Endoventricular remodeling of left ventricular aneurysm. Functional, clinical, and electrophysiological results.

abstract：:A 10 mg bolus of the angiotensin blocker saralasin was injected 113 times in 68 subjects with essential or renovascular hypertension. Ninety percent of injections caused a transient increase in blood pressure, which correlated with plasma renin activity (PRA) (r = -0.54); Mean increase at 2 minutes was 21/13.4 mm Hg (...

journal_title：Circulation

authors： Waks UA,Maxwell MH,Marks L,Zawada ET,Kaufman JJ

更新日期：1978-06-01 00:00:00

abstract：BACKGROUND:From animal studies it emerged that nitric oxide is important for the modulation of CO2-mediated cerebral blood flow (CBF chemoregulation) but not for the pressor-dependent mechanism (mechanoregulation). This hypothesis was tested in 18 healthy subjects. METHODS AND RESULTS:Peak velocity (PV), diastolic vel...

journal_title：Circulation

authors： Lavi S,Egbarya R,Lavi R,Jacob G

更新日期：2003-04-15 00:00:00

abstract：BACKGROUND:Physical activity is associated with lower risk of cardiovascular disease, but the mechanisms are uncertain. Hemostatic and inflammatory markers have been linked with risk of cardiovascular disease. We therefore examined the relationship between physical activity and hemostatic and inflammatory variables. M...

journal_title：Circulation

authors： Wannamethee SG,Lowe GD,Whincup PH,Rumley A,Walker M,Lennon L

更新日期：2002-04-16 00:00:00

abstract：BACKGROUND:Chronic heart failure is associated with endothelial dysfunction including impaired endothelium-mediated, flow-dependent dilation (FDD). Since endothelial function is thought to play an important role in coordinating tissue perfusion and modulating arterial compliance, interventions to improve endothelial dy...

journal_title：Circulation

authors： Hornig B,Maier V,Drexler H

更新日期：1996-01-15 00:00:00

abstract：BACKGROUND:C-reactive protein (CRP), a well-recognized marker of atherosclerosis, has recently been suggested to have a direct proinflammatory effect. The constitutive expression of low levels of CRP in normal plasma suggests the likelihood that a natural factor exists to neutralize the effect of CRP. This factor(s) ha...

journal_title：Circulation

authors： Wadham C,Albanese N,Roberts J,Wang L,Bagley CJ,Gamble JR,Rye KA,Barter PJ,Vadas MA,Xia P

更新日期：2004-05-04 00:00:00

abstract：:Two hundred forty-five patients with variant angina were followed for an average of 80.5 months (range, 36-184 months). Survival rate at 1, 3, 5, and 10 years was 98%, 97%, 97%, and 93%, respectively. Survival rate without myocardial infarction at 1, 3, 5, and 10 years was 86%, 85%, 83%, and 81%, respectively. By univ...

journal_title：Circulation

authors： Yasue H,Takizawa A,Nagao M,Nishida S,Horie M,Kubota J,Omote S,Takaoka K,Okumura K

更新日期：1988-07-01 00:00:00

abstract：BACKGROUND:C-reactive protein (CRP) may have proatherogenic but also vasoprotective properties. We tested the hypothesis that the configuration of CRP (pentameric, or native [nCRP], versus monomeric, or modified [mCRP]) determines these different characteristics in an in vivo model. METHODS AND RESULTS:We investigated...

journal_title：Circulation

authors： Schwedler SB,Amann K,Wernicke K,Krebs A,Nauck M,Wanner C,Potempa LA,Galle J

更新日期：2005-08-16 00:00:00

abstract：:Digital vasospastic phenomena have been reported to result from use of nonselective and cardioselective beta-adrenoreceptor-blocking drugs. The effects of 80 mg/day propranolol and 100 mg/day metoprolol on finger hemodynamics and clinical responses were compared with those of placebo in 16 patients with Raynaud's phen...

journal_title：Circulation

authors： Coffman JD,Rasmussen HM

更新日期：1985-09-01 00:00:00

abstract：BACKGROUND:The use of cells derived from human induced pluripotent stem cells as cellular therapy for myocardial injury has yet to be examined in a large-animal model. METHODS AND RESULTS:Immunosuppressed Yorkshire pigs were assigned to 1 of 3 groups: A myocardial infarction group (MI group; distal left anterior desce...

journal_title：Circulation

authors： Xiong Q,Ye L,Zhang P,Lepley M,Tian J,Li J,Zhang L,Swingen C,Vaughan JT,Kaufman DS,Zhang J

更新日期：2013-03-05 00:00:00

abstract：BACKGROUND:Primum atrial septal defect (ASD) is a defect that is usually associated with few symptoms and can be electively repaired with good results. A review of our experience with primum ASD identified a subset of patients characterized by presentation with congestive heart failure (CHF) in the first months of life...

journal_title：Circulation

authors： Manning PB,Mayer JE Jr,Sanders SP,Coleman EA,Jonas RA,Keane JF,VanPraagh S,Castañeda AR

