Breithardt G,Berkowitz SD,Halperin JL,Hankey GJ,Hacke W,Mahaffey KW,Nessel CC,Singer DE,Fox KA,Patel MR

更新日期：2016-01-26 00:00:00

abstract：:Ventricular mural thrombi complicate many cardiac diseases. The endocardial endothelium can modulate the mechanical performance of subjacent myocardium and mediate responses to certain physiopharmacologic agents. We studied the effects of aggregating platelets on the contractile performance of isolated cardiac muscle....

journal_title：Circulation

authors： Shah AM,Meulemans AL,Brutsaert DL

更新日期：1989-06-01 00:00:00

abstract：BACKGROUND:Thirteen of 14 epidemiological studies have shown an increased risk of approximately 20% for coronary heart disease (CHD) for never-smokers exposed to environmental tobacco smoke (ETS), but this association remains controversial. If true, ETS might account for an estimated 35,000 to 40,000 heart disease deat...

journal_title：Circulation

authors： Steenland K,Thun M,Lally C,Heath C Jr

更新日期：1996-08-15 00:00:00

abstract：BACKGROUND:Altered composition of the gut microbiota is involved in both the onset and progression of obesity and diabetes mellitus. However, the link between gut microbiota and obesity-related cardiovascular complications has not been explored. The present study was designed to investigate the role of Akkermansia muci...

journal_title：Circulation

authors： Li J,Lin S,Vanhoutte PM,Woo CW,Xu A

更新日期：2016-06-14 00:00:00

abstract：BACKGROUND:The patency of AV expanded polytetrafluoroethylene (ePTFE) grafts for hemodialysis is impaired by intimal hyperplasia (IH) at the venous outflow tract. The absence of a functional endothelial monolayer on the prosthetic grafts is an important stimulus for IH. In the present study, we evaluated the feasibilit...

journal_title：Circulation

authors： Rotmans JI,Heyligers JM,Verhagen HJ,Velema E,Nagtegaal MM,de Kleijn DP,de Groot FG,Stroes ES,Pasterkamp G

更新日期：2005-07-05 00:00:00

abstract：:Trapidil (triazolopyrimidine) possesses activity against platelet-derived growth factor-induced cellular proliferation in vitro and intimal proliferation in vivo. The objective of this study was to determine if trapidil could prevent restenosis in experimentally induced atherosclerotic rabbits. New Zealand White rabbi...

journal_title：Circulation

authors： Liu MW,Roubin GS,Robinson KA,Black AJ,Hearn JA,Siegel RJ,King SB 3rd

更新日期：1990-03-01 00:00:00

abstract：BACKGROUND:Out-of-hospital cardiac arrest (OHCA) commonly presents with nonshockable rhythms (asystole and pulseless electric activity). It is unknown whether antiarrhythmic drugs are safe and effective when nonshockable rhythms evolve to shockable rhythms (ventricular fibrillation/pulseless ventricular tachycardia [VF...

journal_title：Circulation

authors： Kudenchuk PJ,Leroux BG,Daya M,Rea T,Vaillancourt C,Morrison LJ,Callaway CW,Christenson J,Ornato JP,Dunford JV,Wittwer L,Weisfeldt ML,Aufderheide TP,Vilke GM,Idris AH,Stiell IG,Colella MR,Kayea T,Egan D,Desvigne-Nick

更新日期：2017-11-28 00:00:00

abstract：BACKGROUND:Estradiol (E2) modulates the kinetics of circulating endothelial progenitor cells (EPCs) and favorably affects neovascularization after ischemic injury. However, the roles of estrogen receptors alpha (ER alpha) and beta (ER beta) in EPC biology are largely unknown. METHODS AND RESULTS:In response to E2, mig...

journal_title：Circulation

authors： Hamada H,Kim MK,Iwakura A,Ii M,Thorne T,Qin G,Asai J,Tsutsumi Y,Sekiguchi H,Silver M,Wecker A,Bord E,Zhu Y,Kishore R,Losordo DW

更新日期：2006-11-21 00:00:00

abstract：BACKGROUND:Symptomatic prolonged sinus pauses on termination of atrial fibrillation (AF) are an indication for pacemaker implantation. We evaluated sinus node function and clinical outcome in patients with prolonged sinus pauses on termination of arrhythmia who underwent ablation of paroxysmal AF. METHODS AND RESULTS:...

journal_title：Circulation

authors： Hocini M,Sanders P,Deisenhofer I,Jaïs P,Hsu LF,Scavée C,Weerasoriya R,Raybaud F,Macle L,Shah DC,Garrigue S,Le Metayer P,Clémenty J,Haïssaguerre M

更新日期：2003-09-09 00:00:00

abstract：BACKGROUND:Household air pollution is the third largest risk factor for global disease burden, but direct links with cardiovascular disease mortality are limited. This study aimed to evaluate the relationship between household fuel use and cardiovascular disease mortality. METHODS AND RESULTS:The Golestan Cohort Study...

