Ticlopidine and clopidogrel.

abstract：BACKGROUND:The T2G1s monoclonal antifibrin antibody binds specifically to fibrin but not to fibrinogen. METHODS AND RESULTS:In a canine model of acute arterial thrombosis, we determined the feasibility of imaging thrombi using a 99mTc-labeled Fab' fragment. In 14 dogs, 10 carotid and 13 femoral artery thrombi were pro...

journal_title：Circulation

authors： Cerqueira MD,Stratton JR,Vracko R,Schaible TF,Ritchie JL

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:Although the left prepectoral site is preferred for "hot can" placement, this site is unavailable in some patients. We evaluated the influence of electrode location on defibrillation thresholds with alternative hot can and transvenous lead configurations. METHODS AND RESULTS:Three interrelated studies were ...

journal_title：Circulation

authors： Yamanouchi Y,Mowrey KA,Niebauer MJ,Tchou PJ,Wilkoff BL

更新日期：1997-12-16 00:00:00

abstract：:Threshold bipolar pacing was performed from one of 12 selected atrial sites with temporary implanted electrodes in 69 patients following open-heart surgery in order to study P wave polarity and morphology and the P-R interval during paced ectopic atrial rhythms. A negative P wave was recorded in lead I only with paci...

journal_title：Circulation

authors： MacLean WA,Karp RB,Kouchoukos NT,James TN,Waldo AL

更新日期：1975-09-01 00:00:00

abstract：BACKGROUND:Laminins are major components of basement membranes, well located to interact with platelets upon vascular injury. Laminin-111 (α1β1γ1) is known to support platelet adhesion but is absent from most blood vessels, which contain isoforms with the α2, α4, or α5 chain. Whether vascular laminins support platelet ...

journal_title：Circulation

authors： Schaff M,Tang C,Maurer E,Bourdon C,Receveur N,Eckly A,Hechler B,Arnold C,de Arcangelis A,Nieswandt B,Denis CV,Lefebvre O,Georges-Labouesse E,Gachet C,Lanza F,Mangin PH

更新日期：2013-07-30 00:00:00

abstract：BACKGROUND:Atherosclerosis is a multifactorial disorder involving inflammatory processes. These responses are associated with robust activation of signaling cascades by diverse cell surface receptors in a variety of cell types. The processes that are involved in atherosclerosis would likely require intact Ras pathways,...

journal_title：Circulation

authors： George J,Afek A,Keren P,Herz I,Goldberg I,Haklai R,Kloog Y,Keren G

更新日期：2002-05-21 00:00:00

abstract：BACKGROUND:The aim of this study was to prospectively test whether the risk of bleeding complications in 212 consecutive outpatients treated with oral anticoagulants could be predicted by levels of endothelium-derived hemostatic variables. METHODS AND RESULTS:All bleeding complications were recorded during 5 years of ...

journal_title：Circulation

authors： Jansson JH,Boman K,Brännström M,Nilsson TK

更新日期：1997-11-04 00:00:00

abstract：BACKGROUND:Despite intensive investigation, how DNA methylation influences endothelial function remains poorly understood. We used methyl-CpG-binding domain protein 2 (MBD2), an interpreter for DNA methylome-encoded information, to dissect the impact of DNA methylation on endothelial function in both physiological and ...

journal_title：Circulation

authors： Rao X,Zhong J,Zhang S,Zhang Y,Yu Q,Yang P,Wang MH,Fulton DJ,Shi H,Dong Z,Wang D,Wang CY

更新日期：2011-06-28 00:00:00

abstract：BACKGROUND:Transluminal stent-graft placement (TSGP) for aortic dissection is a relatively new procedure. We performed TSGPs to seal the primary entry site to treat and prevent complications of aortic dissection. The early to mid-term outcomes were analyzed. METHODS AND RESULTS:Thirty-seven patients with a primary int...

