当前位置： SCI文献检索 > CIRCULATION期刊下所有文献 > Ion channel remodeling is related to intraoperative atrial effective refractory periods in patients with paroxysmal and persistent atrial fibrillation.

Ion channel remodeling is related to intraoperative atrial effective refractory periods in patients with paroxysmal and persistent atrial fibrillation.

Abstract：

BACKGROUND:Sustained shortening of the atrial effective refractory period (AERP), probably due to reduction in the L-type calcium current, is a major factor in the initiation and maintenance of atrial fibrillation (AF). We investigated underlying molecular changes by studying the relation between gene expression of the L-type calcium channel and potassium channels and AERP in patients with AF. METHODS AND RESULTS:mRNA and protein expression were determined in the left and right atrial appendages of patients with paroxysmal (n=13) or persistent (n=16) AF and of 13 controls in sinus rhythm using reverse transcription polymerase chain reaction and slot-blot, respectively. The mRNA content of almost all investigated ion channel genes was reduced in persistent but not in paroxysmal AF. Protein levels for the L-type Ca(2+) channel and 5 potassium channels (Kv4.3, Kv1.5, HERG, minK, and Kir3.1) were significantly reduced in both persistent and paroxysmal AF. Furthermore, AERPs were determined intraoperatively at 5 basic cycle lengths between 250 and 600 ms. Patients with persistent and paroxysmal AF displayed significant shorter AERPs. Protein levels of all ion channels investigated correlated positively with the AERP and with the rate adaptation of AERP. Patients with reduced ion channel protein expression had a shorter AERP duration and poorer rate adaptation. CONCLUSIONS:AF is predominantly accompanied by decreased protein contents of the L-type Ca(2+) channel and several potassium channels. Reductions in L-type Ca(2+) channel correlated with AERP and rate adaptation, and they represent a probable explanation for the electrophysiological changes during AF.

journal_name

Circulation

journal_title

Circulation

authors

Brundel BJ,Van Gelder IC,Henning RH,Tieleman RG,Tuinenburg AE,Wietses M,Grandjean JG,Van Gilst WH,Crijns HJ

doi

10.1161/01.cir.103.5.684

subject

Has Abstract

pub_date

2001-02-06 00:00:00

pages

684-90

issue

5

eissn

0009-7322

issn

1524-4539

journal_volume

103

pub_type

杂志文章

相关文献

CIRCULATION文献大全
  • Regional left ventricular systolic function in humans during off-pump coronary bypass surgery.

    abstract：BACKGROUND:Controversy exists as to whether off-pump CABG with local occlusion results in clinically significant myocardial ischemia during the occlusion period. This study was undertaken to delineate the effects of transient local coronary artery occlusion on regional systolic function. METHODS AND RESULTS:Eight cons...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/01.cir.100.suppl_2.ii-125

    authors： Brown PM Jr,Kim VB,Boyer BJ,Lust RM,Chitwood WR Jr,Elbeery JR

    更新日期：1999-11-09 00:00:00

  • Medical Therapy for Systemic Right Ventricles: A Systematic Review (Part 1) for the 2018 AHA/ACC Guideline for the Management of Adults With Congenital Heart Disease: A Report of the American College of Cardiology/American Heart Association Task Force on

    abstract：:Patients with systemic morphological right ventricles (RVs), including congenitally corrected transposition of the great arteries and dextro-transposition of the great arteries with a Mustard or Senning atrial baffle repair, have a high likelihood of developing systemic ventricular dysfunction. Unfortunately, there ar...

    journal_title：Circulation

    pub_type： 杂志文章,meta分析

    doi：10.1161/CIR.0000000000000604

    authors： Zaragoza-Macias E,Zaidi AN,Dendukuri N,Marelli A

    更新日期：2019-04-02 00:00:00

  • Metformin Use and Clinical Outcomes Among Patients With Diabetes Mellitus With or Without Heart Failure or Kidney Dysfunction: Observations From the SAVOR-TIMI 53 Trial.

    abstract：BACKGROUND:Metformin is first-line therapy for type 2 diabetes mellitus, although its effects on the cardiovascular system are unproved. METHODS:In this post hoc analysis, patients in SAVOR-TIMI 53 (Saxagliptin and Cardiovascular Outcomes in Patients With Type 2 Diabetes Mellitus) with baseline biomarker samples (n=12...

    journal_title：Circulation

    pub_type： 临床试验,杂志文章

    doi：10.1161/CIRCULATIONAHA.119.040144

    authors： Bergmark BA,Bhatt DL,McGuire DK,Cahn A,Mosenzon O,Steg PG,Im K,Kanevsky E,Gurmu Y,Raz I,Braunwald E,Scirica BM,SAVOR-TIMI 53 Steering Committee and Investigators.

