Intramural delivery of recombinant apolipoprotein A-IMilano/phospholipid complex (ETC-216) inhibits in-stent stenosis in porcine coronary arteries.

abstract：BACKGROUND:After a myocardial infarction, the injured region becomes fibrotic and the myocardial scar may expand if the ventricular wall lacks elasticity. Cardiac dilatation may precipitate the vicious cycle of progressive heart failure. The present study evaluated the functional benefits of increasing elastin within a...

journal_title：Circulation

authors： Mizuno T,Yau TM,Weisel RD,Kiani CG,Li RK

更新日期：2005-08-30 00:00:00

abstract：BACKGROUND:Whether reperfusion can cause necrosis of previously viable myocytes (lethal reperfusion injury) remains controversial. Numerous studies examined the ability of various agents to prevent or limit reperfusion injury, but the results were contradictory. In a single-canine-heart model of ischemia-reperfusion, w...

journal_title：Circulation

authors： Zahger D,Yano J,Chaux A,Fishbein MC,Ganz W

更新日期：1995-06-15 00:00:00

abstract：:In 69 patients undergoing coronary artery bypass grafting for complete coronary revascularization, blood flow was measured in 140 grafts with 243 distal anastomoses (3.52 bypasses/patient). Total blood flow in single grafts and double and triple sequential grafts did not differ significantly, although mean distal flow...

journal_title：Circulation

authors： McNamara JJ,Bjerke HS,Chung GK,Dang CR

更新日期：1979-08-01 00:00:00

abstract：:Ultrasonic tissue characterization is a new area of investigation in the field of cardiac ultrasound. The amplitude and frequency of the ultrasound signal are normally altered as the signal penetrates through tissue. It is assumed that the amplitude distribution and frequency shift of diseased or edematous tissue are ...

journal_title：Circulation

authors： Schnittger I,Vieli A,Heiserman JE,Director BA,Billingham ME,Ellis SG,Kernoff RS,Takamoto T,Popp RL

更新日期：1985-07-01 00:00:00

abstract：BACKGROUND:N(omega)-nitro-L-arginine methyl ester (l-NAME) is widely used to inhibit endothelial synthesis of NO in vivo. However, it is controversial whether the long-term vascular effects of l-NAME are mediated primarily by inhibition of endothelial NO synthesis. We addressed this point in mice that are deficient in ...

journal_title：Circulation

authors： Suda O,Tsutsui M,Morishita T,Tanimoto A,Horiuchi M,Tasaki H,Huang PL,Sasaguri Y,Yanagihara N,Nakashima Y

更新日期：2002-09-24 00:00:00

abstract：BACKGROUND:Limited information exists on the intermediate-term graft patency and 5-year clinical outcomes of patients receiving saphenous vein grafts with multiple (m-SVG) versus single distal targets (s-SVG) during coronary artery bypass graft (CABG) surgery in the current era. METHODS AND RESULTS:We studied the asso...

journal_title：Circulation

authors： Mehta RH,Ferguson TB,Lopes RD,Hafley GE,Mack MJ,Kouchoukos NT,Gibson CM,Harrington RA,Califf RM,Peterson ED,Alexander JH,Project of Ex-vivo Vein Graft Engineering via Transfection (PREVENT) IV Investigators.

更新日期：2011-07-19 00:00:00

abstract：:Contracture and collapse often complicate dissection and excision of blood vessels for grafting. Subsequent forceful redilatation and leak checking with cold saline almost always lead to partial or total denudation of endothelium, which increases the risk of early occlusion by thrombi or late occlusion by fibrocellula...

journal_title：Circulation

authors： Haudenschild C,Gould KE,Quist WC,LoGerfo FW

更新日期：1981-08-01 00:00:00

abstract：:Disorders associated with the overproduction or delayed clearance of beta-very low density lipoprotein and low density lipoprotein (LDL) are strikingly related to premature coronary artery disease. There are five recognized classes of LDL-lowering drugs, each acting through different basic mechanisms. The increased pr...

journal_title：Circulation

authors： Levy RI,Troendle AJ,Fattu JM

更新日期：1993-04-01 00:00:00

abstract：BACKGROUND:Each month, the number of transplant candidates added to the waiting list exceeds the number of transplantations performed, and many outpatients deteriorate to require transplantation urgently. The current list of 2400 candidates and the average wait of 8 months continue to increase. METHODS AND RESULTS:To ...

journal_title：Circulation

authors： Stevenson LW,Warner SL,Steimle AE,Fonarow GC,Hamilton MA,Moriguchi JD,Kobashigawa JA,Tillisch JH,Drinkwater DC,Laks H

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND:In contrast to systolic function, which is relatively well preserved with advancing age, diastolic function declines steadily after age 30. Our goal was to determine whether changes in diastolic function that occur with aging could be reversed with exercise training. Methods and Results-- Adult (6-month-old)...