journal_title：Circulation

authors： Mitter SS,Vedanthan R,Islami F,Pourshams A,Khademi H,Kamangar F,Abnet CC,Dawsey SM,Pharoah PD,Brennan P,Fuster V,Boffetta P,Malekzadeh R

更新日期：2016-06-14 00:00:00

abstract：:These types of studies lay the foundation for understanding the human apolipoproteins at the genetic level. In addition, through a few specific examples, we have already shown evidence at the DNA level that lesions in apolipoprotein genes can play a role in human atherosclerosis. This work is in its infancy, but we ho...

journal_title：Circulation

authors： Breslow JL

更新日期：1984-06-01 00:00:00

abstract：:Twenty-one reoperations for relief of angina have been performed at Stanford Medical Center in patients who had had previously unsuccessful direct coronary artery surgery. Complete releif of angina was obtained in seven (33%), improvement of angina in six (29%), and no change in angina in eight (38%) after these opera...

journal_title：Circulation

authors：

更新日期：1975-08-01 00:00:00

abstract：BACKGROUND:Brain natriuretic peptide is a novel natriuretic peptide that is secreted predominantly from the ventricles, and its plasma levels have been shown to be markedly increased in patients with chronic congestive heart failure. This study was designed to examine the plasma levels of brain natriuretic peptide as w...

journal_title：Circulation

authors： Morita E,Yasue H,Yoshimura M,Ogawa H,Jougasaki M,Matsumura T,Mukoyama M,Nakao K

更新日期：1993-07-01 00:00:00

abstract：BACKGROUND:Transplantation of ex vivo expanded circulating endothelial progenitor cells (EPCs) from peripheral blood mononuclear cells improves the neovascularization after critical ischemia. However, the origin of the endothelial progenitor lineage and its characteristics have not yet been clearly defined. Therefore, ...

journal_title：Circulation

authors： Urbich C,Heeschen C,Aicher A,Dernbach E,Zeiher AM,Dimmeler S

更新日期：2003-11-18 00:00:00

abstract：BACKGROUND:Patients with primary amyloidosis (AL type) have a poor prognosis, in part due to frequent cardiac involvement. Although intracardiac thrombus has been reported in anecdotal cases, neither its frequency nor its role in causing mortality is known. Furthermore, the clinical and echocardiographic variables that...

journal_title：Circulation

authors： Feng D,Edwards WD,Oh JK,Chandrasekaran K,Grogan M,Martinez MW,Syed IS,Hughes DA,Lust JA,Jaffe AS,Gertz MA,Klarich KW

更新日期：2007-11-20 00:00:00

abstract：:Absence of continuity between the heart and the pulmonary arteries has the potential for total correction. When the pulmonary arteries are narrow, a palliative first stage systemic-pulmonary arterial anastomosis serves to enlarge the pulmonary arteries so that, with time, they become of adequate caliber for total corr...

journal_title：Circulation

authors： Todd EP,Lindsay WG,Edwards JE

更新日期：1976-11-01 00:00:00

abstract：:We used Doppler echocardiography to quantitate the changes in intracardiac blood flow velocities and right and left ventricular stroke volumes in 80 normal human fetuses from 19 to 40 weeks gestation. Blood flow velocity spectra across the aortic, pulmonary, tricuspid, and mitral valves were digitized to obtain peak v...

journal_title：Circulation

authors： Kenny JF,Plappert T,Doubilet P,Saltzman DH,Cartier M,Zollars L,Leatherman GF,St John Sutton MG

更新日期：1986-12-01 00:00:00

abstract：BACKGROUND:We tested the hypothesis that real-time magnetic resonance imaging (MRI) can guide coronary artery catheterization in swine via a percutaneous femoral artery approach. METHODS AND RESULTS:In 12 pigs, we accessed femoral arteries percutaneously. We used 6- or 7-French coronary Judkins catheters filled with d...

journal_title：Circulation

authors： Omary RA,Green JD,Schirf BE,Li Y,Finn JP,Li D

更新日期：2003-06-03 00:00:00

abstract：BACKGROUND:Development of surgical therapy for aortic aneurysms and dissections has led to treatment of the life-threatening cardiovascular complications associated with Marfan syndrome. The present study determines the effect of surgical therapy on the life expectancy of patients with Marfan syndrome and the clinical ...

journal_title：Circulation

authors： Finkbohner R,Johnston D,Crawford ES,Coselli J,Milewicz DM

更新日期：1995-02-01 00:00:00

abstract：BACKGROUND:Depressed ventricular performance and neurohormonal activation are key pathophysiological features of congestive heart failure (CHF). Although angiotensin-converting enzyme inhibitors and beta-adrenoceptor blockers exert beneficial effects in CHF, mortality remains unacceptably high, and the development of f...

journal_title：Circulation

authors： Kaye DM,Mansfield D,Aggarwal A,Naughton MT,Esler MD

更新日期：2001-05-15 00:00:00