更新日期：1994-11-01 00:00:00

abstract：BACKGROUND:Alterations in myocardial function and systemic vascular tone are well documented in congestive heart failure (CHF), but little information is available on the effects of CHF on pulmonary vessels. We examined the mechanisms of tone regulation of canine pulmonary arteries during pacing-induced CHF. METHODS A...

journal_title：Circulation

authors： Mathew R,Wang J,Gewitz MH,Hintze TH,Wolin MS

更新日期：1993-05-01 00:00:00

abstract：BACKGROUND:The associations between pregnancy hypertensive disorders and common cardiovascular disorders have not been investigated at scale in a contemporaneous population. We aimed to investigate the association between preeclampsia, hypertensive disorders of pregnancy, and subsequent diagnosis of 12 different cardio...

journal_title：Circulation

authors： Leon LJ,McCarthy FP,Direk K,Gonzalez-Izquierdo A,Prieto-Merino D,Casas JP,Chappell L

更新日期：2019-09-24 00:00:00

abstract：BACKGROUND:Health-related quality-of-life instruments have become important measures of early health outcomes after cardiac surgery. The relationship between quality of life after recovery from surgery and subsequent long-term survival has not previously been explored. Our objective was to determine whether the Duke Ac...

journal_title：Circulation

authors： Koch CG,Li L,Lauer M,Sabik J,Starr NJ,Blackstone EH

更新日期：2007-02-13 00:00:00

abstract：BACKGROUND:Chemokines play an essential role in regulating the infiltration of leukocytes into allografts in experimental models. Little is known of their expression or function after human cardiac transplantation. METHODS AND RESULTS:We analyzed 169 sequential human endomyocardial biopsies by immunocytochemistry for ...

journal_title：Circulation

authors： Melter M,Exeni A,Reinders ME,Fang JC,McMahon G,Ganz P,Hancock WW,Briscoe DM

更新日期：2001-11-20 00:00:00

abstract：BACKGROUND:Pathological cardiac hypertrophy induced by stresses such as aging and neurohumoral activation is an independent risk factor for heart failure and is considered a target for the treatment of heart failure. However, the mechanisms underlying pathological cardiac hypertrophy remain largely unknown. We aimed to...

journal_title：Circulation

authors： Tang X,Chen XF,Wang NY,Wang XM,Liang ST,Zheng W,Lu YB,Zhao X,Hao DL,Zhang ZQ,Zou MH,Liu DP,Chen HZ

更新日期：2017-11-21 00:00:00

abstract：:First heart sound (S1) energy spectra in isovolumic systole, hemodynamics, and angiographic left ventricular wall motion (LVWM) at rest and with atrial pacing were compared in 27 patients who underwent diagnostic cardiac catheterization and angiography because of chest pain. Eighteen patients were found to have corona...

journal_title：Circulation

authors： Clarke WB,Austin SM,Shah PM,Griffin PM,Dove JT,McCullough J,Schreiner BF

更新日期：1978-03-01 00:00:00

abstract：:Heart-lung transplantation results in afferent and efferent denervation of the transplanted organs including interruption of the central connections from the low-pressure receptors in the atria and pulmonary veins. We investigated whether the cardiovascular and neurohumoral responses to the postural stimulus of head-u...

journal_title：Circulation

authors： Banner NR,Williams TD,Patel N,Chalmers J,Lightman SL,Yacoub MH

更新日期：1990-09-01 00:00:00

abstract：:The quantitative approaches to the assessment of regional left ventricular (LV) function described in the preceding paper were applied in a well-defined population of patients with coronary artery disease. Two groups were chosen by electrocardiographic and angiographic criteria: group 1 had infarction and regional wal...

journal_title：Circulation

authors： Parisi AF,Moynihan PF,Folland ED,Feldman CL

更新日期：1981-04-01 00:00:00

abstract：BACKGROUND:The use of molecular biological techniques has demonstrated the importance of enteroviral infection of the myocardium in the pathogenesis of myocarditis and dilated cardiomyopathy in adults and adenovirus and enterovirus infection in children. The aim of this study was to determine the frequency of adenovira...

journal_title：Circulation

authors： Pauschinger M,Bowles NE,Fuentes-Garcia FJ,Pham V,Kühl U,Schwimmbeck PL,Schultheiss HP,Towbin JA

更新日期：1999-03-16 00:00:00

abstract：BACKGROUND:We identified a gene (PRKAG2) that encodes the gamma-2 regulatory subunit of AMP-activated protein kinase (AMPK) with a mutation (Arg302Gln) responsible for familial Wolff-Parkinson-White (WPW) syndrome. The human phenotype consists of ventricular preexcitation, conduction abnormalities, and cardiac hypertro...

journal_title：Circulation

authors： Sidhu JS,Rajawat YS,Rami TG,Gollob MH,Wang Z,Yuan R,Marian AJ,DeMayo FJ,Weilbacher D,Taffet GE,Davies JK,Carling D,Khoury DS,Roberts R

