Abstract:
:To determine how survival and clinical status were related to left ventricular (LV) size and systolic function after mitral valve replacement, 104 patients (48 mitral regurgitation [MR], 33 mitral stenosis [MS], and 23 MS/MR) with isolated mitral valve replacement were evaluated before and after surgery. Preoperative hemodynamic abnormalities by cardiac catheterization were improved 6 months after surgery in all three patient groups. The patients with MR exhibited reductions in LV end-diastolic volume index (EDVI) (117 +/- 51 to 89 +/- 27 ml/m2, p less than 0.001) and ejection fraction (EF) (0.56 +/- 0.15 to 0.45 +/- 0.13, p less than 0.001); however, the ratio of forward stroke volume to end-diastolic volume increased (0.32 +/- 0.21 to 0.45 +/- 0.17, p less than 0.001) because of the elimination of regurgitant volume. Survival analysis revealed that mortality was significantly higher in MS or MS/MR patients with postoperative EDVI more than 101 ml/m2 (p less than 0.001 and p less than 0.042, respectively) and in MR patients with postoperative EF less than or equal to 0.50 (p less than 0.031). Also, the majority of patients with MR or MS/MR and postoperative EDVI more than 101 ml/m2 and EF less than or equal to 0.50 were in New York Heart Association class III or IV. Multivariate logistic regression analysis in the patients with MR revealed that the strongest predictor of postoperative EF was preoperative EF (p less than 0.001).(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Circulationjournal_title
Circulationauthors
Crawford MH,Souchek J,Oprian CA,Miller DC,Rahimtoola S,Giacomini JC,Sethi G,Hammermeister KEdoi
10.1161/01.cir.81.4.1173subject
Has Abstractpub_date
1990-04-01 00:00:00pages
1173-81issue
4eissn
0009-7322issn
1524-4539journal_volume
81pub_type
杂志文章相关文献
CIRCULATION文献大全abstract:BACKGROUND:Acute cardiac and cerebrovascular accidents are more frequent in hypertensive subjects with a family history of acute vascular accidents. The mechanisms underlying the susceptibility to vascular disease in these subjects are unknown. We investigated whether a parental history of premature heart attack or str...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.84.1.92
更新日期:1991-07-01 00:00:00
abstract:BACKGROUND:After regular coronary balloon angioplasty, it would be helpful to identify those patients who have a low cardiac event rate. Coronary angiography alone is not sensitive enough for that purpose, but it has been suggested that the combination of optimal angiographic and optimal functional results indicates a ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.99.7.883
更新日期:1999-02-23 00:00:00
abstract:BACKGROUND:Angina symptoms have been reported to predict mortality in men. The aim of this study was to investigate the association between angina symptoms and mortality in women. METHODS AND RESULTS:In 2004, 873 older participants in the Australian Longitudinal Study on Women's Health with self-reported ischemic hear...
journal_title:Circulation
pub_type: 杂志文章,随机对照试验
doi:10.1161/CIRCULATIONAHA.109.887380
更新日期:2009-12-08 00:00:00
abstract:BACKGROUND:Congestive heart failure (CHF) patients with central sleep apnea (CHF-CSA) have elevated plasma norepinephrine (NE) compared with CHF patients without apnea (CHF-N). Patients with CHF-CSA also demonstrate higher mean pulmonary artery pressure (PAP), which is suggestive of worse cardiac function. Whether CSA ...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.0000056520.17353.4f
更新日期:2003-03-18 00:00:00
abstract:BACKGROUND:Arterial relaxation is largely regulated by endothelial nitric oxide (NO). Its diminished activity has been associated with incipient atherosclerosis. We investigated the endothelium-dependent relaxation of aorta in apolipoprotein E-knockout (apoE-KO) mice exposed to single or repeated Chlamydia pneumoniae i...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.102.9.1039
更新日期:2000-08-29 00:00:00
abstract:INTRODUCTION:Patients with congenital heart disease frequently require graft material for repair of cardiac defects. However, currently available grafts lack growth potential and are noncontractile and thrombogenic. We have developed a viable cardiac graft that contracts spontaneously in tissue culture by seeding cells...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.100.suppl_2.ii-63
更新日期:1999-11-09 00:00:00
abstract:BACKGROUND:An association of chronic Chlamydia pneumoniae infection to coronary heart disease has been suggested recently. In a recent study, we demonstrated circulating immune complexes containing chlamydial genus-specific lipopolysaccharide in patients with coronary heart disease. The objective of the present study w...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.87.4.1130
更新日期:1993-04-01 00:00:00
abstract::Between 1976 and 1982, 413 consecutive patients underwent valvular replacement with a bioprosthesis. Aortic valve replacement was performed in 240 patients, mitral valve replacement in 132, and multiple-valve replacement in 41. Four prostheses were employed: Carpentier-Edwards porcine (n = 336), Angel-Shiley porcine (...