    更新日期：2019-09-17 00:00:00

  • L-4F, an apolipoprotein A-1 mimetic, restores nitric oxide and superoxide anion balance in low-density lipoprotein-treated endothelial cells.

    abstract：BACKGROUND:Low-density lipoprotein (LDL) impairs endothelial cell function by uncoupling endothelial nitric oxide synthase (eNOS) activity, which allows superoxide anion (O2*-)) to be generated rather than nitric oxide (*NO). Recent reports indicate that apolipoprotein (apo) A-1 mimetics inhibit the development of athe...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/01.cir.0000061949.17174.b6

    authors： Ou Z,Ou J,Ackerman AW,Oldham KT,Pritchard KA Jr

    更新日期：2003-03-25 00:00:00

  • Catheter stimulation of cardiac parasympathetic nerves in humans: a novel approach to the cardiac autonomic nervous system.

    abstract：BACKGROUND:Cardiac parasympathetic nerves run alongside the superior vena cava (SVC) and accumulate particularly epicardially adjacent to the orifice of the coronary sinus (CS). In animals, these nerves can be electrically stimulated inside the SVC or CS, which results in negative chronotropic/dromotropic effects and n...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/hc4501.099307

    authors： Schauerte P,Mischke K,Plisiene J,Waldmann M,Zarse M,Stellbrink C,Schimpf T,Knackstedt C,Sinha A,Hanrath P

    更新日期：2001-11-13 00:00:00

  • Persistence of functional atrioventricular accessory pathways in postseptated embryonic avian hearts: implications for morphogenesis and functional maturation of the cardiac conduction system.

    abstract：BACKGROUND:During heart development, the ventricular activation sequence changes from a base-to-apex to an apex-to-base pattern. We investigated the possibility of impulse propagation through remnants of atrioventricular (AV) connections in quail hearts. METHODS AND RESULTS:In 86 hearts (group A, HH30-34, n=15; group ...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/CIRCULATIONAHA.106.658807

    authors： Kolditz DP,Wijffels MC,Blom NA,van der Laarse A,Markwald RR,Schalij MJ,Gittenberger-de Groot AC

    更新日期：2007-01-02 00:00:00

  • Effect of torcetrapib on glucose, insulin, and hemoglobin A1c in subjects in the Investigation of Lipid Level Management to Understand its Impact in Atherosclerotic Events (ILLUMINATE) trial.

    abstract：BACKGROUND:High-density lipoproteins have antidiabetic properties in vitro. Furthermore, elevated high-density lipoprotein levels accompanying a genetic deficiency of cholesteryl ester transfer protein are associated with decreased levels of plasma glucose. We now investigate effects on glucose homeostasis of inhibitin...

    journal_title：Circulation

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1161/CIRCULATIONAHA.111.018259

    authors： Barter PJ,Rye KA,Tardif JC,Waters DD,Boekholdt SM,Breazna A,Kastelein JJ

    更新日期：2011-08-02 00:00:00

  • Coronary artery disease in African-Americans.

    abstract：:Contrary to opinions generally accepted in the past, CHD is very common in both African-American men and women, with incidence rates approaching those of US Caucasians. Higher prevalence of hypertension, diabetes, cigarette smoking, and obesity all contribute to the high level of CHD in African-Americans. Additional r...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/01.cir.83.4.1474

    authors： Curry CL

    更新日期：1991-04-01 00:00:00

  • Targeted deletion of Fgl-2/fibroleukin in the donor modulates immunologic response and acute vascular rejection in cardiac xenografts.

    abstract：BACKGROUND:Xenografts ultimately fail as a result of acute vascular rejection (AVR), a process characterized by intravascular thrombosis, fibrin deposition, and endothelial cell activation. METHODS AND RESULTS:We studied whether targeted deletion of Fgl-2, an inducible endothelial cell procoagulant, (Fgl-2-/-) in the ...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/CIRCULATIONAHA.105.534271

    authors： Mendicino M,Liu M,Ghanekar A,He W,Koscik C,Shalev I,Javadi M,Turnbull J,Chen W,Fung L,Sakamoto S,Marsden P,Waddell TK,Phillips MJ,Gorczynski R,Levy GA,Grant D