journal_title：Circulation

authors： Shimono T,Kato N,Yasuda F,Suzuki T,Yuasa U,Onoda K,Hirano T,Takeda K,Yada I

更新日期：2002-09-24 00:00:00

abstract：BACKGROUND:We examined the associations of a range of parental and early life characteristics with systolic blood pressure at 5 years of age. METHODS AND RESULTS:Information from 3864 children who were followed up prospectively from their mother's first antenatal clinic assessment was used. Maternal age, body mass ind...

journal_title：Circulation

authors： Lawlor DA,Najman JM,Sterne J,Williams GM,Ebrahim S,Davey Smith G

更新日期：2004-10-19 00:00:00

abstract：BACKGROUND:To simplify extensive primary repair of the thoracic aorta in acute type A aortic dissection, we developed the open triple-branched stent graft placement technique. The early results of this new technique are reported. METHODS AND RESULTS:Between June 2008 and November 2009, 30 patients with acute Stanford ...

journal_title：Circulation

authors： Chen LW,Dai XF,Lu L,Zhang GC,Cao H

更新日期：2010-10-05 00:00:00

abstract：BACKGROUND:Anthracyclines are the most effective drugs available in the treatment of neoplastic diseases; however, they have profound consequences on the structure and function of the heart, which over time cause a cardiomyopathy that leads to congestive heart failure. METHODS AND RESULTS:Administration of doxorubicin...

journal_title：Circulation

authors： De Angelis A,Piegari E,Cappetta D,Marino L,Filippelli A,Berrino L,Ferreira-Martins J,Zheng H,Hosoda T,Rota M,Urbanek K,Kajstura J,Leri A,Rossi F,Anversa P

更新日期：2010-01-19 00:00:00

abstract：BACKGROUND:After repair of aortic coarctation, patients may develop restenosis, aneurysms, and pseudoaneurysms at the site of prior repair. We assessed the outcomes of late reintervention on the descending aorta after aortic coarctation repair. METHODS AND RESULTS:From March 1954 to July 2008, 130 patients had operati...

journal_title：Circulation

authors： Brown ML,Burkhart HM,Connolly HM,Dearani JA,Hagler DJ,Schaff HV

更新日期：2010-09-14 00:00:00

abstract：BACKGROUND:Aging is associated with increased cardiovascular risk and endothelial dysfunction. Since exercise can improve endothelium-dependent vasodilation, in the present study we tested whether long-term physical activity could prevent aging-related endothelial dysfunction. METHODS AND RESULTS:In 12 young and elder...

journal_title：Circulation

authors： Taddei S,Galetta F,Virdis A,Ghiadoni L,Salvetti G,Franzoni F,Giusti C,Salvetti A

更新日期：2000-06-27 00:00:00

abstract：BACKGROUND:Currently, only anecdotal information exists on the presentation and outcome of coronary arterial injury after ablation procedures. METHODS AND RESULTS:Four patients who sustained coronary artery injury of a cohort of patients undergoing 4655 consecutive ablation procedures (0.09%) are described. The patien...

journal_title：Circulation

authors： Roberts-Thomson KC,Steven D,Seiler J,Inada K,Koplan BA,Tedrow UB,Epstein LM,Stevenson WG

更新日期：2009-10-13 00:00:00

abstract：BACKGROUND:Inhibitors of adenosine membrane transport cause vasodilation and enhance the plasma adenosine concentration. However, it is unclear why the plasma adenosine concentration rises rather than falls when membrane transport is inhibited. We tested the hypothesis that the cytosolic adenosine concentration exceeds...

journal_title：Circulation

authors： Deussen A,Stappert M,Schäfer S,Kelm M

更新日期：1999-04-20 00:00:00

abstract：BACKGROUND:In the Myocardial Infarction, Triage, and Intervention (MITI) registry of acute myocardial infarction, 441 (12%) of 3750 patients had direct angioplasty as initial treatment. Approximately half (233) were performed in hospitals with no on-site surgery. METHODS AND RESULTS:Procedure success rates, use of eme...