journal_title:Circulation
pub_type: 杂志文章
doi:
更新日期:1989-09-01 00:00:00
abstract:BACKGROUND:Chagas heart disease is a frequent cause of morbidity and mortality in Latin America. Echocardiography provides useful diagnostic and prognostic information and is an important tool in the management of patients with Chagas disease. METHODS AND RESULTS:A search for relevant publications was obtained from ME...
journal_title:Circulation
pub_type: 杂志文章,评审
doi:10.1161/CIRCULATIONAHA.106.627323
更新日期:2007-03-06 00:00:00
abstract:BACKGROUND:The evolution of cell phenotypes and matrix architecture in cardiac valves during fetal maturation and postnatal adaptation through senescence remains unexplored. METHODS AND RESULTS:We hypothesized that valvular interstitial (VIC) and endothelial cell (VEC) phenotypes, critical for maintaining valve functi...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.105.591768
更新日期:2006-03-14 00:00:00
abstract:BACKGROUND:Recent advances in surgical techniques for the repair of left ventricular aneurysms (LVAs) include the use of an endoventricular patch to exclude the aneurysm cavity. This technique has replaced conventional linear plication of the aneurysm. The endoventricular patch technique remodels the left ventricular c...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.92.9.98
更新日期:1995-11-01 00:00:00
abstract:BACKGROUND:Mitral leaflet extension (MLE) combined with septal myectomy is a new surgical approach to treat hypertrophic obstructive cardiomyopathy (HOCM) and an enlarged mitral leaflet area. The study presents the long-term clinical results and outcome of this technique. METHODS AND RESULTS:MLE entails grafting a glu...
journal_title:Circulation
pub_type: 临床试验,杂志文章
doi:10.1161/01.CIR.0000092912.57140.14
更新日期:2003-10-28 00:00:00
abstract:BACKGROUND:Marfan syndrome (MFS) is caused by mutations in the fibrillin-1 gene and dysregulation of transforming growth factor-beta (TGF-beta). Recent evidence suggests that losartan, an angiotensin II type 1 blocker that blunts TGF-beta activation, may be an effective treatment for MFS. We hypothesized that dysregula...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.108.841981
更新日期:2009-08-11 00:00:00
abstract:BACKGROUND:Coronary revascularization with bypass has been shown to improve survival in patients with coronary artery disease and left ventricular dysfunction. In these patients, use of nonsurgical revascularization with percutaneous transluminal coronary angioplasty (PTCA) is increasing, although their long-term outco...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.87.1.21
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND:Two phase III trials of enoxaparin for unstable angina/non-Q-wave myocardial infarction have shown it to be superior to unfractionated heparin for preventing a composite of death and cardiac ischemic events. A prospectively planned meta-analysis was performed to provide a more precise estimate of the effects...
journal_title:Circulation
pub_type: 临床试验,杂志文章,meta分析,多中心研究
doi:10.1161/01.cir.100.15.1602
更新日期:1999-10-12 00:00:00
abstract::While continuing a study of immunologic and virologic aspects of the postpericardiotomy syndrome (PPS) in infants and children, we undertook a companion study in adults. Whereas the incidence in 119 children was 27.8%, as is usual for our hospital, the incidence in 142 adults was 17.6%. Most of the operations (95 of 1...
journal_title:Circulation
pub_type: 杂志文章
doi:
更新日期:1981-08-01 00:00:00
abstract::Calcium metabolism may play an important role in the pathogenesis of myocardial ischemic injury. The effect of the sarcolemmal calcium flux inhibitor, verapamil, on myocardial necrosis was studied in dogs subjected to temporary coronary artery occlusion. One group of dogs was untreated. A second group was given 0.8 mg...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.55.4.581
更新日期:1977-04-01 00:00:00
abstract:BACKGROUND:Atrial fibrillation (AF), the most common clinical arrhythmia, is a major cause of morbidity and mortality. Although AF is often associated with other cardiovascular conditions, many patients present without an obvious etiology. Inherited forms of AF exist, but the causative gene has been defined only in a s...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.CIR.0000077910.80718.49
更新日期:2003-06-17 00:00:00
abstract:BACKGROUND:Dual antiplatelet therapy in older versus younger patients with acute coronary syndromes is understudied. Low-dose prasugrel (5 mg/d) is recommended for younger, lower-body-weight patients and elderly patients with acute coronary syndromes to mitigate the bleeding risk of standard-dose prasugrel (10 mg/d). ...