    更新日期：2005-07-12 00:00:00

  • Effect of magnesium on anginal attack induced by hyperventilation in patients with variant angina.

    abstract：:To examine whether or not magnesium suppresses coronary spasm, the effect of magnesium infusion on anginal attacks induced by hyperventilation was studied in 20 patients with variant angina. In all patients, anginal attacks associated with ischemic ST segment changes on the electrocardiogram were repeatedly induced by...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/01.cir.79.3.597

    authors： Miyagi H,Yasue H,Okumura K,Ogawa H,Goto K,Oshima S

    更新日期：1989-03-01 00:00:00

  • Female gender is an independent predictor of operative mortality after coronary artery bypass graft surgery: contemporary analysis of 31 Midwestern hospitals.

    abstract：BACKGROUND:Women have a higher operative mortality (OM) after coronary artery bypass graft (CABG) surgery than men. Suggested contributing factors have included women's increased age, advanced disease, comorbidities, and smaller body surface area (BSA). It is unclear whether women's increased risk factors fully account...

    journal_title：Circulation

    pub_type： 杂志文章,多中心研究

    doi：10.1161/CIRCULATIONAHA.104.525139

    authors： Blankstein R,Ward RP,Arnsdorf M,Jones B,Lou YB,Pine M

    更新日期：2005-08-30 00:00:00

  • Shock occurrence and survival in 241 patients with implantable cardioverter-defibrillator therapy.

    abstract：BACKGROUND:The purpose of this study was to determine the influence of clinical characteristics on shock occurrence and survival in 241 patients with implantable cardioverter-defibrillator (ICD) therapy. METHODS AND RESULTS:Two hundred forty-one consecutive patients underwent ICD implantation between November 1982 and...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/01.cir.87.6.1880

    authors： Grimm W,Flores BT,Marchlinski FE

    更新日期：1993-06-01 00:00:00

  • Bilateral ductal origin of the pulmonary arteries. Systemic-pulmonary arterial anastomosis as first stage in planned total correction.

    abstract：:Absence of continuity between the heart and the pulmonary arteries has the potential for total correction. When the pulmonary arteries are narrow, a palliative first stage systemic-pulmonary arterial anastomosis serves to enlarge the pulmonary arteries so that, with time, they become of adequate caliber for total corr...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/01.cir.54.5.834

    authors： Todd EP,Lindsay WG,Edwards JE

    更新日期：1976-11-01 00:00:00

  • Women have higher left ventricular ejection fractions than men independent of differences in left ventricular volume: the Dallas Heart Study.

    abstract：BACKGROUND:Although gender-specific criteria are common for defining cardiac traits such as left ventricular hypertrophy, left ventricular ejection fraction (LVEF) thresholds widely used in clinical practice have traditionally been the same for women and men, perhaps because it remains uncertain whether there is a syst...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/CIRCULATIONAHA.105.574400

    authors： Chung AK,Das SR,Leonard D,Peshock RM,Kazi F,Abdullah SM,Canham RM,Levine BD,Drazner MH

    更新日期：2006-03-28 00:00:00

  • Myocarditis in beta-thalassemia major. A cause of heart failure.

    abstract：BACKGROUND:Although acute pericarditis is a common complication of beta-thalassemia major, the prevalence and consequences of myocarditis in this disease have not been investigated. METHODS AND RESULTS:A prospective 5-year follow-up study was carried out in all patients with beta-thalassemia major in whom the diagnosi...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/01.cir.91.1.66

    authors： Kremastinos DT,Tiniakos G,Theodorakis GN,Katritsis DG,Toutouzas PK

    更新日期：1995-01-01 00:00:00

  • Antithrombotic effects of thrombolytic agents in a platelet-rich femoral vein thrombosis model in the hamster.

    abstract：BACKGROUND:The extent and mechanism of the antithrombotic properties of fibrin-selective and non-fibrin-selective thrombolytic agents have not yet been established. METHODS AND RESULTS:The antithrombotic, thrombolytic, fibrinogenolytic, and pharmacokinetic properties of the following substances were determined in hams...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/01.cir.91.5.1330

    authors： Stassen JM,Nyström A,Hoylaerts M,Collen D

    更新日期：1995-03-01 00:00:00

  • Concordance for coronary risk factors among spouses.

