L-4F, an apolipoprotein A-1 mimetic, restores nitric oxide and superoxide anion balance in low-density lipoprotein-treated endothelial cells.

abstract：BACKGROUND:Adolescent metabolic syndrome (MetS) predicts type 2 diabetes mellitus and subclinical atherosclerosis in adulthood. Our aim was to establish the relationship between an infancy-onset dietary intervention and risk of having MetS between 15 and 20 years of age. METHODS AND RESULTS:The Special Turku Coronary ...

journal_title：Circulation

authors： Nupponen M,Pahkala K,Juonala M,Magnussen CG,Niinikoski H,Rönnemaa T,Viikari JS,Saarinen M,Lagström H,Jula A,Simell O,Raitakari OT

更新日期：2015-02-17 00:00:00

abstract：BACKGROUND:Previous studies suggested that blockade of RAGE in diabetic apolipoprotein (apo) E-null mice suppressed early acceleration of atherosclerosis. A critical test of the potential applicability of RAGE blockade to clinical settings was its ability to impact established vascular disease. In this study, we tested...

journal_title：Circulation

authors： Bucciarelli LG,Wendt T,Qu W,Lu Y,Lalla E,Rong LL,Goova MT,Moser B,Kislinger T,Lee DC,Kashyap Y,Stern DM,Schmidt AM

更新日期：2002-11-26 00:00:00

abstract：BACKGROUND:Whether knowledge of genetic risk for coronary heart disease (CHD) affects health-related outcomes is unknown. We investigated whether incorporating a genetic risk score (GRS) in CHD risk estimates lowers low-density lipoprotein cholesterol (LDL-C) levels. METHODS AND RESULTS:Participants (n=203, 45-65 year...

journal_title：Circulation

authors： Kullo IJ,Jouni H,Austin EE,Brown SA,Kruisselbrink TM,Isseh IN,Haddad RA,Marroush TS,Shameer K,Olson JE,Broeckel U,Green RC,Schaid DJ,Montori VM,Bailey KR

更新日期：2016-03-22 00:00:00

abstract：BACKGROUND:A low ankle-arm index (AAI) is a strong predictor of mortality and cardiovascular events. A high AAI also appears to be associated with higher mortality risk in select populations. However, mortality and cardiovascular risk across the AAI spectrum have not been described in a more broadly defined population....

journal_title：Circulation

authors： O'Hare AM,Katz R,Shlipak MG,Cushman M,Newman AB

更新日期：2006-01-24 00:00:00

abstract：BACKGROUND:Vasodilator drugs have variable effects on veins and arteries. However, direct measurements of their effects on the splanchnic veins, perhaps the most important volume reservoir, have not been reported. We assessed the effect of acute heart failure and the subsequent administration of hydralazine, enalaprila...

journal_title：Circulation

authors： Wang SY,Manyari DE,Scott-Douglas N,Smiseth OA,Smith ER,Tyberg JV

更新日期：1995-02-15 00:00:00

abstract：BACKGROUND:In PTCA patients with multivessel coronary artery disease, incomplete revascularization (IR) is the result of both pre-PTCA strategy and initial lesion outcome. The unique contribution of these components on long-term patient outcome is uncertain. METHODS AND RESULTS:From the Bypass Angioplasty Revasculariz...

journal_title：Circulation

authors： Kip KE,Bourassa MG,Jacobs AK,Schwartz L,Feit F,Alderman EL,Weiner BH,Weiss MB,Kellett MA Jr,Sharaf BL,Dimas AP,Jones RH,Sopko G,Detre KM

更新日期：1999-08-31 00:00:00

abstract：BACKGROUND:Short-term (<30 day) mortality after Q-wave myocardial infarction (MI) has declined over the decades, but it is unclear if rates of long-term sequelae after Q-wave MI have improved. METHODS AND RESULTS:In 546 Framingham Heart Study subjects (388 men with a mean age of 60 years; 158 women with a mean age of ...