journal_title：Circulation

authors： Brenner DA,Apstein CS,Saupe KW

更新日期：2001-07-10 00:00:00

abstract：:Of 1,801 patients in the 1985-1986 Percutaneous Transluminal Coronary Angioplasty (PTCA) Registry, 122 (6.8%) had periprocedural occlusion (4.9% in the catheterization laboratory, 1.9% outside the laboratory). Baseline patient factors independently associated with increased occlusion rates included triple-vessel disea...

journal_title：Circulation

authors： Detre KM,Holmes DR Jr,Holubkov R,Cowley MJ,Bourassa MG,Faxon DP,Dorros GR,Bentivoglio LG,Kent KM,Myler RK

更新日期：1990-09-01 00:00:00

abstract：BACKGROUND:Long-term implantable left ventricular assist devices (LVADs) are increasingly used as a bridge to cardiac transplantation and may be used as long-term therapy for end-stage heart failure. After insertion of an LVAD, patients frequently become ambulatory. Sensors contained within these devices can measure th...

journal_title：Circulation

authors： Foray A,Williams D,Reemtsma K,Oz M,Mancini D

更新日期：1996-11-01 00:00:00

abstract：BACKGROUND:A subgroup of patients with hypertrophic obstructive cardiomyopathy remain severely symptomatic despite optimal medical therapy. Septal myectomy reduces or eliminates left ventricular outflow obstruction and produces marked symptomatic improvement. With the recent advent of alternative methods for treatment ...

journal_title：Circulation

authors： McCully RB,Nishimura RA,Tajik AJ,Schaff HV,Danielson GK

更新日期：1996-08-01 00:00:00

abstract：:Despite a 2% to 3% prevalence of echocardiographically defined mitral valve prolapse (MVP) in the general population, the actual burden, risk stratification, and treatment of the so-called arrhythmic MVP are unknown. The clinical profile is characterized by a patient, usually female, with mostly bileaflet myxomatous d...

journal_title：Circulation

authors： Basso C,Iliceto S,Thiene G,Perazzolo Marra M

更新日期：2019-09-10 00:00:00

abstract：BACKGROUND:Human leukocyte antigen-G (HLA-G) expression in heart transplant patients has been negatively associated with acute cellular rejection and cardiac allograft vasculopathy. We assessed HLA-G expression in vascular human endothelial and smooth muscle cell cultures to determine if future therapeutic agents can b...

journal_title：Circulation

authors： Sheshgiri R,Rao V,Tumiati LC,Xiao R,Prodger JL,Badiwala M,Librach C,Delgado DH

更新日期：2008-09-30 00:00:00

abstract：:The dynamics between mitral anulus motion, and, thus, motion of the base of the heart, and filling of the left atrium and ventricle were studied by Doppler echocardiography in 12 normal subjects and 28 patients with dilated cardiomyopathy. The normal motion of the mitral anulus is associated with two phases of inflow ...

journal_title：Circulation

authors： Keren G,Sonnenblick EH,LeJemtel TH

更新日期：1988-09-01 00:00:00

abstract：:To test the hypothesis that an area of slow conduction is present during reentrant ventricular tachycardia in man, and that the earliest activation site during ventricular tachycardia is within or orthodromically just distal to the area of slow conduction in the reentry loop, we studied 12 episodes of ventricular tach...

journal_title：Circulation

authors： Okumura K,Olshansky B,Henthorn RW,Epstein AE,Plumb VJ,Waldo AL

更新日期：1987-02-01 00:00:00

abstract：BACKGROUND:Molecular targeted chemotherapies have been shown to significantly improve the outcomes of patients who have cancer, but they often cause cardiovascular side effects that limit their use and impair patients' quality of life. Cardiac dysfunction induced by these therapies, especially trastuzumab, shows a dist...

journal_title：Circulation

authors： Kitani T,Ong SG,Lam CK,Rhee JW,Zhang JZ,Oikonomopoulos A,Ma N,Tian L,Lee J,Telli ML,Witteles RM,Sharma A,Sayed N,Wu JC

更新日期：2019-05-21 00:00:00

abstract：BACKGROUND:In patients with acute coronary syndrome (ACS), percutaneous coronary intervention (PCI) may cause thrombus dislodgment followed by reduced flow and impaired microcirculatory function. We prospectively compared conventional PCI to a strategy of additional pretreatment using the X-sizer thrombectomy system. ...

journal_title：Circulation

authors： Beran G,Lang I,Schreiber W,Denk S,Stefenelli T,Syeda B,Maurer G,Glogar D,Siostrzonek P

更新日期：2002-05-21 00:00:00

abstract：:This is the first scientific statement from the American Heart Association on maternal resuscitation. This document will provide readers with up-to-date and comprehensive information, guidelines, and recommendations for all aspects of maternal resuscitation. Maternal resuscitation is an acute event that involves many ...