    abstract：:Values for several coronary risk factors, including systolic and diastolic blood pressure, serum cholesterol, triglycerides, blood glucose, uric acid, hemoglobin, weight, vitral capacity and cigarette smoking have been found to be similar among spouses in the Framingham Study. However, longitudinal analyses show that...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/01.cir.52.4.589

    authors： Sackett DL,Anderson GD,Milner R,Feinleib M,Kannel WB

    更新日期：1975-10-01 00:00:00

  • Frequency of early occlusion and stenosis in a left internal mammary artery to left anterior descending artery bypass graft after surgery through a median sternotomy on conventional bypass: benchmark for minimally invasive direct coronary artery bypass.

    abstract：BACKGROUND:Uncertainty exists regarding the frequency of early occlusion when the left internal mammary artery (LIMA) is anastomosed to the left anterior descending artery (LAD) through a sternotomy with conventional coronary artery bypass grafting (CABG). The issue has gained importance for comparison with less invasi...

    journal_title：Circulation

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1161/01.cir.100.23.2353

    authors： Berger PB,Alderman EL,Nadel A,Schaff HV

    更新日期：1999-12-07 00:00:00

  • Explaining the increase in coronary heart disease mortality in Beijing between 1984 and 1999.

    abstract：BACKGROUND:Coronary heart disease (CHD) mortality is rising in many developing countries. We examined how much of the increase in CHD mortality in Beijing, China, between 1984 and 1999 could be attributed to changes in major cardiovascular risk factors and assessed the impact of medical and surgical treatments. METHOD...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/01.CIR.0000140668.91896.AE

    authors： Critchley J,Liu J,Zhao D,Wei W,Capewell S

    更新日期：2004-09-07 00:00:00

  • Pulmonary hyperinflation and left ventricular mass: the Multi-Ethnic Study of Atherosclerosis COPD Study.

    abstract：BACKGROUND:Left ventricular (LV) mass is an important predictor of heart failure and cardiovascular mortality, yet determinants of LV mass are incompletely understood. Pulmonary hyperinflation in chronic obstructive pulmonary disease (COPD) may contribute to changes in intrathoracic pressure that increase LV wall stres...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/CIRCULATIONAHA.113.001653

    authors： Smith BM,Kawut SM,Bluemke DA,Basner RC,Gomes AS,Hoffman E,Kalhan R,Lima JA,Liu CY,Michos ED,Prince MR,Rabbani L,Rabinowitz D,Shimbo D,Shea S,Barr RG

    更新日期：2013-04-09 00:00:00

  • Outcome of watchful waiting in asymptomatic severe mitral regurgitation.

    abstract：BACKGROUND:The management of asymptomatic severe mitral regurgitation remains controversial. The aim of this study was to evaluate the outcome of a watchful waiting strategy in which patients are referred to surgery when symptoms occur or when asymptomatic patients develop left ventricular (LV) enlargement, LV dysfunct...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/CIRCULATIONAHA.105.599175

    authors： Rosenhek R,Rader F,Klaar U,Gabriel H,Krejc M,Kalbeck D,Schemper M,Maurer G,Baumgartner H

    更新日期：2006-05-09 00:00:00

  • Combined doppler and phased-array echocardiographic estimation of cardiac output.

    abstract：:The capability of a pulsed Doppler flowmeter combined with a phased-array imaging system to measure volume flow was tested in vitro and in patients undergoing cardiac catheterization. The Doppler-phased-array system (DPA) was used to determine vessel diameter and a superimposed cursor was used to locate the range and ...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/01.cir.63.2.388

    authors： Magnin PA,Stewart JA,Myers S,von Ramm O,Kisslo JA

    更新日期：1981-02-01 00:00:00

  • Circulating microemboli in patients after aortic valve replacement with pulmonary autografts and mechanical valve prostheses.

    abstract：BACKGROUND:The pulmonary autograft procedure (Ross) is now considered the gold standard for aortic valve replacement. One of its advantages is the freedom from macroemboli without anticoagulation. Whether this holds true for circulating microemboli, detectable as high-intensity transient Doppler signals (HITS), has not...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/01.cir.96.6.1843

    authors： Nötzold A,Droste DW,Hagedorn G,Berndt S,Kaps M,Graf B,Sievers HH

    更新日期：1997-09-16 00:00:00

  • Lysozyme M-positive monocytes mediate angiotensin II-induced arterial hypertension and vascular dysfunction.