journal_title：Circulation

authors： Guidry UC,Evans JC,Larson MG,Wilson PW,Murabito JM,Levy D

更新日期：1999-11-16 00:00:00

abstract：BACKGROUND:Peripheral arterial disease (PAD) is associated with significant morbidity and mortality and is an important marker of subclinical coronary heart disease. However, estimates of PAD prevalence in the general US population have varied widely. METHODS AND RESULTS:We analyzed data from 2174 participants aged 40...

journal_title：Circulation

authors： Selvin E,Erlinger TP

更新日期：2004-08-10 00:00:00

abstract：:Coronal, horizontal, and sagittal sections through the mid-line are excellent ways of depicting the anatomical position of the aortic root and for studying its topographical relationship to the surrounding vascular structures. Minimal radiographic abnormalities or no abnormalities at all may be present with an enlarge...

journal_title：Circulation

authors： Viamote M,Camacho M,Cahill DR,Viamonte M,Mori K

更新日期：1975-02-01 00:00:00

abstract：BACKGROUND:DC shock catheter ablation for the treatment of ventricular tachycardia (VT) may induce VT episodes that disappear within days. METHODS AND RESULTS:A 30-J cathodal shock was delivered to the endocardial left ventricular wall in 15 closed-chest dogs. All dogs had VT during the first day after ablation. Eleve...

journal_title：Circulation

authors： Hauer RN,de Bakker JM,de Wilde AA,Straks W,Vermeulen JT,Janse MJ

更新日期：1991-07-01 00:00:00

abstract：BACKGROUND:Few published data describe long-term survival of dialysis patients undergoing surgical versus percutaneous coronary revascularization in the era of drug-eluting stents (DES). METHODS AND RESULTS:Using United States Renal Data System data, we identified 23 033 dialysis patients who underwent coronary revasc...

journal_title：Circulation

authors： Shroff GR,Solid CA,Herzog CA

更新日期：2013-05-07 00:00:00

abstract：BACKGROUND:The mechanism of ECG changes and arrhythmogenesis in Brugada syndrome (BS) patients is unknown. METHODS AND RESULTS:A BS patient without clinically detected cardiac structural abnormalities underwent cardiac transplantation for intolerable numbers of implantable cardioverter/defibrillator discharges. The pa...

journal_title：Circulation

authors： Coronel R,Casini S,Koopmann TT,Wilms-Schopman FJ,Verkerk AO,de Groot JR,Bhuiyan Z,Bezzina CR,Veldkamp MW,Linnenbank AC,van der Wal AC,Tan HL,Brugada P,Wilde AA,de Bakker JM

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND:Theoretically, the efficacy of continuous warm blood cardioplegia may be improved when administered retrogradely (RCWBC) rather than antegradely (ACWBC) in the setting of acute regional ischemia because of enhanced oxygen and substrate delivery to myocardial tissue distal to an acute coronary artery occlusio...

journal_title：Circulation

authors： Misare BD,Krukenkamp IB,Lazer ZP,Levitsky S

更新日期：1992-11-01 00:00:00

abstract：:Although laparoscopic surgery accounts for >2 million surgical procedures every year, the current preoperative risk scores and guidelines do not adequately assess the risks of laparoscopy. In general, laparoscopic procedures have a lower risk of morbidity and mortality compared with operations requiring a midline lapa...

journal_title：Circulation

authors： Atkinson TM,Giraud GD,Togioka BM,Jones DB,Cigarroa JE

更新日期：2017-02-14 00:00:00

abstract：BACKGROUND:The usefulness of adriamycin (ADR), a potent antitumor antibiotic, is limited by the development of life-threatening cardiomyopathy and congestive heart failure. Subcellular changes leading to heart failure are suggested to be mediated by a drug-induced increase in free radicals and lipid peroxidation. In an...

journal_title：Circulation

authors： Siveski-Iliskovic N,Hill M,Chow DA,Singal PK

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND:Factors leading differentially to the development of isolated diastolic (IDH), systolic-diastolic (SDH), and isolated systolic (ISH) hypertension are poorly understood. We examined the relations of blood pressure (BP) and clinical risk factors to the new onset of the 3 forms of hypertension. METHODS AND RES...