更新日期：2005-01-04 00:00:00

abstract：:The benefit of cholesterol-lowering therapy in the prevention of coronary heart disease (CHD) is well established. The secondary prevention Scandinavian Simvastatin Survival Study (4S) and the primary prevention West of Scotland Coronary Prevention Study (WOSCOPS) demonstrated that lipid lowering with a statin can dra...

journal_title：Circulation

authors： Gotto AM Jr,Grundy SM

更新日期：1999-03-02 00:00:00

abstract：BACKGROUND:Since the clinical introduction of dynamic cardiomyoplasty, a discrepancy has been observed between unchanged measurements of cardiac function and improved clinical outcome. METHODS AND RESULTS:We performed a beat-to-beat analysis of cardiac performance at rest in nine cardiomyoplasty patients 6 to 24 month...

journal_title：Circulation

authors： Schreuder JJ,van der Veen FH,van der Velde ET,Delahaye F,Alfieri O,Jegaden O,Lorusso R,Jansen JR,van Ommen V,Finet G

更新日期：1995-04-01 00:00:00

abstract：BACKGROUND:We have previously demonstrated vasculoprotective effects after repeated intravenous administration of recombinant apolipoprotein A-IMilano (apoA-Im)/phospholipid complex. In this study, we sought to determine the effects of local recombinant apoA-Im/1-palmitoyl,2-oleoyl phosphatidylcholine complex (ETC-216)...

journal_title：Circulation

authors： Kaul S,Rukshin V,Santos R,Azarbal B,Bisgaier CL,Johansson J,Tsang VT,Chyu KY,Cercek B,Mirocha J,Shah PK

更新日期：2003-05-27 00:00:00

abstract：:In seven patients who underwent Fontan procedures but in whom no valves were inserted, dynamics of right heart flow were evaluated with the use of a catheter-tipped velocity transducer, pulsed Doppler echocardiography, and angiocardiography. Right atrial (RA) contraction caused a forward flow to the pulmonary artery (...

journal_title：Circulation

authors： Nakazawa M,Nakanishi T,Okuda H,Satomi G,Nakae S,Imai Y,Takao A

更新日期：1984-02-01 00:00:00

abstract：BACKGROUND:It is unclear whether increased left ventricular (LV) mass in overweight individuals is related to their adiposity or to greater fat-free mass (FFM). METHODS AND RESULTS:We compared echocardiographic LV mass to FFM and adipose body mass by bioelectric impedance and to anthropometric measurements in 3107 Ame...

journal_title：Circulation

authors： Bella JN,Devereux RB,Roman MJ,O'Grady MJ,Welty TK,Lee ET,Fabsitz RR,Howard BV

更新日期：1998-12-08 00:00:00

abstract：:Background: Vascular smooth muscle cells (VSMCs) show a remarkable phenotypic plasticity allowing acquisition of contractile or synthetic states but critical information is missing about the physiological signals, promoting formation and maintenance of contractile VSMCs in vivo. BMP9 and BMP10 are known to regulate en...

journal_title：Circulation

authors： Wang L,Rice M,Swist S,Kubin T,Wu F,Wang S,Kraut S,Weissmann N,Böttger T,Wheeler M,Schneider A,Braun T

更新日期：2020-12-18 00:00:00

abstract：BACKGROUND:Immunization with cardiac myosin induces experimental autoimmune heart disease in genetically predisposed mice. These mice produce heart-specific autoantibodies, some of which are directed against the cardiac myosin isoform. METHODS AND RESULTS:We have reported the presence of circulating heart-specific aut...

journal_title：Circulation

authors： Caforio AL,Grazzini M,Mann JM,Keeling PJ,Bottazzo GF,McKenna WJ,Schiaffino S

更新日期：1992-05-01 00:00:00

abstract：BACKGROUND:Hemodynamic efficiency of Fontan circulation is believed to be a major determinant of outcome. Prior research on flow dynamics in different modifications of Fontan circulation used in vitro models and computer-based simulation. This study was designed to compare in vivo flow dynamics in the systemic venous p...

journal_title：Circulation

authors： Be'eri E,Maier SE,Landzberg MJ,Chung T,Geva T

更新日期：1998-12-22 00:00:00

abstract：:Cerebral and retinal ischemic events have been described in mitral valve prolapse. To determine whether platelets play a part in the pathogenesis of thromboembolism we studied 29 patients with mitral valve prolapse, including nine (group I) with thromboembolism (cerebral, retinal and deep venous), eight (group II) wit...

journal_title：Circulation

authors： Walsh PN,Kansu TA,Corbett JJ,Savion PJ,Goldburgh WP,Schatz NJ

更新日期：1981-03-01 00:00:00

abstract：BACKGROUND:Sustained shortening of the atrial effective refractory period (AERP), probably due to reduction in the L-type calcium current, is a major factor in the initiation and maintenance of atrial fibrillation (AF). We investigated underlying molecular changes by studying the relation between gene expression of the...

journal_title：Circulation

authors： Brundel BJ,Van Gelder IC,Henning RH,Tieleman RG,Tuinenburg AE,Wietses M,Grandjean JG,Van Gilst WH,Crijns HJ

更新日期：2001-02-06 00:00:00