journal_title：Circulation

authors： Weaver WD,Litwin PE,Martin JS

更新日期：1993-11-01 00:00:00

abstract：:Cardiac positron emission tomography (PET) has evolved rapidly from a relatively esoteric research tool into clinical applications providing unique, quantitative information on myocardial perfusion, metabolism, and cell membrane function and having a potentially significant impact on cardiovascular medicine. Although ...

journal_title：Circulation

authors： Gould KL

更新日期：1991-09-01 00:00:00

abstract：:Eleven consecutive patients with idiopathic dilated cardiomyopathy and spontaneous, sustained ventricular tachycardia (VT) of uniform morphology underwent programmed ventricular stimulation and serial antiarrhythmic drug testing. The mean ejection fraction was 30 +/- 6.4%. Sustained VT was induced by programmed electr...

journal_title：Circulation

authors： Poll DS,Marchlinski FE,Buxton AE,Doherty JU,Waxman HL,Josephson ME

更新日期：1984-09-01 00:00:00

abstract：BACKGROUND:The left ventricular (LV) dilatation of isolated mitral regurgitation (MR) is associated with an increase in chymase and a decrease in interstitial collagen and extracellular matrix. In addition to profibrotic effects, chymase has significant antifibrotic actions because it activates matrix metalloproteinase...

journal_title：Circulation

authors： Pat B,Chen Y,Killingsworth C,Gladden JD,Shi K,Zheng J,Powell PC,Walcott G,Ahmed MI,Gupta H,Desai R,Wei CC,Hase N,Kobayashi T,Sabri A,Granzier H,Denney T,Tillson M,Dillon AR,Husain A,Dell'italia LJ

更新日期：2010-10-12 00:00:00

abstract：:Ultrasonic tissue characterization is a new area of investigation in the field of cardiac ultrasound. The amplitude and frequency of the ultrasound signal are normally altered as the signal penetrates through tissue. It is assumed that the amplitude distribution and frequency shift of diseased or edematous tissue are ...

journal_title：Circulation

authors： Schnittger I,Vieli A,Heiserman JE,Director BA,Billingham ME,Ellis SG,Kernoff RS,Takamoto T,Popp RL

更新日期：1985-07-01 00:00:00

abstract：BACKGROUND:Matrix metalloproteinase-9 could exhibit an important role in the destabilization of atherosclerotic carotid plaques. We hypothesized that in patients with carotid stenosis, elevated levels of plasma matrix metalloproteinase-9 are associated with ipsilateral stroke or cardiovascular death. METHODS AND RESUL...

journal_title：Circulation

authors： Eldrup N,Grønholdt ML,Sillesen H,Nordestgaard BG

更新日期：2006-10-24 00:00:00

abstract：BACKGROUND:Lung hypoplasia and persistent pulmonary hypertension of the newborn limit survival in congenital diaphragmatic hernia (CDH). Unlike other diseases resulting in persistent pulmonary hypertension of the newborn, infants with CDH are refractory to inhaled nitric oxide (NO). Nitric oxide mediates pulmonary vaso...

journal_title：Circulation

authors： Luong C,Rey-Perra J,Vadivel A,Gilmour G,Sauve Y,Koonen D,Walker D,Todd KG,Gressens P,Kassiri Z,Nadeem K,Morgan B,Eaton F,Dyck JR,Archer SL,Thébaud B

更新日期：2011-05-17 00:00:00

abstract：:We have studied the effects of cardioplegic solution (CS) on angiographic and histologic anatomy of bilateral vein grafts interposed into the carotid arteries of 10 dogs for up to 1 year. One vein (exp) was infused with cardioplegic solution (pH 7.7, K + 25 mEq/l, temperature 12 degrees C) every 15 min four times at p...