journal_title：Circulation

authors： Franklin SS,Pio JR,Wong ND,Larson MG,Leip EP,Vasan RS,Levy D

更新日期：2005-03-08 00:00:00

abstract：BACKGROUND:The cellular content of cAMP generated by activation of adenylylcyclase (AC) through the beta-adrenergic receptor (betaAR) is a key determinant of a cell's response to catecholamine stimulation. We tested the hypothesis that increased AC content, independently of betaAR number, increases responsiveness to ca...

journal_title：Circulation

authors： Gao MH,Lai NC,Roth DM,Zhou J,Zhu J,Anzai T,Dalton N,Hammond HK

更新日期：1999-03-30 00:00:00

abstract：:Organ donor scarcity has resulted in an increasing number of long-distance cardiac allograft procurements. The effect on short-term (90-day) survival and cardiac function was assessed in a consecutive series of 167 heart transplants performed between April 1981 and July 1988. During that time, total allograft ischemic...

journal_title：Circulation

authors： Pflugfelder PW,Thomson D,Singh NR,Menkis AH,McKenzie FN,Kostuk WJ

更新日期：1989-11-01 00:00:00

abstract：BACKGROUND:Chlamydia pneumoniae (Cp) has been demonstrated in arteries and abdominal aortic aneurysms (AAAs). However, the validity of the methods used is questioned, and antibiotic treatment trials have thus far shown disappointing results. Nevertheless, antibodies against the Cp outer membrane proteins (OMPs) have be...

journal_title：Circulation

authors： Lindholt JS,Støvring J,Østergaard L,Urbonavicius S,Henneberg EW,Honoré B,Vorum H

更新日期：2004-05-04 00:00:00

abstract：BACKGROUND:The estrogen receptor-alpha (ER-alpha) IVS1-401 polymorphism identifies a group of women (approximately 20%) who have augmented effects of hormone replacement therapy (HRT) on levels of HDL cholesterol. This study sought to determine if this augmentation extends to HRT regulation of E-selectin and C-reactive...

journal_title：Circulation

authors： Herrington DM,Howard TD,Brosnihan KB,McDonnell DP,Li X,Hawkins GA,Reboussin DM,Xu J,Zheng SL,Meyers DA,Bleecker ER

更新日期：2002-04-23 00:00:00

abstract：BACKGROUND:Sympathetic activation and respiratory abnormalities may each be implicated in the pathophysiology of congestive heart failure (CHF). Chemoreflexes are an important mechanism regulating both sympathetic drive and breathing. We therefore tested the hypothesis that chemoreflex function is altered in CHF. METH...

journal_title：Circulation

authors： Narkiewicz K,Pesek CA,van de Borne PJ,Kato M,Somers VK

更新日期：1999-07-20 00:00:00

abstract：BACKGROUND:The incidence of perinatal morbidity arising from birth hypoxia or asphyxia has not changed significantly in recent years despite marked improvements in labor management. Perinatal mortality in these circumstances may therefore reflect antenatal compromise and subsequent alteration of the fetal capacity to r...

journal_title：Circulation

authors： Gardner DS,Fowden AL,Giussani DA

更新日期：2002-10-22 00:00:00

abstract：BACKGROUND:Drug-coated balloons (DCBs) are a predominant revascularization therapy for symptomatic femoropopliteal artery disease. Because of the differences in excipients, paclitaxel dose, and coating morphologies, varying clinical outcomes have been observed with different DCBs. We report the results of 2 studies inv...

journal_title：Circulation

authors： Krishnan P,Faries P,Niazi K,Jain A,Sachar R,Bachinsky WB,Cardenas J,Werner M,Brodmann M,Mustapha JA,Mena-Hurtado C,Jaff MR,Holden AH,Lyden SP