journal_title：Circulation

authors： Jeejeebhoy FM,Zelop CM,Lipman S,Carvalho B,Joglar J,Mhyre JM,Katz VL,Lapinsky SE,Einav S,Warnes CA,Page RL,Griffin RE,Jain A,Dainty KN,Arafeh J,Windrim R,Koren G,Callaway CW,American Heart Association Emergency Cardio

更新日期：2015-11-03 00:00:00

abstract：BACKGROUND:There is no treatment proven to limit the growth of abdominal aortic aneurysms, in which the histological hallmarks include inflammation and medial atrophy, with apoptosis of smooth muscle cells and destruction of elastin. METHODS AND RESULTS:Aneurysm biopsies were used for explant cultures, the preparation...

journal_title：Circulation

authors： Walton LJ,Franklin IJ,Bayston T,Brown LC,Greenhalgh RM,Taylor GW,Powell JT

更新日期：1999-07-06 00:00:00

abstract：BACKGROUND:Atherosclerosis is complicated by cardiovascular events such as myocardial infarction, stroke, or peripheral arterial occlusive disease. Inflammation and pathological neovascularization are thought to precipitate plaque rupture or erosion, both causes of arterial thrombosis and cardiovascular events. We test...

journal_title：Circulation

authors： Fleiner M,Kummer M,Mirlacher M,Sauter G,Cathomas G,Krapf R,Biedermann BC

更新日期：2004-11-02 00:00:00

abstract：:This study was undertaken to determine if computerized tomography (CT scanning) with an EMI cranial scanner could detect edema associated with myocardial ischemia in canine hearts. A localized area of decreased density in the posterior papillary muscle and surrounding myocardium was detected on serial 8 mm CT scan sli...

journal_title：Circulation

authors： Powell WJ Jr,wittenberg J,Maturi RA,Dinsmore RE,Miller SW

更新日期：1977-01-01 00:00:00

abstract：:In a porcine preparation of cardiac arrest, we demonstrated that there is a marked paradox of venous acidemia and arterial alkalemia. This paradox is related to decreased clearance of CO2 from the lungs when pulmonary blood flow is critically reduced. Accordingly, increased venous PCO2 rather than metabolic acidosis d...

journal_title：Circulation

authors： Grundler W,Weil MH,Rackow EC

更新日期：1986-11-01 00:00:00

abstract：BACKGROUND:Vascular endothelial growth factor (VEGF) is an endothelial cell-specific mitogen that is angiogenic in vitro and in vivo. It has been hypothesized that VEGF plays a role in myocardial collateral formation; however, the effects of VEGF on collateral flow to ischemic myocardium are unknown. METHODS AND RESUL...

journal_title：Circulation

authors： Banai S,Jaklitsch MT,Shou M,Lazarous DF,Scheinowitz M,Biro S,Epstein SE,Unger EF

更新日期：1994-05-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to determine the influence of clinical characteristics on shock occurrence and survival in 241 patients with implantable cardioverter-defibrillator (ICD) therapy. METHODS AND RESULTS:Two hundred forty-one consecutive patients underwent ICD implantation between November 1982 and...

journal_title：Circulation

authors： Grimm W,Flores BT,Marchlinski FE

更新日期：1993-06-01 00:00:00

abstract：BACKGROUND:Familial hypercholesterolemia (FH), an autosomal codominant disease, is characterized by high levels of LDL cholesterol and a high incidence of coronary artery disease (CAD). To date, genetic heterogeneity has hindered the proper assessment of the relation between risk factors and CAD in FH patients. METHOD...

journal_title：Circulation

authors： Ferrières J,Lambert J,Lussier-Cacan S,Davignon J

更新日期：1995-08-01 00:00:00

abstract：:We have previously shown that a brief episode of ischemia slows the rate of ATP depletion during subsequent ischemic episodes. Additionally, intermittent reperfusion may be beneficial to the myocardium by washing out catabolites that have accumulated during ischemia. Thus, we proposed that multiple brief ischemic epis...

journal_title：Circulation

authors： Murry CE,Jennings RB,Reimer KA

更新日期：1986-11-01 00:00:00

abstract：:Acute cardiac rejection, syndrome X, and arterial hypertension can induce small vessel damage and, therefore, restriction of coronary reserve in the presence of normal epicardial coronary arteries. A characteristic response pattern to dipyridamole (DIP) infusion has been previously described in syndrome X and arterial...

journal_title：Circulation

authors： Picano E,De Pieri G,Salerno JA,Arbustini E,Distante A,Martinelli L,Pucci A,Montemartini C,Viganò M,Donato L

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND:Albuminuria is an established risk marker for both cardiovascular and renal outcomes. Albuminuria can be reduced with drugs that block the renin-angiotensin system (RAS). We questioned whether the short-term drug-induced change in albuminuria would predict the long-term cardioprotective efficacy of RAS inter...

journal_title：Circulation

authors： de Zeeuw D,Remuzzi G,Parving HH,Keane WF,Zhang Z,Shahinfar S,Snapinn S,Cooper ME,Mitch WE,Brenner BM

更新日期：2004-08-24 00:00:00