journal_title:Circulation
pub_type: 杂志文章,随机对照试验
doi:10.1161/CIRCULATIONAHA.113.002303
更新日期:2013-08-20 00:00:00
abstract:BACKGROUND:Cellular electrophysiological alterations may contribute to arrhythmogenesis in cardiac hypertrophy. An L-like current occurs in left ventricular myocytes (LVMs) isolated from the hypertrophied heart of old spontaneously hypertensive rats (SHR). Factors that influence L occurrence during development of cardi...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.94.7.1674
更新日期:1996-10-01 00:00:00
abstract:BACKGROUND:ε protein kinase C (εPKC) is involved in vascular smooth muscle cell (VSMC) activation, but little is known about its function in vascular pathology. We aimed at assessing the role of εPKC in the development of restenosis. METHODS AND RESULTS:Rat models of aortic balloon injury with or without subsequent st...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.109.927640
更新日期:2010-09-14 00:00:00
abstract:BACKGROUND:The pathophysiology of mental stress-induced myocardial ischemia, which occurs at lower heart rates than during physical stress, is not well understood. METHODS AND RESULTS:The Psychophysiological Investigations of Myocardial Ischemia Study (PIMI) evaluated the physiological and neuroendocrine functioning i...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.94.10.2402
更新日期:1996-11-15 00:00:00
abstract::We quantitated the growth patterns of the normal fetal heart and the right and left ventricles from postmortem hearts obtained from 55 spontaneously aborted human fetuses from the completion of cardiogenesis to term. Fetal gestational age was assessed by menstrual history of the mother, crown-rump length, head circumf...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.70.6.935
更新日期:1984-12-01 00:00:00
abstract:BACKGROUND:Acetylsalicylic acid (ASA), or aspirin, plus clopidogrel is becoming the standard antithrombotic treatment in people with coronary disease. Novel approaches such as the use of platelet-selective nitric oxide (NO) donors may provide additional protection against thrombosis. We evaluated the antithrombotic pro...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.CIR.0000142296.19558.99
更新日期:2004-09-21 00:00:00
abstract:BACKGROUND:Recent studies indicate that serotonin (5-HT) has a growth-promoting effect on several different cell types, including smooth muscle cells. After percutaneous transluminal coronary angioplasty, there is damage and denudation of vascular endothelial cells, which promotes platelet aggregation at the site of in...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.90.4.1919
更新日期:1994-10-01 00:00:00
abstract:BACKGROUND:Regression of left ventricular hypertrophy (LVH) after surgical correction for aortic stenosis is not fully understood on the molecular level. The aim of this study was to examine whether there is an association between LVH regression and extracellular matrix (ECM) gene expression. METHODS AND RESULTS:A sta...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/hc37t1.094777
更新日期:2001-09-18 00:00:00
abstract:BACKGROUND:The arrhythmia burden in tetralogy of Fallot, types of arrhythmias encountered, and risk profile may change as the population ages. METHODS AND RESULTS:The Alliance for Adult Research in Congenital Cardiology (AARCC) conducted a multicenter cross-sectional study to quantify the arrhythmia burden in tetralog...
journal_title:Circulation
pub_type: 杂志文章,多中心研究
doi:10.1161/CIRCULATIONAHA.109.928481
更新日期:2010-08-31 00:00:00
abstract::In studies to ascertain the basis of dynamic changes in the P wave, bipolar epicardial potentials were recorded from multiple atrial electrodes in dogs. One hundred to 120 activation times were displayed by a digital computer and used to construct atrial isotemporal activation sequence maps. Changes in heart rate or b...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.58.6.1036
更新日期:1978-12-01 00:00:00
abstract:BACKGROUND:More than 300 000 out-of-hospital cardiac arrests (OHCA) occur each year in the United States. The relationship between time of day and OHCA outcomes in the prehospital setting is unknown. Any such association may have important implications for emergency medical services resource allocation. METHODS AND RE...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/CIRCULATIONAHA.113.002058
更新日期:2013-04-16 00:00:00
abstract::In vitro experiments on precontracted canine coronary arteries were performed to study the direct relaxant effects of molsidomine (MOLS) and its active metabolite, SIN-1, and to determine if there is a relationship between effect and cGMP level elevations. The effects of MOLS and SIN-1 were compared with those of a cl...
journal_title:Circulation
pub_type: 杂志文章
doi:10.1161/01.cir.68.6.1315
更新日期:1983-12-01 00:00:00