    abstract：BACKGROUND:Angiotensin II (ATII), a potent vasoconstrictor, causes hypertension, promotes infiltration of myelomonocytic cells into the vessel wall, and stimulates both vascular and inflammatory cell NADPH oxidases. The predominant source of reactive oxygen species, eg, vascular (endothelial, smooth muscle, adventitial...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/CIRCULATIONAHA.111.034470

    authors： Wenzel P,Knorr M,Kossmann S,Stratmann J,Hausding M,Schuhmacher S,Karbach SH,Schwenk M,Yogev N,Schulz E,Oelze M,Grabbe S,Jonuleit H,Becker C,Daiber A,Waisman A,Münzel T

    更新日期：2011-09-20 00:00:00

  • Diurnal changes in coronary blood flow in conscious dogs.

    abstract：:The purpose of the present study was to evaluate potential diurnal changes in resting coronary blood flow under conditions of comparable myocardial oxygen requirements. We studied 21 conscious, resting dogs instrumented for the measurement of coronary flow, left ventricular pressure, and regional myocardial segment le...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/01.cir.76.2.488

    authors： Fujita M,Franklin D

    更新日期：1987-08-01 00:00:00

  • Ultrasonic angioplasty in totally occluded peripheral arteries. Initial clinical, histological, and angiographic results.

    abstract：BACKGROUND:Ultrasonic angioplasty was recently shown to ablate thrombi and atherosclerotic plaques in vitro and to recanalize occluded arteries in experimental animal models. The goal of the present study was to examine the clinical feasibility of ultrasonic angioplasty. METHODS AND RESULTS:Intraoperative ultrasonic a...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/01.cir.83.6.1976

    authors： Rosenschein U,Rozenszajn LA,Kraus L,Marboe CC,Watkins JF,Rose EA,David D,Cannon PJ,Weinstein JS

    更新日期：1991-06-01 00:00:00

  • Impaired coronary tissue plasminogen activator release is associated with coronary atherosclerosis and cigarette smoking: direct link between endothelial dysfunction and atherothrombosis.

    abstract：BACKGROUND:The aim of the study was to establish the influence of proximal coronary artery atheroma and smoking habit on the stimulated release of tissue plasminogen activator (tPA) from the heart. METHODS AND RESULTS:After diagnostic coronary angiography in 25 patients, the left anterior descending coronary artery (L...

    journal_title：Circulation

    pub_type： 临床试验,杂志文章

    doi：10.1161/01.cir.103.15.1936

    authors： Newby DE,McLeod AL,Uren NG,Flint L,Ludlam CA,Webb DJ,Fox KA,Boon NA

    更新日期：2001-04-17 00:00:00

  • Amplification of flecainide-induced ventricular conduction slowing by exercise. A potentially significant clinical consequence of use-dependent sodium channel blockade.

    abstract：:Proarrhythmic effects of flecainide acetate have been reported during exercise, but the mechanism for the arrhythmogenic interaction between flecainide and exercise is unknown. We hypothesized that the sinus tachycardia of exercise may enhance flecainide-induced conduction slowing by increasing use-dependent sodium ch...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/01.cir.79.5.1000

    authors： Ranger S,Talajic M,Lemery R,Roy D,Nattel S

    更新日期：1989-05-01 00:00:00

  • Does myocardial stunning contribute to infarct size limitation by ischemic preconditioning?

    abstract：BACKGROUND:The mechanism through which ischemic preconditioning causes cardioprotection is unknown. The present study investigated the role of stunning in preconditioning. METHODS AND RESULTS:We studied three different protocols of preconditioning: two cycles of 2-minute ischemia separated by 5-minute reperfusion (2'P...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/01.cir.84.6.2504

    authors： Miura T,Goto M,Urabe K,Endoh A,Shimamoto K,Iimura O

    更新日期：1991-12-01 00:00:00

  • Changes in phasic coronary blood flow velocity profile and relative coronary flow reserve in patients with hypertrophic obstructive cardiomyopathy.

    abstract：BACKGROUND:In this study, we both investigated coronary flow velocity in hypertrophic obstructive cardiomyopathy (HOCM) and tested the hypothesis of differing coronary flow reserve (CFR) of coronary arteries perfusing left ventricular regions with nonuniform myocardial hypertrophy by measuring the relative CFR. METHOD...

    journal_title：Circulation

    pub_type： 杂志文章

    doi：10.1161/01.cir.96.3.834

    authors： Kyriakidis MK,Dernellis JM,Androulakis AE,Kelepeshis GA,Barbetseas J,Anastasakis AN,Trikas AG,Tentolouris CA,Gialafos JE,Toutouzas PK

    更新日期：1997-08-05 00:00:00