更新日期：2017-09-19 00:00:00

abstract：BACKGROUND:Factor Xa plays a central role in the generation of thrombin, making it a novel target for treatment of arterial thrombosis. Fondaparinux is a synthetic factor Xa inhibitor that has been shown to be superior to standard therapies for the prevention of venous thrombosis. We performed a randomized trial to det...

journal_title：Circulation

authors： Mehta SR,Steg PG,Granger CB,Bassand JP,Faxon DP,Weitz JI,Afzal R,Rush B,Peters RJ,Natarajan MK,Velianou JL,Goodhart DM,Labinaz M,Tanguay JF,Fox KA,Yusuf S,ASPIRE Investigators.

更新日期：2005-03-22 00:00:00

abstract：BACKGROUND:Bolus thrombolytic therapy is a simplified means of administering thrombolysis that facilitates rapid time to treatment. TNK-tissue plasminogen activator (TNK-tPA) is a highly fibrin-specific single-bolus thrombolytic agent. METHODS AND RESULTS:In TIMI 10B, 886 patients with acute ST-elevation myocardial in...

journal_title：Circulation

authors： Cannon CP,Gibson CM,McCabe CH,Adgey AA,Schweiger MJ,Sequeira RF,Grollier G,Giugliano RP,Frey M,Mueller HS,Steingart RM,Weaver WD,Van de Werf F,Braunwald E

更新日期：1998-12-22 00:00:00

abstract：:The quantitative approaches to the assessment of regional left ventricular (LV) function described in the preceding paper were applied in a well-defined population of patients with coronary artery disease. Two groups were chosen by electrocardiographic and angiographic criteria: group 1 had infarction and regional wal...

journal_title：Circulation

authors： Parisi AF,Moynihan PF,Folland ED,Feldman CL

更新日期：1981-04-01 00:00:00

abstract：BACKGROUND:Recent studies of beta-adrenergic receptor (beta-AR) subtype signaling in in vitro preparations have raised doubts as to whether the cAMP/protein kinase A (PKA) signaling is activated in the same manner in response to beta2-AR versus beta1-AR stimulation. METHODS AND RESULTS:The present study compared, in t...

journal_title：Circulation

authors： Kuschel M,Zhou YY,Spurgeon HA,Bartel S,Karczewski P,Zhang SJ,Krause EG,Lakatta EG,Xiao RP

更新日期：1999-05-11 00:00:00

abstract：:A technique is described to control recurrent or sustained supraventricular tachycardia associated with rapid ventricular rates following open heart surgery. The technique utilizes a pair of temporarily implanted atrial epicardial wire electrodes to pace the heart. In one group of patients with recurrent atrial flutte...

journal_title：Circulation

authors： Waldo AL,MacLean WA,Karp RB,Kouchoukos NT,James TN

更新日期：1976-08-01 00:00:00

abstract：BACKGROUND:The incidence of pulmonary arterial hypertension secondary to the use of indirect serotinergic agonists such as aminorex and dexfenfluramine led to the "serotonin hypothesis" of pulmonary arterial hypertension; however, the role of serotonin in dexfenfluramine-induced pulmonary arterial hypertension remains ...

journal_title：Circulation

authors： Dempsie Y,Morecroft I,Welsh DJ,MacRitchie NA,Herold N,Loughlin L,Nilsen M,Peacock AJ,Harmar A,Bader M,MacLean MR

更新日期：2008-06-03 00:00:00

abstract：BACKGROUND:The therapeutic effects of nonspecific beta-blockers are limited by vasoconstriction, thus justifying the interest in molecules with ancillary vasodilating properties. Nebivolol is a selective beta1-adrenoreceptor antagonist that releases nitric oxide (NO) through incompletely characterized mechanisms. We id...

journal_title：Circulation

authors： Dessy C,Saliez J,Ghisdal P,Daneau G,Lobysheva II,Frérart F,Belge C,Jnaoui K,Noirhomme P,Feron O,Balligand JL

更新日期：2005-08-23 00:00:00