journal_title：Circulation

authors： Singh AK,Capone RJ,O'Shea P,Karlson KE

更新日期：1983-09-01 00:00:00

abstract：:To determine whether a ventricular (LV) end-systolic dimension (ESD) greater than or equal to 55 mm and LV left fractional shortening less than 25% are risk factors for aortic valve replacement (AVR) in patients with aortic insufficiency, we analyzed the clinical course and M-mode echocardiograms in 47 consecutive pat...

journal_title：Circulation

authors： Fioretti P,Roelandt J,Bos RJ,Meltzer RS,van Hoogenhuijze D,Serruys PW,Nauta J,Hugenholtz PG

更新日期：1983-01-01 00:00:00

abstract：BACKGROUND:The estrogen receptor-alpha (ER-alpha) IVS1-401 polymorphism identifies a group of women (approximately 20%) who have augmented effects of hormone replacement therapy (HRT) on levels of HDL cholesterol. This study sought to determine if this augmentation extends to HRT regulation of E-selectin and C-reactive...

journal_title：Circulation

authors： Herrington DM,Howard TD,Brosnihan KB,McDonnell DP,Li X,Hawkins GA,Reboussin DM,Xu J,Zheng SL,Meyers DA,Bleecker ER

更新日期：2002-04-23 00:00:00

abstract：BACKGROUND:C-reactive protein (CRP) plasma levels have been associated with short- and long-term occurrence of coronary events. We investigated whether circulating inflammatory cell responsiveness to low-grade stimuli could contribute to the reported association between CRP and coronary events. METHODS AND RESULTS:We ...

journal_title：Circulation

authors： Liuzzo G,Angiolillo DJ,Buffon A,Rizzello V,Colizzi C,Ginnetti F,Biasucci LM,Maseri A

更新日期：2001-05-08 00:00:00

abstract：BACKGROUND:The identification of sites of dominant activation frequency during atrial fibrillation (AF) in humans and the effect of ablation at these sites have not been reported. METHODS AND RESULTS:Thirty-two patients undergoing AF ablation (19 paroxysmal, 13 permanent) during ongoing arrhythmia were studied. Electr...

journal_title：Circulation

authors： Sanders P,Berenfeld O,Hocini M,Jaïs P,Vaidyanathan R,Hsu LF,Garrigue S,Takahashi Y,Rotter M,Sacher F,Scavée C,Ploutz-Snyder R,Jalife J,Haïssaguerre M

更新日期：2005-08-09 00:00:00

abstract：:To examine whether nicardipine, a dihydropyridine derivative, limits size of myocardial infarction, and to compare the protective effects of nicardipine administered before and early and late after coronary artery occlusion, 99mTc-labeled albumin microspheres were injected into the left atrium during 5 min temporary c...

journal_title：Circulation

authors： Endo T,Nejima J,Fujita S,Kiuchi K,Iida N,Kikuchi K,Hayakawa H,Okumura H

更新日期：1986-08-01 00:00:00

abstract：BACKGROUND:The ability of apolipoprotein (apo)A-I to induce regression of preexisting atherosclerotic lesions has not been determined, and a mouse model of atherosclerosis regression has not yet been reported. METHODS AND RESULTS:LDL receptor-deficient mice were fed a western-type diet for 5 weeks to induce atheroscle...

journal_title：Circulation

authors： Tangirala RK,Tsukamoto K,Chun SH,Usher D,Puré E,Rader DJ

更新日期：1999-10-26 00:00:00

abstract：BACKGROUND:Although several loci for familial dilated cardiomyopathy (DCM) have been mapped, the origin of a large percentage of DCM remains unclear. Mdm2, a p53-negative regulator, protects cardiomyocytes from ischemic and reperfusion-induced cell death. Mdm4, a homolog of Mdm2, inhibits p53 activity in numerous cell ...

journal_title：Circulation

authors： Xiong S,Van Pelt CS,Elizondo-Fraire AC,Fernandez-Garcia B,Lozano G

更新日期：2007-06-12 00:00:00